| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Tan, Xiujuan Deng, Xiaoning Tan, Guangbo Ta. Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets. Medicine. vol 103. issue 43. 2024-10-29. PMID:39470521. |
lpl, that lowered serum tg levels, was positively associated with the risk of sleep apnea syndrome (or = 1.193; 95% ci = 1.101-1.294; p = 1.77e-05). |
2024-10-29 |
2024-10-31 |
Not clear |
| Hua Yu, Zhao-Xia Zou, Wei Wei, Ying L. Conjugated Linoleic Acid Reduces Lipid Accumulation via Down-regulation Expression of Lipogenic Genes and Up-regulation of Apoptotic Genes in Grass Carp (Ctenopharyngodon idella) Adipocyte In Vitro. Marine biotechnology (New York, N.Y.). 2024-01-15. PMID:38224425. |
the results showed that cla reduced the size of adipocyte and lipid droplet and decreased the content of intracellular lipid and tg, which was accompanied by a significant down-regulation of mrna abundance in transcriptional regulators including peroxisome proliferator-activated receptor (ppar) γ, ccaat/enhancer-binding protein (c/ebp) α, sterol regulatory element-binding protein (srebp) 1c, lipase genes including fatty acid synthase (fas), acetyl-coa carboxylase (acc), lipoprotein lipase (lpl). |
2024-01-15 |
2024-01-17 |
Not clear |
| Chris J Packard, Angela Pirillo, Sotirios Tsimikas, Brian A Ference, Alberico L Catapan. Exploring apolipoprotein C-III: Pathophysiological and pharmacological relevance. Cardiovascular research. 2023-12-01. PMID:38039351. |
apolipoprotein c-iii (apoc-iii) is a key regulator of tg metabolism and hence circulating levels through several mechanisms including the inhibition of lipoprotein lipase (lpl) activity and alterations in the affinity of apoc-iii-containing lipoproteins for both the hepatic receptors involved in their removal and extracellular matrix in the arterial wall. |
2023-12-01 |
2023-12-10 |
Not clear |
| Ziyi Pan, Guoqing Du, Guoyu Li, Dongsheng Wu, Xingyong Chen, Zhaoyu Gen. Apolipoprotein H: a novel regulator of fat accumulation in duck myoblasts. Journal of animal science and technology. vol 64. issue 6. 2023-02-22. PMID:36812035. |
cs2s overexpressing apoh showed enhanced triglyceride (tg) and cholesterol (chol) contents and elevated the mrna and protein expression of akt serine/threonine kinase 1 (akt1), elovl fatty acid elongase 6 (elovl6), and acetyl-coa carboxylase 1 (acc1) while reducing the expression of protein kinase amp-activated catalytic subunit alpha 1 (ampk), peroxisome proliferator activated receptor gamma (pparg), acyl-coa synthetase long chain family member 1 (acsl1), and lipoprotein lipase (lpl). |
2023-02-22 |
2023-08-14 |
Not clear |
| Sang Ryong Kim, Hyo Jin Park, Un Ju Jun. Anti-adiposity and lipid-lowering effects of schisandrol A in diet-induced obese mice. Journal of food biochemistry. 2022-11-04. PMID:36332134. |
furthermore, sola upregulated adipose lpl mrna expression and decreased plasma free fatty acid (ffa), triglyceride (tg), apolipoprotein (apo) b, aspartate aminotransferase levels and tg/hdl-cholesterol and apob/apoa1 ratios as well as hepatic lipid droplets. |
2022-11-04 |
2023-08-14 |
mouse |
| Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C Cohen, Helen H Hobb. ANGPTL8 has both endocrine and autocrine effects on substrate utilization. JCI insight. vol 5. issue 17. 2021-06-16. PMID:32730227. |
the angiopoietin-like protein angptl8 (a8) is one of 3 angptls (a8, a3, a4) that coordinate changes in triglyceride (tg) delivery to tissues by inhibiting lipoprotein lipase (lpl), an enzyme that hydrolyzes tg. |
2021-06-16 |
2023-08-13 |
mouse |
| Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C Cohen, Helen H Hobb. ANGPTL8 has both endocrine and autocrine effects on substrate utilization. JCI insight. vol 5. issue 17. 2021-06-16. PMID:32730227. |
mice lacking hepatic a8 have no circulating a8, high intravascular lpl activity, low plasma tg levels, and evidence of decreased delivery of dietary lipids to adipose tissue. |
