| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chia-Hwa Lee, Kai-Wen Hsu, Yao-Yu Hsieh, Wei-Ting Li, Yuqing Long, Chun-Yu Lin, Shu-Huey Che. Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection. Cells. vol 13. issue 7. 2024-04-12. PMID:38607055. |
however, a notable proportion of cml patients develop resistance to imatinib, often due to the persistence of leukemia stem cells and resistance mechanisms independent of bcr::abl1 this study investigates the roles of il6r, il7r, and myc in imatinib resistance by employing crispr/cas9 for gene editing and the non-invasive apoptosis detection sensor version 2 (niads v2) for apoptosis assessment. |
2024-04-12 |
2024-04-14 |
Not clear |
| Atena Yousefi, Fattah Sotoodehnejadnematalahi, Nahid Nafissi, Sirous Zeinali, Masoumeh Aziz. MicroRNA-561-3p indirectly regulates the PD-L1 expression by targeting ZEB1, HIF1A, and MYC genes in breast cancer. Scientific reports. vol 14. issue 1. 2024-03-11. PMID:38462658. |
the aim of this study was to investigate the inhibitory effect of mir-561-3p on zeb1, hif1a, and myc expression as oncogenes that have the most impact on pd-l1 overexpression and cellular processes such as proliferation, apoptosis, and cell cycle in breast cancer (bc) cell lines. |
2024-03-11 |
2024-03-14 |
human |
| Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy, Capucine Heraud, Albert Grinshpun, Qi Zhang, Allegra Freelander, Matthew Joseph Leventhal, Avery Feit, Gabriella Cohen Feit, Ariel Feiglin, Weihan Liu, Francisco Hermida-Prado, Nikolas Kesten, Wen Ma, Carmine De Angelis, Antonio Morlando, Madison O'Donnell, Sergey Naumenko, Shixia Huang, Quang-De Nguyen, Ying Huang, Luca Malorni, Johann S Bergholz Villafane, Jean J Zhao, Ernest Fraenkel, Elgene Lim, Rachel Schiff, Geoffrey I Shapiro, Rinath Jeselsoh. Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024-02-21. PMID:38381406. |
selective cdk7 inhibition suppresses cell cycle progression and myc signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer. |
2024-02-21 |
2024-02-23 |
Not clear |
| Gerhard Hamilton, Sandra Stickler, Barbara Rat. Bromodomain Protein-directed Agents and MYC in Small Cell Lung Cancer. Current cancer drug targets. 2024-01-26. PMID:38275056. |
myc and paralogs have key roles in the oncogenic process, orchestrating proliferation, apoptosis, differentiation, and metabolism. |
2024-01-26 |
2024-01-28 |
Not clear |
| Stefan Schütz, Christian Bergsdorf, Sandra Hänni-Holzinger, Andreas Lingel, Martin Renatus, Alvar D Gossert, Wolfgang Jahnk. Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions. Biochemistry. 2024-01-24. PMID:38264995. |
at promoters containing these sequence motifs, myc controls fundamental cellular processes such as cell cycle progression, metabolism, and apoptosis. |
2024-01-24 |
2024-01-26 |
Not clear |
| Van S Tompkins, Zheng Xue, Jake M Peterson, Warren B Rouse, Collin A O'Leary, Walter N Mos. Identification of MYC intron 2 regions that modulate expression. PloS one. vol 19. issue 1. 2024-01-18. PMID:38236931. |
myc pre-mrna is spliced with high fidelity to produce the transcription factor known to regulate cellular differentiation, proliferation, apoptosis, and alternative splicing. |
2024-01-18 |
2024-01-21 |
Not clear |
| Zi-Tan Peng, Rong Hu, Jing-Yu F. Sulforaphane suppresses cell proliferation and induces apoptosis in glioma via the ACTL6A/PGK1 axis. Toxicology mechanisms and methods. 2024-01-15. PMID:38221767. |
cell viability, proliferation, and apoptosis were assessed using standard assays, and levels of mrnas encoding actl6a, pgk1, cyclin d1, myc, bax or bcl-2 were measured using quantitative real-time polymerase chain reaction (qrt-pcr). |
2024-01-15 |
2024-01-17 |
Not clear |
| Li Zhang, Yuhan Zhang, Kaixuan Li, Shuai Xu. Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020914. |
gli is reported to activate the main dna repair pathways, to interact with cell cycle regulators like cyclin d and cyclin e, to inhibit apoptosis via the activation of b-cell lymphoma-2, forkhead box m1, and the myc proto-oncogene, to upregulate cell stemness related genes (nanog, pou class 5 homeobox 1, sry-box transcription factor 2, and the bmi1 proto-oncogene), and to promote cancer stem cell transformation. |
2023-12-01 |
2023-12-07 |
mouse |
| Li Zhang, Yuhan Zhang, Kaixuan Li, Shuai Xu. Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020914. |
gli is reported to activate the main dna repair pathways, to interact with cell cycle regulators like cyclin d and cyclin e, to inhibit apoptosis via the activation of b-cell lymphoma-2, forkhead box m1, and the myc proto-oncogene, to upregulate cell stemness related genes (nanog, pou class 5 homeobox 1, sry-box transcription factor 2, and the bmi1 proto-oncogene), and to promote cancer stem cell transformation. |
2023-11-29 |
2023-12-07 |
mouse |
| Tingting Xia, Bin Wang, Lingling Su. The nucleolar protein NIFK accelerates the progression of colorectal cancer via activating MYC pathway. Bioscience, biotechnology, and biochemistry. 2023-11-11. PMID:37950567. |
silencing nifk could inhibit cell growth and metastasis, and promoted apoptosis, as well as regulated fatty acid metabolism by inhibiting myc pathway in crc. |
