| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haidong Yao, Xue Chen, Ting Wang, Muhammad Kashif, Xi Qiao, Elin Tüksammel, Lars-Gunnar Larsson, Sam Okret, Volkan I Sayin, Hong Qian, Martin O Berg. A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561633. |
these results identify a redox-controlled mechanism for myc's role in maintaining proliferation and preventing apoptosis, offering a potential therapeutic rationale for evaluating nac or vitc in patients with myc-driven b cell lymphoma. |
2023-08-10 |
2023-08-16 |
Not clear |
| Zhongbo Xu, Manyang Shen, Lin L. Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking. Medicine. vol 102. issue 29. 2023-07-21. PMID:37478218. |
the central core targets were il6, mapk14, signal transducer and activator of transcription 3, rela, vegfa, ccnd1, casp3, ar, fos, jun, egfr, mapk1, akt1, myc, and esr1; gene ontology functional enrichment analysis yielded 911 gene ontology items (p < .01), while kyoto encyclopedia of genes and genomes pathway enrichment yielded 138 signal pathways (p < .01), primarily including oxidative reactions, vascular regulation, apoptosis, and pi3k-akt signaling pathway. |
2023-07-21 |
2023-08-14 |
Not clear |
| Rut Espinosa-Sotelo, Noel P Fusté, Irene Peñuelas-Haro, Ania Alay, Gabriel Pons, Xènia Almodóvar, Júlia Albaladejo, Ismael Sánchez-Vera, Ricard Bonilla-Amadeo, Francesco Dituri, Grazia Serino, Emilio Ramos, Teresa Serrano, Mariona Calvo, María Luz Martínez-Chantar, Gianluigi Giannelli, Esther Bertran, Isabel Fabrega. Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma. Redox biology. vol 65. 2023-07-18. PMID:37463530. |
tgf-β-mediated inhibition of cell proliferation and viability is attenuated in nox4 silenced cells, correlating with decreased response in terms of apoptosis, and maintenance of high expression of myc and cyclin d1. |
2023-07-18 |
2023-08-14 |
human |
| Ka Iong Chan, Siyuan Zhang, Guodong Li, Yida Xu, Liao Cui, Yitao Wang, Huanxing Su, Wen Tan, Zhangfeng Zhon. MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products. Aging and disease. 2023-07-14. PMID:37450923. |
we also discuss the multifunctional capacity of myc in various cellular cancer processes, including its influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, and intestinal flora. |
2023-07-14 |
2023-08-14 |
Not clear |
| Xinyuan Chen, Harry Taegyun Yang, Beatrice Zhang, John W Phillips, Donghui Cheng, Frank Rigo, Owen N Witte, Yi Xing, Douglas L Blac. The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 28. 2023-07-03. PMID:37399401. |
interestingly, hnrnpf expression showed a positive correlation with myc hallmarks and thus was not consistent with the observed effects of hnrnp f. loss of hnrnp h/f altered cell cycle progression and induced apoptosis in the pc3 prostate cancer cell line. |
2023-07-03 |
2023-08-14 |
human |
| Zhe Zhang, Xiaoyi Zhang, Zhaojun Ren, Xiaoliu Wu, Haishi Qiao, Xin Huang, Wei Zhao, Yuanying Zhang, Kexin Lo. Biomimetic black phosphorus nanosheets codeliver CDK9 and BRD4 inhibitors for gastric cancer targeted therapy. Journal of materials chemistry. B. 2023-06-22. PMID:37345728. |
combining the brd4 and cdk9 inhibitors can trigger the significant down-regulation of the myc oncogene as well as anti-apoptotic genes and induce tumor cell apoptosis by synergistically impairing rna synthesis in cancer cells. |
2023-06-22 |
2023-08-14 |
Not clear |
| Zao Zhang, Meiying Ning, Li Li, Zhuangzhuang Li, Yanrong Wang, Jing Zha. Knockdown of ASF1B inhibits cell proliferation, migration, invasion and cisplatin resistance in gastric cancer through the Myc pathway. Oncology letters. vol 25. issue 6. 2023-05-08. PMID:37153049. |
in conclusion, the results indicate that knockdown of asf1b may suppress gc cell proliferation, migration and invasion, and promote cell apoptosis and cisplatin sensitivity by modulating the myc pathway, thereby offering novel possibilities for reversing cisplatin resistance in gc. |
2023-05-08 |
2023-08-14 |
human |
| Dong Chen, Huiming You, Xiaoping Xu, Daocheng Liu, Minmin Shen, Yuan Pan, Zhaohui Liu, Lei Zhang, Huijuan Wan. MYC-activated CERS6-AS1 sponges miR-6838-5p and regulates the expression of RUBCNL in colorectal cancer. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 12. 2023-05-02. PMID:37130182. |
