| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kun Ni, Jixiang Zhu, Xuan Xu, Yue Liu, Shuai Yang, Yulin Huang, Rui Xu, Li Jiang, Juan Zhang, Wei Zhang, Zhengliang M. Hippocampal Activated Microglia May Contribute to Blood-Brain Barrier Impairment and Cognitive Dysfunction in Post-Traumatic Stress Disorder-Like Rats. Journal of molecular neuroscience : MN. 2022-02-15. PMID:35167061. |
hippocampal activated microglia may contribute to blood-brain barrier impairment and cognitive dysfunction in post-traumatic stress disorder-like rats. |
2022-02-15 |
2023-08-13 |
rat |
| Kun Ni, Jixiang Zhu, Xuan Xu, Yue Liu, Shuai Yang, Yulin Huang, Rui Xu, Li Jiang, Juan Zhang, Wei Zhang, Zhengliang M. Hippocampal Activated Microglia May Contribute to Blood-Brain Barrier Impairment and Cognitive Dysfunction in Post-Traumatic Stress Disorder-Like Rats. Journal of molecular neuroscience : MN. 2022-02-15. PMID:35167061. |
nevertheless, it is unclear whether microglia activation and bbb injury involve in ptsd-associated cognitive dysfunction. |
2022-02-15 |
2023-08-13 |
rat |
| Yi-Sha Guo, Mei Yuan, Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Xia B. Effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment. Neurochemistry international. 2022-02-05. PMID:35121010. |
this study was designed to explore the beneficial effects of enriched environment (ee) on white matter recovery and cognitive dysfunction after stroke, and further explore the potential mechanism of ee on white matter recovery from the perspective of microglia and microglia-mediated neuroinflammation. |
2022-02-05 |
2023-08-13 |
rat |
| Qing Tian, Hui-Ling Tang, Yi-Yun Tang, Ping Zhang, Xuan Kang, Wei Zou, Xiao-Qing Tan. Hydrogen Sulfide Attenuates the Cognitive Dysfunction in Parkinson's Disease Rats via Promoting Hippocampal Microglia M2 Polarization by Enhancement of Hippocampal Warburg Effect. Oxidative medicine and cellular longevity. vol 2022. 2022-01-14. PMID:35028004. |
hydrogen sulfide attenuates the cognitive dysfunction in parkinson's disease rats via promoting hippocampal microglia m2 polarization by enhancement of hippocampal warburg effect. |
2022-01-14 |
2023-08-13 |
rat |
| Blake R McAlpin, Rajasekaran Mahalingam, Anand K Singh, Shruti Dharmaraj, Taylor T Chrisikos, Nabila Boukelmoune, Annemieke Kavelaars, Cobi J Heijne. HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics. vol 12. issue 2. 2022-01-03. PMID:34976203. |
hdac6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. |
2022-01-03 |
2023-08-13 |
Not clear |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Yi Li, Lixia DU, Xiaofeng Guo, Xijing Zhan. [Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809734. |
conclusion the expression level of α7nachr protein in hippocampus of sae male mice is significantly lower than that of sae female mice, and the proportion of m2 microglia is relatively lower, which lead to the cognitive dysfunction of sae male mice. |
2021-11-24 |
2023-08-13 |
mouse |
| Xianshengjie Lang, Na Zhao, Qiang He, Xun Li, Xuejiao Li, Chuanning Sun, Xianliang Zhan. Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM. Brain research bulletin. vol 165. 2021-10-26. PMID:32987101. |
we found that treadmill exercise for 8 weeks can significantly improve the cognitive dysfunction, alleviate activation of proinflammatory microglia m1 (iba1 labeling) in the hippocampus of t2dm mice, and reduce the levels of proinflammatory factors il-1β, il-6, tnf-α, increase the expression levels of anti-inflammatory factors il-10, tgf-β1, and promote the release of bdnf. |
2021-10-26 |
2023-08-13 |
mouse |
| Li Lu, Hailin Wang, Xuan Liu, Liping Tan, Xiaoyue Qiao, Jiali Ni, Yang Sun, Jun Liang, Yayi Hou, Huan Do. Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway. Journal of neuroinflammation. vol 18. issue 1. 2021-10-22. PMID:34645459. |
in this study, we explored the role of microglia in the cognitive dysfunction of npsle mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Di Wu, Jay Prakash P Kumal, Xiaodi Lu, Yixuan Li, Dongsheng Mao, Xudong Tang, Meitong Nie, Xin Liu, Liang Sun, Bin Liu, Yafang Zhan. Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model. Frontiers in neurology. vol 12. 2021-09-21. PMID:34539542. |
