Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Kaushiki Mukherjee, Paul C Guest, Kolja Schiltz, Gabriela Meyer-Lotz, Henrik Dobrowolny, Katrin Borucki, Hans-Gert Bernstein, Thomas Nickl-Jockschat, Borna Relja, Johann Steine. Longitudinal analysis of astrocyte-derived protein levels in the blood of drug-naive and relapsed patients with schizophrenia. Journal of psychiatric research. vol 180. 2024-11-01. PMID:39486269. |
our findings suggest that lowered gfap and fabp7 may serve as trait markers of astrocyte pathology in schizophrenia, even prior to antipsychotic treatment. |
2024-11-01 |
2024-11-05 |
human |
Manish Ravikumar, Brindha Durairaj, Deenathayalan Uvaraja. Necrostatin-1 as a Potential Anticonvulsant: Insights from Zebrafish Larvae Model of PTZ-Induced Seizures. Molecular neurobiology. 2024-10-28. PMID:39465486. |
additionally, c-fos expression was measured as an indicator of neuronal activation and analyzed mrna levels of the astrocyte activation marker (gfap) along with various inflammatory cytokines. |
2024-10-28 |
2024-10-30 |
human |
Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
Janelle E Stanton, Sakshi Hans, Ioannis Zabetakis, Andreas M Grabrucke. Zinc signaling controls astrocyte-dependent synapse modulation via the PAF receptor pathway. Journal of neurochemistry. 2024-10-25. PMID:39450676. |
since zinc deficiency has been consistently linked to increased pro-inflammatory signaling, we aimed to identify cellular zinc-dependent signaling pathways that may lead to astrocyte activation using techniques such as immunocytochemistry and protein biochemistry to detect astrocyte gfap expression, fluorescent imaging to detect oxidative stress levels in activated astrocytes, cytokine profiling, and analysis of primary neurons subjected to astrocyte secretomes. |
2024-10-25 |
2024-10-28 |
Not clear |
Regina Andressa Caetano, Joelma Alves, Thiago A Smaniotto, Francisco Daroda Dutra, Eduardo Z B de Assis, Luisa Soares Pedroso, Ariadni Peres, Alessandra G Machado, Rachel Krolow, Pauline Maciel August, Cristiane Matté, Marina Seady, Marina C Leite, Brenda G Machado, Carolina Marques, Laura Saraiva, Randriely Merscher Sobreira de Lima, Carla Dalma. Impacts of linseed oil diets on anxiety and memory extinction after early life stress: A sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and inflammation in the amygdala. Brain research. 2024-10-07. PMID:39374840. |
amygdalae were evaluated for inflammatory cytokines (interleukin (il)-1beta, il-6, and tumor-necrose factor (tnf)-alpha), mitochondrial functionality, and astrocyte markers (glial fibrillary acidic protein - gfap, s100b, and glutamine synthetase activity). |
2024-10-07 |
2024-10-10 |
rat |
Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhi. Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels. Neurochemistry international. 2024-09-30. PMID:39349219. |
concomitantly, mrna and protein levels for astrocyte and microglial activation markers; gfap and iba-1, were increased in mcao animals. |
2024-09-30 |
2024-10-03 |
Not clear |
Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
an increase in the expression of the gfap, slc1a2, slc1a1, il1b, tnfa, bdnf, and fgf2 genes, and the a2 astrocyte condition marker s100a10, was observed. |
2024-09-21 |
2024-09-24 |
rat |
Pei-Hao Lin, Hai-Yan Yao, Li Huang, Cong-Cong Fu, Xiao-Li Yao, Chun Lian, Shi-Feng Zhang, Wen-Dong Lai, Guan-Yan Lin, Sha Liao, Jie Yang, Zhi-Feng Mao, Ding Liu, Bao-Yi Long, Jia-Jia Yue, Cong Gao, You-Ming Lon. Autoimmune astrocytopathy double negative for AQP4-IgG and GFAP-IgG: Retrospective research of clinical practice, biomarkers, and pathology. CNS neuroscience & therapeutics. vol 30. issue 9. 2024-09-16. PMID:39279053. |
the objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin-4 or glial fibrillary acidic protein (gfap) antibodies, while evaluating associated biomarkers and pathologies. |
2024-09-16 |
2024-09-18 |
Not clear |
Dianjun Liu, Xiangwen Yao, Hao Zhan. Effect of general anesthesia drugs on GFAP/Iba-1 expression: a meta-analysis. American journal of translational research. vol 16. issue 8. 2024-09-12. PMID:39262705. |
glial fibrillary acidic protein (gfap) is a marker associated with astrocyte activation and plays a role in various pathologic processes, including traumatic brain injury, stroke, and neurodegenerative diseases. |
2024-09-12 |
2024-09-14 |
Not clear |
Maggie L Bartlett, Heather Goux, Linwood Johnson, Kevin L Schully, Melissa Gregory, Joost Brandsma, Josh G Chenoweth, Danielle V Clark, Luis Felipe Rivera, Carlos Lezcano-Coba, Amy Y Vittor, Ronald Hayes, Josefrancisco Galué, Jean-Paul Carrera, Darci R Smit. Retrospective Analysis of Blood Biomarkers of Neurological Injury in Human Cases of Viral Infection and Bacterial Sepsis. The Journal of infectious diseases. 2024-09-10. PMID:39255068. |
