| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sai Liu, Long Chen, Jinran Li, Yuan Sun, Yue Xu, Zhaoxing Li, Zheying Zhu, Xinuo L. Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569347. |
our current study reveals that as, when administered (40 mg/kg) in vivo, can mitigate cognitive dysfunction and attenuate neuroinflammation by inhibiting the activation of microglia and proinflammatory factors in aβ |
2023-08-12 |
2023-08-16 |
Not clear |
| Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Rodney M Ritzel, Alan I Faden, Bogdan A Stoic. Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546932. |
interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. |
2023-08-07 |
2023-08-14 |
mouse |
| Yun Qiao, Huiru Li, Yan Li, Enboer Su, Zhe Wang, Limuge Che, Yiri D. Study on the Mechanism of Eerdun Wurile's Effects on Post-operative Cognitive Dysfunction by the TLR4/NF-κB Pathway. Molecular neurobiology. 2023-08-07. PMID:37548853. |
intracerebroventricular injection of lipopolysaccharide combined with nephrectomy induced cognitive dysfunction in mice, stimulated tlr4/nf-κb and microglia, and promoted the secretion of murine tnf-α, il-1β, and il-6. |
2023-08-07 |
2023-08-14 |
mouse |
| Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
aβ monomers transform into aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. |
2023-07-05 |
2023-08-14 |
mouse |
| Hongwei Wang, Xu Wang, Yubin Shen, Yanmin Wang, Tianyun Yang, Jinyuan Sun, Song Li. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. International immunopharmacology. vol 119. 2023-05-03. PMID:37137262. |
inflammation of microglia induced by cih, plays a vital role in osas-associated cognitive dysfunction. |
2023-05-03 |
2023-08-14 |
mouse |
| Danielle Kerkhofs, Robin Helgers, Denise Hermes, Hellen P J Steinbusch, Helma Van Essen, Peter Leenders, Jos Prickaerts, Julie Staals, Erik A Biessen, Robert J Van Oostenbrugge, Sébastien Foulquie. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of hypertension. 2023-04-18. PMID:37071429. |
amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. |
2023-04-18 |
2023-08-14 |
mouse |
| Danielle Kerkhofs, Robin Helgers, Denise Hermes, Hellen P J Steinbusch, Helma Van Essen, Peter Leenders, Jos Prickaerts, Julie Staals, Erik A Biessen, Robert J Van Oostenbrugge, Sébastien Foulquie. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of hypertension. 2023-04-18. PMID:37071429. |
we aimed to study the ability of amlopidine to alleviate microglia inflammation, and slow down cognitive dysfunction in aged hypertensive mice. |
2023-04-18 |
2023-08-14 |
mouse |
| Mengran Zhang, Huaqing Chen, Wenlong Zhang, Yan Liu, Liuyan Ding, Junwei Gong, Runfang Ma, Shaohui Zheng, Yunlong Zhan. Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-02-17. PMID:36799538. |
neuroinflammation, for which microglia are the predominant contributors, is a significant risk factor for cognitive dysfunction. |
2023-02-17 |
2023-08-14 |
mouse |
| Mai M Anwar, Esra Özkan, Narges Shomalizadeh, Selin Sapancı, Ceyda Özler, Judy Kesibi, Yasemin Gürsoy-Özdemi. Assessing the role of primary healthy microglia and gap junction blocker in hindering Alzheimer's disease neuroinflammatory type: Early approaches for therapeutic intervention. Frontiers in neuroscience. vol 16. 2023-01-27. PMID:36704003. |
the localized administration of primary healthy microglia (phm) is suggested to play a role in mitigating ad hallmark depositions and associated cognitive dysfunction. |
2023-01-27 |
2023-08-14 |
rat |
| Xiaoxiang Tan, Jiajia Wang, Juan Yao, Jing Yuan, Yuchen Dai, Menghan Sun, Tianhao Zhang, Jiaojiao Yang, Wenlan Cai, Lili Qiu, Jie Su. Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway. Neuroscience letters. 2023-01-07. PMID:36608926. |
microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway. |
2023-01-07 |
2023-08-14 |
mouse |
| Xiaoxiang Tan, Jiajia Wang, Juan Yao, Jing Yuan, Yuchen Dai, Menghan Sun, Tianhao Zhang, Jiaojiao Yang, Wenlan Cai, Lili Qiu, Jie Su. Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway. Neuroscience letters. 2023-01-07. PMID:36608926. |
