| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M Hatch, Ming Zhang, Li Che. Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia. Immunity & ageing : I & A. vol 20. issue 1. 2023-11-18. PMID:37978517. |
exercise improves cognitive dysfunction and neuroinflammation in mice through histone h3 lactylation in microglia. |
2023-11-18 |
2023-11-20 |
mouse |
| Xiang Gao, Chuantao Lin, Yebin Feng, Yi You, Zhe Jin, Mengyun Li, Yufeng Zhou, Kai Che. Akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the TLR2/4 signaling. Biochimica et biophysica acta. Molecular cell research. 2023-11-15. PMID:37967793. |
akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the tlr2/4 signaling. |
2023-11-15 |
2023-11-20 |
mouse |
| Yanchang Yang, Wenxin Hang, Jun Li, Tiantian Liu, Yuhan Hu, Fuquan Fang, Dandan Yan, Patrick M McQuillan, Mi Wang, Zhiyong H. Effect of General Anesthetic Agents on Microglia. Aging and disease. 2023-11-14. PMID:37962460. |
microglial activation by gaas induces anti-inflammatory and pro-inflammatory effects in microglia, suggesting that gaas play a dual role in the mechanism of postoperative cognitive dysfunction. |
2023-11-14 |
2023-11-20 |
Not clear |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jaclyn B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-11-03. PMID:37919439. |
author correction: microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in huntington's disease. |
2023-11-03 |
2023-11-08 |
Not clear |
| Xue Yang, Jianjiang Wu, Hu Cheng, Siyu Chen, Jiang Wan. DEXMEDETOMIDINE AMELIORATES ACUTE BRAIN INJURY INDUCED BY MYOCARDIAL ISCHEMIA-REPERFUSION VIA UPREGULATING THE HIF-1 PATHWAY. Shock (Augusta, Ga.). vol 60. issue 5. 2023-11-03. PMID:37647083. |
the impact of dex on brain injury elicited by myocardial ir was assessed via elisa for inflammatory factors in serum and brain; evans blue for blood-brain barrier permeability; hematoxylin-eosin staining for pathological injury in brain; immunofluorescence for microglia activation in brain; morris water maze for cognitive dysfunction; western blot for the expression level of hif-1α, occludin, cleaved caspase-3, nf-κb p65, and p-nf-κb p65 in the brain. |
2023-11-03 |
2023-11-08 |
mouse |
| Yansong Li, Tao Jiang, Mengyu Du, Shuxuan He, Ning Huang, Bo Cheng, Chaoying Yan, Wenxin Tang, Wei Gao, Hongyan Guo, Qiao Li, Qiang Wan. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Experimental & molecular medicine. 2023-11-01. PMID:37907746. |
ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. |
2023-11-01 |
2023-11-08 |
mouse |
| Yansong Li, Tao Jiang, Mengyu Du, Shuxuan He, Ning Huang, Bo Cheng, Chaoying Yan, Wenxin Tang, Wei Gao, Hongyan Guo, Qiao Li, Qiang Wan. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Experimental & molecular medicine. 2023-11-01. PMID:37907746. |
our findings demonstrated that enhanced endogenous fructose metabolism in microglia plays a dominant role in diabetes-associated cognitive dysfunction and could become a potential target for dacd. |
2023-11-01 |
2023-11-08 |
mouse |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jacyln B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-10-09. PMID:37814059. |
microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in huntington's disease. |
2023-10-09 |
2023-10-15 |
Not clear |
| Fang Qiu, Yueming Liu, Yang Liu, Zhuyun Zhao, Lile Zhou, Pengfei Chen, Yunbo Du, Yanmei Wang, Huimin Sun, Changchun Zeng, Xiaokang Wang, Yuqiang Liu, Haobo Pan, Changneng K. CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. Neuromolecular medicine. 2023-10-05. PMID:37796401. |
these findings suggest that cd137l upregulation in activated microglia critically contributes to neuroinflammation, anxiety-like behavior, and cognitive dysfunction in the mouse model of lps-induced sepsis. |
2023-10-05 |
2023-10-07 |
mouse |
| Yi-Huan Guan, Ling-Jing Zhang, Shi-Ya Wang, Ya-Dan Deng, Hong-Su Zhou, Dong-Qing Chen, Lan-Chun Zhan. The role of microglia in Alzheimer's disease and progress of treatment. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786418. |
