| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dina Y Hegab, Nabela I El-Sharkawy, Gihan G Moustafa, Yasmina M Abd-Elhakim, Enas N Said, Mohamed M M Metwally, Taghred M Sabe. Pumpkin seeds oil rescues colchicine-induced neurotoxicity in rats via modifying oxidative stress, DNA damage, and immunoexpression of BDNF and GFAP. Tissue & cell. vol 94. 2025-02-18. PMID:39965508. |
the results displayed that chc exposure induced neurobehavioral disorders and a remarkable decline in the serotonin and dopamine levels and the immunoexpression of bdnf and gfap in the brain. |
2025-02-18 |
2025-02-23 |
rat |
| Dina Y Hegab, Nabela I El-Sharkawy, Gihan G Moustafa, Yasmina M Abd-Elhakim, Enas N Said, Mohamed M M Metwally, Taghred M Sabe. Pumpkin seeds oil rescues colchicine-induced neurotoxicity in rats via modifying oxidative stress, DNA damage, and immunoexpression of BDNF and GFAP. Tissue & cell. vol 94. 2025-02-18. PMID:39965508. |
however, concurrent treatment with the pso effectively attenuated the chc-induced toxic effects as evidenced by a noticeable increase in the serotonin (33 ± 3.05) and dopamine (2.48 ± 0.40) concentrations, and the bdnf and gfap immunoexpression in the brain. |
2025-02-18 |
2025-02-23 |
rat |
| Ming Liu, Youyi Lu, Fengze Sun, Yongwei Li, Jitao Wu, Qingsong Zo. The Nerve-Induced Adipose Stem Cells Promote Nerve Repair in Stress Urinary Incontinence by Regulating Schwann Cell Repair Phenotype Conversion Through Activation of the Notch Pathway. Molecular neurobiology. 2025-01-29. PMID:39881114. |
however, when co-cultured with ni-adscs, scs showed upregulated expression of repair-related phenotypic markers (bdnf, gdnf, and gfap). |
2025-01-29 |
2025-02-01 |
rat |
| Guang-Jing Xie, Bo Xu, Jing Xia, Zi-Xuan Xu, Fei-Zhou Li, Ping Wan. [Protective effect of Anmeidan on hippocampal neuronal damage and synaptic microenvironment in sleep-deprived rats based on NRG1/ErbB4 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 18. 2024-12-19. PMID:39701678. |
the expression of glial fibrillary acidic protein(gfap), γ-aminobutyric acid a(gabaa), glutamate receptor n1(glun1), postsynaptic density-95(psd95), synaptophysin(syp), brain-derived neurotrophic factor(bdnf), and nerve growth factor(ngf) were detected by immunofluorescence staining. |
2024-12-19 |
2024-12-22 |
rat |
| Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswin. Extracellular vesicles released by ALL patients contain HNE-adducted proteins: implications of collateral damage. Free radical biology & medicine. 2024-12-06. PMID:39643137. |
evs were measured throughout the collection points for: 1) number of ev particles generated using nanoparticle tracking analysis (nta); 2) markers of neurons (neun), astrocyte activation (gfap), neuronal stability (bdnf), 3) markers of pre-b cell all (cd19 and cd22); and ) 4-hydroxy-2-nonenal (hne) adducted proteins. |
2024-12-06 |
2024-12-10 |
Not clear |
| Ya-Qi Yang, Murezati Tiliwaerde, Na-Na Gao, Wei Gu, Ting-Ting Zhang, Zeng-Liang Ji. GW117 induces anxiolytic effects by improving hippocampal functions. Pharmacology, biochemistry, and behavior. 2024-11-29. PMID:39613193. |
mechanistic studies revealed that gw117 notably increased the expression of bdnf, gfap, and bcl-2, while reducing bax and cleaved caspase-3 levels in the hippocampus of cums model rats. |
2024-11-29 |
2024-12-02 |
rat |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
an increase in the expression of the gfap, slc1a2, slc1a1, il1b, tnfa, bdnf, and fgf2 genes, and the a2 astrocyte condition marker s100a10, was observed. |
2024-09-21 |
2024-09-24 |
rat |
| Siyu Liu, Xiaoqiang Du, Ziyan Chen, Ruying Zhou, Hongqi Wang, Xin Mao, Jiahe Du, Guitao Zhang, Hui Li, Yizhi Song, Lirong Chang, Yan W. Activation of astrocytic NMDA receptors counteracted Aβ-induced reduction of BDNF and elevation of GFAP and complement 3 in the hippocampal astrocytes. Neuroscience. 2024-09-14. PMID:39276842. |