the purpose of this study was to determine whether microglia and complement system were involved in cognitive dysfunction in aged mice. |
2023-01-07 |
2023-08-14 |
mouse |
| Ye Tian, Lin Wang, Xiaojing Fan, Hui Zhang, Zhiwei Dong, Tianzhu Ta. β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 signaling pathway. PloS one. vol 18. issue 1. 2023-01-06. PMID:36608000. |
β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through sirt1/nrf2 signaling pathway. |
2023-01-06 |
2023-08-14 |
mouse |
| Ya Hui, Zhiqiang Xu, Jiaxiu Li, Liuyu Kuang, Yuanmei Zhong, Yunyun Tang, Junjie Wei, Huimin Zhou, Tianpeng Zhen. Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization. Metabolism: clinical and experimental. 2022-10-27. PMID:36302455. |
nonenzymatic function of dpp4 promotes diabetes-associated cognitive dysfunction through igf-2r/pka/sp1/erp29/ip3r2 pathway-mediated impairment of treg function and m1 microglia polarization. |
2022-10-27 |
2023-08-14 |
Not clear |
| Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Ya. Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation. International immunopharmacology. vol 110. 2022-08-18. PMID:35978505. |
overactivation of microglia induced neuroinflammation is well acknowledged to contribute to the impaired neurogenesis in pathologies of these diseases and then leading to cognitive dysfunction. |
2022-08-18 |
2023-08-14 |
mouse |
| Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Ya. Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation. International immunopharmacology. vol 110. 2022-08-18. PMID:35978505. |
taken together, these results suggested under lps induced neuroinflammation, the h3r antagonist thioperamide inhibited microglia activity and inflammatory response, and ameliorated impairment of neurogenesis and cognitive dysfunction via enhancing histamine release. |
2022-08-18 |
2023-08-14 |
mouse |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the results showed that carnosol can improve the cognitive dysfunction and reduce neuroinflammation in aged rats induced by sev; carnosol can reduce the activation of microglia and inhibit neuronal apoptosis in aged rats induced by sev; carnosol can phosphorylate p65 and nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha regulates the nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2022-07-05 |
2023-08-14 |
rat |
| Yun Teng, Jingyao Mu, Fangyi Xu, Xiangcheng Zhang, Mukesh K Sriwastva, Qiaohong M Liu, Xiaohong Li, Chao Lei, Kumaran Sundaram, Xin Hu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Eric C Rouchka, Xiang Zhang, Jun Yan, Michael L Merchant, Huang-Ge Zhan. Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death. Cell host & microbe. 2022-06-02. PMID:35654045. |
gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death. |
2022-06-02 |
2023-08-14 |
mouse |
| Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N Madhu, Dinesh Upadhya, Bing Shuai, Ashok K Shett. Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. Frontiers in immunology. vol 13. 2022-05-16. PMID:35572589. |
previous studies in a rat model have revealed that cognitive dysfunction in chronic gwi is associated with neuroinflammation, typified by astrocyte hypertrophy, activated microglia, and enhanced proinflammatory cytokine levels. |
2022-05-16 |
2023-08-13 |
mouse |
| Jonas J Nehe. InFlamiN' the brain in Alzheimer's disease. Immunity. vol 55. issue 5. 2022-05-11. PMID:35545031. |
now demonstrate that type i ifns may drive cognitive dysfunction through acting not only on microglia but, surprisingly, also on neurons. |
2022-05-11 |
2023-08-13 |
Not clear |
| Liu Yang, Zhen Li, Zujin Xu, Bin Zhang, Anpeng Liu, Feng Zheng, Jia Zha. Protective effects of cannabinoid type 2 receptor against microglia overactivation and neuronal pyroptosis in sepsis-associated encephalopathy. Neuroscience. 2022-04-23. PMID:35460837. |
clp could induce microglia hyperactivation and neuronal pyroptosis, aggravating brain tissue destruction and cognitive dysfunction. |
2022-04-23 |
2023-08-13 |
Not clear |