Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
however, in contrast to the changes observed in the cortex, the changes in the hippocampus were opposite for the il1rn, bdnf, tgfb, and arg1 genes. |
2024-09-21 |
2024-09-24 |
rat |
GuoQing Wang, YanZhen Zhou, YanYing Wang, DaiDi Li, Jie Liu, Feng Zhan. Age-Associated Dopaminergic Neuron Loss and Midbrain Glia Cell Phenotypic Polarization. Neuroscience. vol 415. 2020-09-23. PMID:31325563. |
the expressions of astroglia markers (glial fibrillary acidic protein, gfap), microglia markers (ionized calcium binding adaptor molecule 1, iba-1), m1 markers (tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β), m2 markers (arginase 1 (arg1) and il-10), a1 markers (lipocalin-2 (lcn2) and complement c3 (c3), a2 markers (brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) were examined by real time rt-pcr and western blotting. |
2020-09-23 |
2023-08-13 |
rat |
Zhe Li, Xuezhao Cao, Hong Ma, Yong Cui, Xiaoqian Li, Na Wang, Yongjian Zho. Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. Journal of neuropathology and experimental neurology. vol 77. issue 8. 2019-10-03. PMID:29939299. |
hippocampal interleukin-1β, cx3cl1, cx3cr1, brain derived neurotrophic factor (bdnf), ionized calcium-binding adapter molecule 1 (iba-1), and arginase-1 (arg1) levels were measured. |
2019-10-03 |
2023-08-13 |
rat |
Zhe Li, Fang Liu, Hong Ma, Paul F White, Roya Yumul, Yanhua Jiang, Na Wang, Xuezhao Ca. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain research. vol 1665. 2018-03-22. PMID:28414034. |
brain derived neurotrophic factor (bdnf), synaptophysin, ionized calcium-binding adapter molecule 1 (iba-1), microglial m2 phenotype marker arg1, and cd200 were also examined in the hippocampus. |
2018-03-22 |
2023-08-13 |
rat |