| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Suzuki, H Matsubara, M Urakami, M Inad. Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circulation research. vol 73. issue 3. 1993-09-10. PMID:8348688. |
ang ii action exerted through the increased number of ang ii receptors may contribute to the growth of the heart and thus to the maintenance of established hypertrophy as one of the hormones involved in hypertrophy development. |
1993-09-10 |
2023-08-12 |
rat |
| H Ito, Y Hirata, S Adachi, M Tanaka, M Tsujino, A Koike, A Nogami, F Murumo, M Hiro. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. The Journal of clinical investigation. vol 92. issue 1. 1993-08-12. PMID:8326007. |
to elucidate the cellular mechanism by which angiotensin ii (ang ii) induces cardiac hypertrophy, we investigated the possible autocrine/paracrine role of endogenous endothelin-1 (et-1) in ang ii-induced hypertrophy of neonatal rat cardiomyocytes by use of synthetic et-1 receptor antagonist and antisense oligonucleotides to preproet-1 (ppet-1) mrna. |
1993-08-12 |
2023-08-12 |
rat |
| H Ito, Y Hirata, S Adachi, M Tanaka, M Tsujino, A Koike, A Nogami, F Murumo, M Hiro. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. The Journal of clinical investigation. vol 92. issue 1. 1993-08-12. PMID:8326007. |
these results suggest that endogenous et-1 locally generated and secreted by cardiomyocytes may contribute to ang ii-induced cardiac hypertrophy via an autocrine/paracrine fashion. |
1993-08-12 |
2023-08-12 |
rat |
| G L Bakris, R N R. Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells. The American journal of physiology. vol 264. issue 6 Pt 2. 1993-08-05. PMID:8322895. |
angiotensin ii (ang ii) elicits either a hypertrophic or hyperplastic response depending on culture conditions. |
1993-08-05 |
2023-08-12 |
human |
| A F Leve. Slow developing pressor effect of angiotensin II and vascular structure. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 11. issue 3. 1993-07-29. PMID:8315515. |
other rats infused with ang ii and given hydralazine to prevent the rise in pressure also developed vascular hypertrophy. |
1993-07-29 |
2023-08-12 |
rat |
| A F Leve. Slow developing pressor effect of angiotensin II and vascular structure. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 11. issue 3. 1993-07-29. PMID:8315515. |
experiment 2: the results of a second experiment suggested that ang ii caused vascular hypertrophy by a mechanism that involves the proto-oncogene c-fos, an intermediary in growth factor action. |
1993-07-29 |
2023-08-12 |
rat |
| Y Koibuchi, W S Lee, G H Gibbons, R E Prat. Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II. Hypertension (Dallas, Tex. : 1979). vol 21. issue 6 Pt 2. 1993-07-02. PMID:8505090. |
we have shown that angiotensin ii (ang ii)-induced hypertrophy of vascular smooth muscle cells is dependent on the balance between proliferative and antiproliferative growth factors, specifically basic fibroblast growth factor and transforming growth factor-beta 1 (tgf-beta 1), respectively. |
1993-07-02 |
2023-08-12 |
Not clear |
| Y Koibuchi, W S Lee, G H Gibbons, R E Prat. Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II. Hypertension (Dallas, Tex. : 1979). vol 21. issue 6 Pt 2. 1993-07-02. PMID:8505090. |
two separate cultures were examined, one in which ang ii induces hypertrophy and the other in which ang ii induces hyperplasia. |
1993-07-02 |
2023-08-12 |
Not clear |
| Y Koibuchi, W S Lee, G H Gibbons, R E Prat. Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II. Hypertension (Dallas, Tex. : 1979). vol 21. issue 6 Pt 2. 1993-07-02. PMID:8505090. |
in the culture that responds with hypertrophy, ang ii induces the expression of the active form of tgf-beta 1 twofold to threefold. |
1993-07-02 |
2023-08-12 |
Not clear |
| L G Meggs, J Coupet, H Huang, W Cheng, P Li, J M Capasso, C J Homcy, P Anvers. Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. Circulation research. vol 72. issue 6. 1993-06-22. PMID:8495545. |
reactive hypertrophy was accompanied by a 1.84- and 1.85-fold increase in the density of ang ii receptors on left and right myocytes, respectively. |
1993-06-22 |
2023-08-12 |
rat |
| H Itoh, M Mukoyama, R E Pratt, G H Gibbons, V J Dza. Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. The Journal of clinical investigation. vol 91. issue 5. 1993-06-04. PMID:8486785. |
