| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manveen Bhardwaj, Anil Kuma. Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition. Pharmacological reports : PR. vol 68. issue 6. 2017-03-23. PMID:27693857. |
neuroprotective mechanism of coenzyme q10 (coq10) against ptz induced kindling and associated cognitive dysfunction: possible role of microglia inhibition. |
2017-03-23 |
2023-08-13 |
Not clear |
| Lauren L Williamson, Erin A McKenney, Zoie E Holzknecht, Christine Belliveau, John F Rawls, Susan Poulton, William Parker, Staci D Bilb. Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection. Brain, behavior, and immunity. vol 51. 2017-01-10. PMID:26162711. |
we have demonstrated previously that rats infected with bacteria as newborns display life-long vulnerabilities to cognitive dysfunction, a vulnerability that is specifically linked to long-term hypersensitivity of microglial cell function, the resident immune cells of the brain. |
2017-01-10 |
2023-08-13 |
rat |
| H Pflugrad, G-J Meyer, M Dirks, P Raab, A B Tryc, A Goldbecker, H Worthmann, F Wilke, R Boellaard, M Yaqub, G Berding, K Weissenbor. Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction. Journal of viral hepatitis. vol 23. issue 5. 2016-12-19. PMID:26768955. |
cerebral microglia activation in hepatitis c virus infection correlates to cognitive dysfunction. |
2016-12-19 |
2023-08-13 |
Not clear |
| Chung-Hsi Hsing, Shih-Kai Hung, Yeong-Chang Chen, Tsui-Shan Wei, Ding-Ping Sun, Jhi-Joung Wang, Ching-Hua Ye. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators of inflammation. vol 2015. 2016-05-02. PMID:26273133. |
excessive production of cytokines by microglia may cause cognitive dysfunction and long-lasting behavioral changes. |
2016-05-02 |
2023-08-13 |
mouse |
| Xiang Zhang, Hongquan Dong, Susu Zhang, Shunmei Lu, Jie Sun, Yanning Qia. Enhancement of LPS-induced microglial inflammation response via TLR4 under high glucose conditions. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 4. 2015-12-21. PMID:25790769. |
microglia activation mediated by toll-like receptor 4 (tlr4) plays an important role in neuroinflammation and postoperative cognitive dysfunction (pocd). |
2015-12-21 |
2023-08-13 |
Not clear |
| Mingchao Liu, Juan Li, Peng Dai, Fang Zhao, Gang Zheng, Jinfei Jing, Jiye Wang, Wenjing Luo, Jingyuan Che. Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction. Stress (Amsterdam, Netherlands). vol 18. issue 1. 2015-12-14. PMID:25472821. |
microglia activation regulates glur1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction. |
2015-12-14 |
2023-08-13 |
rat |
| Rodney W Johnso. Feeding the beast: can microglia in the senescent brain be regulated by diet? Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25451610. |
thus, whereas in younger individuals where microglia respond to signals from the peripheral immune system and induce a well-controlled neuroinflammatory response that is adaptive (e.g., when well controlled, fever and sickness behavior facilitate recovery from infection), in older individuals with an infection, microglia overreact and produce excessive levels of inflammatory cytokines causing behavioral pathology including cognitive dysfunction. |
2015-08-07 |
2023-08-13 |
Not clear |
| A Bogaczewicz, T Sobow, J Bogaczewicz, B Kaleta, A Sysa-Jedrzejowska, E Robak, J Lukaszkiewicz, S Dariusz, A Wozniack. Toll-like receptor 4 gene polymorphism 1196 C/T does not influence the risk of neuropsychiatric systemic lupus erythematosus in Polish population--a preliminary report. Lupus. vol 22. issue 14. 2014-08-29. PMID:24243911. |
recent data indicate that toll-like receptors (tlrs) participate in various neuropathologic conditions, including ictogenesis, myelin disruptions associated with chronic alcohol abuse, behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage, and activation of microglia to reduce amyloid β deposits. |
2014-08-29 |
2023-08-12 |
Not clear |
| Ya-Nan Zhao, Fang Wang, Yan-Xia Fan, Guan-Fang Ping, Jing-Yu Yang, Chun-Fu W. Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure. Behavioural brain research. vol 236. issue 1. 2013-04-23. PMID:22985845. |
here, we investigated whether activated microglia were implicated in neurodegeneration and cognitive dysfunctions in adult rats after intermittent alcohol abuse. |
2013-04-23 |
2023-08-12 |
human |
| Ya-Nan Zhao, Fang Wang, Yan-Xia Fan, Guan-Fang Ping, Jing-Yu Yang, Chun-Fu W. Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure. Behavioural brain research. vol 236. issue 1. 2013-04-23. PMID:22985845. |