an fda-approved assay for mild traumatic brain injury (tbi) measures glial fibrillary acidic protein (gfap) and ubiquitin carboxy-terminal hydrolase l1 (uch-l1), which signal astrocyte and neuronal injury, respectively. |
2024-09-10 |
2024-09-13 |
human |
Jie Chen, Chenxu Liu, Li Li, WeiTing Tao, Xiaonan Zhang, Shidi Zhao, Chun Wang, Li Huan. Exogenous leptin alleviates glutamate-excitotoxic damage caused by cerebral ischemia-reperfusion in mice by affecting the expression of glutamate transporters. Brain research. 2024-08-28. PMID:39197570. |
on this basis, we observed the changes of cortical apoptosis injury, intracellular calcium fluorescence intensity and astrocyte glial fibrillary acidic protein (gfap) expression and morphological changes. |
2024-08-28 |
2024-09-01 |
mouse |
Nosarieme Omoregie Abey, Osaretin Albert Taiwo Ebuehi, Ngozi Awa Imag. Effect of perinatal dietary protein deficiency on some neurochemicals and cytoarchitectural balance, in F1 and F2 generations of rats. Nutritional neuroscience. vol 27. issue 9. 2024-08-27. PMID:37995096. |
gfap astrocyte expression was observed to be increased in the prefrontal cortex (pfc) and hippocampal sections, indicating heightened reactivity. |
2024-08-27 |
2024-08-30 |
rat |
Tharick Pascoal, Francieli Rohden, Pamela Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Lussier, Douglas Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault Therriault, Stijn Servaes, Jenna Stevenson, Andrea Benedet, Nicholas Ashton, Thomas Karikari, Dana Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo Zimmer, Diogo Souza, Pedro Rosa-Net. Glial reactivity is linked to synaptic dysfunction across the aging and Alzheimer's disease spectrum. Research square. 2024-08-26. PMID:39184102. |
here, we investigated the association between biomarkers of astrocyte and microglial reactivity and synaptic dysfunction in 478 individuals across the aging and ad spectrum from two cohorts with available csf measures of amyloid-β(aβ), phosphorylated tau(ptau181), astrocyte reactivity(gfap), microglial activation(strem2), and synaptic biomarkers(gap43 and neurogranin). |
2024-08-26 |
2024-08-28 |
Not clear |
Brenda Lizeth Gutiérrez-Esparza, Marina Liliana González-Torres, Andrés Quintanar-Stephano, J Luis Quintana. Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist. Metabolic brain disease. 2024-08-23. PMID:39177865. |
in this study, we aim to evaluate the effects of la treatment on hippocampus of rats with he induced by portocaval anastomosis (pca) trough cognitive tests, histology analysis and expression of neuronal recovery marker proteins, such as neurofilament (nf200) and neurabin ii, and astrocyte marker glial fibrillary acidic protein (gfap). |
2024-08-23 |
2024-08-25 |
rat |
Goksu Ozcelikay-Akyildiz, Leyla Karadurmus, Ahmet Cetinkaya, İnci Uludag, Burcu Ozcan, Mehmet Altay Unal, Mustafa Kemal Sezginturk, Sibel A Ozka. The Evaluation of Clinical Applications for the Detection of the Alzheimer's Disease Biomarker GFAP. Critical reviews in analytical chemistry. 2024-08-23. PMID:39178137. |
glial fibrillary acidic protein (gfap) is released from tissue into the bloodstream due to astrocyte breakdown in neurological diseases. |
2024-08-23 |
2024-08-26 |
human |
Vittoria Borgonetti, Martina Morozzi, Nicoletta Galeott. Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain. Neuropharmacology. 2024-08-19. PMID:39159835. |
in coincidence with the peak of scratching behavior, sni mice showed a spinal overexpression of iba1 and gfap, microglia and astrocyte markers respectively. |
2024-08-19 |
2024-08-22 |
mouse |
Jae Soo Kim, Mi-Hye Kim, Myeung Ju Kim, Hee Jung Ki. Licochalcone A attenuates NMDA-induced neurotoxicity. Animal cells and systems. vol 28. issue 1. 2024-08-14. PMID:39139398. |
the response of astrocyte and microglia was also evaluated by immunostaining for glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor molecule 1 (iba-1) and tumor necrosis factor alpha (tnf-α). |
2024-08-14 |
2024-08-16 |
rat |
Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. 2024-07-25. PMID:39051915. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-07-25 |
2024-07-28 |
mouse |
Ariel Y Zhang, Elias Elias, Melissa T Manner. Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions. Neurobiology of disease. 2024-07-20. PMID:39032799. |
to evaluate stress-induced morphological changes in astrocyte complexity, we measured gfap fluorescent intensity for astrocyte expression, branch bifurcation by quantifying branch points and terminal points, branch arborization by conducting sholl analysis, and calculated the ramification index. |
2024-07-20 |
2024-07-24 |
Not clear |