| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenlu Li, Haolong Luo, Mengyuan Chen, Fuxing Lin, Xiangmei Ren, Yefei Huang, Li Zho. Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway. Reproductive toxicology (Elmsford, N.Y.). 2025-03-15. PMID:40089166. |
bisphenol af induces cell cycle arrest and apoptosis in tm3 leydig cells via the p53 signaling pathway. |
2025-03-15 |
2025-03-18 |
Not clear |
| Chenlu Li, Haolong Luo, Mengyuan Chen, Fuxing Lin, Xiangmei Ren, Yefei Huang, Li Zho. Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway. Reproductive toxicology (Elmsford, N.Y.). 2025-03-15. PMID:40089166. |
furthermore, pifithrin-α (pft-α), a p53 inhibitor, attenuated bpaf-induced g2/m cell cycle arrest and apoptosis. |
2025-03-15 |
2025-03-18 |
Not clear |
| Chenlu Li, Haolong Luo, Mengyuan Chen, Fuxing Lin, Xiangmei Ren, Yefei Huang, Li Zho. Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway. Reproductive toxicology (Elmsford, N.Y.). 2025-03-15. PMID:40089166. |
these results demonstrate that the p53 signaling pathway mediates bpaf-induced cell cycle arrest and apoptosis in leydig cells, providing mechanistric insights into bpaf's toxicological effects on the male reproductive system. |
2025-03-15 |
2025-03-18 |
Not clear |
| Mahmoud Faezi, Alireza Motavalizadehkakhky, Masoud Homayouni Tabrizi, Samaneh Dolatabadi, Ali Es-Hagh. Zein-sodium caseinate-diosmin nanoparticles as a promising anti-cancer agent with targeted efficacy against A2780 cell line. Scientific reports. vol 15. issue 1. 2025-03-14. PMID:40082691. |
flow cytometry analysis confirmed that zcd-nps induced apoptosis and necrosis in a2780 cells, as evidenced by increased expression of apoptotic genes such as p53 and caspases 8 and 9. |
2025-03-14 |
2025-03-16 |
Not clear |
| Meifeng Chen, Hongbing Pang, Pham Thi Thai Hoa, Yongfei He, Qiang Gao, Yuan Liao, Chunyi Zhu, Linqian Chen, Guohong Yan, Shutian Mo, Chuangye Ha. 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis. Toxicology and applied pharmacology. 2025-03-14. PMID:40086489. |
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione from averrhoa carambola l. roots: suppressing hepatocellular carcinoma progression through ros accumulation and p53 pathway-mediated apoptosis. |
2025-03-14 |
2025-03-17 |
mouse |
| Meifeng Chen, Hongbing Pang, Pham Thi Thai Hoa, Yongfei He, Qiang Gao, Yuan Liao, Chunyi Zhu, Linqian Chen, Guohong Yan, Shutian Mo, Chuangye Ha. 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis. Toxicology and applied pharmacology. 2025-03-14. PMID:40086489. |
rna-seq revealed significant enrichment of p53 and apoptosis signaling pathways among differentially expressed genes. |
2025-03-14 |
2025-03-17 |
mouse |
| Thi-Kem Nguyen, Duc-Vinh Pham, Pil-Hoon Par. Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation. Biochemical pharmacology. 2025-03-13. PMID:40081766. |
mechanistically, nlrp3 inflammasomes signaling critically contributes to leptin-induced apoptosis of adsc by upregulating p53 and puma. |
2025-03-13 |
2025-03-16 |
Not clear |
| Mozhgan Soltani, Negar Ahmadzadeh, Sarah Rajabi, Nazanin Besharati, Niloufar Khatamian, Masoud Homayouni Tabriz. Efficacy of graphene quantum dot-hyaluronic acid nanocomposites containing quinoline for target therapy against cancer cells. Scientific reports. vol 15. issue 1. 2025-03-13. PMID:40074749. |
this finding indicates that the p53 pathway is predominant in mediating gqd-ha-qu ncs-induced apoptosis. |
2025-03-13 |
2025-03-15 |
Not clear |
| Swapnil Oak, Onkar Karajgikar, Nikhil Gadewal, Prasad Sulkshane, Tripti Verma, Sanjay Gupta, Tanuja Ten. The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting. The FEBS journal. 2025-03-12. PMID:40070163. |
notably, wp1130 reactivated mutp53 via induction of a wild-type-like p53 conformation, upregulating its downstream effectors and inducing apoptosis, possibly due to its targeted binding near the mutation site, as suggested by our in silico analysis. |
2025-03-12 |
2025-03-14 |
Not clear |
| Md Sohe. Breaking Barriers; Phytoestrogens in the Fight Against Triple-Negative Breast Cancer: A Comprehensive Review. Medicinal research reviews. 2025-03-12. PMID:40072262. |
chemotherapeutics activities are regulated through varieties of mechanisms, including targeting signaling pathways such as phosphor-akt, pi3k/akt/mtor, nf-κb, tnf-α; apoptosis such as fasl, bcl2, bax, bak, bad, apfa1, ask1, capase, and parp; metastasis such as mmps (1,2,3,9), wnt/-β catenin, angiogenesis (e&n cadherin, vimentin), cell proliferation (cyclins-a, b1, d1, e1, and cdks 1, 6,7), inflammatory molecules (tnf-α, nf-κb, il-1β, il-8), regulating tumor suppressor genes (p21, p27, p51, p53) and some nonspecific pathways like dna damage and repair (γh2ax, rad51, and surviving), autophagy (mtor, ulk1, and cathepsin b), epigenetic (hdac1, dnmt1, telomerase production) and metabolism regulation (glucose regulation-glut1 and glut4), showing antioxidant and many other pathways. |