2021-06-16 |
2023-08-13 |
mouse |
| Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C Cohen, Helen H Hobb. ANGPTL8 has both endocrine and autocrine effects on substrate utilization. JCI insight. vol 5. issue 17. 2021-06-16. PMID:32730227. |
in contrast, mice lacking a8 in adipose tissue have higher postprandial tg levels and similar intravascular lpl activity and plasma a8 levels and higher levels of plasma tg. |
2021-06-16 |
2023-08-13 |
mouse |
| Jie Gao, Gangqiang Ding, Qi Li, Lingxiao Gong, Jian Huang, Yaxin San. Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats. Food research international (Ottawa, Ont.). vol 121. 2020-09-21. PMID:31108749. |
tkm feeding reduced abdominal fat mass from 33.9 g to 24.0 g and serum triglyceride (tg) from 0.75 mmol/l to 0.47 mmol/l, and caused lipoprotein lipase (lpl) to decrease from 395.8 ± 36.0 ng/l to 362.3 ± 64.4 ng/l in fat and increase from 287.3 ± 40.8 ng/l to 329.8 ± 48.5 ng/l and 312.5 ± 22.0 to 375.1 ± 30.8 ng/l in liver and serum, respectively. |
2020-09-21 |
2023-08-13 |
human |
| Hidekatsu Yana. [Diagnosis of Secondary Hyperlipidemia due to Diabetes]. Rinsho byori. The Japanese journal of clinical pathology. vol 64. issue 5. 2019-04-22. PMID:30695359. |
relative insulin deficiency or insulin resistance induces the activation of hormone-sensitive lipase, reduced degradation of apob100, increased microsomal triglyceride (tg) transfer protein, and inactivation of lpl and activation of hepatic tg lipase, which induce diabetic dyslipidemia. |
2019-04-22 |
2023-08-13 |
Not clear |
| Vijay Mani, Sivaranjani Arivalagan, Aktarul Islam Siddique, Nalini Namasivaya. Antihyperlipidemic and antiapoptotic potential of zingerone on alcohol induced hepatotoxicity in experimental rats. Chemico-biological interactions. vol 272. 2017-06-20. PMID:28442378. |
ethanol alone administered rats showed increased levels/activities of plasma total cholesterol (tc), triglycerides (tg), free fatty acids (ffa), phospholipids (pl), low density lipoproteins (ldl), very low density lipoproteins (vldl), tissue tc, tg, ffa, pl, hmg-coa reductase, phase i xenobiotic enzymes, collagen and fat accumulation, dna damage and increased bax, caspase-3 and caspase-9 expressions and decrease in the levels/activities of plasma high density lipoproteins (hdl), lipoprotein lipase (lpl), lecithin cholesterol acyl transferase (lcat), phase ii xenobiotic enzymes and a decreased bcl-2 expression. |
2017-06-20 |
2023-08-13 |
rat |
| Ren Zhan. The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking. Open biology. vol 6. issue 4. 2016-12-26. PMID:27053679. |
our recent data that angptl8 negatively regulates lpl activity specifically in cardiac and skeletal muscles suggest an angptl3-4-8 model: feeding induces angptl8, activating the angptl8-angptl3 pathway, which inhibits lpl in cardiac and skeletal muscles, thereby making circulating tg available for uptake by wat, in which lpl activity is elevated owing to diminished angptl4; the reverse is true during fasting, which suppresses angptl8 but induces angptl4, thereby directing tg to muscles. |
2016-12-26 |
2023-08-13 |
Not clear |
| Jintian He, Li Dong, Wen Xu, Kaiwen Bai, Changhui Lu, Yanan Wu, Qiang Huang, Lili Zhang, Tian Wan. Dietary Tributyrin Supplementation Attenuates Insulin Resistance and Abnormal Lipid Metabolism in Suckling Piglets with Intrauterine Growth Retardation. PloS one. vol 10. issue 8. 2016-05-24. PMID:26317832. |
piglets with iugr showed higher (p < 0.05) concentrations of insulin in the serum, higher (p < 0.05) homa-ir and total cholesterol, triglycerides (tg), non-esterified fatty acid (nefa) in the liver, and lower (p < 0.05) enzyme activities (hepatic lipase [hl], lipoprotein lipase [lpl], total lipase [tl]) and concentration of glycogen in the liver than the nbw group. |
2016-05-24 |
2023-08-13 |
Not clear |
