| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junli Du, Chao Chen, Jie Che. Cirsilineol improves anesthesia/surgery-induced postoperative cognitive dysfunction through attenuating oxidative stress and modulating microglia M1/M2 polarization. PeerJ. vol 12. 2024-11-19. PMID:39559329. |
cirsilineol improves anesthesia/surgery-induced postoperative cognitive dysfunction through attenuating oxidative stress and modulating microglia m1/m2 polarization. |
2024-11-19 |
2024-11-22 |
Not clear |
| Tao Zong, Na Li, Fubing Han, Junru Liu, Mingru Deng, Vincent Li, Meng Zhang, Yu Zhou, Ming Y. Microglial depletion rescues spatial memory impairment caused by LPS administration in adult mice. PeerJ. vol 12. 2024-11-19. PMID:39559328. |
they also suggest that targeting microglia may be a potential approach to treating neuroinflammation-associated cognitive dysfunction seen in neurodegenerative diseases. |
2024-11-19 |
2024-11-22 |
mouse |
| Yang Hu, Honggang Qi, Jiurong Yang, Feiyu Wang, Xintao Peng, Xiang Chen, Xinjian Zh. Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 135. 2024-11-15. PMID:39547095. |
however, activated microglia can excessively prune synapses, exacerbating neuronal damage and cognitive dysfunction following epilepsy. |
2024-11-15 |
2024-11-18 |
Not clear |
| Jie Sun, Daoyun Le. CD200-CD200R Pathway: A Regulator of Microglial Polarization in Postoperative Cognitive Dysfunction. Journal of inflammation research. vol 17. 2024-11-14. PMID:39530002. |
as the resident immune cells of the brain, changes in the functional state of microglia play a crucial role in the progression of postoperative cognitive dysfunction. |
2024-11-14 |
2024-11-17 |
Not clear |
| Huiwen Kang, Danyang Huang, Wei Zhang, JingYu Wang, Ziyan Liu, Ziyan Wang, Guangyu Jiang, Ai Ga. Pulmonary Flora-Derived Lipopolysaccharide Mediates Lung-Brain Axis through Activating Microglia Involved in Polystyrene Microplastic-Induced Cognitive Dysfunction. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-11-05. PMID:39499619. |
pulmonary flora-derived lipopolysaccharide mediates lung-brain axis through activating microglia involved in polystyrene microplastic-induced cognitive dysfunction. |
2024-11-05 |
2024-11-08 |
mouse |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
[resistance exercise regulates hippocampal microglia polarization through trem2/nf-κb/stat3 signal pathway to improve cognitive dysfunction in t2dm mice]. |
2024-10-29 |
2024-10-31 |
mouse |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the above results suggest that re can improve cognitive dysfunction in t2dm mice, and its mechanism may be related to regulating microglia polarization via trem2/nf-κb/stat3 signaling pathway. |
2024-10-29 |
2024-10-31 |
mouse |
| Yan Zhang, Ji-Cong Chen, Jia-Hao Zheng, Ying-Zhe Cheng, Wei-Pin Weng, Rong-Ling Zhong, Sheng-Lu Sun, Yu-Sheng Shi, Xiao-Dong Pa. Pterosin B improves cognitive dysfunction by promoting microglia M1/M2 polarization through inhibiting Klf5/Parp14 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 135. 2024-10-16. PMID:39413455. |
pterosin b improves cognitive dysfunction by promoting microglia m1/m2 polarization through inhibiting klf5/parp14 pathway. |
2024-10-16 |
2024-10-19 |
Not clear |
| Yang Liu, Xiaokang Meng, Changfa Tang, Lan Zheng, Kun Tao, Wen Gu. Aerobic exercise modulates RIPK1-mediated MAP3K5/JNK and NF-κB pathways to suppress microglia activation and neuroinflammation in the hippocampus of D-gal-induced accelerated aging mice. Physiology & behavior. vol 286. 2024-08-25. PMID:39181380. |
microglia activation-induced neuroinflammation is a risk factor for cognitive dysfunction in the hippocampus during the early stages of neurodegenerative diseases. |
2024-08-25 |
2024-08-28 |
mouse |
| Wanqing Zheng, Genghua Xu, Zhengwei Lue, Xinyu Zhou, Ning Wang, Yun Ma, Wenyue Yuan, Lushan Yu, Danyan Zhu, Xiangnan Zhan. Nervonic acid protects against oligodendrocytes injury following chronic cerebral hypoperfusion in mice. European journal of pharmacology. 2024-08-25. PMID:39182543. |
