| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Liang Yu, Jiajia Wang, Ying Xia, Wugang Hou, Xi Yao, Yaru Guo, Jin Wang, Haidong Wei, Shiquan Wan. Adiponectin Promotes Neurogenesis After Transient Cerebral Ischemia Through STAT3 Mediated BDNF Upregulation in Astrocytes. Neurochemical research. 2022-10-31. PMID:36315369. |
moreover, inhibition of stat3 not only prevented the increase of bdnf but also the improved neurogenesis and functional recovery after stroke. |
2022-10-31 |
2023-08-14 |
mouse |
| Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Po-Sheng Yang, Jen-Kun Cheng, Hsueh-Hsiao Wang, Kuan-Hung Lin, Siao-Tong Nie, Tzer-Bin Lin, Hsien-Yu Pen. MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn. Neuropharmacology. 2022-03-19. PMID:35304174. |
moreover, snl-induced decrease in mir-489-3p expression increased the expression of dek, which recruited tet1 to the promoter fragments of the bdnf, grm5, and stat3 genes, thereby enhancing their transcription in the dorsal horn. |
2022-03-19 |
2023-08-13 |
rat |
| Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J Guillemi. Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue s1. 2018-04-06. PMID:28269780. |
the result of the present study indicated that the chronic administration of alcl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of ide and cdk5 (enzymes involved in the metabolism of tau and amyloid proteins), ptau, gfap and iba-1, il-1β, il-6, tnf-α, inos, nf-κb, cox-2, cdk5, bdnf, and stat3. |
2018-04-06 |
2023-08-13 |
rat |
| C Cirelli, G Tonon. Gene expression in the brain across the sleep-waking cycle. Brain research. vol 885. issue 2. 2001-03-01. PMID:11102586. |
known genes that were upregulated in waking and sleep deprivation can be grouped into the following categories: immediate early genes/transcription factors (arc, chop, ier5, ngfi-a, ngfi-b, n-ras, stat3), genes related to energy metabolism (glucose type i transporter glut1, vgf), growth factors/adhesion molecules (bdnf, trkb, f3 adhesion molecule), chaperones/heat shock proteins (bip, erp72, grp75, hsp60, hsp70), vesicle- and synapse-related genes (chromogranin c, synaptotagmin iv), neurotransmitter/hormone receptors (adrenergic receptor alpha(1a) and beta(2), gaba(a) receptor beta(3), glutamate nmda receptor 2a, glutamate ampa receptor glur2 and glur3, nicotinic acetylcholine receptor beta(2), thyroid hormone receptor trbeta), neurotransmitter transporters (glutamate/aspartate transporter glast, na(+)/cl(-) transporter ntt4/rxt1), enzymes (aryl sulfotransferase, c-jun n-terminal kinase 1, serum/glucocorticoid-induced serine/threonine kinase), and a miscellaneous group (calmodulin, cyclin d2, lmo-4, metallothionein 3). |
2001-03-01 |
2023-08-12 |
rat |