| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georg Karpel-Massler, Chang Shu, Lily Chau, Matei Banu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Yulian Ramirez, Alonzo H Ross, Jeffrey N Bruce, Peter Canoll, Markus D Siegeli. Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:26008975. |
moreover, knock-down of usp9x or bag3 depleted endogenous mcl-1 protein levels and in turn enhanced apoptosis induced through bcl-2/bcl-xl inhibition. |
2016-05-12 |
2023-08-13 |
Not clear |
| Deepa Kushwaha, Colin O'Leary, Kyle R Cron, Peter Deraska, Kaya Zhu, Alan D D'Andrea, David Kozon. USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1. Cancer biology & therapy. vol 16. issue 3. 2016-01-01. PMID:25692226. |
usp9x inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high mcl1. |
2016-01-01 |
2023-08-13 |
Not clear |
| Lawrence H Bois. DUB-ling down on B-cell malignancies. Blood. vol 125. issue 23. 2015-08-13. PMID:26045592. |
in this issue of blood, peterson et al demonstrate that inhibition of both usp9x and usp24 results in efficient degradation of mcl-1, induction of apoptosis, and inhibition of tumor growth in b-cell malignancies. |
2015-08-13 |
2023-08-13 |
Not clear |
| Luke F Peterson, Hanshi Sun, Yihong Liu, Harish Potu, Malathi Kandarpa, Monika Ermann, Stephen M Courtney, Matthew Young, Hollis D Showalter, Duxin Sun, Andrzej Jakubowiak, Sami N Malek, Moshe Talpaz, Nicholas J Donat. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. vol 125. issue 23. 2015-08-12. PMID:25814533. |
in this study, we found that the partially selective usp9x deubiquitinase inhibitor wp1130 induced apoptosis and reduced mcl-1 protein levels. |
2015-08-12 |
2023-08-13 |
mouse |
| Luke F Peterson, Hanshi Sun, Yihong Liu, Harish Potu, Malathi Kandarpa, Monika Ermann, Stephen M Courtney, Matthew Young, Hollis D Showalter, Duxin Sun, Andrzej Jakubowiak, Sami N Malek, Moshe Talpaz, Nicholas J Donat. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. vol 125. issue 23. 2015-08-12. PMID:25814533. |
however, short hairpin rna-mediated knockdown (kd) of usp9x in myeloma cells resulted in transient induction of apoptosis, followed by a sustained reduction in cell growth. |
2015-08-12 |
2023-08-13 |
mouse |
| Luke F Peterson, Hanshi Sun, Yihong Liu, Harish Potu, Malathi Kandarpa, Monika Ermann, Stephen M Courtney, Matthew Young, Hollis D Showalter, Duxin Sun, Andrzej Jakubowiak, Sami N Malek, Moshe Talpaz, Nicholas J Donat. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. vol 125. issue 23. 2015-08-12. PMID:25814533. |
furthermore, we improved the drug-like properties of wp1130 and demonstrated that the novel compound eoai3402143 dose-dependently inhibited usp9x and usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. |
2015-08-12 |
2023-08-13 |
mouse |
| Mi Zhou, Ting Wang, Huiling Lai, Xuejiao Zhao, Qin Yu, Jianfeng Zhou, Yang Yan. Targeting of the deubiquitinase USP9X attenuates B-cell acute lymphoblastic leukemia cell survival and overcomes glucocorticoid resistance. Biochemical and biophysical research communications. vol 459. issue 2. 2015-06-22. PMID:25735983. |
we investigated the role of usp9x in b-all and found that usp9x knockdown significantly reduced leukemic cell growth and increased spontaneous apoptosis, thereby improving survival in immunodeficient mice. |
2015-06-22 |
2023-08-13 |
mouse |
| J Yan, N Zhong, G Liu, K Chen, X Liu, L Su, S Singha. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell death & disease. vol 5. 2015-06-04. PMID:24991768. |
mechanistically, noxa upregulation likely reduces the availability of usp9x to mcl-1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells. |
2015-06-04 |
2023-08-13 |
human |
| Jing Cui, Wendong Sun, Xuexi Hao, Minli Wei, Xiaonan Su, Yajing Zhang, Ling Su, Xiangguo Li. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer cell international. vol 15. issue 1. 2015-02-16. PMID:25685062. |
furthermore, down-regulation of the deubiquitinase usp9x by bix-01294 results in downstream reduction of mcl1 expression, leading to apoptosis eventually. |
2015-02-16 |
2023-08-13 |
human |
| Donatella Trivigno, Frank Essmann, Stephan M Huber, Justine Rudne. Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia (New York, N.Y.). vol 14. issue 10. 2013-04-04. PMID:23097624. |
usp9x knockdown enhanced radiation-induced decrease of mcl-1 and sensitized the radioresistant cells to apoptosis induction, whereas usp9x knockdown alone did not change mcl-1 level in unirradiated cells. |
2013-04-04 |
2023-08-12 |
Not clear |
| Donatella Trivigno, Frank Essmann, Stephan M Huber, Justine Rudne. Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia (New York, N.Y.). vol 14. issue 10. 2013-04-04. PMID:23097624. |
together, our results indicate that radiation-induced activation of usp9x inhibits mcl-1 degradation and apoptosis resulting in increased radioresistance. |
2013-04-04 |
2023-08-12 |
Not clear |
| Domagoj Vucic, Vishva M Dixit, Ingrid E Wert. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nature reviews. Molecular cell biology. vol 12. issue 7. 2011-09-28. PMID:21697901. |
for example, ubiquitin e3 ligases, such as mdm2 (which ubiquitylates p53) and inhibitor of apoptosis (iap) proteins, and deubiquitinases, such as a20 and ubiquitin-specific protease 9x (usp9x) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (rip1) and myeloid leukaemia cell differentiation 1 (mcl1), respectively), have important roles in apoptosis. |
2011-09-28 |
2023-08-12 |
Not clear |
| Hanshi Sun, Vaibhav Kapuria, Luke F Peterson, Dexing Fang, William G Bornmann, Geoffrey Bartholomeusz, Moshe Talpaz, Nicholas J Donat. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. vol 117. issue 11. 2011-05-11. PMID:21248063. |
bcr-abl ubiquitination and usp9x inhibition block kinase signaling and promote cml cell apoptosis. |
2011-05-11 |
2023-08-12 |
Not clear |
| Hanshi Sun, Vaibhav Kapuria, Luke F Peterson, Dexing Fang, William G Bornmann, Geoffrey Bartholomeusz, Moshe Talpaz, Nicholas J Donat. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. vol 117. issue 11. 2011-05-11. PMID:21248063. |
wp1130, but not bcr-abl kinase inhibitors, directly inhibits usp9x deubiquitinase activity, resulting in the down-regulation of the prosurvival protein mcl-1 and facilitating apoptosis. |
2011-05-11 |
2023-08-12 |
Not clear |