2023-11-11 |
2023-11-20 |
Not clear |
| Rajiv Kumar Jha, Fedor Kouzine, David Leven. MYC function and regulation in physiological perspective. Frontiers in cell and developmental biology. vol 11. 2023-11-09. PMID:37941901. |
myc, a key member of the myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. |
2023-11-09 |
2023-11-20 |
Not clear |
| Renata Woroniecka, Grzegorz Rymkiewicz, Zbigniew Bystydzienski, Barbara Pienkowska-Grela, Jolanta Rygier, Natalia Malawska, Katarzyna Wojtkowska, Nikolina Goral, Katarzyna Blachnio, Marcin Chmielewski, Magdalena Bartnik-Glaska, Beata Grygalewic. Cytogenomic features of Richter transformation. Molecular cytogenetics. vol 16. issue 1. 2023-11-08. PMID:37941034. |
in recent years, there has been a deeper understanding of rt molecular pathogenesis, and disruptions of apoptosis (tp53) and proliferation (cdkn2a, myc, notch1) has been described as typical aberrations in rt. |
2023-11-08 |
2023-11-20 |
Not clear |
| Melanie M Frigault, Arushi Mithal, Harvey Wong, Beatrix Stelte-Ludwig, Vinay Mandava, Xin Huang, Joseph Birkett, Amy J Johnson, Raquel Izumi, Ahmed M Hamd. Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription. Cancer research communications. 2023-10-26. PMID:37882668. |
tumor growth inhibition reaching 0.5% of control treated su-dhl-10 xenografts is achieved in vivo and myc and mcl1 depletion as well as evidence of apoptosis activation after enitociclib treatment is demonstrated. |
2023-10-26 |
2023-11-08 |
Not clear |
| Matthew Hurd, Jeffrey Pino, Kay Jang, Michael M Allevato, Marina Vorontchikhina, Wataru Ichikawa, Yifan Zhao, Ryan Gates, Emily Villalpando, Michael J Hamilton, Francesco Faiola, Songqin Pan, Yue Qi, Yu-Wen Hung, Thomas Girke, David Ann, Victoria Seewaldt, Ernest Martine. MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival. Genes & development. 2023-10-18. PMID:37852796. |
lysine-to-arginine substitutions indicate that although none of the ack residues is required for myc stimulation of adherent cell proliferation, individual ack sites have gene-specific functions controlling select myc-regulated processes in cell adhesion, contact inhibition, apoptosis, and/or metabolism and are required for the malignant cell transformation activity of myc. |
2023-10-18 |
2023-11-08 |
mouse |
| Janne Purhonen, Juha Klefström, Jukka Kallijärv. MYC-an emerging player in mitochondrial diseases. Frontiers in cell and developmental biology. vol 11. 2023-09-21. PMID:37731815. |
in addition to being a metabolic regulator, myc promotes cellular proliferation and modifies the cell cycle kinetics and, especially at high expression levels, promotes replication stress and genomic instability, and sensitizes cells to apoptosis. |
2023-09-21 |
2023-10-07 |
mouse |
| Chorong Jang, Scott W Blume, Hyoung Soo Cho. Novel protein products encoded by upstream open reading frames of the MYCN gene in pediatric embryonal tumors. Journal of cellular biochemistry. 2023-09-08. PMID:37682868. |
significant levels of apoptosis were observed in each pediatric embryonal tumor cell line but not t47d breast carcinoma cells, suggesting that response to jq1 transcriptional inhibition is greatest in tumor cells, which depend on myc to maintain an undifferentiated phenotype. |
2023-09-08 |
2023-10-07 |
Not clear |
| María P Gervé, Juan A Sánchez, María C Ingaramo, Andrés Dekant. Myc-regulated miRNAs modulate p53 expression and impact animal survival under nutrient deprivation. PLoS genetics. vol 19. issue 8. 2023-08-28. PMID:37639481. |
the conserved transcription factor myc regulates cell growth, proliferation and apoptosis, and its deregulation has been associated with human pathologies. |
2023-08-28 |
2023-09-07 |
human |
| Barbara Illi, Sergio Nas. Myc beyond Cancer: Regulation of Mammalian Tissue Regeneration. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 30. issue 3. 2023-08-22. PMID:37606389. |
in healthy cells, myc controls molecular mechanisms involved in pivotal functions, such as cell cycle (and proliferation thereof), apoptosis, metabolism and cell size, angiogenesis, differentiation and stem cell self-renewal. |
2023-08-22 |
2023-09-07 |
Not clear |
| Haidong Yao, Xue Chen, Ting Wang, Muhammad Kashif, Xi Qiao, Elin Tüksammel, Lars-Gunnar Larsson, Sam Okret, Volkan I Sayin, Hong Qian, Martin O Berg. A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561633. |
here, we report that high myc expression stimulates proliferation and protects b lymphoma cells from apoptosis under normal oxidative stress levels and that compounds including n-acetylcysteine (nac) and vitamin c (vitc) induce apoptosis by reducing oxidative stress. |
2023-08-10 |
2023-08-16 |
Not clear |
| Haidong Yao, Xue Chen, Ting Wang, Muhammad Kashif, Xi Qiao, Elin Tüksammel, Lars-Gunnar Larsson, Sam Okret, Volkan I Sayin, Hong Qian, Martin O Berg. A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561633. |
mechanistically, nac and vitc stimulate myc binding to egr1 through cys117 of myc, shifting its transcriptional output from cell cycle to apoptosis gene expression. |
2023-08-10 |
2023-08-16 |
Not clear |