traumatic brain injury accelerates the onset of cognitive dysfunction and aggravates alzheimer's-like pathology in the hippocampus by altering the phenotype of microglia in the app/ps1 mouse model. |
2021-09-21 |
2023-08-13 |
mouse |
| Xiaoyue Qiao, Hailin Wang, Li Lu, Jinglei Chen, Qinpei Cheng, Meng Guo, Yayi Hou, Huan Do. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. Journal of neuroimmunology. vol 357. 2021-09-13. PMID:34062352. |
hippocampal microglia cd40 mediates npsle cognitive dysfunction in mice. |
2021-09-13 |
2023-08-13 |
mouse |
| Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin L. Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34229406. |
our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of il-1β and er stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation. |
2021-07-28 |
2023-08-13 |
Not clear |
| Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin L. Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34229406. |
neuronal apoptosis induced by prolonged activation of microglia was partially involved in the arsenic-induced cognitive dysfunction. |
2021-07-28 |
2023-08-13 |
Not clear |
| Xiaoliang Wang, Lihai Chen, Yajie Xu, Wanling Wang, Youran Wang, Zhiyuan Zhang, Jing Zheng, Hongguang Ba. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. European journal of pharmacology. vol 892. 2021-05-18. PMID:33220272. |
furthermore, surgery induced more serious cognitive dysfunction, inflammatory factors, activation of microglia, and phosphorylation of gsk-3β and tau in gsk-3β overexpressing aged mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Sheng Peng, Pengyi Li, Peirong Liu, Hongzhu Yan, Juan Wang, Weihua Lu, Chunliang Liu, Yixin Zho. Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-05-10. PMID:31802591. |
taken together, we demonstrated that cistanche can exert antioxidant, anti-inflammatory, anti-apoptosis and anti-activation of microglia effects on the development of sevoflurane-induced cognitive dysfunction by activating ppar-γ signalling. |
2021-05-10 |
2023-08-13 |
rat |
| Maria Serena Paladini, Xi Feng, Karen Krukowski, Susanna Ros. Microglia depletion and cognitive functions after brain injury: From trauma to galactic cosmic ray. Neuroscience letters. vol 741. 2021-05-04. PMID:33259927. |
microglia depletion achieved either by pharmacological or genetic techniques represents not only a useful tool for more extensive investigations of microglia roles, but also a potential therapeutic approach to ameliorate or prevent cognitive dysfunctions following brain injury. |
2021-05-04 |
2023-08-13 |
Not clear |
| Bo Yang, Li-Yin Zhang, Ye Chen, Yi-Ping Bai, Jing Jia, Jian-Guo Feng, Ke-Xuan Liu, Jun Zho. Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. International immunopharmacology. vol 85. 2021-04-29. PMID:32442902. |
these findings showed that melatonin might relieve neuroinflammation and cognitive dysfunction caused by intestinal i/r, which could be, at least partially, related to the inhibition of the tlr4/myd88 signaling in microglia. |
2021-04-29 |
2023-08-13 |
rat |
| Yiyun Cao, Taotao Liu, Zhengqian Li, Jiao Yang, Lijun Ma, Xinning Mi, Ning Yang, Aihua Qi, Xiangyang Guo, Aizhong Wan. Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats. Aging. vol 12. issue 24. 2021-04-20. PMID:33232265. |
evident cognitive dysfunction, excessive microglia activation, neuroinflammatory responses and upregulated nfs in hippocampus were observed in the pocd group. |
2021-04-20 |
2023-08-13 |
rat |
| Nannan Lan, Yongxin Liu, Zhaodong Juan, Rui Zhang, Baoyu Ma, Keliang Xie, Lina Sun, Hao Feng, Meng Sun, Jianfeng Li. The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy. Frontiers in pharmacology. vol 11. 2021-03-13. PMID:33708121. |
these findings suggested that pk11195 may alleviate the damage of lps-induced cognitive dysfunction of rats by inhibiting microglia activation and autophagy. |
2021-03-13 |
2023-08-13 |
rat |
| Yan Chen, Jing-Xian Sun, Wan-Kun Chen, Gen-Cheng Wu, Yan-Qing Wang, Ke-Ying Zhu, Jun Wan. miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation. Signal transduction and targeted therapy. vol 4. 2021-01-29. PMID:31637007. |
activation of microglia and the subsequently elevated inflammatory cytokine release in the brain during surgery predispose individuals to cognitive dysfunction, also known as postoperative cognitive dysfunction (pocd). |
2021-01-29 |
2023-08-13 |
rat |