angiotensin (ang) ii stimulates hypertrophic growth of vascular smooth muscle cells (vsmc). |
1993-06-04 |
2023-08-12 |
Not clear |
| M S Fernandez-Alfonso, D Ganten, M Pau. Mechanisms of cardiac growth. The role of the renin-angiotensin system. Basic research in cardiology. vol 87 Suppl 2. 1993-05-11. PMID:1299208. |
various mechanisms, such as pressure overload and angiotensin ii (ang ii), have been proposed to trigger cardiocyte growth and left-ventricular hypertrophy (lvh). |
1993-05-11 |
2023-08-11 |
Not clear |
| H Schunkert, B Jackson, S S Tang, F J Schoen, J F Smits, C S Apstein, B H Lorel. Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts. Circulation. vol 87. issue 4. 1993-04-30. PMID:8384939. |
the intracardiac conversion rate of angiotensin (ang) i to ang ii and the expression of angiotensin converting enzyme (ace) mrna are amplified in rat hearts with left ventricular hypertrophy (lvh). |
1993-04-30 |
2023-08-12 |
rat |
| K Reiss, J M Capasso, H E Huang, L G Meggs, P Li, P Anvers. ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure. The American journal of physiology. vol 264. issue 3 Pt 2. 1993-04-22. PMID:8456979. |
to determine the relationship between reactive cardiac hypertrophy and the expression of angiotensin ii (ang ii) receptors in surviving myocytes after infarction, large infarcts were produced in rats that were killed 2-3 days later. |
1993-04-22 |
2023-08-12 |
rat |
| G Wolf, G Zahner, U Mondorf, W Schoeppe, R A Stah. Angiotensin II stimulates cellular hypertrophy of LLC-PK1 cells through the AT1 receptor. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 8. issue 2. 1993-04-19. PMID:7681154. |
ang ii incubation of cells significantly lowered intracellular camp, and the hypertrophogenic action of ang ii was abolished by co-incubation with the relative stable analogue dibutyryl-camp, suggesting the involvement of intracellular nucleotides in the signal-transduction processes leading to hypertrophy. |
1993-04-19 |
2023-08-12 |
Not clear |
| G Wolf, G Zahner, U Mondorf, W Schoeppe, R A Stah. Angiotensin II stimulates cellular hypertrophy of LLC-PK1 cells through the AT1 receptor. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 8. issue 2. 1993-04-19. PMID:7681154. |
considering the importance of tubular hypertrophy in the progression of renal failure in many models, strategies to block the action of ang ii on tubular cells may offer an attractive alternative way to control deterioration of renal function besides modulation of haemodynamics. |
1993-04-19 |
2023-08-12 |
Not clear |
| G A Stouffer, R T Shimizu, M B Turla, G K Owen. ANG II- or AVP-induced increases in protein synthesis are not dependent on autocrine secretion of PDGF-AA. The American journal of physiology. vol 264. issue 2 Pt 1. 1993-04-02. PMID:8447369. |
previous studies have demonstrated that angiotensin ii (ang ii) and arginine vasopressin (avp) stimulate increased protein synthesis and cellular hypertrophy in cultured rat aortic smooth muscle cells (smc). |
1993-04-02 |
2023-08-12 |
rat |
| S B Harrap, G A Mitchell, D J Casley, C Mirakian, A E Doyl. Angiotensin II, sodium, and cardiovascular hypertrophy in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 21. issue 1. 1993-02-01. PMID:8418023. |
angiotensin ii (ang ii) may cause cardiovascular hypertrophy as a consequence of increased blood pressure or possibly by direct trophic actions. |
1993-02-01 |
2023-08-12 |
rat |
| S B Harrap, G A Mitchell, D J Casley, C Mirakian, A E Doyl. Angiotensin II, sodium, and cardiovascular hypertrophy in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 21. issue 1. 1993-02-01. PMID:8418023. |
because increased structure occurred despite perindopril treatment, we conclude that direct trophic actions of ang ii are not essential for the development of cardiovascular hypertrophy in young shr and that the antitrophic actions of angiotensin converting enzyme inhibitors depend more on changes in blood pressure than on ang ii. |
1993-02-01 |
2023-08-12 |
rat |
| G Wolf, E G Neilso. Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene. The American journal of physiology. vol 263. issue 5 Pt 2. 1992-12-22. PMID:1332507. |
angiotensin ii (ang ii) normally induces cellular hypertrophy in proximal tubular epithelium by engaging receptor systems that use a g-protein-signaling mechanism. |
1992-12-22 |
2023-08-11 |
rat |