activation of astrocytic nmda receptors counteracted aβ-induced reduction of bdnf and elevation of gfap and complement 3 in the hippocampal astrocytes. |
2024-09-14 |
2024-09-18 |
Not clear |
| En Zhao, Qian Yu, Meilei Wang, Zhengqiu Wang, Bin Jiang, Xiang Ma, Bin Zhou, Qingyong Dai, Jinyu Li, Shiming Wang, Fengjuan Chen, Xiaojun Yan. Value of serum brain-derived neurotrophic factor and glial fibrillary acidic protein for detecting depression in patients with Helicobacter pylori infection. Neuroscience letters. 2024-02-25. PMID:38403261. |
this study aimed to evaluate the value of serum brain-derived neurotrophic factor (bdnf) and glial fibrillary acidic protein (gfap) for predicting depression in h. pylori-positive patients. |
2024-02-25 |
2024-02-28 |
Not clear |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
moreover, rtms ameliorated the reduction in gfap and glt-1 expression, alleviated the decrease in bdnf, psd95 and synapsin-1 expression, also reversed the expression levels of bax and bcl2 in the hippocampus of cums-induced rats. |
2023-12-30 |
2024-01-05 |
rat |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Moein Salari, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Somayeh Solhjou, Maryam Amiri, Meysam Ahmadi-Zeidabad. Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study. Brain and behavior. 2023-04-10. PMID:37032465. |
in the study, we examined the effects of ketamine and extremely low-frequency electromagnetic fields (elf-emf) on depression-like behavior, learning and memory, expression of gfap, caspase-3, p53, bdnf, and nmda receptor in animals subjected to chronic unpredictable stress (cus). |
2023-04-10 |
2023-08-14 |
rat |
| Shaoyu Yen, Hong-Yi Wu, Yuhling Wang, Chih-Mao Huang, Changwei W Wu, Jyh-Horng Chen, Lun-De Lia. Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques. iScience. vol 26. issue 4. 2023-04-10. PMID:37035001. |
western blot results in the exe group showed significant increases in bdnf, gfap, and neun levels and significant decreases in neurodegenerative disease markers. |
2023-04-10 |
2023-08-14 |
rat |
| Guanlan Liu, Israr Khan, Yuxi Li, Yun Yang, Xuerui Lu, Yafei Wang, Junxiang Li, Chunjiang Zhan. Overcoming Anxiety Disorder by Probiotic Foods (Basel, Switzerland). vol 11. issue 22. 2023-03-08. PMID:36429192. |
lzu-j-tsl6 was able to effectively increase the gaba content in the mice hippocampus (p < 0.0001) and restore some markers related to anxiety such as brain-derived neurotrophic factor (bdnf), glial fibrillary acidic protein (gfap), and 5-hydroxytryptamine (5-ht). |
2023-03-08 |
2023-08-16 |
mouse |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Arianne S Gravesteijn, Heleen Beckerman, Eline Aj Willemse, Hanneke E Hulst, Brigit A de Jong, Charlotte E Teunissen, Vincent de Groo. Brain-derived neurotrophic factor, neurofilament light and glial fibrillary acidic protein do not change in response to aerobic training in people with MS-related fatigue - a secondary analysis of a randomized controlled trial. Multiple sclerosis and related disorders. vol 70. 2023-01-09. PMID:36621163. |
brain-derived neurotrophic factor (bdnf), neurofilament light (nfl), and glial fibrillary acidic protein (gfap) are blood-based biomarkers for neurogenesis, axonal damage and astrocyte reactivity, respectively. |
2023-01-09 |
2023-08-14 |
Not clear |
| Ying Zhang, Guiping Wang, Rui Li, Ruitong Liu, Zengli Yu, Zengli Zhang, Zhongxiao Wa. Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise. Neurochemistry international. 2022-12-02. PMID:36460238. |
tmao group has significantly upregulated bace1 from both hippocampus and cortex, also increased cathepsin b, p-tau at ser396&ser404, gfap, p-nf-κb p65 in cortex, while reduced bdnf, synaptophysin and psd95 in hippocampus, also reduced occludin and zo-1 from cortex, and reduced occludin from colon. |
2022-12-02 |
2023-08-14 |
mouse |