2025-03-12 |
2025-03-14 |
Not clear |
| Xiaohong Pan, Xiuluan Du, Suhong Ji. DNA methyltransferase DNMT3A inhibits TP53AIP1 expression and promotes cervical cancer development and metastasis. Cytotechnology. vol 77. issue 2. 2025-03-10. PMID:40062226. |
p53-regulated apoptosis-inducing protein 1 (tp53aip1) was lowly expressed in cc tissues and cell lines, and tp53aip1 overexpression repressed proliferation, migration, and invasion, and induced apoptosis of cc cells by activating the p53 signaling. |
2025-03-10 |
2025-03-12 |
Not clear |
| Piotr Remiszewski, Wiktor Gaik, Aleksandra Skora, Julia Wąż, Kinga Filipek, Agata Pisklak, Monika Dudzisz-Śledź, Piotr Rutkowski, Anna Czarneck. Selinexor in the treatment of liposarcoma: from preclinical evidence to clinical practice. Medical oncology (Northwood, London, England). vol 42. issue 4. 2025-03-08. PMID:40056309. |
as a first-in-class oral exportin-1 (xpo1) inhibitor, selinexor has shown anti-tumour activity in preclinical models, particularly in mdm2- and cdk4-amplified ddlps, where it induces apoptosis, inhibits tumour growth and promotes nuclear retention of p53. |
2025-03-08 |
2025-03-11 |
Not clear |
| Yuan Sui, Xiaofei Dong, Enkang Tong, Cuicui Zhao, Rongrong Nie, Xiangfeng Men. Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation. International immunopharmacology. vol 152. 2025-03-08. PMID:40056514. |
artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under lps-induced inflammation. |
2025-03-08 |
2025-03-11 |
human |
| Liu Zhang, Xiangyu Wang, Shuoming Zhou, Yongjian Fen. LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. Brain research bulletin. 2025-03-08. PMID:40057050. |
ldha enhances brain injury and apoptosis after intracerebral hemorrhage by promoting p53 transcription through increasing p53 lactylation. |
2025-03-08 |
2025-03-12 |
mouse |
| Liu Zhang, Xiangyu Wang, Shuoming Zhou, Yongjian Fen. LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. Brain research bulletin. 2025-03-08. PMID:40057050. |
p53 plays a key role in apoptosis. |
2025-03-08 |
2025-03-12 |
mouse |
| Liu Zhang, Xiangyu Wang, Shuoming Zhou, Yongjian Fen. LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. Brain research bulletin. 2025-03-08. PMID:40057050. |
moreover, p53 overexpression restored apoptosis and brain injury after ich improved by ldha knockdown. |
2025-03-08 |
2025-03-12 |
mouse |
| Liu Zhang, Xiangyu Wang, Shuoming Zhou, Yongjian Fen. LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. Brain research bulletin. 2025-03-08. PMID:40057050. |
in conclusion, we demonstrated that ldha enhanced brain injury and apoptosis after ich by promoting p53 transcription through increasing lactylation on p53 promoter. |
2025-03-08 |
2025-03-12 |
mouse |
| H Helena Wu, Sarah Leng, David D Eisenstat, Consolato Sergi, Roger Len. Targeting p53 for Immune Modulation: Exploring Its Functions in Tumor Immunity and Inflammation. Cancer letters. 2025-03-07. PMID:40054656. |
in addition to its well-known functions of maintaining genomic stability and inducing apoptosis, p53 orchestrates a complex interaction between innate and adaptive immune responses. |
2025-03-07 |
2025-03-12 |
Not clear |
| Vikas Sharma, Arti Gupta, Mohini Singh, Anshul Singh, Anis Ahmad Chaudhary, Zakir Hassain Ahmed, Salah-Ud-Din Khan, Sarvesh Rustagi, Sanjay Kumar, Sandeep Kuma. Phytochemical baicalin potentially inhibits Bcl-2 and VEGF: an Frontiers in bioinformatics. vol 5. 2025-03-06. PMID:40046778. |
central to cancer development are proteins such as nf-kb, p53, vegf, and bax/bcl-2, which play important roles in angiogenesis, cell apoptosis regulation, and tumor growth. |
2025-03-06 |
2025-03-08 |
Not clear |
| E David Cohen, Min Yee, Kyle Roethlin, Irina Prelipcean, Eric M Small, George A Porter, Michael A O'Reill. Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia. American journal of physiology. Heart and circulatory physiology. 2025-03-06. PMID:40047849. |
while hyperoxia activated p53 target genes in both chambers, it caused greater dna damage, phosphorylation of the dna damage responsive ataxia telangiectasia mutated (atm) kinase, mitochondrial stress, and apoptosis in the atrium. |
2025-03-06 |
2025-03-08 |
mouse |