| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chan. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-03-01. PMID:38427092. |
although we have demonstrated that anti-inflammatory intervention successfully attenuated cognitive dysfunction by preventing increase of cytokines and activation of microglia, how sustained activation of microglia and cognitive dysfunction occur is still a mystery. |
2024-03-01 |
2024-03-03 |
mouse |
| Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chan. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-03-01. PMID:38427092. |
in this study, we investigated the role of c3 in mediating activation of microglia and cognitive dysfunction by using laparotomy in adult male mouse only as the experimental model of systemic inflammation and aav9-c3shrna. |
2024-03-01 |
2024-03-03 |
mouse |
| Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chan. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-03-01. PMID:38427092. |
furthermore, inhibition of c3 by aav9-c3shrna prevented synaptic engulfment by microglia and attenuated cognitive dysfunctions after laparotomy. |
2024-03-01 |
2024-03-03 |
mouse |
| Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chan. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-03-01. PMID:38427092. |
current findings demonstrated that c3 plays significant roles in sustained activation of microglia and cognitive dysfunctions, which suggests that c3 is the valuable molecule target to attenuate in neurological conditions characterised by neuroinflammation and cognitive dysfunction. |
2024-03-01 |
2024-03-03 |
mouse |
| Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M Rocha, Konstantinos Chioti. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 2785. 2024-03-01. PMID:38427196. |
alzheimer's disease (ad) - the most common neurodegenerative disorder - is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells, i.e., astrocytes and microglia, and neuroinflammatory response, leading to neurodegeneration and cognitive dysfunction. |
2024-03-01 |
2024-03-03 |
Not clear |
| Wenwen Xu, Xinyu Wang, Xunyao Hou, Yan Yang, Rongrong Ma, Renjun Lv, Qingqing Yi. The role of microglia in the pathogenesis of diabetic-associated cognitive dysfunction. Frontiers in endocrinology. vol 14. 2024-01-26. PMID:38274227. |
the role of microglia in the pathogenesis of diabetic-associated cognitive dysfunction. |
2024-01-26 |
2024-01-28 |
Not clear |
| Siyi Han, Xiaoman Yuan, Fengtian Zhao, Anne Manyande, Feng Gao, Jie Wang, Wen Zhang, Xuebi Tia. Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024-01-06. PMID:38183431. |
activation of lxrs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via pi3k/akt pathway. |
2024-01-06 |
2024-01-09 |
Not clear |
| Xiaoxiang Tan, Hongyu Ma, Xinqi Guo, Meng Mao, Lili Qiu, Hongyu Dai, Yuchen Dai, Jinyuan Cao, Huijie Ma, Jie Su. Disinhibition of hippocampal parvalbumin interneurons on pyramidal neurons participates in LPS-induced cognitive dysfunction. Neuroscience letters. 2023-12-30. PMID:38159880. |
multiple researches revealed that neuroinflammation together with microglia activation and parvalbumin (pv) interneurons participated in the pathogenesis of cognitive dysfunction. |
2023-12-30 |
2024-01-05 |
Not clear |
| Xiaoxiang Tan, Hongyu Ma, Xinqi Guo, Meng Mao, Lili Qiu, Hongyu Dai, Yuchen Dai, Jinyuan Cao, Huijie Ma, Jie Su. Disinhibition of hippocampal parvalbumin interneurons on pyramidal neurons participates in LPS-induced cognitive dysfunction. Neuroscience letters. 2023-12-30. PMID:38159880. |
this study aimed to determine whether microglia activation would induce pv interneurons impairment and py neurons disinhibition, and as a result, promote cognitive dysfunction after lipopolysaccharide (lps) challenge. |
2023-12-30 |
2024-01-05 |
Not clear |
| Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M Hatch, Ming Zhang, Li Che. Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia. Immunity & ageing : I & A. vol 20. issue 1. 2023-11-18. PMID:37978517. |
exercise improves cognitive dysfunction and neuroinflammation in mice through histone h3 lactylation in microglia. |
2023-11-18 |
2023-11-20 |
mouse |
| Xiang Gao, Chuantao Lin, Yebin Feng, Yi You, Zhe Jin, Mengyun Li, Yufeng Zhou, Kai Che. Akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the TLR2/4 signaling. Biochimica et biophysica acta. Molecular cell research. 2023-11-15. PMID:37967793. |
akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the tlr2/4 signaling. |
2023-11-15 |
2023-11-20 |
mouse |
| Yanchang Yang, Wenxin Hang, Jun Li, Tiantian Liu, Yuhan Hu, Fuquan Fang, Dandan Yan, Patrick M McQuillan, Mi Wang, Zhiyong H. Effect of General Anesthetic Agents on Microglia. Aging and disease. 2023-11-14. PMID:37962460. |
microglial activation by gaas induces anti-inflammatory and pro-inflammatory effects in microglia, suggesting that gaas play a dual role in the mechanism of postoperative cognitive dysfunction. |
2023-11-14 |
2023-11-20 |
Not clear |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jaclyn B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-11-03. PMID:37919439. |
author correction: microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in huntington's disease. |
2023-11-03 |
2023-11-08 |
Not clear |
| Xue Yang, Jianjiang Wu, Hu Cheng, Siyu Chen, Jiang Wan. DEXMEDETOMIDINE AMELIORATES ACUTE BRAIN INJURY INDUCED BY MYOCARDIAL ISCHEMIA-REPERFUSION VIA UPREGULATING THE HIF-1 PATHWAY. Shock (Augusta, Ga.). vol 60. issue 5. 2023-11-03. PMID:37647083. |
the impact of dex on brain injury elicited by myocardial ir was assessed via elisa for inflammatory factors in serum and brain; evans blue for blood-brain barrier permeability; hematoxylin-eosin staining for pathological injury in brain; immunofluorescence for microglia activation in brain; morris water maze for cognitive dysfunction; western blot for the expression level of hif-1α, occludin, cleaved caspase-3, nf-κb p65, and p-nf-κb p65 in the brain. |
2023-11-03 |
2023-11-08 |
mouse |
| Yansong Li, Tao Jiang, Mengyu Du, Shuxuan He, Ning Huang, Bo Cheng, Chaoying Yan, Wenxin Tang, Wei Gao, Hongyan Guo, Qiao Li, Qiang Wan. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Experimental & molecular medicine. 2023-11-01. PMID:37907746. |
ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. |
2023-11-01 |
2023-11-08 |
mouse |
| Yansong Li, Tao Jiang, Mengyu Du, Shuxuan He, Ning Huang, Bo Cheng, Chaoying Yan, Wenxin Tang, Wei Gao, Hongyan Guo, Qiao Li, Qiang Wan. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Experimental & molecular medicine. 2023-11-01. PMID:37907746. |
our findings demonstrated that enhanced endogenous fructose metabolism in microglia plays a dominant role in diabetes-associated cognitive dysfunction and could become a potential target for dacd. |
2023-11-01 |
2023-11-08 |
mouse |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jacyln B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-10-09. PMID:37814059. |
microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in huntington's disease. |
2023-10-09 |
2023-10-15 |
Not clear |
| Fang Qiu, Yueming Liu, Yang Liu, Zhuyun Zhao, Lile Zhou, Pengfei Chen, Yunbo Du, Yanmei Wang, Huimin Sun, Changchun Zeng, Xiaokang Wang, Yuqiang Liu, Haobo Pan, Changneng K. CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. Neuromolecular medicine. 2023-10-05. PMID:37796401. |
these findings suggest that cd137l upregulation in activated microglia critically contributes to neuroinflammation, anxiety-like behavior, and cognitive dysfunction in the mouse model of lps-induced sepsis. |
2023-10-05 |
2023-10-07 |
mouse |
| Yi-Huan Guan, Ling-Jing Zhang, Shi-Ya Wang, Ya-Dan Deng, Hong-Su Zhou, Dong-Qing Chen, Lan-Chun Zhan. The role of microglia in Alzheimer's disease and progress of treatment. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786418. |
cognitive dysfunction occurs when activated microglia induce an increase in beta oligomers, promoting the production of pro-inflammatory factors that alter the shape, composition, and density of synapses. |
2023-10-03 |
2023-10-07 |
Not clear |
| Heike Mrowetz, Mohamed H Kotob, Jennifer Forster, Iren Aydin, Michael Stefan Unger, Jana Lubec, Ahmed M Hussein, Jovana Malikovic, Daniel Daba Feyissa, Volker Korz, Harald Höger, Gert Lubec, Ludwig Aigne. Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600518. |
recently, leukotrienes (lts), i.e., small lipid mediators of inflammation produced by microglia along aging and neurodegeneration, got in the focus of geroscience as they might determine cognitive dysfunctions in aging. |
2023-08-21 |
2023-09-07 |
Not clear |