| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, Keigo Okada, Ayako Nogami, Osamu Miur. Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress. Cancer letters. vol 453. 2020-03-25. PMID:30946869. |
inhibition of usp9x induces apoptosis in flt3-itd-positive aml cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress. |
2020-03-25 |
2023-08-13 |
Not clear |
| Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, Keigo Okada, Ayako Nogami, Osamu Miur. Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress. Cancer letters. vol 453. 2020-03-25. PMID:30946869. |
here we show that inhibition of the deubiquitinase usp9x by its inhibitor wp1130 or eoai3402143 (g9) induces apoptosis preferentially in cells transformed by these mutant kinases, including flt3-itd-positive aml cell line mv4-11 and primary aml cells. |
2020-03-25 |
2023-08-13 |
Not clear |
| Wei Chen, Yue Zhou, Xiao Zhi, Tao Ma, Hao Liu, Brayant Wei Chen, Xiaoxiao Zheng, Shangzhi Xie, Bin Zhao, Xinhua Feng, Xiaowei Dang, Tingbo Lian. Delivery of miR-212 by chimeric peptide-condensed supramolecular nanoparticles enhances the sensitivity of pancreatic ductal adenocarcinoma to doxorubicin. Biomaterials. vol 192. 2020-03-06. PMID:30553134. |
in terms of mechanism, combined mir-212 intervention by pl-1/mir-212 nanoparticles resulted in obvious decrease of usp9x expression (ubiquitin specific peptidase 9, x-linked, usp9x) and eventually enhanced the doxorubicin induced apoptosis and autophagy of pdac cells. |
2020-03-06 |
2023-08-13 |
human |
| Yan Liu, Xiaofeng Xu, Peng Lin, Yuanming He, Yawen Zhang, Biyin Cao, Zubin Zhang, Gautam Sethi, Jinbao Liu, Xiumin Zhou, Xinliang Ma. Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis. The Journal of biological chemistry. vol 294. issue 12. 2019-12-13. PMID:30718275. |
inhibition of the deubiquitinase usp9x induces pre-b cell homeobox 1 (pbx1) degradation and thereby stimulates prostate cancer cell apoptosis. |
2019-12-13 |
2023-08-13 |
Not clear |
| Yan Liu, Xiaofeng Xu, Peng Lin, Yuanming He, Yawen Zhang, Biyin Cao, Zubin Zhang, Gautam Sethi, Jinbao Liu, Xiumin Zhou, Xinliang Ma. Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis. The Journal of biological chemistry. vol 294. issue 12. 2019-12-13. PMID:30718275. |
moreover, the usp9x inhibitor wp1130 markedly induced pbx1 degradation and promoted pca cell apoptosis. |
2019-12-13 |
2023-08-13 |
Not clear |
| E Bianchetti, S J Bates, S L Carroll, M D Siegelin, K A Rot. Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30478285. |
although both usp9x and mcl-1 knockdown elicited some features of apoptosis, broad spectrum caspase inhibition was ineffective in preventing knockdown-induced mpnst cell death suggesting that caspase-independent death pathways were also activated. |
2019-10-18 |
2023-08-13 |
human |
| Anupama Pal, Michele Dziubinski, Marina Pasca Di Magliano, Diane M Simeone, Scott Owens, Dafydd Thomas, Luke Peterson, Harish Potu, Moshe Talpaz, Nicholas J Donat. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia (New York, N.Y.). vol 20. issue 2. 2018-12-18. PMID:29248719. |
usp9x inhibition by shrna-knockdown or by g9 treatment reduced 3d colony formation in panc1 and pdx cell lines, induced rapid apoptosis in miapaca2 cells, and associated with reduced mcl-1 and itch protein levels. |
2018-12-18 |
2023-08-13 |
mouse |
| Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Re. Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer. Oncology reports. vol 38. issue 6. 2018-07-23. PMID:29130109. |
deubiquitinase usp9x promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer. |
2018-07-23 |
2023-08-13 |
human |
| Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Re. Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer. Oncology reports. vol 38. issue 6. 2018-07-23. PMID:29130109. |
the present study focused on the effect of usp9x on the migration, invasion and apoptosis of padc cells. |
2018-07-23 |
2023-08-13 |
human |
| Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Re. Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer. Oncology reports. vol 38. issue 6. 2018-07-23. PMID:29130109. |
knockdown of endogenous usp9x expression evidently inhibited the migration and invasion of panc-1 cells, and promoted cell apoptosis. |
2018-07-23 |
2023-08-13 |
human |
| Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Re. Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer. Oncology reports. vol 38. issue 6. 2018-07-23. PMID:29130109. |
in brief, usp9x promoted the migration and invasion of panc-1 cells probably by provoking epithelial-mesenchymal transition, and also inhibited apoptosis. |
