Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Ali Hosseinpour, Arsh Haj Mohamad Ebrahim Ketabforoush, Elnaz Daneshzad, Ali Babanezhad Gajouti, Samaneh Hajimollarab. Unexpected multiple sclerosis-like symptoms in a rheumatoid arthritis patient treated with Etanercept: A case report. Clinical case reports. vol 12. issue 11. 2024-10-29. PMID:39469322. |
multiple sclerosis syndrome is one of the rare complications following treatment with tnf inhibitor. |
2024-10-29 |
2024-10-31 |
Not clear |
Yinbin Xu, Enhao Zhang, Liangzhe Wei, Zifeng Dai, Siqi Chen, Shengjun Zhou, Yi Huan. NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target. International immunopharmacology. vol 141. 2024-08-28. PMID:39197295. |
abbreviations: ms, multiple sclerosis; cns, central nervous system; bbb, blood-brain barrier; gsdmd, gasdermin-d; eae, experimental autoimmune encephalitis; hmgb-1, high mobility group box-1 protein; ldh, lactate dehydrogenase; pmr, plasma membrane rupture; dmf, dimethyl fumarate; dusp1, dual-specificity phosphatase 1; pamps, pathogen-associated molecular patterns; damps, danger-associated molecular patterns; prrs, pattern recognition receptors; gm-csf, granulocyte-macrophage colony stimulating factor; ifn-γ, interferon gamma; tnf, tumor necrosis factor; apcs, antigen-presenting cells; ecs, endothelial cells; tgf-β, transforming growth factor-β; pbmcs, peripheral blood mononuclear cells; facs, fluorescence-activated cell sorting; mcp-1, monocyte chemoattractant protein-1; nlrp3, pyrin domain-containing 3; tcr, t cell receptor; ros, reactive oxygen species; ap-1, activator protein-1; ang1, angiopoietin 1; bmdms, bone marrow-derived macrophages; arp2/3, actin-related protein 2/3; emt, epithelial-mesenchymal transition; fak, focal adhesion kinase; limk1, lim domain kinase 1; pak1, p21-activated kinases 1; rac1, ras-related c3 botulinum toxin substrate 1; β-cat, β-caten; myd88, myeloid differentiation primary response gene 88; tirap, toll/interleukin-1 receptor domain-containing adapter protein; tlr4, toll-like receptor 4; iraks, interleukin-1 receptor-associated kinases; traf6, tnf receptor associated factor 6; tab2/3, tak1 binding protein 2/3; tak1, transforming growth factor-β-activated kinase 1; jnk, c-jun n-terminal kinase; erk1/2, extracellular signal regulated kinase 1/2; ikk, inhibitor of kappa b kinase; iκb, inhibitor of nf-κb; nf-κb, nuclear factor kappa-b; ap-1, activator protein-1; asc, apoptosis-associated speck-like protein containing a card; nek7, nima-related kinase 7; nlrp3, pyrin domain-containing 3; creb, camp response element-binding protein. |
2024-08-28 |
2024-09-01 |
Not clear |
Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D Smith, Peter A Calabresi, Pavan Bhargav. BAFF blockade in experimental autoimmune encephalomyelitis reduces inflammation in the meninges and synaptic and neuronal loss in adjacent brain regions. Journal of neuroinflammation. vol 20. issue 1. 2023-10-07. PMID:37805549. |
since baff [b cell-activating factor of the tumor necrosis factor (tnf) family] promotes b cell survival and maturation and is a co-stimulator of t cells, we used anti-baff antibody 10f4 as a baff antagonist to study its effect on meningeal inflammation and adjacent brain regions in a relapsing-remitting plp-eae (rr-eae) model of multiple sclerosis in sjl/j mice. |
2023-10-07 |
2023-10-15 |
mouse |
Anthony DeRenzi, Jessie Penic. Lymphoproliferative Disease in a Non-Transplant Patient and Spironolactone's Activity Against Epstein Barr Virus. HCA healthcare journal of medicine. vol 2. issue 4. 2023-07-10. PMID:37424841. |
we present a case of a 66-year-old female who had been immunosuppressed through use of interferon and tumor necrosis factor (tnf)-active agents for multiple sclerosis (ms). |
2023-07-10 |
2023-08-14 |
Not clear |
Jean-Guillaume Letarouilly, Patrick Vermersch, René-Marc Flip. Therapeutic consequences in patients with both inflammatory rheumatic diseases and multiple sclerosis. Rheumatology (Oxford, England). vol 62. issue 7. 2023-07-07. PMID:36440887. |
