| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Peng, Pengyi Li, Peirong Liu, Hongzhu Yan, Juan Wang, Weihua Lu, Chunliang Liu, Yixin Zho. Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-05-10. PMID:31802591. |
taken together, we demonstrated that cistanche can exert antioxidant, anti-inflammatory, anti-apoptosis and anti-activation of microglia effects on the development of sevoflurane-induced cognitive dysfunction by activating ppar-γ signalling. |
2021-05-10 |
2023-08-13 |
rat |
| Maria Serena Paladini, Xi Feng, Karen Krukowski, Susanna Ros. Microglia depletion and cognitive functions after brain injury: From trauma to galactic cosmic ray. Neuroscience letters. vol 741. 2021-05-04. PMID:33259927. |
microglia depletion achieved either by pharmacological or genetic techniques represents not only a useful tool for more extensive investigations of microglia roles, but also a potential therapeutic approach to ameliorate or prevent cognitive dysfunctions following brain injury. |
2021-05-04 |
2023-08-13 |
Not clear |
| Bo Yang, Li-Yin Zhang, Ye Chen, Yi-Ping Bai, Jing Jia, Jian-Guo Feng, Ke-Xuan Liu, Jun Zho. Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. International immunopharmacology. vol 85. 2021-04-29. PMID:32442902. |
these findings showed that melatonin might relieve neuroinflammation and cognitive dysfunction caused by intestinal i/r, which could be, at least partially, related to the inhibition of the tlr4/myd88 signaling in microglia. |
2021-04-29 |
2023-08-13 |
rat |
| Yiyun Cao, Taotao Liu, Zhengqian Li, Jiao Yang, Lijun Ma, Xinning Mi, Ning Yang, Aihua Qi, Xiangyang Guo, Aizhong Wan. Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats. Aging. vol 12. issue 24. 2021-04-20. PMID:33232265. |
evident cognitive dysfunction, excessive microglia activation, neuroinflammatory responses and upregulated nfs in hippocampus were observed in the pocd group. |
2021-04-20 |
2023-08-13 |
rat |
| Nannan Lan, Yongxin Liu, Zhaodong Juan, Rui Zhang, Baoyu Ma, Keliang Xie, Lina Sun, Hao Feng, Meng Sun, Jianfeng Li. The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy. Frontiers in pharmacology. vol 11. 2021-03-13. PMID:33708121. |
these findings suggested that pk11195 may alleviate the damage of lps-induced cognitive dysfunction of rats by inhibiting microglia activation and autophagy. |
2021-03-13 |
2023-08-13 |
rat |
| Yan Chen, Jing-Xian Sun, Wan-Kun Chen, Gen-Cheng Wu, Yan-Qing Wang, Ke-Ying Zhu, Jun Wan. miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation. Signal transduction and targeted therapy. vol 4. 2021-01-29. PMID:31637007. |
activation of microglia and the subsequently elevated inflammatory cytokine release in the brain during surgery predispose individuals to cognitive dysfunction, also known as postoperative cognitive dysfunction (pocd). |
2021-01-29 |
2023-08-13 |
rat |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in app/psen1 mice via the cd33/trem2/tyrobp signaling pathway in microglia. |
2020-11-23 |
2023-08-13 |
mouse |
| Huimin Kong, Huaili Wang, Zhihong Zhuo, Zhenbiao Li, Peichao Tian, Jing Wu, Jian Liu, Zheng Chen, Jiyao Zhang, Qiang Lu. Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 9. 2020-11-23. PMID:32461588. |
inhibition of mir-181a-5p protected the hippocampus against epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, oxidative stress, mitochondrial function, and cognitive dysfunction. |
2020-11-23 |
2023-08-13 |
rat |
| Celia G Fernandez, Mary E Hamby, Morgan L McReynolds, William J Ra. The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30804776. |
apoe in the brain is primarily expressed by astrocytes and microglia, cell types that are now widely appreciated to play key roles in the pathogenesis of ad; thus, a picture is emerging wherein apoe4 disrupts normal glial cell biology, intersecting with changes that occur during normal aging to ultimately cause neurodegeneration and cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tsuyoshi Hashizume, Bo-Kyung Son, Sakiko Taniguchi, Koichi Ito, Yoshihiro Noda, Tamao Endo, Michiko Nanao-Hamai, Sumito Ogawa, Masahiro Akishit. Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction. Scientific reports. vol 9. issue 1. 2020-09-30. PMID:30858535. |
iba1/mhcii-double-positive microglia activation was also seen in the hippocampus, suggesting that vascular inflammation drives neuroinflammation and subsequent cognitive dysfunction. |
2020-09-30 |
2023-08-13 |
mouse |
