Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Mariam Merchant, Javaria Ashraf, Kiran Iqbal Masood, Maliha Yameen, Rabia Hussain, Asghar Nasir, Zahra Hasa. SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains. Scientific reports. vol 14. issue 1. 2024-10-29. PMID:39468120. |
we analysed transcriptional signatures of covid-19 patients comparing those infected with wildtype (wt), alpha, delta or omicron strains seeking insights into infection in asymptomatic cases.comparison of transcriptional profiles of symptomatic and asymptomatic covid-19 cases showed increased differentially regulated gene (degs) of inflammatory, apoptosis and blood coagulation pathways, with decreased t cell and interferon stimulated genes (isg) activation. |
2024-10-29 |
2024-10-31 |
Not clear |
Areege Ibrahim Salih, Basma Talib Al-Sudani, Bahir Abdul-Razzaq Mshimes. Targeting POLD1 to suppress the proliferation and migration of breast cancer MDA-MB-231 cell lines by downregulation of SIRT1. Toxicology research. vol 13. issue 4. 2024-07-22. PMID:39036524. |
sirt1 is a class iii histone deacetylase nad + -dependent enzyme that is interlinked in tumor progression, apoptosis, metastasis, and other mechanisms of tumorigenesis, while dna polymerase delta 1 (pold1) functions as a gene coding for p125, which plays an important role in genome stability and dna replication. |
2024-07-22 |
2024-07-24 |
Not clear |
Nan Chen, Yuanqi Xu, Yushuang Liu, Hanshu Zhao, Ruijia Liu, Zhongling Zhan. CEBPD aggravates apoptosis and oxidative stress of neuron after ischemic stroke by Nrf2/HO-1 pathway. Experimental cell research. 2024-06-10. PMID:38857839. |
ccaat enhancer binding protein delta (cebpd) is a transcription factor and plays an important role in apoptosis and oxidative stress, which are the main pathogenesis of ischemic stroke. |
2024-06-10 |
2024-06-14 |
rat |
Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Rigant. The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition. Translational oncology. vol 43. 2024-02-27. PMID:38412661. |
the highly selective and oral phosphoinositide 3-kinase delta (pi3k-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition. |
2024-02-27 |
2024-03-01 |
Not clear |
Trisiani Affandi, Ami Haas, Angela M Ohm, Gregory M Wright, Joshua C Black, Mary E Reylan. PKCð regulates chromatin remodeling and DNA repair through SIRT6. Molecular cancer research : MCR. 2023-10-27. PMID:37889141. |
we have previously shown that protein kinase c delta (pkcð) is required for ir-induced apoptosis and that inhibition of pkcð activity provides radioprotection in vivo. |
2023-10-27 |
2023-11-08 |
Not clear |
Hamid Soltani Zangbar, Solmaz Fallahi, Leila Hosseini, Meysam Ghorbani, Mohsen Jafarzadehgharehziaaddin, Parviz Shahab. Spinal cord injury leads to more neurodegeneration in the hippocampus of aged male rats compared to young rats. Experimental brain research. 2023-05-02. PMID:37129669. |
the locomotion, hippocampal apoptosis, hippocampal rhythms (delta, theta, beta, gamma) max frequency (max.rf) and power, hippocampal neurogenesis, and hippocampal receptors (nmda, gaba a, muscarinic1/m1), which are important in the generation of rhythms and neurogenesis, were compared in aged rats in contrast to young rats. |
2023-05-02 |
2023-08-14 |
human |
Ran Zhang, Meixuan Chen, Zhongfang Deng, Lingchao Kong, Bing Shen, Lesha Zhan. Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. Pharmaceutics. vol 15. issue 1. 2023-01-21. PMID:36678674. |
delta opioid peptide targets brain microvascular endothelial cells reducing apoptosis to relieve hypoxia-ischemic/reperfusion injury. |
2023-01-21 |
2023-08-14 |
rat |
Sandeep Saini, Savi Khurana, Dikshant Saini, Saru Rajput, Chander Jyoti Thakur, Jeevisha Singh, Akanksha Jaswal, Yogesh Kapoor, Varinder Kumar, Avneet Sain. In silico analysis of genomic landscape of SARS-CoV-2 and its variant of concerns (Delta and Omicron) reveals changes in the coding potential of miRNAs and their target genes. Gene. 2022-12-05. PMID:36470485. |
the go and kegg pathways terms analysis revealed the involvement of delta mirnas targeted genes in the pathways such as human cytomegalovirus infection, breast cancer, apoptosis, neurotrophin signaling, and axon guidance whereas the sphingolipid signaling pathway was found for the omicron. |
2022-12-05 |
2023-08-14 |
human |
Xi Wu, Jian Wang, Yan Kang, Qiang Wang, Jingwen Qu, Xiaomei Sun, Dejun Ji, Yongjun L. Regulation of Proliferation and Apoptosis of Hair Follicle Stem Cells by miR-145-5p in Yangtze River Delta White Goats. Genes. vol 13. issue 11. 2022-11-11. PMID:36360210. |
regulation of proliferation and apoptosis of hair follicle stem cells by mir-145-5p in yangtze river delta white goats. |
2022-11-11 |
2023-08-14 |
Not clear |
Yan Wang, Dianli Zhao, Jingjie Hu, Zhenmin Bao, Mengqiang Wan. Proteomic analysis of exosomes in pacific oyster Crassostrea gigas during bacterial stimulation. Fish & shellfish immunology. 2022-07-23. PMID:35870748. |
