| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Cong Wang, Jing Dong, Heng Huang, Kegui Zhou, Zhenguo Liu, Richard Milner, Longxuan L. Astrocyte-TREM2 alleviates brain injury by regulating reactive astrocyte states following ischemic stroke. Glia. 2024-07-26. PMID:39056459. |
in addition, astrocyte-specific trem2 knockout mice exhibited much greater brain injury than trem2 flox/flox controls following ais, as evidenced by increased cerebral infarct volume, neuronal apoptosis and neurological deficit, which was associated with an increased expression of pro-inflammatory molecule complement component 3 (c3) on reactive astrocytes and activation of microglia/macrophages but decreased expression of s100 calcium binding protein a10 (s100a10) and arginase1 (arg1) on reactive astrocytes. |
2024-07-26 |
2024-07-28 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
rna-seq analysis showed that il-4 induced the expression of a program of genes including arg1 and ap1b1 in microglia, which showed an attenuated response to il-4 when trem2 expression was decreased. |
2021-08-30 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
additionally, the suppressed neuroinflammation might be ascribed to the m2 activation of microglia induced by trem2, as the expression of m2 phenotype makers including arg1, retnla, il4 and il10 was markedly increased. |
2017-06-13 |
2023-08-13 |
mouse |