| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W L Sun, L Wang, J Luo, H W Zhu, Z W Ca. Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells by modulating the Bim/mitochondrial pathway. Neoplasma. vol 66. issue 3. 2019-09-09. PMID:30784282. |
here, we show that ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells. |
2019-09-09 |
2023-08-13 |
Not clear |
| W L Sun, L Wang, J Luo, H W Zhu, Z W Ca. Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells by modulating the Bim/mitochondrial pathway. Neoplasma. vol 66. issue 3. 2019-09-09. PMID:30784282. |
thus, ambra1 is a protein that makes breast cancer cells resistant to apoptosis by modulating the bim/mitochondrial pathway. |
2019-09-09 |
2023-08-13 |
Not clear |
| Flavie Strappazzon, Anthea Di Rita, Valentina Cianfanelli, Melania D'Orazio, Francesca Nazio, Gian Maria Fimia, Francesco Ceccon. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123694. |
prosurvival ambra1 turns into a proapoptotic bh3-like protein during mitochondrial apoptosis. |
2017-11-13 |
2023-08-13 |
Not clear |
| Flavie Strappazzon, Anthea Di Rita, Valentina Cianfanelli, Melania D'Orazio, Francesca Nazio, Gian Maria Fimia, Francesco Ceccon. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123694. |
here we report that the crucial proautophagic factor ambra1 can act as a positive mediator of mitochondrial apoptosis. |
2017-11-13 |
2023-08-13 |
Not clear |
| Flavie Strappazzon, Anthea Di Rita, Valentina Cianfanelli, Melania D'Orazio, Francesca Nazio, Gian Maria Fimia, Francesco Ceccon. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123694. |
indeed, we show that, in a proapoptotic positive feedback loop, the c-terminal part of ambra1, generated by casp/caspase cleavage upon apoptosis induction, inhibits the antiapoptotic factor bcl2 by a direct binding through its bh3-like domain. |
2017-11-13 |
2023-08-13 |
Not clear |
| A Di Rita, F Strappazzo. AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1-BCL2-Family Proteins Relationship. International review of cell and molecular biology. vol 330. 2017-11-06. PMID:28215535. |
we found that the ambra1-bcl2 couple have a "dual role" in autophagy and apoptosis: the mitochondrial pool of bcl2 is able to inhibit ambra1-dependent autophagy, whereas in cell death conditions, the cleaved form of ambra1 (ambra1 |
2017-11-06 |
2023-08-13 |
Not clear |
| Xiaoyan Li, Lijuan Zhang, Lili Yu, Wei Wei, Xueyan Lin, Xiaoman Hou, Yongjie Tia. shRNA-mediated AMBRA1 knockdown reduces the cisplatin-induced autophagy and sensitizes ovarian cancer cells to cisplatin. The Journal of toxicological sciences. vol 41. issue 1. 2016-09-22. PMID:26763392. |
in this study, we hypothesized that ambra1 is an important regulator of autophagy and apoptosis in ovarian cancer cells. |
2016-09-22 |
2023-08-13 |
human |
| Xiaoyan Li, Lijuan Zhang, Lili Yu, Wei Wei, Xueyan Lin, Xiaoman Hou, Yongjie Tia. shRNA-mediated AMBRA1 knockdown reduces the cisplatin-induced autophagy and sensitizes ovarian cancer cells to cisplatin. The Journal of toxicological sciences. vol 41. issue 1. 2016-09-22. PMID:26763392. |
in conclusion, ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. |
2016-09-22 |
2023-08-13 |
human |
| M Yazdankhah, S Farioli-Vecchioli, A B Tonchev, A Stoykova, F Ceccon. The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell death & disease. vol 5. 2015-09-08. PMID:25188513. |
here we show that the proautophagic proteins ambra1 and beclin 1, involved in the initial steps of autophagosome formation, are highly expressed in the adult subventricular zone (svz), whereas their downregulation in adult neural stem cells in vitro leads to a decrease in cell proliferation, an increase in basal apoptosis and an augmented sensitivity to dna-damage-induced death. |
2015-09-08 |
2023-08-13 |
Not clear |
| Jane L Armstrong, David S Hill, Christopher S McKee, Sonia Hernandez-Tiedra, Mar Lorente, Israel Lopez-Valero, Maria Eleni Anagnostou, Fiyinfoluwa Babatunde, Marco Corazzari, Christopher P F Redfern, Guillermo Velasco, Penny E Lova. Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. The Journal of investigative dermatology. vol 135. issue 6. 2015-07-29. PMID:25674907. |
treatment with Δ(9)-tetrahydrocannabinol (thc) resulted in the activation of autophagy, loss of cell viability, and activation of apoptosis, whereas cotreatment with chloroquine or knockdown of atg7, but not beclin-1 or ambra1, prevented thc-induced autophagy and cell death in vitro. |
2015-07-29 |
2023-08-13 |
mouse |
| Conghong Shi, Jing Wu, Min Fu, Baohong Zhang, Juan Wang, Xi Yang, Yunpeng Ch. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25117440. |
in this study, we hypothesized that ambra1 is an important regulator of autophagy and apoptosis in cardiomyocytes. |
2015-02-25 |
2023-08-13 |
Not clear |
| Conghong Shi, Jing Wu, Min Fu, Baohong Zhang, Juan Wang, Xi Yang, Yunpeng Ch. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25117440. |
when ambra1 expression was reduced by sirna, the cardiomyocytes were more sensitive to staurosporine-induced apoptosis. |
2015-02-25 |
2023-08-13 |
Not clear |
| Conghong Shi, Jing Wu, Min Fu, Baohong Zhang, Juan Wang, Xi Yang, Yunpeng Ch. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25117440. |
in conclusion, ambra1 is a crucial regulator of autophagy and apoptosis through ampk signaling pathway in cardiomyocytes that maintains the balance between autophagy and apoptosis. |
2015-02-25 |
2023-08-13 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
ambra1 is an essential regulator of autophagy and apoptosis in sw620 cells: pro-survival role of ambra1. |
2014-10-16 |
2023-08-12 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
in this study, we hypothesized that ambra1 is an important regulator of autophagy and apoptosis in crc cell lines. |
2014-10-16 |
2023-08-12 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
to examine the role of ambra1 in apoptosis, ambra1 knockdown cells were treated with staurosporine and etoposide. |
2014-10-16 |
2023-08-12 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
ambra1 expression decreased during staurosporine- or etoposide-induced apoptosis. |
2014-10-16 |
2023-08-12 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
when ambra1 expression was reduced by sirna, sw620 cells were more sensitive to staurosporine- or etoposide-induced apoptosis. |
2014-10-16 |
2023-08-12 |
Not clear |
| Wen Gu, Daiwei Wan, Qinyi Qian, Bin Yi, Zhilong He, Yilin Gu, Liang Wang, Songbing H. Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587252. |
in conclusion, ambra1 is a crucial regulator of autophagy and apoptosis in crc cells that maintains the balance between autophagy and apoptosis. |
2014-10-16 |
2023-08-12 |
Not clear |
| G M Fimia, M Corazzari, M Antonioli, M Piacentin. Ambra1 at the crossroad between autophagy and cell death. Oncogene. vol 32. issue 28. 2013-09-12. PMID:23069654. |
this review is focused on the role that ambra1, a central component of the autophagosome formation machinery, has in the switch between autophagy and apoptosis and its implication in cancer development and chemotherapy resistance. |
2013-09-12 |
2023-08-12 |
Not clear |