Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Ke-Rong Qi, Xue Chen, Jian-Chao Si, Qing-Qing Liu, Sheng-Chang Yan. [Exogenous EPO protects HT22 cells from intermittent hypoxia-induced injury by activating JAK2-STAT5 signaling pathway]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468806. |
mouse hippocampal neuron ht22 cells were exposed to ih for different durations (1% o |
2024-10-29 |
2024-10-31 |
mouse |
Yao He, Yan Zhao, Ren-Jun Lv, Na Dong, Xiao Wang, Qin Yu, Hong-Mei Yu. Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia. Tissue & cell. vol 91. 2024-10-25. PMID:39454474. |
in vivo, ih caused hippocampal damage and inhibited wβc pathway activity in mice, which was ameliorated by cur treatment. |
2024-10-25 |
2024-10-29 |
mouse |
Amir Rezagholizadeh, Amir Shojaei, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Kristi Anne Kohlmeier, Yaghoub Fathollah. Astrocytes contribute to the functional differentiation of the hippocampal longitudinal axis during reward and aversion processing in the adult male rat. Neuroscience. 2024-10-07. PMID:39374644. |
this study aims to investigate whether glial cells, in particular putative astrocytes, contribute to functional distinctions between the dorsal (dh), intermediate (ih), and ventral (vh) hippocampus. |
2024-10-07 |
2024-10-10 |
rat |
Yao He, Yan Zhao, Ren-Jun Lv, Na Dong, Xiao Wang, Qin Yu, Hong-Mei Yu. Curcumin activates the Wnt/β-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification. International immunopharmacology. vol 143. issue Pt 1. 2024-10-03. PMID:39362017. |
the hematoxylin and eosin (h&e) and nissl staining indicated that cur could alleviate damage to the hippocampus caused by ih. |
2024-10-03 |
2024-10-07 |
mouse |
Mohammad J Eslamizade, Fatemeh Saffarzadeh, Sanaz Khatami, Shima Davoudi, Zahra Soleimani, Sara Anajafi, Amineh Khoshnazar, Mehdi Mehdizadeh, Samira Mohammadi-Yeganeh, Mahyar Janahmad. Deregulation of Melatonin Receptors and Differential Modulation of After-Hyperpolarization and Ih Currents Using Melatonin Treatment Due to Amyloid-β-Induced Neurotoxicity in the Hippocampus. Cell biochemistry and function. vol 42. issue 7. 2024-09-30. PMID:39344779. |
deregulation of melatonin receptors and differential modulation of after-hyperpolarization and ih currents using melatonin treatment due to amyloid-β-induced neurotoxicity in the hippocampus. |
2024-09-30 |
2024-10-02 |
rat |
Haiming Yang, Ying Yuan, Ke Yang, Ning Wang, Xiao L. ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea. Brain research bulletin. 2024-08-22. PMID:39173777. |
intermittent hypoxia (ih) in patients with obstructive sleep apnea (osa) syndrome elicited neuron injury (especially in the hippocampus and cortex), contributing to cognitive dysfunction. |
2024-08-22 |
2024-08-25 |
mouse |
Natalie E Doody, Nicole J Smith, Elizabeth C Akam, Graham N Askew, Jessica C F Kwok, Ronaldo M Ichiyam. Differential expression of genes in the RhoA/ROCK pathway in the hippocampus and cortex following intermittent hypoxia and high intensity interval training. Journal of neurophysiology. 2024-07-10. PMID:38985935. |
we investigated whether the rhoa/rock signaling pathway (known to restrict neuroplasticity) is also modulated by ih and hiit in the hippocampus, cortex, and lumbar spinal cord of male wistar rats. |
2024-07-10 |
2024-07-13 |
rat |
Shuying Wang, Jin Tan, Qiang Zhan. Cytosolic Escape of Mitochondrial DNA Triggers cGAS-STING Pathway-Dependent Neuronal PANoptosis in Response to Intermittent Hypoxia. Neurochemical research. 2024-06-04. PMID:38833090. |
our study found that panoptosis occurred in primary cultures of hippocampal neurons and ht22 cell lines exposed to ih. |
2024-06-04 |
2024-06-06 |
Not clear |
Sohrab Anvari, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollah. Repeated Morphine Exposure Alters Temporoamonic-CA1 Synaptic Plasticity in Male Rat Hippocampus. Neuroscience. 2024-03-21. PMID:38513764. |
in this study, the electrophysiological and biochemical consequences of repeated exposure to morphine in male rats on glutamatergic synaptic transmission, synaptic plasticity, the expression of gaba receptors and glutamate receptors at the temporoammonic-ca1 synapse along the longitudinal axis of the hippocampus (dorsal, intermediate, ventral, dh, ih, vh, respectively) were investigated. |
2024-03-21 |
2024-03-24 |
rat |
Yinpei Huang, Zhili Liu, Xin Wang, Yaoxu Li, Lian Liu, Bing L. TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI. Neurochemical research. 2023-05-04. PMID:37140776. |
hippocampal neurons are considered to be critical cells affected by ih. |
2023-05-04 |
2023-08-14 |
human |