cognitive dysfunction occurs when activated microglia induce an increase in beta oligomers, promoting the production of pro-inflammatory factors that alter the shape, composition, and density of synapses. |
2023-10-03 |
2023-10-07 |
Not clear |
| Heike Mrowetz, Mohamed H Kotob, Jennifer Forster, Iren Aydin, Michael Stefan Unger, Jana Lubec, Ahmed M Hussein, Jovana Malikovic, Daniel Daba Feyissa, Volker Korz, Harald Höger, Gert Lubec, Ludwig Aigne. Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600518. |
recently, leukotrienes (lts), i.e., small lipid mediators of inflammation produced by microglia along aging and neurodegeneration, got in the focus of geroscience as they might determine cognitive dysfunctions in aging. |
2023-08-21 |
2023-09-07 |
Not clear |
| Sai Liu, Long Chen, Jinran Li, Yuan Sun, Yue Xu, Zhaoxing Li, Zheying Zhu, Xinuo L. Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569347. |
our current study reveals that as, when administered (40 mg/kg) in vivo, can mitigate cognitive dysfunction and attenuate neuroinflammation by inhibiting the activation of microglia and proinflammatory factors in aβ |
2023-08-12 |
2023-08-16 |
Not clear |
| Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Rodney M Ritzel, Alan I Faden, Bogdan A Stoic. Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546932. |
interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. |
2023-08-07 |
2023-08-14 |
mouse |
| Yun Qiao, Huiru Li, Yan Li, Enboer Su, Zhe Wang, Limuge Che, Yiri D. Study on the Mechanism of Eerdun Wurile's Effects on Post-operative Cognitive Dysfunction by the TLR4/NF-κB Pathway. Molecular neurobiology. 2023-08-07. PMID:37548853. |
intracerebroventricular injection of lipopolysaccharide combined with nephrectomy induced cognitive dysfunction in mice, stimulated tlr4/nf-κb and microglia, and promoted the secretion of murine tnf-α, il-1β, and il-6. |
2023-08-07 |
2023-08-14 |
mouse |
| Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
aβ monomers transform into aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. |
2023-07-05 |
2023-08-14 |
mouse |
| Hongwei Wang, Xu Wang, Yubin Shen, Yanmin Wang, Tianyun Yang, Jinyuan Sun, Song Li. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. International immunopharmacology. vol 119. 2023-05-03. PMID:37137262. |
inflammation of microglia induced by cih, plays a vital role in osas-associated cognitive dysfunction. |
2023-05-03 |
2023-08-14 |
mouse |
| Danielle Kerkhofs, Robin Helgers, Denise Hermes, Hellen P J Steinbusch, Helma Van Essen, Peter Leenders, Jos Prickaerts, Julie Staals, Erik A Biessen, Robert J Van Oostenbrugge, Sébastien Foulquie. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of hypertension. 2023-04-18. PMID:37071429. |
amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. |
2023-04-18 |
2023-08-14 |
mouse |
| Danielle Kerkhofs, Robin Helgers, Denise Hermes, Hellen P J Steinbusch, Helma Van Essen, Peter Leenders, Jos Prickaerts, Julie Staals, Erik A Biessen, Robert J Van Oostenbrugge, Sébastien Foulquie. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of hypertension. 2023-04-18. PMID:37071429. |
we aimed to study the ability of amlopidine to alleviate microglia inflammation, and slow down cognitive dysfunction in aged hypertensive mice. |
2023-04-18 |
2023-08-14 |
mouse |
| Mengran Zhang, Huaqing Chen, Wenlong Zhang, Yan Liu, Liuyan Ding, Junwei Gong, Runfang Ma, Shaohui Zheng, Yunlong Zhan. Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-02-17. PMID:36799538. |
neuroinflammation, for which microglia are the predominant contributors, is a significant risk factor for cognitive dysfunction. |
2023-02-17 |
2023-08-14 |
mouse |
| Mai M Anwar, Esra Özkan, Narges Shomalizadeh, Selin Sapancı, Ceyda Özler, Judy Kesibi, Yasemin Gürsoy-Özdemi. Assessing the role of primary healthy microglia and gap junction blocker in hindering Alzheimer's disease neuroinflammatory type: Early approaches for therapeutic intervention. Frontiers in neuroscience. vol 16. 2023-01-27. PMID:36704003. |
the localized administration of primary healthy microglia (phm) is suggested to play a role in mitigating ad hallmark depositions and associated cognitive dysfunction. |
2023-01-27 |
2023-08-14 |
rat |