thus, the present study indicated that activated microglia might be involved in neurodegeneration and cognitive dysfunctions induced by intermittent ethanol exposure, and neurotrophic microglia appear to have a contribution to the recovery during abstinence. |
2013-04-23 |
2023-08-12 |
human |
| Lucy J Garvey, Nicola Pavese, Anil Ramlackhansingh, Emma Thomson, Joanna M Allsop, Marios Politis, Ranjababu Kulasegaram, Janice Main, David J Brooks, Simon D Taylor-Robinson, Alan Winsto. Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. PloS one. vol 7. issue 7. 2013-03-26. PMID:22808022. |
acute hcv/hiv coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
2013-03-26 |
2023-08-12 |
Not clear |
| Jaclyn M Schwarz, Staci D Bilb. Sex, glia, and development: interactions in health and disease. Hormones and behavior. vol 62. issue 3. 2013-03-14. PMID:22387107. |
microglia influence processes including neural development, synaptic plasticity and cognition; while their activation and production of immune molecules can induce stereotyped sickness behaviors or pathologies including cognitive dysfunction. |
2013-03-14 |
2023-08-12 |
Not clear |
| Jingji Jin, Lucy Lam, Edin Sadic, Frank Fernandez, Jun Tan, Brian Giunt. HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND. American journal of translational research. vol 4. issue 3. 2012-10-02. PMID:22937208. |
microglia become activated in humans subsequent to infection with hiv, and uncontrolled brain inflammation plays a key role in neuronal injury and and cognitive dysfunction during hiv infection. |
2012-10-02 |
2023-08-12 |
mouse |
| Ye Chen, Jun Zhou, Jun Li, Shi-Bin Yang, Li-Qun Mo, Jie-Hui Hu, Wan-Li Yua. Electroacupuncture pretreatment prevents cognitive impairment induced by limb ischemia-reperfusion via inhibition of microglial activation and attenuation of oxidative stress in rats. Brain research. vol 1432. 2012-09-10. PMID:22129788. |
these findings indicate that li/r can result in cognitive dysfunction related to activated microglia and elevated oxidative stress, and that ea has neuroprotective potential mediated, at least in part, by inhibition of microglial activation and attenuation of oxidative stress. |
2012-09-10 |
2023-08-12 |
rat |
| Holly F Green, Eimear Treacy, Aoife K Keohane, Aideen M Sullivan, Gerard W O'Keeffe, Yvonne M Nola. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Molecular and cellular neurosciences. vol 49. issue 3. 2012-07-13. PMID:22270046. |
prolonged release of interleukin-1β (il-1β) from activated microglia has a deleterious effect on hippocampal neurons and is implicated in the impaired neurogenesis and cognitive dysfunction associated with aging, alzheimer's disease and depression. |
2012-07-13 |
2023-08-12 |
rat |
| T Panigada, R-D Gosseli. Behavioural alteration in chronic pain: are brain glia involved? Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21741179. |
hence, the possibility arises that brain astrocytes and microglia react in upper brain structures as well, mediating the related mood and cognitive dysfunctions in chronic pain. |
2011-12-29 |
2023-08-12 |
Not clear |
| G Mandolesi, G Grasselli, G Musumeci, Diego Centonz. Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue Suppl 2. 2011-03-07. PMID:20635112. |
increasing evidence from a mouse model of ms, the experimental autoimmune encephalomyelitis (eae), suggests a correlation between the synaptopathy induced by microglia activation in the early phase of the disease and cognitive dysfunction. |
2011-03-07 |
2023-08-12 |
mouse |
| Klaus G Petry, Bruno Brochet, Vincent Dousset, Jean Rodolphe Vignes, Claudine Boizia. Inflammation induced neurological handicap processes in multiple sclerosis: new insights from preclinical studies. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571836. |
blood-borne immune cell infiltration and microglia activation are causing both neuronal destruction and myelin loss, which are responsible for progressive motor deficiencies, organic and cognitive dysfunctions. |
2010-11-30 |
2023-08-12 |
Not clear |
| Christine T Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, Olle Lindval. Inflammation is detrimental for neurogenesis in adult brain. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14581618. |
our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation. |
2004-01-05 |
2023-08-12 |
rat |
| J Limoges, Y Persidsky, P Bock, H E Gendelma. Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. The Journal of infectious diseases. vol 175. issue 6. 1997-06-27. PMID:9180176. |
cognitive dysfunction revolves around the secretion of neurotoxins from immunologically competent virus-infected brain macrophages and microglia. |
1997-06-27 |
2023-08-12 |
mouse |