| Bingying Du, Hailong Li, Huiwen Zheng, Cunxiu Fan, Meng Liang, Yongjie Lian, Zelan Wei, Yanbo Zhang, Xiaoying B. Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31695615. |
we explored the potential mechanisms that link microglia activation with gci-induced depression and cognitive dysfunction by studying effects of minocycline on white matter damage, cytokine levels, and the monoaminergic neurotransmitters. |
2020-09-29 |
2023-08-13 |
Not clear |
| Barrett D Allen, Lauren A Apodaca, Amber R Syage, Mineh Markarian, Al Anoud D Baddour, Harutyun Minasyan, Leila Alikhani, Celine Lu, Brian L West, Erich Giedzinski, Janet E Baulch, Munjal M Achary. Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31753024. |
thus, either elimination of microglia or restoration of microglial function could ameliorate cognitive dysfunction. |
2020-09-25 |
2023-08-13 |
mouse |
| Emily F Willis, Kelli P A MacDonald, Quan H Nguyen, Adahir Labrador Garrido, Ellen R Gillespie, Samuel B R Harley, Perry F Bartlett, Wayne A Schroder, Abi G Yates, Daniel C Anthony, Stefan Rose-John, Marc J Ruitenberg, Jana Vukovi. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner. Cell. vol 180. issue 5. 2020-08-17. PMID:32142677. |
cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (tbi), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood. |
2020-08-17 |
2023-08-13 |
mouse |
| Yu Zhang, Hang Xu, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang, Weiwen Wan. Deficiencies of microglia and TNFα in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30772475. |
the present study further determined the role of microglia and the inflammatory cytokine tumor necrosis factor alpha (tnfα) in cognitive dysfunction. |
2020-05-13 |
2023-08-13 |
mouse |
| Dan Zhang, Na Li, Yuanyuan Wang, Wenbin Lu, Yongyan Zhang, Yuanjie Chen, Xiaoming Deng, Xiya Y. Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice. International immunopharmacology. vol 71. 2019-12-12. PMID:30877874. |
methane ameliorates post-operative cognitive dysfunction by inhibiting microglia nf-κb/mapks pathway and promoting il-10 expression in aged mice. |
2019-12-12 |
2023-08-13 |
mouse |
| Yohei Minami, Noriyuki Sonoda, Eiichi Hayashida, Hiroaki Makimura, Makoto Ide, Noriko Ikeda, Masahiro Ohgidani, Takahiro A Kato, Yoshihiro Seki, Yasutaka Maeda, Shigenobu Kanba, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguch. p66Shc Signaling Mediates Diabetes-Related Cognitive Decline. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:29453337. |
moreover, p66shc (-/-) diabetic mice show significantly less cognitive dysfunction and decreased levels of os and the numbers of microglia. |
2019-10-16 |
2023-08-13 |
mouse |
| Zhuangzhuang Chen, Di Zhong, Guozhong L. The role of microglia in viral encephalitis: a review. Journal of neuroinflammation. vol 16. issue 1. 2019-08-05. PMID:30967139. |
on the other hand, microglia mediate presynaptic membrane damage in the hippocampus through complement, resulting in long-term memory impairment and cognitive dysfunction in patients with encephalitis. |
2019-08-05 |
2023-08-13 |
Not clear |
| Tianhai Wang, Hongge Zhu, Yanshen Hou, Weixin Gu, Haichuan Wu, Yiwen Luan, Cheng Xiao, Chunyi Zho. Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus. European journal of pharmacology. vol 846. 2019-07-29. PMID:30586550. |
interestingly, daily intraperitoneal administration of galantamine, an inhibitor of acetylcholinesterase, reversed cognitive dysfunction in surgery mice and attenuated accumulation of microglia and protein levels of il-1β, il-6 and tnf-α in the hippocampus. |
2019-07-29 |
2023-08-13 |
mouse |
| Chen Luo, Li-Hong Fan, Hua Zhang, Jing Zhao, Lei Li, Lian Zhang, Hai-Xiao Zhang, Ming-Ming M. Effects of ginkgo biloba extract on the cognitive function and expression profile of inflammatory factors in a rat model of hemorrhagic stroke. Neuroreport. vol 29. issue 15. 2019-04-18. PMID:30096131. |
ginkgo biloba extract could alleviate the cognitive dysfunction after hemorrhagic stroke in sd rats; this is associated with regulating the expression of inflammatory factors secreted by microglia. |
2019-04-18 |
2023-08-13 |
rat |
| Fabricio M Locatelli, Takashi Kawano, Hideki Iwata, Bun Aoyama, Satoru Eguchi, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Masataka Yokoyam. Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats. Journal of pharmacological sciences. vol 137. issue 4. 2018-11-06. PMID:30196020. |
the maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (pocd). |
2018-11-06 |
2023-08-13 |
rat |