dealing with patients with both multiple sclerosis (ms) and inflammatory rheumatic disorders (irds) is not uncommon for a rheumatologist, as there is a statistical association between spa and ms. as several cns demyelinating events have been reported in patients treated with tnf inhibitor (tnfi), the pre-existing demyelinating disease was considered a contraindication for tnfi. |
2023-07-07 |
2023-08-16 |
Not clear |
Henri Chédotal, Dilip Narayanan, Katrine Povlsen, Charlotte H Gotfredsen, Roberta Brambilla, Michael Gajhede, Anders Bach, Mads H Clause. Small-molecule modulators of tumor necrosis factor signaling. Drug discovery today. 2023-04-01. PMID:37003513. |
tumor necrosis factor (tnf) is a pleiotropic cytokine with a major role in immune system homeostasis and is involved in many inflammatory and autoimmune diseases, such as rheumatoid arthritis (ra), psoriasis, alzheimer's disease (ad), and multiple sclerosis (ms). |
2023-04-01 |
2023-08-14 |
Not clear |
Eva M M Strijbis, Marcus W Koc. TNF Alfa Blockers and the Risk of Multiple Sclerosis. Neurology. 2022-10-28. PMID:36307218. |
tnf alfa blockers and the risk of multiple sclerosis. |
2022-10-28 |
2023-08-14 |
Not clear |
Delphine Stephan, Anais Roger, Jehanne Aghzadi, Sylvie Carmona, Christophe Picard, Jean-Philippe Dales, Sophie Desplat-Jég. TWEAK and TNFα, Both TNF Ligand Family Members and Multiple Sclerosis-Related Cytokines, Induce Distinct Gene Response in Human Brain Microvascular Endothelial Cells. Genes. vol 13. issue 10. 2022-10-27. PMID:36292599. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a member of the tnf ligand family involved in various diseases including brain inflammatory pathologies such as multiple sclerosis. |
2022-10-27 |
2023-08-14 |
human |
Damiano Marastoni, Anna I Pisani, Gianmarco Schiavi, Valentina Mazziotti, Marco Castellaro, Agnese Tamanti, Francesca Bosello, Francesco Crescenzo, Giuseppe K Ricciardi, Stefania Montemezzi, Francesca B Pizzini, Massimiliano Calabres. CSF TNF and osteopontin levels correlate with the response to dimethyl fumarate in early multiple sclerosis. Therapeutic advances in neurological disorders. vol 15. 2022-06-27. PMID:35755969. |
csf tnf and osteopontin levels correlate with the response to dimethyl fumarate in early multiple sclerosis. |
2022-06-27 |
2023-08-14 |
Not clear |
Roberta Magliozzi, Francesco Pezzini, Mairi Pucci, Stefania Rossi, Francesco Facchiano, Damiano Marastoni, Martina Montagnana, Giuseppe Lippi, Richard Reynolds, Massimiliano Calabres. Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation. Cells. vol 10. issue 7. 2021-10-28. PMID:34359880. |
changes in cerebrospinal fluid balance of tnf and tnf receptors in naïve multiple sclerosis patients: early involvement in compartmentalised intrathecal inflammation. |
2021-10-28 |
2023-08-13 |
human |
Roberta Magliozzi, Francesco Pezzini, Mairi Pucci, Stefania Rossi, Francesco Facchiano, Damiano Marastoni, Martina Montagnana, Giuseppe Lippi, Richard Reynolds, Massimiliano Calabres. Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation. Cells. vol 10. issue 7. 2021-10-28. PMID:34359880. |
an imbalance of tnf signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (ms), and its animal model may lead to increased cortical pathology. |
2021-10-28 |
2023-08-13 |
human |
Laura Torre-Fuentes, Jordi A Matías-Guiu, Vanesa Pytel, Paloma Montero-Escribano, Paolo Maietta, Sara Álvarez, Ulises Gómez-Pinedo, Jorge Matías-Gui. Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis. CNS neuroscience & therapeutics. vol 26. issue 11. 2021-10-25. PMID:32951330. |
variants of genes encoding tnf receptors and ligands and proteins regulating tnf activation in familial multiple sclerosis. |
2021-10-25 |
2023-08-13 |
Not clear |
Neida K Mita-Mendoza, Ariel Magallon-Tejada, Priyanka Parmar, Raquel Furtado, Margaret Aldrich, Alex Saidi, Terrie Taylor, Joe Smith, Karl Seydel, Johanna P Dail. Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro. Malaria journal. vol 19. issue 1. 2021-05-31. PMID:33087130. |
