| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amedra Basgaran, Eva Lymberopoulos, Ella Burchill, Maryam Reis-Dehabadi, Nikhil Sharm. Machine learning determines the incidence of Alzheimer's disease based on population gut microbiome profile. Brain communications. vol 7. issue 2. 2025-04-16. PMID:40235960. |
influences of the gut microbiome on brain microglia have been identified as a potential mechanism contributing to neurodegenerative diseases, such as alzheimer's disease, motor neurone disease and parkinson's disease (boddy sl, giovannelli i, sassani m, |
2025-04-16 |
2025-04-18 |
human |
| Yi Ling Low, Ethan Kreutzer, Indu R Chandrashekaran, Luke A Adams, Jason Pun, Bradley C Doak, Yijun Pan, Jennifer L Short, Martin J Scanlon, Joseph A Nicolazz. Evaluation of the Anti-Inflammatory Effects of Novel Fatty Acid-Binding Protein 4 Inhibitors in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 20. issue 1. 2025-04-15. PMID:40234265. |
fatty acid-binding protein 4 (fabp4) is a key lipid binding protein expressed in microglia, which has been demonstrated to play a critical role in microglial-mediated neuroinflammation, a component of many neurodegenerative diseases. |
2025-04-15 |
2025-04-18 |
Not clear |
| Clara Bartra, Kristijan Vuraić, Yi Yuan, Sandra Codony, Haydeé Valdés-Quiroz, Carme Casal, Mark Slevin, Leonardo Máquez-Kisinousky, Anna M Planas, Christian Griñán-Ferré, Mercè Pallàs, Christophe Morisseau, Bruce D Hammock, Santiago Vázquez, Cristina Suñol, Coral Sanfeli. Microglial pro-inflammatory mechanisms induced by monomeric C-reactive protein are counteracted by soluble epoxide hydrolase inhibitors. International immunopharmacology. vol 155. 2025-04-11. PMID:40215773. |
therefore, the direct activation of microglia by mcrp provides evidence of its role in triggering and exacerbating neurodegenerative diseases with a neuroinflammatory component, such as ad. |
2025-04-11 |
2025-04-14 |
mouse |
| Alexis M Johnson, John R Luken. Glia get RIPped in ALS. Immunity. vol 58. issue 4. 2025-04-09. PMID:40203806. |
while neuroinflammatory responses driven by microglia and astrocytes have been extensively linked to neurodegenerative disease progression in amyotrophic lateral sclerosis (als), the specific pathways that coordinate glial cell-dependent neuroinflammation in als remain poorly defined. |
2025-04-09 |
2025-04-12 |
Not clear |
| Elena B Riel, Weiming Bu, Thomas T Joseph, Leila Khajoueinejad, Roderic G Eckenhoff, Paul M Riegelhaup. The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel. Proceedings of the National Academy of Sciences of the United States of America. vol 122. issue 14. 2025-04-03. PMID:40178898. |
with microglia recognized as critical to the pathogenesis of neurodegenerative diseases, thik1 channels are putative therapeutic targets to control microglia dysfunction. |
2025-04-03 |
2025-04-04 |
Not clear |
| Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Ya. Potential targets of microglia in the treatment of neurodegenerative diseases: mechanism and therapeutic implications. Neural regeneration research. 2025-03-27. PMID:40145977. |
potential targets of microglia in the treatment of neurodegenerative diseases: mechanism and therapeutic implications. |
2025-03-27 |
2025-03-30 |
Not clear |
| Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Ya. Potential targets of microglia in the treatment of neurodegenerative diseases: mechanism and therapeutic implications. Neural regeneration research. 2025-03-27. PMID:40145977. |
this review summarizes the role of microglia neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, multiple sclerosis, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, cortical degeneration, lewy body dementia, and huntington's disease. |
2025-03-27 |
2025-03-30 |
Not clear |
| Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Ya. Potential targets of microglia in the treatment of neurodegenerative diseases: mechanism and therapeutic implications. Neural regeneration research. 2025-03-27. PMID:40145977. |
the aim is to identify potential targets for microglial cell therapy in neurodegenerative diseases. |
2025-03-27 |
2025-03-30 |
Not clear |
| Adeline E Walsh, John R Luken. Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases. Current opinion in immunology. vol 94. 2025-03-26. PMID:40138748. |
given the growing evidence linking microglia to the onset and progression of various neurodegenerative diseases, these brain-resident macrophages have emerged as a promising cell type for targeted therapeutic interventions. |
2025-03-26 |
2025-03-30 |
human |
| Patricia Sinclair, William Jeffries, Nadege Lebert, Maheen Saeed, Aman Ullah, Nadine Kabban. A predictive machine learning model for cannabinoid effect based on image detection of reactive oxygen species in microglia. PloS one. vol 20. issue 3. 2025-03-25. PMID:40131976. |
neuroinflammation is a key feature of human neurodisease including neuropathy and neurodegenerative disease and is driven by the activation microglia, immune cells of the nervous system. |
