| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruno Rizzuti, Juan L Iovanna, José L Neir. Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499669. |
the oncoprotein myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. |
2022-12-11 |
2023-08-14 |
Not clear |
| Joaquim Carreras, Giovanna Roncador, Rifat Hamoud. Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358737. |
oncogenes and tumor suppressor genes were highlighted (myc, bcl2, and tp53), along with immune microenvironment markers of tumor-associated macrophages (m2-like tams), t-cells and regulatory t lymphocytes (tregs) (cd68, cd163, marco, csf1r, csf1, pd-l1/cd274, sirpa, cd85a/lilrb3, cd47, il10, tnfrsf14/hvem, tnfaip8, ikaros, stat3, nfkb, mapk, pd-1/pdcd1, btla, and foxp3), apoptosis (bcl2, casp3, casp8, parp, and pathway-related mdm2, e2f1, cdk6, myb, and lmo2), and metabolism (eno3, gga3). |
2022-11-11 |
2023-08-14 |
Not clear |
| Aleksandra Boikova, Megan J Bywater, Gregory A Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D Littlewood, Gerard I Evan, James E Hudson, Catherine H Wilso. HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes. Frontiers in cardiovascular medicine. vol 9. 2022-11-07. PMID:36337898. |
hras and myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes. |
2022-11-07 |
2023-08-14 |
mouse |
| Lívia Bassani Lins de Miranda, Keli Lima, Juan Luiz Coelho-Silva, Fabiola Traina, Susumu S Kobayashi, João Agostinho Machado-Net. NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells. Scientific reports. vol 12. issue 1. 2022-10-12. PMID:36224313. |
besides, nt157 decreased expression of oncogenes bcl2, ccnd1, myb, and myc and increased genes related to cellular stress and apoptosis, jun, bbc3, cdkn1a, cdkn1b, fos, and egr1 (p < 0.05), favoring a tumor-suppressive cell signaling network in the context of lung cancer. |
2022-10-12 |
2023-08-14 |
Not clear |
| Stefan Schütz, Christian Bergsdorf, Benedikt Goretzki, Andreas Lingel, Martin Renatus, Alvar D Gossert, Wolfgang Jahnk. The disordered MAX N-terminus modulates DNA binding of the transcription factor MYC:MAX. Journal of molecular biology. 2022-09-29. PMID:36174765. |
in complex with its cognate binding partner max, myc preferentially binds to e-box promotor sequences where it controls fundamental cellular processes such as cell cycle progression, metabolism, and apoptosis. |
2022-09-29 |
2023-08-14 |
Not clear |
| Mohamed E M Saeed, Joelle C Boulos, Sabrina B Mücklich, Ellen Leich, Manik Chatterjee, Sabine M Klauck, Thomas Effert. Disruption of Lipid Raft Microdomains, Regulation of CD38, TP53, and MYC Signaling, and Induction of Apoptosis by Lomitapide in Multiple Myeloma Cells. Cancer genomics & proteomics. vol 19. issue 5. 2022-08-19. PMID:35985681. |
disruption of lipid raft microdomains, regulation of cd38, tp53, and myc signaling, and induction of apoptosis by lomitapide in multiple myeloma cells. |
2022-08-19 |
2023-08-14 |
Not clear |
| Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J Patti, Andrew H Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R Kranc, Maria Christophorou, Erika L Pearce, Ingo Ringshausen, Andrew J Finc. MYC sensitises cells to apoptosis by driving energetic demand. Nature communications. vol 13. issue 1. 2022-08-09. PMID:35945217. |
myc sensitises cells to apoptosis by driving energetic demand. |
2022-08-09 |
2023-08-14 |
Not clear |
| Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J Patti, Andrew H Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R Kranc, Maria Christophorou, Erika L Pearce, Ingo Ringshausen, Andrew J Finc. MYC sensitises cells to apoptosis by driving energetic demand. Nature communications. vol 13. issue 1. 2022-08-09. PMID:35945217. |
the myc oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. |
2022-08-09 |
2023-08-14 |
Not clear |
| Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J Patti, Andrew H Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R Kranc, Maria Christophorou, Erika L Pearce, Ingo Ringshausen, Andrew J Finc. MYC sensitises cells to apoptosis by driving energetic demand. Nature communications. vol 13. issue 1. 2022-08-09. PMID:35945217. |
myc induces several biosynthetic programmes and primary cells overexpressing myc are highly sensitive to glutamine withdrawal suggesting that myc-induced sensitisation to apoptosis may be due to imbalance of metabolic/energetic supply and demand. |
2022-08-09 |
2023-08-14 |
Not clear |
| Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M Guardia, Amy Kullas, Kevin Crosby, Robin R Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D Rosenzweig, Juan S Bonifacino, Gulbu Uzel, Peter R Williamson, Erwin W Gelfan. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in Autophagy. 2022-07-15. PMID:35838483. |
autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in bcl2: bcl2 apoptosis regulator; bcl10: bcl10 immune signaling adaptor; card11: caspase recruitment domain family member 11; cbm: card11-bcl10-malt1; cr2: complement c3d receptor 2; ebna: epstein barr nuclear antigen; ebv: epstein-barr virus; fcgr3a; fc gamma receptor iiia; glild: granulomatous-lymphocytic interstitial lung disease; hv: healthy volunteer; ikbkb/ikb kinase: inhibitor of nuclear factor kappa b kinase subunit beta; il2ra: interleukin 2 receptor subunit alpha; malt1: malt1 paracaspase; ms4a1: membrane spanning 4-domain a1; mtor: mechanistic target of rapamycin kinase; myc: myc proto-oncogene, bhlh: transcription factor; ncam1: neural cell adhesion molecule 1; nfkb: nuclear factor kappa b; niaid: national institute of allergy and infectious diseases; nk: natural killer; ptprc: protein tyrosine phosphatase receptor type c; sell: selectin l; pbmcs: peripheral blood mononuclear cells; tr: t cell receptor; tregs: regulatory t cells; wt: wild-type. |
2022-07-15 |
2023-08-14 |
human |
| Brian C Grieb, Christine M Eische. MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging. Biology. vol 11. issue 6. 2022-06-24. PMID:35741402. |
myc regulates a wide range of critical cellular and oncogenic activities including proliferation, metabolism, metastasis, apoptosis, and differentiation by transcriptionally activating or repressing the expression of a large number of genes. |
2022-06-24 |
2023-08-14 |
human |
| Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wan. Transcriptome Reveals Granulosa Cells Coping through Redox, Inflammatory and Metabolic Mechanisms under Acute Heat Stress. Cells. vol 11. issue 9. 2022-05-19. PMID:35563749. |
downregulation of mdm4, tp53, pidd1, parp3, mapk14 and myc, and upregulation of stk26, stk33, tgfb2, cdkn1a and cdkn2a, at the interface of the mapk and p53 signaling pathway, can be attributed to transient cellular senescence and apoptosis in gcs. |
2022-05-19 |
2024-08-30 |
cat |
| Feng Zhang, Xia Yang, Zhijun Ba. Bioinformatics network analyses of growth differentiation factor 11. Open life sciences. vol 17. issue 1. 2022-05-18. PMID:35582621. |
our findings suggested that gdf11 is involved in a variety of functions, such as apoptosis, dna repair, telomere maintenance, and interaction with key transcription factors, such as myc proto-oncogene, specificity protein 1, and ets proto-oncogene 2. |
2022-05-18 |
2023-08-13 |
human |
| Florian Sperling, Danny Misiak, Stefan Hüttelmaier, Patrick Michl, Heidi Griesman. IGF2BP1 Promotes Proliferation of Neuroendocrine Neoplasms by Post-Transcriptional Enhancement of EZH2. Cancers. vol 14. issue 9. 2022-05-14. PMID:35565249. |
combined targeting of igf2bp1, ezh2, and myc, a transcriptional activator of ezh2 and well-known target of igf2bp1 cooperatively induces tumor cell apoptosis. |
2022-05-14 |
2023-08-13 |
Not clear |
| E A Klimov, V V Sobolev, N A Batashkov, Z G Kokaeva, A V Tretiakov, Z A Nevozinskaya, I M Korsunskaya, T N Sukhova, O E Evina, A Z Khashukoev. Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus. Bulletin of experimental biology and medicine. 2022-05-02. PMID:35501640. |
we assessed the level of transcriptional activity of apaf1, bax, bcl2, birc5, ccnd1, dapk1, mcl1, and myc genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). |
2022-05-02 |
2023-08-13 |
Not clear |
| Hodaka Takeuchi, Tsutomu Miyamoto, Chiho Fuseya, Ryoichi Asaka, Koichi Ida, Motoki Ono, Yasuhiro Tanaka, Manaka Shinagawa, Hirofumi Ando, Shiho Asaka, Tanri Shiozaw. PIM1 is a Poor Prognostic Factor for and Potential Therapeutic Target in Serous Carcinoma of the Endometrium. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2022-04-20. PMID:35443252. |
pim1 is a serine/threonine kinase involved in various cellular functions, such as cell cycle progression, apoptosis, and transcriptional activation via the phosphorylation of many target proteins, including myc. |
2022-04-20 |
2023-08-13 |
mouse |
| Guiqin Xie, Ailin Zhu, Xinbin G. Converged DNA Damage Response Renders Human Hepatocellular Carcinoma Sensitive to CDK7 Inhibition. Cancers. vol 14. issue 7. 2022-04-12. PMID:35406486. |
importantly, transcription-inhibition-induced apoptosis is associated with dna damage, and exogenous myc expression further enhanced the thz1-induced dna damage response in myc-overexpressing hepg2 cells. |
2022-04-12 |
2023-08-13 |
mouse |
| Irene Marchesi, Milena Fais, Francesco Paolo Fiorentino, Valentina Bordoni, Luca Sanna, Stefano Zoroddu, Luigi Bagell. Bromodomain Inhibitor JQ1 Provides Novel Insights and Perspectives in Rhabdomyosarcoma Treatment. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408939. |
jq1 induces g1 arrest in cells with the highest steady-state levels of myc, whereas apoptosis is associated with myc downregulation. |
2022-04-12 |
2023-08-13 |
Not clear |
| Colin J Daniel, Carl Pelz, Xiaoyan Wang, Michael W Munks, Aaron Ko, Dhaarini Murugan, Sarah A Byers, Eleonora Juarez, Karyn L Taylor, Guang Fan, Lisa M Coussens, Jason M Link, Rosalie C Sear. T-cell dysfunction upon expression of MYC with altered phosphorylation at Threonine 58 and Serine 62. Molecular cancer research : MCR. 2022-04-05. PMID:35380701. |
as a transcription factor that promotes cell growth, proliferation and apoptosis, c-myc (myc) expression in the cell is tightly controlled. |
2022-04-05 |
2023-08-13 |
mouse |
| Shantanu Gupta, Ronaldo F Hashimot. Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer. Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327612. |
furthermore, mir-34a induces senescence and apoptosis in breast, glioma, cervical cancer including nsclc by targeting myc. |
2022-03-25 |
2023-08-13 |
Not clear |