a potentially protective role of the nuclear factor e2-related factor 2 (nrf2) pathway, which serves as a therapeutic target in brain microvascular diseases and central nervous system (cns) inflammatory diseases such as multiple sclerosis was tested to protect endothelial cells in an in vitro culture system subjected to tumour necrosis factor (tnf) or infected red blood cell exposure. |
2021-05-31 |
2023-08-13 |
Not clear |
Roberta Magliozzi, Damiano Marastoni, Massimiliano Calabres. The BAFF / APRIL system as therapeutic target in multiple sclerosis. Expert opinion on therapeutic targets. vol 24. issue 11. 2021-04-21. PMID:32900236. |
the complex system of baff (b-cell-activating factor of the tnf family) and april (a proliferation-inducing ligand) has been studied in animal models of autoimmune diseases such as those resembling human systemic lupus erythematosus and sjogren's syndrome and multiple sclerosis (ms). |
2021-04-21 |
2023-08-13 |
human |
Pernille M Madsen, Haritha L Desu, Juan Pablo de Rivero Vaccari, Yoleinny Florimon, Ditte G Ellman, Robert W Keane, Bettina H Clausen, Kate L Lambertsen, Roberta Brambill. Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling. Brain, behavior, and immunity. vol 84. 2021-03-12. PMID:31785393. |
the pleotropic cytokine tumor necrosis factor (tnf) is involved in the pathophysiology of multiple sclerosis (ms). |
2021-03-12 |
2023-08-13 |
mouse |
Stephanie Trend, Jonatan Leffler, Matthew N Cooper, Scott N Byrne, Allan G Kermode, Martyn A French, Prue H Har. Narrowband UVB phototherapy reduces TNF production by B-cell subsets stimulated via TLR7 from individuals with early multiple sclerosis. Clinical & translational immunology. vol 9. issue 10. 2020-10-23. PMID:33088505. |
narrowband uvb phototherapy reduces tnf production by b-cell subsets stimulated via tlr7 from individuals with early multiple sclerosis. |
2020-10-23 |
2023-08-13 |
Not clear |
Caterina Veroni, Barbara Serafini, Barbara Rosicarelli, Corrado Fagnani, Francesca Aloisi, Cristina Agrest. Connecting Immune Cell Infiltration to the Multitasking Microglia Response and TNF Receptor 2 Induction in the Multiple Sclerosis Brain. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32733206. |
connecting immune cell infiltration to the multitasking microglia response and tnf receptor 2 induction in the multiple sclerosis brain. |
2020-09-28 |
2023-08-13 |
mouse |
Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aricò, Rachel James, Carolina Cruciani, Cheryl Reeves, Federico Roncaroli, Richard Nicholas, Richard Reynold. Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis. Journal of neuroinflammation. vol 16. issue 1. 2020-05-27. PMID:31810488. |
meningeal inflammation changes the balance of tnf signalling in cortical grey matter in multiple sclerosis. |
2020-05-27 |
2023-08-13 |
Not clear |
Claudia Mara Ribeiro, Sayonara Rangel Oliveira, Daniela Frizon Alfieri, Tamires Flauzino, Damacio Ramón Kaimen-Maciel, Andréa Name Colado Simão, Michael Maes, Edna Maria Vissoci Reich. Tumor necrosis factor alpha (TNF-α) and its soluble receptors are associated with disability, disability progression and clinical forms of multiple sclerosis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 68. issue 12. 2020-04-03. PMID:31559449. |
the association between tumor necrosis factor (tnf)-α, soluble tnf receptor (stnfr)1 and stnfr2 with clinical characteristics of multiple sclerosis (ms) remains unclear. |
2020-04-03 |
2023-08-13 |
Not clear |
b' Juraj Javor, Ivana Shawkatov\\xc3\\xa1, Vladim\\xc3\\xadra \\xc4\\x8eurmanov\\xc3\\xa1, Zuzana P\\xc3\\xa1rnick\\xc3\\xa1, Daniel \\xc4\\x8cierny, Jozef Michalik, Daniela \\xc4\\x8cop\\xc3\\xadkov\\xc3\\xa1-Cudr\\xc3\\xa1kov\\xc3\\xa1, Barbora Smahov\\xc3\\xa1, Karin Gmitterov\\xc3\\xa1, \\xc4\\xbdubica Peterajov\\xc3\\xa1, M\\xc3\\xa1ria Bucov\\xc3\\xa. TNFRSF1A polymorphisms and their role in multiple sclerosis susceptibility and severity in the Slovak population. International journal of immunogenetics. 2019-11-20. PMID:30009568.' |
tumour necrosis factor (tnf)-mediated signalling plays a key role in inflammatory and neurodegenerative processes leading to the development of multiple sclerosis (ms). |
2019-11-20 |
2023-08-13 |
Not clear |