| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Holly F Green, Eimear Treacy, Aoife K Keohane, Aideen M Sullivan, Gerard W O'Keeffe, Yvonne M Nola. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Molecular and cellular neurosciences. vol 49. issue 3. 2012-07-13. PMID:22270046. |
prolonged release of interleukin-1β (il-1β) from activated microglia has a deleterious effect on hippocampal neurons and is implicated in the impaired neurogenesis and cognitive dysfunction associated with aging, alzheimer's disease and depression. |
2012-07-13 |
2023-08-12 |
rat |
| T Panigada, R-D Gosseli. Behavioural alteration in chronic pain: are brain glia involved? Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21741179. |
hence, the possibility arises that brain astrocytes and microglia react in upper brain structures as well, mediating the related mood and cognitive dysfunctions in chronic pain. |
2011-12-29 |
2023-08-12 |
Not clear |
| G Mandolesi, G Grasselli, G Musumeci, Diego Centonz. Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue Suppl 2. 2011-03-07. PMID:20635112. |
increasing evidence from a mouse model of ms, the experimental autoimmune encephalomyelitis (eae), suggests a correlation between the synaptopathy induced by microglia activation in the early phase of the disease and cognitive dysfunction. |
2011-03-07 |
2023-08-12 |
mouse |
| Klaus G Petry, Bruno Brochet, Vincent Dousset, Jean Rodolphe Vignes, Claudine Boizia. Inflammation induced neurological handicap processes in multiple sclerosis: new insights from preclinical studies. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571836. |
blood-borne immune cell infiltration and microglia activation are causing both neuronal destruction and myelin loss, which are responsible for progressive motor deficiencies, organic and cognitive dysfunctions. |
2010-11-30 |
2023-08-12 |
Not clear |
| Christine T Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, Olle Lindval. Inflammation is detrimental for neurogenesis in adult brain. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14581618. |
our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation. |
2004-01-05 |
2023-08-12 |
rat |
| J Limoges, Y Persidsky, P Bock, H E Gendelma. Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. The Journal of infectious diseases. vol 175. issue 6. 1997-06-27. PMID:9180176. |
cognitive dysfunction revolves around the secretion of neurotoxins from immunologically competent virus-infected brain macrophages and microglia. |
1997-06-27 |
2023-08-12 |
mouse |