moreover, cers6-as1 activated by myc could sequestermir-6838-5p, and then regulate rubicon-like autophagy enhancer (rubcnl) expression level to influence the crc cell proliferation, migration and apoptosis. |
2023-05-02 |
2023-08-14 |
Not clear |
| Hong-Beom Park, Yosuk Min, Sohyun Hwang, Kwang-Hyun Bae. Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-16. PMID:37062218. |
moreover, it also known that usp7 functions in the cell cycle, apoptosis, dna repair, chromatin remodeling, and epigenetic regulation through deubiquitination of several substrates including p53, mouse double minute 2 homolog (mdm2), myc, and phosphatase and tensin homolog (pten). |
2023-04-16 |
2023-08-14 |
mouse |
| Leonie I Weber, Markus Hart. Strategies to target the cancer driver MYC in tumor cells. Frontiers in oncology. vol 13. 2023-03-27. PMID:36969025. |
myc is required for fundamental cellular processes triggering proliferation, growth, differentiation, or apoptosis and also represents a major cancer driver being aberrantly activated in most human tumors. |
2023-03-27 |
2023-08-14 |
human |
| Julie F Foley, Brian Elgart, Dhiral Phadke, Deepak Mav, Ignacio Tripodi, Nicholas Clausen, Madeleine Weick, Wes Gladwell, Kevin Gerrish, Ruchir Shah, B Alex Merric. Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats. Journal of applied toxicology : JAT. 2023-03-13. PMID:36908029. |
these included hallmark gene sets associated with cell proliferation (myc targets version 1 and version 2, e2f targets), cell cycle (g2m checkpoint, mitotic spindle), cell death (apoptosis), and dna damage (dna repair, uv response up, reactive oxygen species) pathways. |
2023-03-13 |
2023-08-14 |
rat |
| Dalila Boi, Elisabetta Rubini, Sara Breccia, Giulia Guarguaglini, Alessandro Paiardin. When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902175. |
myc transcription factors are key regulators of many cellular processes, with myc target genes crucially implicated in the management of cell proliferation and stem pluripotency, energy metabolism, protein synthesis, angiogenesis, dna damage response, and apoptosis. |
2023-03-11 |
2023-08-14 |
Not clear |
| Takehiro Miyazaki, Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Chihiro Yabe-Nishimura, Hongliang Zhang, Yves Pommier, Andreas Trumpp, Takashi Shinohar. Glutamine protects mouse spermatogonial stem cells against NOX1-derived ROS for sustaining self-renewal division in vitro. Development (Cambridge, England). 2023-03-10. PMID:36897562. |
gln induced myc expression to drive ssc self-renewal in vitro, whereas gln deprivation triggered trp53-dependent apoptosis and impaired ssc activity. |
2023-03-10 |
2023-08-14 |
mouse |
| Atsushi Kimura, Yo-Han Kim, Kazuyoshi Hashizume, Akira Ito, Katsuyuki Mukai, Keiichiro Kizaki, Shigeru Sat. Effects of oral β-cryptoxanthin administration on the transcriptomes of peripheral neutrophil and liver tissue using microarray analysis in post-weaned Holstein calves. Journal of animal physiology and animal nutrition. 2023-03-06. PMID:36876888. |
an in silico analysis revealed that myc, which is related to the regulation of cellular differentiation and apoptosis, was the most significant upstream regulator in neutrophils and liver tissue. |
2023-03-06 |
2023-08-14 |
Not clear |
| Yan Xiong, Lulu Wang, Shiyao Xu, Beibei Fu, Yuchen Che, Mohamed Y Zaky, Rong Tian, Rui Yao, Dong Guo, Zhou Sha, Feng Lin, Xiaoyuan Lin, Haibo W. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth. Clinical and translational medicine. vol 13. issue 1. 2023-01-13. PMID:36639831. |
the myc oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others. |
2023-01-13 |
2023-08-14 |
human |
| Xue-Qin Chen, Ling-Lan Li, Guo-Tao Fu, Li-Xin Han, Rui-Peng Wu, Yong-Min Xiong, Chuan-Dao Shi, Qi-Ling Liu, Rong-Qiang Zhan. [Expression and Regulatory Mechanism of Autophagy-related Genes in Synovial Tissues of Patients with Rheumatoid Arthritis]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 44. issue 6. 2023-01-09. PMID:36621784. |
