| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
the aim is to investigate the effect of neuregulin-1beta (nrg-1beta) on the neuronal apoptosis and the expressions of signal transducer and activator of transcription (stat3) and glial fibrillary acidic protein (gfap) in rats following cerebral ischemia/reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
effect of neuregulin on apoptosis and expressions of stat3 and gfap in rats following cerebral ischemic reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Makoto Ohno, Jun Kohyama, Masakazu Namihira, Tsukasa Sanosaka, Jun A Takahashi, Nobuo Hashimoto, Kinichi Nakashim. Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3. Cytokine. vol 36. issue 1-2. 2007-02-27. PMID:17161614. |
np stimulation leads to promoter activation of the gene for an astrocyte marker, glial fibrillary acidic protein (gfap), which is clearly inhibited by either expression of a dominant-negative form of a transcription factor, signal transducer and activator of transcription 3 (stat3) or by a nucleotide-substitution in the stat3-binding element within the gene promoter. |
2007-02-27 |
2023-08-12 |
Not clear |
| Yuichiro Watanabe, Shinya Hashimoto, Akiyoshi Kakita, Hitoshi Takahashi, Jan Ko, Makoto Mizuno, Toshiyuki Someya, Paul H Patterson, Hiroyuki Naw. Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats. Neuroscience research. vol 48. issue 3. 2004-07-06. PMID:15154680. |
subcutaneous lif injection induced stat3 phosphorylation in many brain regions and increased glial fibrillary acidic protein (gfap) immunoreactivity in the neocortex, suggesting that lif had direct effects in the central nervous system. |
2004-07-06 |
2023-08-12 |
rat |
| Hiromi Takanaga, Tomoko Yoshitake, Shuntaro Hara, Chieri Yamasaki, Manabu Kunimot. cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. The Journal of biological chemistry. vol 279. issue 15. 2004-06-01. PMID:14754894. |
treatment of cells with n(6),2'-o-dibutyryl camp (bt(2)amp) and theophylline caused the delayed phosphorylation of signal transducer and activator of transcription 3 (stat3), as well as the expression of an astrocyte marker, glial fibrillary acidic protein (gfap). |
2004-06-01 |
2023-08-12 |
Not clear |
| Atsumi Uemura, Takumi Takizawa, Wataru Ochiai, Makoto Yanagisawa, Kinichi Nakashima, Tetsuya Tag. Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. vol 18. issue 1. 2003-02-21. PMID:12090754. |
clc-stimulation led to promoter activation of the gene for an astrocyte marker, glial fibrillary acidic protein (gfap), which was clearly inhibited by expression of a dominant negative form of a transcription factor, stat3, or by introduction of a mutation in a single stat3-binding site in the promoter, suggesting a critical role of stat3 in the clc-induced gfap transcription. |
2003-02-21 |
2023-08-12 |
mouse |
| W Ochiai, M Yanagisawa, T Takizawa, K Nakashima, T Tag. Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Cytokine. vol 14. issue 5. 2001-09-27. PMID:11444906. |
ct-1-stimulation led to promoter activation of the gene for an astrocyte marker, glial fibrillary acidic protein (gfap), which was clearly inhibited by expression of a dominant negative form of a gp130-downstream transcription factor, signal transducer and activator of transcription 3(stat3), or by introduction of a mutation in a single stat3-binding site in the promoter, suggesting a critical role of stat3 in the ct-1-induced gfap transcription. |
2001-09-27 |
2023-08-12 |
mouse |
| L Acarin, B González, B Castellan. STAT3 and NFkappaB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. Journal of neuropathology and experimental neurology. vol 59. issue 2. 2000-04-19. PMID:10749104. |
in contrast, the milder glial response occurring in the distal thalamus is not preceded by immunocytochemically detectable stat3 and nfkappab activation, although microglial response, astroglial hypertrophy, and glial fibrillary acidic protein (gfap) overexpression do occur. |
2000-04-19 |
2023-08-12 |
rat |
| L Acarin, B González, B Castellan. STAT3 and NFkappaB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. Journal of neuropathology and experimental neurology. vol 59. issue 2. 2000-04-19. PMID:10749104. |
in the cortex, astrocytes show stat3 and nfkappab activation already at 2 to 4 hours post-lesion, preceding cell hypertrophy and gfap upregulation, and being maintained in the long-term formed glial scar. |
2000-04-19 |
2023-08-12 |
rat |
| M Yanagisawa, K Nakashima, H Arakawa, K Ikenaka, K Yoshida, T Kishimoto, T Hisatsune, T Tag. Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737606. |
this differentiation process is totally dependent on the gp130-mediated signal-transduction pathway involving activation of a latent cytoplasmic transcription factor, stat3 (for signal transducer and activator of transcription 3), because (a) il-11-induced astrocyte differentiation is not observed when neuroepithelial cells prepared from gp130-deficient mice were used, (b) stimulation of neuroepithelial cells by il-11 rapidly induces tyrosine-phosphorylation of stat3, and (c) transfection of neuroepithelial cells with a dominant-negative form of stat3 inhibits il-11-induced activation of the gfap gene promoter. |
2000-04-11 |
2023-08-12 |
mouse |