Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Peter M Andrew, Jeremy A MacMahon, Pedro N Bernardino, Yi-Hua Tsai, Brad A Hobson, Valerie A Porter, Sydney L Huddleston, Audrey S Luo, Donald A Bruun, Naomi H Saito, Danielle J Harvey, Amy Brooks-Kayal, Abhijit J Chaudhari, Pamela J Lei. Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate. Journal of neuroinflammation. vol 21. issue 1. 2024-11-05. PMID:39497181. |
colocalization of iba-1, a marker for microglia, with inos or arg1 was used to identify pro- and anti-inflammatory microglia, respectively; colocalization of gfap, a marker for astrocytes, with c3 or s100a10, pro- and anti-inflammatory astrocytes, respectively. |
2024-11-05 |
2024-11-07 |
rat |
Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
Ruixin Zhang, Makiko Ohshima, David Brodin, Yu Wang, Antonin Morancé, Marianne Schultzberg, Gefei Chen, Jan Johansso. Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes. Translational psychiatry. vol 14. issue 1. 2024-10-25. PMID:39448576. |
sequencing of rna from cortical microglia cells showed that brichos treatment normalized the expression of identified plaque-induced genes in mice and humans, including clusterin and gfap. |
2024-10-25 |
2024-10-28 |
mouse |
Gabriela C De Paula, Rui F Simões, Alba M Garcia-Serrano, João M N Duart. High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice. Neurochemical research. 2024-09-20. PMID:39302596. |
we determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers iba1, cd68, gfap and emr1 in the hypothalamus, and analyzed morphology of microglia (iba-1 |
2024-09-20 |
2024-09-22 |
mouse |
Olawande Bamisi, Adesua Olukayode Oluwalabani, Tolulope Timothy Arogundade, Olayemi Joseph Olajid. Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium. Neurotoxicology and teratology. 2024-09-20. PMID:39303770. |
immunohistochemical labelling of gfap and iba-1 revealed increased expression of reactive astrocytes and microglia respectively, while the accompanying tnfα upregulation in both the hippocampus (dentate gyrus) and pfc causally linked intrauterine d. stramonium exposure with neuroinflammatory responses postnatally. |
2024-09-20 |
2024-09-23 |
rat |
Ashwani Arya, Manish Dhall, Vineet Mittal, Deepak Kaushik, Priya Mudgal, Tarun Kumar, Manisha Pandey, Renu Kadian, Prerna Sharma, Nidhi Rani, Thakur Gurjeet Sing. Multiple Sclerosis: Pathogenesis Mechanism and Biomarkers. Central nervous system agents in medicinal chemistry. 2024-09-05. PMID:39234910. |
cortical inflammation, neurodegeneration, demyelination, axonal injury, axonal loss, oligodendrocytes, mitochondrial dysfunction, microglia activation, oxidative and nitrosative stress are the pathological hallmarks of the ms. cns neurofilaments, chitinase and chitinase 3-like proteins, soluble circulating form (scd163), chemokine ligand 13 (cxcl13), immunoglobulin m, microrna (mirna) and messenger ribonucleic acid (mrna), glial fibrillary acidic protein (gfap), serum osteopontin, 8-iso-prostaglandin f2α (8-iso-pgf2 α), apo-lipoprotein e and myelinreactive t cells are some of the therapeutically valuable biomarkers for such multifarious disorder. |
2024-09-05 |
2024-09-08 |
Not clear |
Vittoria Borgonetti, Martina Morozzi, Nicoletta Galeott. Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain. Neuropharmacology. 2024-08-19. PMID:39159835. |
in coincidence with the peak of scratching behavior, sni mice showed a spinal overexpression of iba1 and gfap, microglia and astrocyte markers respectively. |
2024-08-19 |
2024-08-22 |
mouse |
Jae Soo Kim, Mi-Hye Kim, Myeung Ju Kim, Hee Jung Ki. Licochalcone A attenuates NMDA-induced neurotoxicity. Animal cells and systems. vol 28. issue 1. 2024-08-14. PMID:39139398. |
the response of astrocyte and microglia was also evaluated by immunostaining for glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor molecule 1 (iba-1) and tumor necrosis factor alpha (tnf-α). |
2024-08-14 |
2024-08-16 |
rat |
Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
Zsolt Gáll, Ágnes Csüdör, István-Gábor Sável, Krisztina Kelemen, Melinda Kolcsá. Cholecalciferol Supplementation Impacts Behavior and Hippocampal Neuroglial Reorganization in Vitamin D-Deficient Rats. Nutrients. vol 16. issue 14. 2024-07-27. PMID:39064769. |
