Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
Jiapeng Huang, Chuncha Bao, Chunlan Yang, Yun Q. Dual-tDCS Ameliorates Cerebral Injury and Promotes Motor Function Recovery via cGAS-STING Signaling Pathway in a Rat Model of Ischemic Stroke. Molecular neurobiology. 2024-10-25. PMID:39455539. |
dual-tdcs improved motor function and infarct volume, inhibited neuronal apoptosis, promoted the expression of neurotrophins (bdnf and ngf), cd31, and vegf, and suppressed inflammation reaction after mcao via the cgas-sting pathway. |
2024-10-25 |
2024-10-29 |
rat |
Thibaut Gellé, Théodore Vinais, Aurélie Lacroix, Brigitte Plansont, Philippe Nubukpo, Murielle Girar. Serum BDNF and pro-BDNF levels in alcohol use disorders according to depression status: An exploratory study of their evolution two months after withdrawal. Heliyon. vol 10. issue 19. 2024-10-21. PMID:39430530. |
the bdnf precursor, pro-bdnf, has different effects, as it mainly promotes neuronal apoptosis. |
2024-10-21 |
2024-10-23 |
Not clear |
Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
Jun He, Peng Xie, Xiao-Qiong An, Dong-Fen Guo, Bin Bi, Gang Wu, Wen-Feng Yu, Zhen-Kui Ren, Li Zu. LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF. Current medical science. 2024-08-15. PMID:39145838. |
lncrna nptn-it1-201 ameliorates depressive-like behavior by targeting mir-142-5p and regulating inflammation and apoptosis via bdnf. |
2024-08-15 |
2024-08-17 |
Not clear |
Dan Hou, Jialing Zhong, Yujie Hu, Guoshuai Yan. The effect of miR‑155‑5p on long‑term memory of sleep‑deprived mice through the BDNF/NF‑κB pathway. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087835. |
the upregulation of bdnf effectively mitigated hippocampal damage by attenuating cell apoptosis and reducing inflammation levels in sd mice. |
2024-08-01 |
2024-08-03 |
mouse |
Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
the aim of the present study was to evaluate the effect of rosiglitazone (rsg) or pioglitazone (pog) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (bdnf), and nitric oxide (no) metabolites in the hippocampus of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
then, the hippocampal tissues were collected to determine bdnf and no levels and the degree of apoptosis. |
2024-08-01 |
2024-08-03 |
rat |
Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
this study's results revealed that pog or rsg normalized ltp impairment, neuronal apoptosis, and improved bdnf content in the hippocampal tissue of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
Xin Zhang, Wen Ma, Huanyi Liu, Yuanchu Liu, Yaling Zhang, Sitong He, Xiaoli Ding, Baolin Li, Yaping Ya. Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2/HO-1 pathway. Journal of neuropathology and experimental neurology. vol 83. issue 8. 2024-07-19. PMID:38819094. |
furthermore, in vitro experiments utilizing isolated rat neurons assessing rna expression profiling, immunofluorescence, tunel assay, and western-blot analysis, suggested the potential of daph for regulating bdnf and gm-csf expression and mitigating aβ1-42-induced cortical injury, synaptic loss, and apoptosis. |
2024-07-19 |
2024-07-21 |
mouse |
Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
Amira A El-Gazar, Soad Z El-Emam, Shorouk M El-Sayyad, Shereen S El-Mancy, Sahar M Fayez, Nermin M Sheta, Asmaa K Al-Mokaddem, Ghada M Raga. Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a/BDNF/ Klotho/Foxo3a cue. International immunopharmacology. vol 134. 2024-05-05. PMID:38705029. |
besides, connexin43 (cx43) expression as well as klotho and brain-derived neurotrophic factor (bdnf) were upregulated with diminished neuronal cell death and apoptosis because of reduced forkhead box class o3a(foxo3a) expression in the pmbs-treated group. |
2024-05-05 |
2024-05-08 |
rat |
Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosav. Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metabolic brain disease. 2024-04-30. PMID:38687459. |
therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (bdnf), and vascular endothelial growth factor (vegf) in aged rats. |
2024-04-30 |
2024-05-03 |
rat |
Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosav. Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metabolic brain disease. 2024-04-30. PMID:38687459. |
the study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating sod activity, which in turn enhances vegf and bdnf. |
2024-04-30 |
2024-05-03 |
rat |
Yuhai Xu, Xin Xin, Tianzhu Ta. Decoding the Neurotoxic Effects of Propofol: Insights into the RARα-Snhg1-Bdnf Regulatory Cascade. American journal of physiology. Cell physiology. 2024-04-15. PMID:38618701. |
the findings draw a clear link between propofol-induced neurotoxicity and the amplification of rar signaling pathways, impacting hippocampal development and apoptosis and leading to increased rarα and snhg1 and decreased bdnf. |
2024-04-15 |
2024-04-17 |
Not clear |
Mina Makvand, Seyed Davood Mirtorabi, Arezoo Campbell, Alireza Zali, Ghasem Ahangar. Exploring neuroadaptive cellular pathways in chronic morphine exposure: An in-vitro analysis of cabergoline and Mdivi-1 co-treatment effects on the autophagy-apoptosis axis. Journal of cellular biochemistry. 2024-04-05. PMID:38577900. |
this combination therapy normalized autophagy and reduced oxidative stress by enhancing total-antioxidant capacity, mitigating apoptosis, restoring bdnf expression, and balancing apoptotic elements. |
2024-04-05 |
2024-04-07 |
human |
Umit Yilmaz, Kevser Tanbek, Semir Gul, Ahmet Koc, Mehmet Gul, Suleyman Sanda. Intracerebroventricular BDNF infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-03-23. PMID:38520223. |
intracerebroventricular bdnf infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis. |
2024-03-23 |
2024-03-26 |
rat |
Chunyan Gong, Xiaona He, Guiliang Li, Dayu Wang, Yonghua Yang, Yanping Shi, Wenbing Su, Yuanxian W. miR-497-5p promoted neuronal injury in ischemic stroke by inhibiting the BDNF/TrkB/PI3K/Akt pathway. General physiology and biophysics. vol 43. issue 2. 2024-03-13. PMID:38477607. |
bdnf inhibited cell apoptosis and oxidative stress injury in pc12 cells. |
2024-03-13 |
2024-03-15 |
Not clear |
Kening Liu, Xu Zhou, Chunjin Li, Caomeihui Shen, Guitian He, Tong Chen, Maosheng Cao, Xue Chen, Boqi Zhang, Lu Che. YTHDF2 as a Mediator in BDNF-Induced Proliferation of Porcine Follicular Granulosa Cells. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397033. |
in female mammals, the proliferation and apoptosis of granulosa cells (gcs) are critical in determining the fate of follicles and are influenced by various factors, including brain-derived neurotrophic factor (bdnf). |
2024-02-24 |
2024-02-26 |
Not clear |
Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hs. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis. Environmental toxicology. 2024-02-14. PMID:38351887. |
overall, our results revealed that n. nucifera leaf extracts and q3g promoted adult hippocampus neurogenesis and prevented apoptosis to mitigate scopolamine-induced cognition dysfunction through the regulation of bdnf signaling pathway. |
2024-02-14 |
2024-02-16 |
mouse |