2025-03-25 |
2025-03-28 |
human |
| Yuchen Zhang, Shibo Zhang, Xuyu Zhao, Peiru Wu, Yiwei Ying, Lingling Wu, Junyi Zhuang, Zixin Chen, Yufan Chao, Xin Dong, Robert Chunhua Zhao, Jiao Wan. ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology. MedComm. vol 6. issue 4. 2025-03-24. PMID:40123832. |
abnormal lipid metabolism in microglia leads to the formation of pathological lipid droplets (lds), a phenomenon also observed in neurodegenerative diseases such as alzheimer's disease (ad). |
2025-03-24 |
2025-03-26 |
Not clear |
| Chih-Wei Zen. Immune Cell-NSPC interactions: Friend or foe in CNS injury and repair? Differentiation; research in biological diversity. vol 143. 2025-03-20. PMID:40112742. |
beyond macrophages and microglia, the roles of other immune cells, including t cells and neutrophils, particularly in injury and neurodegenerative disease contexts, in the context of cns injury and disease are emerging areas of interest. |
2025-03-20 |
2025-03-23 |
Not clear |
| Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Stroope. A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases. Molecular neurodegeneration. vol 20. issue 1. 2025-03-12. PMID:40069774. |
a versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases. |
2025-03-12 |
2025-03-14 |
mouse |
| Marcus Augusto-Oliveira, Gabriela de Paula Arrifano, Caio Gustavo Leal-Nazaré, Adriano Chaves-Filho, Leticia Santos-Sacramento, Amanda Lopes-Araujo, Marie-Ève Tremblay, Maria Elena Crespo-Lope. Morphological diversity of microglia: implications for learning, environmental adaptation, ageing, sex differences and neuropathology. Neuroscience and biobehavioral reviews. 2025-03-06. PMID:40049541. |
several reports show that microglia undergo soma and branch remodelling in response to environmental stimuli, ageing, neurodegenerative diseases, trauma, and systemic inflammation, suggesting a complex form and function link. |
2025-03-06 |
2025-03-09 |
Not clear |
| Seong-Hun Bong, Hayoung Choi, Hyun-Ho Song, Dong Kyu Kim, Inhee Mook-Jung, Do Yup Le. Metabolic Reprogramming in Primary Microglial Cell and Extracellular Vesicle Triggered by Aβ Exposure. Journal of neurochemistry. vol 169. issue 3. 2025-03-05. PMID:40042046. |
our study sheds new light on the role of microglia and evs in neurodegenerative diseases, offering promising avenues for future therapeutic interventions. |
2025-03-05 |
2025-03-07 |
Not clear |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
studies utilizing rodent models of neurodegenerative disease reveal heightened activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and nod like receptor 3 (nlrp3) mediate microglia activation and associated neuronal injury. |
2025-03-04 |
2025-03-07 |
mouse |
| Jack Humphrey, Erica Brophy, Roman Kosoy, Biao Zeng, Elena Coccia, Daniele Mattei, Ashvin Ravi, Tatsuhiko Naito, Anastasia G Efthymiou, Elisa Navarro, Claudia De Sanctis, Victoria Flores-Almazan, Benjamin Z Muller, Gijsje J L J Snijders, Amanda Allan, Alexandra Münch, Reta Birhanu Kitata, Steven P Kleopoulos, Stathis Argyriou, Periklis Malakates, Konstantina Psychogyiou, Zhiping Shao, Nancy Francoeur, Chia-Feng Tsai, Marina A Gritsenko, Matthew E Monroe, Vanessa L Paurus, Karl K Weitz, Tujin Shi, Robert Sebra, Tao Liu, Lot D de Witte, Alison M Goate, David A Bennett, Vahram Haroutunian, Gabriel E Hoffman, John F Fullard, Panos Roussos, Towfique Ra. Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing. Nature genetics. 2025-03-03. PMID:40033057. |
microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. |
2025-03-03 |
2025-03-06 |
human |
| Andrew Baumgartner, Max Robinson, Nilufer Ertekin-Taner, Todd E Golde, Suman Jaydev, Sui Huang, Jennifer Hadlock, Cory Fun. Fokker-Planck diffusion maps of microglial transcriptomes reveal radial differentiation into substates associated with Alzheimer's pathology. Communications biology. vol 8. issue 1. 2025-02-23. PMID:39987247. |
the identification of microglia subtypes is important for understanding the role of innate immunity in neurodegenerative diseases. |
2025-02-23 |
2025-02-25 |
Not clear |
| Mengqi Fang, Yuan Zhou, Keren He, Yangyuxiao Lu, Fangfang Tao, Hong Huan. Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative Diseases and Targeted Therapy. Molecular neurobiology. 2025-02-22. PMID:39987285. |
glucose metabolic reprogramming in microglia: implications for neurodegenerative diseases and targeted therapy. |
2025-02-22 |
2025-02-25 |
Not clear |
| Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savar. Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes. Frontiers in molecular neuroscience. vol 18. 2025-02-17. PMID:39958993. |
microglia, the immune cells of the central nervous system, activate neuroinflammatory pathways in response to homeostatic disturbances, a process implicated in the pathogenesis of various neurodegenerative diseases. |
2025-02-17 |
2025-02-23 |
Not clear |