chronic cerebral hypoperfusion (cch) has been acknowledged as a potential contributor to cognitive dysfunction and brain injury, causing progressive demyelination of white matter, oligodendrocytes apoptosis and microglia activation. |
2024-08-25 |
2024-08-28 |
mouse |
| Yujia Liu, Xue Han, Yan Su, Yiming Zhou, Minhui Xu, Jiyan Xu, Zhengliang Ma, Xiaoping Gu, Tianjiao Xi. Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice. Neural regeneration research. 2024-07-12. PMID:38993135. |
recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via m2 microglia polarization in postoperative cognitive dysfunction mice. |
2024-07-12 |
2024-07-14 |
mouse |
| Kimberly S Williams, Jaimie A Seawell, Viktoriya Zhuravleva, Kersten Pierre, Rick B Meeke. Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV. Journal of neurovirology. 2024-05-31. PMID:38822196. |
neural damage due to inflammatory activation of macrophages and microglia is a consequence of hiv infection that leads to cognitive dysfunction. |
2024-05-31 |
2024-06-02 |
Not clear |
| Xiwen Ou, Hongwei Wang, Yubin Shen, Weiyu Zhang, Jinyuan Sun, Song Li. SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via Wnt/β-catenin pathway. European journal of pharmacology. 2024-05-18. PMID:38762158. |
senp1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/β-catenin pathway. |
2024-05-18 |
2024-05-27 |
mouse |
| Hong-Yu Dai, Ze-Xin Zhang, Cheng Tan, Xian Xian, Dong Ji, Jing Yang, Jie Sun, Hao Ya. Propionic acid ameliorates cognitive function through immunomodulatory effects on Th17 cells in perioperative neurocognitive disorders. Heliyon. vol 10. issue 8. 2024-05-03. PMID:38699705. |
the purpose of this study was to determine whether microglia and short-chain fatty acids were involved in cognitive dysfunction in aged rats. |
2024-05-03 |
2024-05-05 |
rat |
| Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Rodney M Ritzel, Alan I Faden, Bogdan A Stoic. Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. Journal of neuroinflammation. vol 21. issue 1. 2024-04-30. PMID:38685031. |
interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. |
2024-04-30 |
2024-05-03 |
mouse |
| Qi-Cheng Lin, Jiao Wang, Xin-Lin Wang, Chi Pan, Shao-Wu Jin, Steven Char, Yuan-Xiang Tao, Hong Cao, Jun L. Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice. Biochimica et biophysica acta. Molecular basis of disease. 2024-03-25. PMID:38527593. |
this study aimed to figure out whether hdac6 could regulate nlrp3-induced pyroptosis by modulating the functions of hsp70 and hsp90 in microglia to participate in postoperative cognitive dysfunction in aged mice. |
2024-03-25 |
2024-03-28 |
mouse |
| Guopeng Chen, Yuhui Zhang, Ruiling Li, Liuyin Jin, Keke Hao, Jingtong Rong, Hao Duan, Yiwei Du, Lihua Yao, Dan Xiang, Zhongchun Li. Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity. Neurobiology of stress. vol 30. 2024-03-25. PMID:38524250. |
maternal rats subjected to ms developed depression-like behavior and cognitive dysfunction together with evidence of significant neuroinflammation including microglia activation, neuronal apoptosis, and impaired synaptic plasticity. |
2024-03-25 |
2024-03-27 |
rat |
| Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Gua. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481801. |
the activation of nlrp3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (pocd) induced by sevoflurane. |
2024-03-14 |
2024-03-16 |
mouse |
| Zhan Zhou, Ying Yang, Yi Wei, Yubo Xi. Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway. Neurochemical research. 2024-03-13. PMID:38472553. |
these results demonstrate that remimazolam can up-regulate α7nachr, cyto-nrf2, ho-1, and cognitive-related (creb, bdnf, psd95) protein expressions, suppress m1 microglia, ameliorate neuroinflammation or systemic inflammation, and reverse cognitive dysfunction. |
2024-03-13 |
2024-03-15 |
rat |
| Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chan. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-03-01. PMID:38427092. |
complement c3 from astrocytes plays significant roles in sustained activation of microglia and cognitive dysfunctions triggered by systemic inflammation after laparotomy in adult male mice. |
2024-03-01 |
2024-03-03 |
mouse |