an immunohistochemical analysis of the brain regions involved in learning and memory was performed by quantifying the neurons, astrocytes, and microglia labelled with anti-neuronal nuclei (neun), glial fibrillary acidic protein (gfap), and ionized calcium-binding adaptor molecule 1 (iba-1) antibodies, respectively. |
2024-07-27 |
2024-07-29 |
rat |
Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. 2024-07-25. PMID:39051915. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-07-25 |
2024-07-28 |
mouse |
Ryan K Shahidehpour, Peter T Nelson, Adam D Bachstette. A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC. Acta neuropathologica communications. vol 12. issue 1. 2024-07-12. PMID:38997773. |
using multiplexed immunohistochemistry and digital pathology tools, we conducted pathological analyses to investigate the relationship between lin bodies and glial markers (gfap for astrocytes, iba1 for microglia) and ferritin. |
2024-07-12 |
2024-07-15 |
Not clear |
D K Avrova, L V Bayunova, N F Avrova, I O Zakharov. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury. Bulletin of experimental biology and medicine. 2024-06-21. PMID:38907060. |
the immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (iba1) and astrocytes (gfap) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. |
2024-06-21 |
2024-06-24 |
rat |
Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
Bruna da Silva Oliveira, Eliana Cristina de Brito Toscano, Larissa Katharina Sabino Abreu, Heliana de Barros Fernandes, Renan Florindo Amorim, Rodrigo Novaes Ferreira, Caroline Amaral Machado, Brener Cunha Carvalho, Maria Carolina Machado da Silva, Antônio Carlos Pinheiro de Oliveira, Milene Alvarenga Rachid, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Elizabeth Ribeiro da Silva, Aline Silva de Mirand. Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson's Disease. Neuroscience. vol 549. 2024-05-22. PMID:38750924. |
iba-1 and gfap expressions were increased in the sn, suggesting an activated state of microglia and astrocytes. |
2024-05-22 |
2024-05-27 |
mouse |
Jit Poddar, Suresh B Rangasamy, Kalipada Paha. Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI. Neurochemistry international. 2024-04-19. PMID:38641028. |
oral delivery of cinnamein through gavage brought down the activation of microglia and astrocytes to decrease the expression of inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) in hippocampus and cortex of tbi mice. |
2024-04-19 |
2024-04-22 |
mouse |
Pengjun Wang, Chen Chen, Min Sha. Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways. Journal of biochemical and molecular toxicology. vol 38. issue 5. 2024-04-17. PMID:38629493. |
microglial and astrocyte activation was examined through immunofluorescence staining of iba-1 (microglia marker) and gfap (astrocyte marker) in the sn. |
2024-04-17 |
2024-04-19 |
mouse |
Ameer Elena Rasool, Teri Furlong, Asheeta A Prasa. Microglia activity in the human basal ganglia is altered in alcohol use disorder and reversed with remission from alcohol. Addiction biology. vol 29. issue 2. 2024-02-21. PMID:38380734. |
immunohistochemistry was performed to analyze cell count, staining intensity, and morphology of microglia and astrocytes, using markers iba-1 and gfap. |
2024-02-21 |
2024-02-23 |
human |
Guido S Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E Ron de Kloet, Alejandro F De Nicola, Laura I Gara. effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis. The Journal of steroid biochemistry and molecular biology. 2024-01-14. PMID:38219844. |
the mr blocker (a) significantly decreased the inflammatory parameters tlr4, myd88, il-1β, and inos mrnas; (b) attenuated hmgb1, nlrp3, tgf-β mrnas, microglia, and aquaporin4 immunoreaction without modifying gfap. |
2024-01-14 |
2024-01-17 |
mouse |
Kentaro Suda, Jaime Pignatelli, Laura Genis, Ana M Fernandez, Estrella Fernandez de Sevilla, Ines Fernandez de la Cruz, Andrea Pozo-Rodrigalvarez, Maria L de Ceballos, Sonia Díaz-Pacheco, Raquel Herrero-Labrador, Ignacio Torres Alema. A role for astrocytic insulin-like growth factor I receptors in the response to ischemic insult. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-11-28. PMID:38017004. |
further, greater damage was also accompanied by altered glial reactivity as reflected by changes in the morphology of gfap astrocytes, and relative abundance of ionized calcium binding adaptor molecule 1 (iba 1) microglia. |
2023-11-28 |
2023-12-07 |
mouse |