| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Goldfar. The renin-angiotensin system. New concepts in regulation of blood pressure and renal function. The Urologic clinics of North America. vol 21. issue 2. 1994-06-07. PMID:8178386. |
ang ii also plays a role in the kidney, not only as a regulator of hemodynamics, but in the development of structural changes (hypertrophy, sclerosis), which are important in the pathogenesis of a variety of renal disorders. |
1994-06-07 |
2023-08-12 |
Not clear |
| H San. [Effect of angiotensin II on collagen metabolism in cultured rat cardiac fibroblasts: its relation to cardiac hypertrophy]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 69. issue 1. 1994-04-04. PMID:8119655. |
thus, ang ii may play an important role in collagen accumulation in hypertensive cardiac hypertrophy. |
1994-04-04 |
2023-08-12 |
rat |
| S W Rabki. Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 22 Suppl 6. 1994-03-08. PMID:7508059. |
angiotensin ii (ang)-receptor stimulation with ang ii and muscarinic-receptor stimulation with carbachol, accentuate camp stimulation in cardiac hypertrophy, whereas the reverse or inhibition was noted in normal myocardium. |
1994-03-08 |
2023-08-12 |
rat |
| M L Burgess, W E Carver, L Terracio, S P Wilson, M A Wilson, T K Bor. Integrin-mediated collagen gel contraction by cardiac fibroblasts. Effects of angiotensin II. Circulation research. vol 74. issue 2. 1994-02-28. PMID:8293568. |
angiotensin ii (ang ii), a vasoactive octapeptide, has been implicated in cardiac growth and the development of hypertrophy and fibrosis secondary in hypertensive disease. |
1994-02-28 |
2023-08-12 |
Not clear |
| R Natarajan, N Gonzales, L Lanting, J Nadle. Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 23. issue 1 Suppl. 1994-02-16. PMID:8282345. |
however, the relation between lipoxygenase activation and ang ii-induced vascular smooth muscle cell hypertrophy is not known. |
1994-02-16 |
2023-08-12 |
Not clear |
| R Natarajan, N Gonzales, L Lanting, J Nadle. Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 23. issue 1 Suppl. 1994-02-16. PMID:8282345. |
these results suggest that 12-lipoxygenase activation plays a key role in ang ii-induced vascular smooth muscle cell hypertrophy. |
1994-02-16 |
2023-08-12 |
Not clear |
| F J Villarreal, N N Kim, G D Ungab, M P Printz, W H Dillman. Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation. vol 88. issue 6. 1994-01-13. PMID:8252698. |
recent evidence indicates that angiotensin ii (ang ii) might have an important role in the development of myocardial fibrosis accompanying cardiac hypertrophy. |
1994-01-13 |
2023-08-12 |
rat |
| J Sadoshima, Y Xu, H S Slayter, S Izum. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. vol 75. issue 5. 1994-01-10. PMID:8252633. |
using an in vitro model of load (stretch)-induced cardiac hypertrophy, we demonstrate that mechanical stretch causes release of angiotensin ii (ang ii) from cardiac myocytes and that ang ii acts as an initial mediator of the stretch-induced hypertrophic response. |
1994-01-10 |
2023-08-12 |
Not clear |
| C J Oddie, R J Dilley, P Kanellakis, A Bobi. Chronic angiotensin II type 1 receptor antagonism in genetic hypertension: effects on vascular structure and reactivity. Journal of hypertension. vol 11. issue 7. 1993-12-07. PMID:8228190. |
the aim of the study was to assess the role of angiotensin ii (ang ii) in the maintenance of cardiovascular hypertrophy and the abnormal vascular amplifier properties in spontaneously hypertensive rats (shr) with established hypertension. |
1993-12-07 |
2023-08-12 |
rat |
| C J Oddie, R J Dilley, P Kanellakis, A Bobi. Chronic angiotensin II type 1 receptor antagonism in genetic hypertension: effects on vascular structure and reactivity. Journal of hypertension. vol 11. issue 7. 1993-12-07. PMID:8228190. |
losartan, a type 1 ang ii receptor antagonist, was administered to shr and wistar-kyoto (wky) rats, and its effects on blood pressure, cardiac hypertrophy, vascular morphology and hindquarter vascular amplifier properties assessed at the end of treatment and 3 months later. |
