| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Tracy L Hagemann, Sierra Coyne, Alder Levin, Liqun Wang, Mel B Feany, Albee Messin. STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease. Cells. vol 12. issue 7. 2023-04-13. PMID:37048051. |
stat3 drives gfap accumulation and astrocyte pathology in a mouse model of alexander disease. |
2023-04-13 |
2023-08-14 |
mouse |
| Kana Hamada, Laura B Ferguson, R Dayne Mayfield, Harish R Krishnan, Mark Maienschein-Cline, Amy W Lase. Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex. Genes, brain, and behavior. 2021-04-21. PMID:33641239. |
here, we show alk activation and upregulation of known stat3 target genes (socs3, gfap and tnfrsf1a) in the prefrontal cortex (pfc) and ventral hippocampus (hpc) of mice after 4 days of binge-like ethanol drinking. |
2021-04-21 |
2023-08-13 |
mouse |
| Enas Ahmed Mohamed, Walaa Mohamed Saye. Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. Scientific reports. vol 10. issue 1. 2020-11-26. PMID:32483368. |
immunohistochemical reaction of the cerebellum to gfap and caspase-3 was assessed and the expression of jak1, stat3, socs3 proteins was also evaluated. |
2020-11-26 |
2023-08-13 |
rat |
| Yao-Feng Zhu, Wei-Ping Wang, Xue-Feng Zheng, Zhi Chen, Tao Chen, Zi-Yun Huang, Lin-Ju Jia, Wan-Long Le. Characteristic response of striatal astrocytes to dopamine depletion. Neural regeneration research. vol 15. issue 4. 2020-09-28. PMID:31638097. |
western blot assay was used to measure the protein expression of gfap, s100b, and stat3 in the striatum. |
2020-09-28 |
2023-08-13 |
rat |
| Yao-Feng Zhu, Wei-Ping Wang, Xue-Feng Zheng, Zhi Chen, Tao Chen, Zi-Yun Huang, Lin-Ju Jia, Wan-Long Le. Characteristic response of striatal astrocytes to dopamine depletion. Neural regeneration research. vol 15. issue 4. 2020-09-28. PMID:31638097. |
immunohistochemical staining was used to detect the immunoreactivity of glial fibrillary acidic protein (gfap), calcium-binding protein b (s100b), and signal transducer and activator of transcription 3 (stat3) in the striatum, and to investigate the co-expression of gfap with s100b and stat3. |
2020-09-28 |
2023-08-13 |
rat |
| Yao-Feng Zhu, Wei-Ping Wang, Xue-Feng Zheng, Zhi Chen, Tao Chen, Zi-Yun Huang, Lin-Ju Jia, Wan-Long Le. Characteristic response of striatal astrocytes to dopamine depletion. Neural regeneration research. vol 15. issue 4. 2020-09-28. PMID:31638097. |
striatal dopamine deprivation increased the number of gfap/s100b and gfap/stat3 double-labeled cells, and increased the protein levels of gfap, s100b, and stat3. |
2020-09-28 |
2023-08-13 |
rat |
| Gang Luo, Yinuo Huang, Dapeng Mo, Ning Ma, Feng Gao, Ligang Song, Xuan Sun, Xiaotong Xu, Lian Liu, Xiaochuan Huo, Bo Wang, Xiaoqing Li, Baixue Jia, Yiming Deng, Xuelei Zhang, Alejandro Fernandez-Escobar, Guangge Peng, Zhongrong Mia. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation. Neurochemistry international. vol 121. 2019-09-13. PMID:30291953. |
the reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of stat3 signaling pathway since tyrosol attenuated the expression level of gfap (glial fibrillary acidic protein) and the phosphorylation of stat3. |
2019-09-13 |
2023-08-13 |
Not clear |
| Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J Guillemi. Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue s1. 2018-04-06. PMID:28269780. |
the result of the present study indicated that the chronic administration of alcl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of ide and cdk5 (enzymes involved in the metabolism of tau and amyloid proteins), ptau, gfap and iba-1, il-1β, il-6, tnf-α, inos, nf-κb, cox-2, cdk5, bdnf, and stat3. |
2018-04-06 |
2023-08-13 |
rat |
| Hyesook Yoon, Grant Walters, Alex R Paulsen, Isobel A Scarisbric. Astrocyte heterogeneity across the brain and spinal cord occurs developmentally, in adulthood and in response to demyelination. PloS one. vol 12. issue 7. 2017-09-25. PMID:28700615. |
notably, increases in spinal cord compared to whole brain gfap were paralleled by higher levels of il-6 and stat3. |
2017-09-25 |
2023-08-13 |
Not clear |
| Osamu Imamura, Masaaki Arai, Minori Dateki, Kunio Takishim. Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis. Journal of neurochemistry. vol 140. issue 2. 2017-07-28. PMID:27664791. |
moreover, donepezil increased oligodendrocyte differentiation, resulting in a reduction in the differentiation of nscs into astrocytes, by suppressing the activation of signal transducer and activator of transcription 3 (stat3), smad1/5/9, and the downstream target gene gfap, even under astrocyte-inducing conditions. |