several proteins related to apoptosis, including e3 ubiquitin-protein ligase, eukaryotic translation initiation factor 3, and protein kinase c delta type were found up-regulated in the s. aureus stimulation group, indicating that the apoptosis process was involved in the response to s. aureus stimulation. |
2022-07-23 |
2023-08-14 |
Not clear |
Kuan-Ho Lin, Shang-Chuan Ng, Catherine R Paul, Hong-Chen Chen, Ren-You Zeng, Jian-Sheng Liu, Viswanadha V Padma, Chih-Yang Huang, Wei-Wen Ku. MicroRNA-210 repression facilitates advanced glycation end-product (AGE)-induced cardiac mitochondrial dysfunction and apoptosis via JNK activation. Journal of cellular biochemistry. vol 122. issue 12. 2021-12-10. PMID:34545968. |
our previous study showed that age-induced reactive oxygen species-dependent apoptosis is mediated via protein kinase c delta (pkcδ)-enhanced mitochondrial damage in cardiomyocytes. |
2021-12-10 |
2023-08-13 |
Not clear |
Qiong Xiang, Shuai Dong, Xian-Hui L. A Review of Phosphocreatine 3 Kinase δ Subtype (PI3Kδ) and Its Inhibitors in Malignancy. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-11-03. PMID:34625526. |
the phosphocreatine 3- kinase (pi3k) family includes the i-iii classes, with class i divided into 4 subtypes (alpha, ß, γ, delta); and pi3k signaling participates in the regulatory processes of cell proliferation, differentiation, apoptosis, and glucose transport. |
2021-11-03 |
2023-08-13 |
Not clear |
Jae Seok Yoon, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Ja Il Koo, Bum Sang Shim, Sung-Hoon Ki. Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha. Phytotherapy research : PTR. 2021-10-28. PMID:34709688. |
moracin d induces apoptosis in prostate cancer cells via activation of ppar gamma/pkc delta and inhibition of pkc alpha. |
2021-10-28 |
2023-08-13 |
Not clear |
Jiaqi Zhu, Peter Langer, Claas Ulrich, Jürgen Eberl. Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells. Antioxidants (Basel, Switzerland). vol 10. issue 10. 2021-10-26. PMID:34679649. |
concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic pkcδ (protein kinase c delta), inhibition of stat3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic xiap (x-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic bcl-2 protein puma and the cell cycle inhibitor p21 were obtained. |
2021-10-26 |
2023-08-13 |
Not clear |
JanWillem Duitman, Leonie Hartl, Joris J T H Roelofs, Maarten F Bijlsma, C Arnold Spe. Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation. Biomolecules. vol 11. issue 8. 2021-10-25. PMID:34439745. |
ccaat/enhancer-binding protein delta (c/ebpδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (pdac) cells. |
2021-10-25 |
2023-08-13 |
mouse |
Lizhi Lin, Jialiang Wen, Bangyi Lin, Hao Chen, Adheesh Bhandari, Yufeng Qi, Danni Zheng, Ouchen Wan. Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway. Acta biochimica et biophysica Sinica. vol 53. issue 4. 2021-07-16. PMID:33674820. |
phospholipase c delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via hippo pathway. |
2021-07-16 |
2023-08-13 |
Not clear |
Chunjuan Song, Adhithiya Charli, Jie Luo, Zainab Riaz, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 169. issue 2. 2020-05-04. PMID:30796443. |
prolonged endosulfan exposure (>9 h) triggered apoptotic signaling, including caspase-2 and -3 activation and protein kinase c delta (pkcδ) proteolytic activation, ultimately leading to cell death, thus demonstrating that autophagy precedes apoptosis during endosulfan neurotoxicity. |
2020-05-04 |
2023-08-13 |
Not clear |
X H Liu, D E Tang, Y Dai, X J Gao, L X Li. PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis. Neoplasma. vol 67. issue 1. 2020-03-13. PMID:31607135. |
proliferating cell nuclear antigen (pcna), as an auxiliary protein for dna polymerase delta, which regulates dna replication and repair, has been reported to play an important role in regulating apoptosis. |
2020-03-13 |
2023-08-13 |
Not clear |
Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Maria Oliveira-Souz. Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis. Scientific reports. vol 8. issue 1. 2019-12-02. PMID:30573754. |
using immunofluorescence images, flow cytometry and immunoblotting, we observed a time-dependent intracellular accumulation of fluorescent albumin-fitc-bsa, followed by concentration-and time-dependent effect of intracellular albumin overload on podocyte apoptosis, which was mediated by increased expression of the chaperone glucose-regulated-protein 78 (grp 78) and phosphorylated inositol-requiring enzyme 1 alpha (pire1-α), as well as protein kinase c delta (pkc-δ), p38mapk and cleaved caspase 12 expression. |
2019-12-02 |
2023-08-13 |
mouse |
Pengyu Liu, Wanlu Cao, Buyun Ma, Meng Li, Kan Chen, Kostandinos Sideras, Jan-Willem Duitman, Dave Sprengers, T C Khe Tran, Jan N M Ijzermans, Katharina Biermann, Joanne Verheij, C Arnold Spek, Jaap Kwekkeboom, Qiuwei Pan, Maikel P Peppelenbosc. Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma. Carcinogenesis. vol 40. issue 1. 2019-11-07. PMID:30325409. |
ccaat/enhancer-binding protein delta (cebpd) is associated with the regulation of apoptosis and cell proliferation and is a candidate tumor suppressor gene. |
2019-11-07 |
2023-08-13 |
mouse |