1993-12-07 |
2023-08-12 |
rat |
| G Wolf, E Mueller, R A Stahl, F N Ziyade. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. The Journal of clinical investigation. vol 92. issue 3. 1993-10-15. PMID:7690779. |
previous studies by our group have demonstrated that angiotensin ii (ang ii), as a single factor in serum-free medium, induces cellular hypertrophy of a cultured murine proximal tubular cell line (mct). |
1993-10-15 |
2023-08-12 |
Not clear |
| G Wolf, E Mueller, R A Stahl, F N Ziyade. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. The Journal of clinical investigation. vol 92. issue 3. 1993-10-15. PMID:7690779. |
exogenous tgf-beta 1 (1 ng/ml) mimicked the growth effects observed with 10(-8) m ang ii (inhibition of dna synthesis and induction of cellular hypertrophy). |
1993-10-15 |
2023-08-12 |
Not clear |
| G Wolf, E Mueller, R A Stahl, F N Ziyade. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. The Journal of clinical investigation. vol 92. issue 3. 1993-10-15. PMID:7690779. |
our data indicate that the ang ii-induced hypertrophy in mct cells is mediated by synthesis and activation of endogenous tgf-beta. |
1993-10-15 |
2023-08-12 |
Not clear |
| G Wolf, E Mueller, R A Stahl, F N Ziyade. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. The Journal of clinical investigation. vol 92. issue 3. 1993-10-15. PMID:7690779. |
it is intriguing to speculate that tgf-beta may play a role in the early tubular cell hypertrophy and the subsequent interstitial scarring observed in several models of chronic renal injury that are characterized by increased activity of intrarenal ang ii. |
1993-10-15 |
2023-08-12 |
Not clear |
| V J Dza. Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. Basic research in cardiology. vol 88 Suppl 1. 1993-09-23. PMID:8395169. |
evidence also points to a role for ang ii in the development of left ventricular hypertrophy in hypertension. |
1993-09-23 |
2023-08-12 |
Not clear |
| J Sadoshima, S Izum. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348686. |
the ang ii-induced hypertrophic response of myocytes and mitogenic response of fibroblasts were mediated primarily by the at1 receptor. |
1993-09-10 |
2023-08-12 |
rat |
| J Sadoshima, S Izum. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348686. |
ang ii induced "late" markers for cardiac hypertrophy, skeletal alpha-actin and atrial natriuretic factor expression, within 6 hours in myocytes. |
1993-09-10 |
2023-08-12 |
rat |
| J Sadoshima, S Izum. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348686. |
these results indicate that: (1) ang ii causes hypertrophy of cardiac myocytes and mitogenesis of cardiac fibroblasts, (2) the phenotypic changes of cardiac cells in response to ang ii in vitro closely mimic those of growth factor response in vitro and of load-induced hypertrophy in vivo, (3) all biological effects of ang ii examined here are mediated primarily by the at1 receptor subtype, and (4) ang ii may initiate a positive-feedback regulation of cardiac hypertrophic response by inducing the angiotensinogen gene and transforming growth factor-beta 1 gene. |
1993-09-10 |
2023-08-12 |
rat |
| J Sadoshima, S Izum. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348687. |
angiotensin ii (ang ii) causes a rapid induction of immediate-early genes and hypertrophy in the cardiac myocyte. |
1993-09-10 |
2023-08-12 |
rat |
| J Suzuki, H Matsubara, M Urakami, M Inad. Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348688. |
the cardiac hypertrophy established in spontaneously hypertensive rats or two-kidney one-clip renovascular hypertensive rats resulted in substantial increases in ventricular at1a mrna levels (threefold) and ang ii receptor densities (twofold) as compared with those in respective control rats, whereas the receptor affinity was similar. |
1993-09-10 |
2023-08-12 |
rat |