2018-07-23 |
2023-08-13 |
human |
| Jean-François Spinella, Pauline Cassart, Chantal Richer, Virginie Saillour, Manon Ouimet, Sylvie Langlois, Pascal St-Onge, Thomas Sontag, Jasmine Healy, Mark D Minden, Daniel Sinnet. Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations. Oncotarget. vol 7. issue 40. 2018-02-23. PMID:27602765. |
u2af1 p.r35l was shown to induce aberrant splicing of downstream target genes, and shrna knockdown of med12 and usp9x was shown to confer resistance to apoptosis following t-all relevant chemotherapy drug treatment in jurkat leukemia cells. |
2018-02-23 |
2023-08-13 |
Not clear |
| Bo Yang, Shiming Zhang, Zhihao Wang, Chunxu Yang, Wen Ouyang, Fuxiang Zhou, Yunfeng Zhou, Conghua Xi. Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth. Oncotarget. vol 7. issue 48. 2018-02-22. PMID:27783990. |
knockdown of usp9x suppresses cell proliferation, inhibits g1/s phase conversion, and induces apoptosis in u251 and a172 cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Georg Karpel-Massler, Doruntina Ramani, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N Bruce, Peter Canoll, Markus D Siegeli. Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo. Oncotarget. vol 7. issue 23. 2018-01-17. PMID:27172899. |
l-asparaginase-mediated apoptosis was accompanied by modulation of pro- and anti-apoptotic bcl-2 family members, including noxa, mcl-1 and the deubiquitinase usp9x. |
2018-01-17 |
2023-08-13 |
Not clear |
| Georg Karpel-Massler, Matei A Banu, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N Bruce, Peter Canoll, Markus D Siegeli. Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo. Oncotarget. vol 7. issue 11. 2017-12-04. PMID:26872380. |
moreover, wp1130 and sirnas targeting usp9x reduce the expression of anti-apoptotic bcl-2 family members and inhibitor of apoptosis proteins, xiap and survivin. |
2017-12-04 |
2023-08-13 |
Not clear |
| Katharina Engel, Martina Rudelius, Jolanta Slawska, Laura Jacobs, Behnaz Ahangarian Abhari, Bettina Altmann, Julia Kurutz, Abirami Rathakrishnan, Vanesa Fernández-Sáiz, Andrä Brunner, Bianca-Sabrina Targosz, Felicia Loewecke, Christian Johannes Gloeckner, Marius Ueffing, Simone Fulda, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Ulrich Keller, Philipp J Jost, Andreas Rosenwald, Christian Peschel, Florian Basserman. USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma. EMBO molecular medicine. vol 8. issue 8. 2017-09-13. PMID:27317434. |
here, we identify usp9x as the mitotic deubiquitinase of the x-linked inhibitor of apoptosis protein (xiap) and demonstrate that deubiquitylation and stabilization of xiap by usp9x lead to increased resistance toward mitotic spindle poisons. |
2017-09-13 |
2023-08-13 |
human |
| F Wolfsperger, S A Hogh-Binder, J Schittenhelm, T Psaras, V Ritter, L Bornes, S M Huber, V Jendrossek, J Rudne. Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms. Cell death & disease. vol 7. 2016-11-09. PMID:26775694. |
although mcl-1 knockdown by sirna increased apoptosis induction after irradiation in all glioblastoma cell lines, usp9x knockdown significantly improved radiation-induced apoptosis in one of four cell lines and slightly increased apoptosis in another cell line. |
2016-11-09 |
2023-08-13 |
human |
| F Wolfsperger, S A Hogh-Binder, J Schittenhelm, T Psaras, V Ritter, L Bornes, S M Huber, V Jendrossek, J Rudne. Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms. Cell death & disease. vol 7. 2016-11-09. PMID:26775694. |
the massive downregulation of mcl-1 and apoptosis induction in a172 cells transfected with usp9x sirna shows that the deubiquitinase regulates cell survival by regulating mcl-1 levels. |
2016-11-09 |
2023-08-13 |
human |
| Wen Ouyang, Shimin Zhang, Bo Yang, Chunxu Yang, Junhong Zhang, Fuxiang Zhou, Conghua Xi. β-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast cancer. Oncology reports. vol 35. issue 2. 2016-09-30. PMID:26717875. |
β-catenin is regulated by usp9x and mediates resistance to trail-induced apoptosis in breast cancer. |
2016-09-30 |
2023-08-13 |
Not clear |
| Georg Karpel-Massler, Chang Shu, Lily Chau, Matei Banu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Yulian Ramirez, Alonzo H Ross, Jeffrey N Bruce, Peter Canoll, Markus D Siegeli. Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:26008975. |
on the molecular level, gx15-070 enhanced apoptosis by posttranslational down-regulation of the deubiquitinase, usp9x, and the chaperone bag3, leading to a sustained depletion of mcl-1 protein levels. |
2016-05-12 |
2023-08-13 |
Not clear |