Yinpei Huang, Zhili Liu, Xin Wang, Yaoxu Li, Lian Liu, Bing L. TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI. Neurochemical research. 2023-05-04. PMID:37140776. |
second-generation sequencing (rna-seq) and subsequent experiments supported that ih decreased tgf-β3 expression and stimulated reactive oxygen species (ros)-induced oxidative stress and apoptosis in rat hippocampus. |
2023-05-04 |
2023-08-14 |
human |
Sohrab Anvari, Forough Foolad, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollah. A distinct impact of repeated morphine exposure on synaptic plasticity at Schaffer collateral-CA1, temporoammonic-CA1, and perforant pathway-dentate gyrus synapses along the longitudinal axis of the hippocampus. Hippocampus. 2022-12-14. PMID:36514833. |
for this, recording and measuring of field excitatory postsynaptic potentials (fepsps) were utilized to test the effects of repeated morphine exposure on paired-pulse evoked responses and long-term potentiation (ltp) at schaffer collateral-ca1 (sch-ca1), temporoammonic-ca1 (ta-ca1) and perforant pathway-dentate gyrus (pp-dg) synapses in transverse slices from the dorsal (dh), intermediate (ih), and ventral (vh) hippocampus in adult male rats. |
2022-12-14 |
2023-08-14 |
rat |
Alejandra Arias-Cavieres, Alfredo Garci. Postnatal age influences how Intermittent Hypoxia impacts hippocampal synaptic plasticity and NMDA receptor subunit expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35551929. |
based on these findings, we sought do determine how ih exposure during early postnatal life impacts hippocampal neurophysiology. |
2022-05-13 |
2023-08-13 |
mouse |
Alejandra Arias-Cavieres, Alfredo Garci. Postnatal age influences how Intermittent Hypoxia impacts hippocampal synaptic plasticity and NMDA receptor subunit expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35551929. |
electrophysiological studies and protein analyses were performed using hippocampal brain slices taken from mice (p14-p15) exposed to ten days of neonatal ih (nih, starting at p4-p5). |
2022-05-13 |
2023-08-13 |
mouse |
Alejandra Arias-Cavieres, Alfredo Garci. Postnatal age influences how Intermittent Hypoxia impacts hippocampal synaptic plasticity and NMDA receptor subunit expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35551929. |
these findings indicate that postnatal age is a significant factor influencing the mechanistic consequences of ih on hippocampal neurophysiology. |
2022-05-13 |
2023-08-13 |
mouse |
Ashleigh K Polo, Brigitte Browe, Lin Piao, Willard W Sharp, Alfredo J Garci. Intermittent Hypoxia (IH) Impairs Hippocampal Oxygen Consumption and Neurophysiological Responses to Metabolic Challenge. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556367. |
intermittent hypoxia (ih) impairs hippocampal oxygen consumption and neurophysiological responses to metabolic challenge. |
2022-05-13 |
2023-08-13 |
Not clear |
Ashleigh K Polo, Brigitte Browe, Lin Piao, Willard W Sharp, Alfredo J Garci. Intermittent Hypoxia (IH) Impairs Hippocampal Oxygen Consumption and Neurophysiological Responses to Metabolic Challenge. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556367. |
previous work has shown that ih impairs many neurophysiological functions such as hippocampal adult neurogenesis and nmdar-dependent synaptic plasticity. |
2022-05-13 |
2023-08-13 |
Not clear |
Ashleigh K Polo, Brigitte Browe, Lin Piao, Willard W Sharp, Alfredo J Garci. Intermittent Hypoxia (IH) Impairs Hippocampal Oxygen Consumption and Neurophysiological Responses to Metabolic Challenge. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556367. |
while ih produces hippocampal oxidative stress, ih-dependent changes in hippocampal metabolism may also contribute to impaired neurophysiology. |
2022-05-13 |
2023-08-13 |
Not clear |
Ashleigh K Polo, Brigitte Browe, Lin Piao, Willard W Sharp, Alfredo J Garci. Intermittent Hypoxia (IH) Impairs Hippocampal Oxygen Consumption and Neurophysiological Responses to Metabolic Challenge. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556367. |
the objective of this study is to understand how ih impacts hippocampal physiology in response to metabolic challenge. |
2022-05-13 |
2023-08-13 |
Not clear |
Ashleigh K Polo, Brigitte Browe, Lin Piao, Willard W Sharp, Alfredo J Garci. Intermittent Hypoxia (IH) Impairs Hippocampal Oxygen Consumption and Neurophysiological Responses to Metabolic Challenge. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556367. |
we hypothesize that ten days of ih perturbs hippocampal synaptic transmission when metabolically challenged. |
2022-05-13 |
2023-08-13 |
Not clear |