| Jintian He, Li Dong, Wen Xu, Kaiwen Bai, Changhui Lu, Yanan Wu, Qiang Huang, Lili Zhang, Tian Wan. Dietary Tributyrin Supplementation Attenuates Insulin Resistance and Abnormal Lipid Metabolism in Suckling Piglets with Intrauterine Growth Retardation. PloS one. vol 10. issue 8. 2016-05-24. PMID:26317832. |
tb supplementation decreased (p < 0.05) the concentrations of insulin, homa-ir, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in the serum, and the concentrations of tg and nefa in the liver, and increased (p < 0.05) enzyme activities (hl, lpl, and tl) and concentration of glycogen in the liver of the it group. |
2016-05-24 |
2023-08-13 |
Not clear |
| D D Li, D Y Su, L Xue, W Gao, W Y Pan. Relationship between a lipoprotein lipase gene polymorphism in placental tissue and insulin resistance in patients with gestational diabetes mellitus. Genetics and molecular research : GMR. vol 14. issue 3. 2016-05-16. PMID:26214456. |
the relationships between fasting plasma glucose (fpg), postprandial plasma glucose (ppg), fasting insulin (fins), cholesterol (tc), triglyceride (tg), high density lipoprotein (hdl), low density lipoprotein (ldl), body mass index (bmi), and ir indices and the lpl polymorphism in the two study groups and their offspring were determined. |
2016-05-16 |
2023-08-13 |
Not clear |
| Subramanian Kumar, Pichavaram Prahalathan, Murugesan Saravanakumar, Boobalan Raj. Vanillic acid prevents the deregulation of lipid metabolism, endothelin 1 and up regulation of endothelial nitric oxide synthase in nitric oxide deficient hypertensive rats. European journal of pharmacology. vol 743. 2015-08-11. PMID:25239071. |
a significant increase in the levels of plasma cholesterol, low density lipoprotein-cholesterol (ldl-c), very low density lipoprotein-cholesterol (vldl-c), triglycerides (tg), free fatty acids (ffa), phospholipids (pl), 3-hydroxy 3-methylglutaryl coenzyme a (hmg-coa) reductase in the plasma, liver and kidney and decreased level of high density lipoprotein-cholesterol (hdl-c) are observed, whereas there is a decrease in the activities of plasma lipoprotein lipase (lpl) and lecithin cholesterol acyl transferase (lcat) in nitric oxide deficient rats. |
2015-08-11 |
2023-08-13 |
rat |
| Melissa A Babilonia-Rosa, Saskia B Nehe. Purification, cellular levels, and functional domains of lipase maturation factor 1. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24909692. |
lipoprotein lipase (lpl), a dimeric enzyme, is the main lipase responsible for tg clearance from the blood after food intake. |
2014-09-21 |
2023-08-13 |
Not clear |
| Margaret J R Heerwagen, Michael S Stewart, Becky A de la Houssaye, Rachel C Janssen, Jacob E Friedma. Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice. PloS one. vol 8. issue 6. 2014-02-07. PMID:23825686. |
e18.5 fetuses from wt-hfd mothers had larger placentas (p<0.02), as well as increased placenta and fetal liver tg deposition (p<0.01 and p<0.02, respectively) and increased placental lpl tg-hydrolase activity (p<0.02), which correlated with degree of maternal insulin resistance (r = 0.59, p<0.02). |
2014-02-07 |
2023-08-12 |
mouse |
| Ewa Szalowska, Kees Meijer, Niels Kloosterhuis, Farhad Razaee, Marion Priebe, Roel J Von. Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight. Peptides. vol 32. issue 5. 2011-09-23. PMID:21334410. |
afterwards, serum lpl activity and several biochemical parameters (tg, ffa, cholesterol, glucose, insulin, resistin, il-6, il-1β, tnfα, gip) were measured. |
2011-09-23 |
2023-08-12 |
mouse |
| Elissa K Kluger, Muriel Caslake, Randolph M Baral, Richard Malik, Merran Govendi. Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous. Journal of feline medicine and surgery. vol 12. issue 8. 2010-10-18. PMID:20594884. |
further investigations using larger numbers of cats should focus on reduced lpl activity and insulin resistance as potential causes of delayed tg clearance. |
2010-10-18 |
2023-08-12 |
Not clear |