2017-07-28 |
2023-08-13 |
mouse |
| Mallika Valapala, Malia Edwards, Stacey Hose, Jianfei Hu, Eric Wawrousek, Gerard A Lutty, J Samuel Zigler, Jiang Qian, Debasish Sinh. βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes. Scientific reports. vol 5. 2016-04-01. PMID:25736717. |
this stoichiometric co-regulation of stat3 and cryba1 could potentiate expression of gfap and secretion of vegf, both of which are essential for maintaining astrocyte and blood vessel homeostasis in the retina. |
2016-04-01 |
2023-08-13 |
mouse |
| Yan Fan, Khalid Amine Timani, Johnny J H. STAT3 and its phosphorylation are involved in HIV-1 Tat-induced transactivation of glial fibrillary acidic protein. Current HIV research. vol 13. issue 1. 2015-12-03. PMID:25613134. |
taken together, these findings show that stat3 is involved in and acts upstream of egr1 and p300 in the tat-induced gfap transactivation cascade and suggest important roles of stat3 in controlling astrocyte proliferation and activation in the hiv-infected central nervous system. |
2015-12-03 |
2023-08-13 |
human |
| Ron Bouchard, Thomas Chong, Subbiah Pugazhenth. Laser capture microdissection of neurons from differentiated human neuroprogenitor cells in culture. Journal of visualized experiments : JoVE. issue 79. 2014-04-10. PMID:24084642. |
glial fibrillary acidic protein (gfap) and stat3, astrocyte markers, were detected in 10-15% of differentiated npcs. |
2014-04-10 |
2023-08-12 |
mouse |
| Sujeong Yeo, Susanta Bandyopadhyay, Albee Messing, Michael Brenne. Transgenic analysis of GFAP promoter elements. Glia. vol 61. issue 9. 2014-02-21. PMID:23832770. |
whereas mutation of the conserved consensus ap-1 site unexpectedly had little effect on transgene expression; nfi, sp1, stat3, and nf-κb were identified as having important roles in regulating the strength of gfap promoter activity and/or its astrocyte specificity. |
2014-02-21 |
2023-08-12 |
mouse |
| T E Nelson, A Olde Engberink, R Hernandez, A Puro, S Huitron-Resendiz, C Hao, P N E De Graan, D L Gruo. Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6. Brain, behavior, and immunity. vol 26. issue 6. 2012-11-20. PMID:22609298. |
western blot analysis showed enhanced levels of the gfap and stat3 in the il-6 tg hippocampus compared with the non-tg hippocampus, but no difference for several other proteins. |
2012-11-20 |
2023-08-12 |
mouse |
| Zucai Xu, Tao Xue, Zuxia Zhang, Xuefeng Wang, Ping Xu, Jun Zhang, Xianze Lei, Yuqin Li, Yunlan Xie, Liang Wang, Min Fang, Yangmei Che. Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. Neurochemical research. vol 36. issue 12. 2012-03-12. PMID:21833841. |
these findings indicate that epilepsy involves the activation of stat3 that up-regulates the expression of gfap, which may play an important role in epileptogenesis. |
2012-03-12 |
2023-08-12 |
rat |
| Zucai Xu, Tao Xue, Zuxia Zhang, Xuefeng Wang, Ping Xu, Jun Zhang, Xianze Lei, Yuqin Li, Yunlan Xie, Liang Wang, Min Fang, Yangmei Che. Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. Neurochemical research. vol 36. issue 12. 2012-03-12. PMID:21833841. |
recent studies have demonstrated that signal transducer and activator of transcription-3, stat3 regulates gfap expression after brain injuries. |
2012-03-12 |
2023-08-12 |
rat |
| Matthias Kirsch, Nikolaus Trautmann, Matthias Ernst, Hans-Dieter Hofman. Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion. Glia. vol 58. issue 7. 2010-06-29. PMID:20091786. |
in the retina of cntf(-/-) mice, basal gfap expression was reduced, but unexpectedly, injury-induced upregulation in activated müller cells was increased during the first 3 days after lesion as compared to wild-type animals and this corresponded with higher phosphorylation level of stat3, an indicator of cytokine signaling. |
2010-06-29 |
2023-08-12 |
mouse |
| Qi Xiao, Yang Du, Wutian Wu, Henry K Yi. Bone morphogenetic proteins mediate cellular response and, together with Noggin, regulate astrocyte differentiation after spinal cord injury. Experimental neurology. vol 221. issue 2. 2010-02-16. PMID:20005873. |
noggin treatment did not block phosphorylation of stat3 and the induction of gfap in the injured spinal cord, suggesting that in addition to the bmp/smad pathway, the jak/stat pathway may also be involved in the regulation of gfap expression after spinal cord injury. |
2010-02-16 |
2023-08-12 |
mouse |