objective to investigate the expression regulation of autophagy-related genes(atg)and the mechanism of autophagy in rheumatoid arthritis(ra).methods the differentially expressed genes(deg)of ra were identified from gse55235 and gse55457,on the basis of which the differentially expressed autophagy-related genes(de-atg)were selected from the human autophagy database.string 11.0 and genemania were used to establish protein-protein interaction networks.further,the transcription factor-gene-mirna co-expression network was established via networkanalyst and cytoscape.finally,receiver operating characteristic(roc)curve and drugbank were employed to evaluate the efficacy of the predicted biomarkers and the performance of drugs targeting de-atg.graphpad prism 8.2.1 and r 4.0.3 were used for statistical analysis and graphics.results a total of 485 deg were enriched in signaling pathways such as t cell activation,hormone regulation,osteoclast differentiation,ra,and chemokines.eleven de-atg regulated the expression of runx1,tp53,sox2,and hsa-mir-155-5p in synovial tissues of ra patients and were involved in the response to environmental factors such as 2,3,7,8-tetrachlorodibenzodioxin and silicon dioxide.the roc curve analysis identified the de-atg with good sensitivity and specificity,such as myc,mapk8,cdkn1a,and tnfsf10,which can be used to distinguish certain phenotypes and serve as novel biomarkers for ra.conclusions in ra,down-regulated de-atg expression may promote apoptosis and lysis of chondrocytes.the identified novel biomarkers provides new ideas and methods for diagnosing and treating ra.the establishment of transcription factor-mirna-gene co-expression network provides direct evidence for dissecting synovial inflammation and articular cartilage destruction. |
2023-01-09 |
2023-08-14 |
human |
| Simonas Valiuska, Alexandra Maria Psaras, Véronique Noé, Tracy A Brooks, Carlos J Ciuda. Targeting MYC Regulation with Polypurine Reverse Hoogsteen Oligonucleotides. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613820. |
in cancer cells addicted to their aberrant myc function, suppression can lead to apoptosis, with minimal effects on non-addicted, non-oncogenic cells, providing a wide therapeutic window for specific and efficacious anti-tumor treatment. |
2023-01-08 |
2023-08-14 |
Not clear |
| Wen-Hsuan Chang, Yinzhe Liu, Emma A Hammes, Kirsten L Bryant, Richard A Cerione, Marc A Antonya. Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein (IAP) family member Survivin. The Journal of biological chemistry. 2022-12-29. PMID:36581205. |
oncogenic ras promotes myc protein stability by upregulating the expression of the inhibitor of apoptosis protein (iap) family member survivin. |
2022-12-29 |
2023-08-14 |
Not clear |
| Wen-Hsuan Chang, Yinzhe Liu, Emma A Hammes, Kirsten L Bryant, Richard A Cerione, Marc A Antonya. Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein (IAP) family member Survivin. The Journal of biological chemistry. 2022-12-29. PMID:36581205. |
here, we identify how this essential signaling connection between oncogenic kras and myc expression is mediated by the inhibitor of apoptosis protein (iap) family member survivin. |
2022-12-29 |
2023-08-14 |
Not clear |
| Brian C Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jenifer Charlton, Agnes Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gome. Overexpression of Notch Signaling in Renin Cells Leads to a Polycystic Kidney Phenotype. Clinical science (London, England : 1979). 2022-12-12. PMID:36503993. |
while the genetic basis of pkd is known, the downstream molecular mechanisms and signaling pathways which lead to deregulation of proliferation, apoptosis, and differentiation are not completely understood. the notch pathway plays critical roles during kidney development including directing differentiation of various progenitor cells, and aberrant notch signaling results in gross alternations in cell fate. in this study, we generated and studied transgenic mice which have overexpression of an intracellular fragment of mouse notch1 ("notchic") in renin-expressing cells. mice with overexpression of notchic in renin-expressing cells developed numerous fluid-filled cysts, enlarged kidneys, anemia, renal insufficiency, and early death. cysts developed in both glomeruli and proximal tubules, had increased proliferation marks, and had increased levels of myc. |
2022-12-12 |
2023-08-14 |
mouse |