| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Jie Zou, Yaxuan Wang, Xinyue Zhang, Xue Pan, Te Fang, Dasheng Cai, Lili Guo, Yu Li, Yi He, Xuezhao Ca. CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. Molecular neurobiology. 2024-08-01. PMID:39088031. |
this study explored the impact of cd33 and trem2 on pocd in aged mice and revealed that surgery and anesthesia increased cd33 expression, leading to spatial learning and memory impairments. |
2024-08-01 |
2024-08-03 |
mouse |
| Jie Zou, Yaxuan Wang, Xinyue Zhang, Xue Pan, Te Fang, Dasheng Cai, Lili Guo, Yu Li, Yi He, Xuezhao Ca. CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. Molecular neurobiology. 2024-08-01. PMID:39088031. |
cd33 ameliorates surgery-induced spatial learning and memory impairments through trem2. |
2024-08-01 |
2024-08-03 |
mouse |
| Jianxiong Gui, Jie Liu, Lingman Wang, Hanyu Luo, Dishu Huang, Xiaoyue Yang, Honghong Song, Ziyao Han, Ran Ding, Jiaxin Yang, Li Jian. TREM2 mitigates NLRP3-mediated neuroinflammation through the NF-κB and PI3k/Akt signaling pathways in juvenile rats exposed to ambient particulate matter. Environmental science and pollution research international. 2023-11-06. PMID:37930574. |
trem2 overexpression attenuated pm-induced spatial learning and memory deficits in rats. |
2023-11-06 |
2023-11-08 |
rat |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
we found that hippocampus-dependent learning and memory were impaired in pocd mice, which was accompanied by activation of microglia and downregulation of trem2. |
2022-08-30 |
2023-08-14 |
mouse |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
activation of trem2 can attenuate neuroinflammation by modulating pi3k/protein kinase b (akt) signaling, thereby alleviating postoperative learning and memory deficits. |
2022-08-30 |
2023-08-14 |
mouse |
| Jamal Ahmad Ansari, Rajib K Dey, Shubhendra K Mishra, Opalina Roy, Shaivya Kushwaha, Vikas Singh, Satyakam Patnaik, Debabrata Ghos. Perinatal arsenic exposure-induced sustained microglial activation leads to impaired cognitive response in BALB/c mice. Neurotoxicology. 2022-07-01. PMID:35777461. |
enhanced phagocytosis and phagocytic receptor trem2, along with decreased expression of snap25 and psd95, were correlated for enhanced neuronal pruning leading to impaired learning and memory response. |
2022-07-01 |
2023-08-14 |
mouse |
| Wenwen Jiang, Fang Liu, Hongqing Li, Kexin Wang, Xuezhao Cao, Xiaohan Xu, Yongjian Zhou, Jie Zou, Xinyue Zhang, Xiaotong Cu. TREM2 ameliorates anesthesia and surgery-induced cognitive impairment by regulating mitophagy and NLRP3 inflammasome in aged C57/BL6 mice. Neurotoxicology. 2022-04-21. PMID:35447280. |
our findings demonstrate that trem2 rescues anesthesia and surgery-induced spatial learning and memory impairment and neuro-inflammation in aged c57/bl6 mice, which may be at least partially mediated through the activation of mitophagy and subsequent inhibition of the nlrp3 inflammasome. |
2022-04-21 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
we found that trem2 shrna injection can improve learning and memory ability in elderly mice, as demonstrated by improved learning ability and memory performance in the morris water maze (mwm) test, an increased freezing duration in the contextual fear conditioning test, a higher preference ratio in the novel object recognition (nor) test and a higher alternation rate in the t-maze test. |
2021-11-15 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
our results suggest that decreased astrocytic trem2 levels have beneficial effects on learning and memory ability in elderly mice, which may provide new insight into the pathological mechanism and potential targets of age-related dementia. |
2021-11-15 |
2023-08-13 |
mouse |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
interestingly, overexpression of trem2 by intracerebroventricular injection of a lentiviral vector that encoded trem2 (lv-trem2) significantly improved the spatial learning and memory and attenuated the hippocampal neural loss in vd mice. |
2021-06-30 |
2023-08-13 |
mouse |
| Wen Niu, Lei Ma, Tianqi Tao, Fangfang Tian, Tao He, Min Qiao, Haimeng He, Xiuhua Liu, Xiayong Zha. Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32381365. |
therefore, our study indicated that up-regulation of trem2 alleviated neuroinflammation and improved learning and memory function after surgery in mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Wen Niu, Lei Ma, Tianqi Tao, Fangfang Tian, Tao He, Min Qiao, Haimeng He, Xiuhua Liu, Xiayong Zha. Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32381365. |
we used adult c57bl/6 mice subjected to intramedullary fixation surgery, and found that surgery did not impair the motor ability of mice, but worsened the learning and memory function, and reduced the expression of trem2. |
2021-06-07 |
2023-08-13 |
mouse |
| Wen Niu, Lei Ma, Tianqi Tao, Fangfang Tian, Tao He, Min Qiao, Haimeng He, Xiuhua Liu, Xiayong Zha. Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32381365. |
meanwhile, up-regulated trem2 expression in the brain of mice, induced by selective trem2 agonist hsp60, significantly improved the learning and memory, alleviated the neuroinflammation, and decreased the neuronal cell apoptosis in mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
we found that learning and memory functions were improved in aged trem2 tg mice, with the opposite effects in ko mice. |
2019-06-11 |
2023-08-13 |
mouse |