| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Wang, Robert H Ecke. Lipoprotein lipase: from gene to obesity. American journal of physiology. Endocrinology and metabolism. vol 297. issue 2. 2009-08-18. PMID:19318514. |
mice with overexpression of lpl in skeletal muscle accumulate tg in muscle, develop insulin resistance, are protected from excessive weight gain, and increase their metabolic rate in the cold. |
2009-08-18 |
2023-08-12 |
mouse |
| Hong Wang, Robert H Ecke. Lipoprotein lipase: from gene to obesity. American journal of physiology. Endocrinology and metabolism. vol 297. issue 2. 2009-08-18. PMID:19318514. |
mice with lpl deletion in skeletal muscle have reduced tg accumulation and increased insulin action on glucose transport in muscle. |
2009-08-18 |
2023-08-12 |
mouse |
| Chunchun Han, Jiwen Wang, Liang Li, Li Wang, Zhongxian Zhan. The role of LXR alpha in goose primary hepatocyte lipogenesis. Molecular and cellular biochemistry. vol 322. issue 1-2. 2009-08-05. PMID:18975056. |
triglyceride (tg) accumulation, acetyl-coa carboxylase alpha (acc alpha) and fatty acid synthase (fas) activities, and gene expression levels of lxr alpha, sterol regulatory element-binding proteins-1 (srebp-1), fas, acc alpha and lipoprotein lipase (lpl) were measured in primary hepatocytes. |
2009-08-05 |
2023-08-12 |
Not clear |
| Anne Liese Magnusson-Olsson, Susanne Lager, Bo Jacobsson, Thomas Jansson, Theresa L Powel. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. American journal of physiology. Endocrinology and metabolism. vol 293. issue 1. 2007-09-13. PMID:17299085. |
to further investigate the role of maternal lipids in placental lpl regulation, we isolated placental cytotrophoblasts from term placentas and studied lpl activity and protein and mrna expression after incubation in intralipid (as a source of tg) and oleic, linoleic, and a combination of oleic, linoleic, and arachidonic acids as well as insulin. |
2007-09-13 |
2023-08-12 |
Not clear |
| Junji Kobayashi, Atsushi Nohara, Masa-aki Kawashiri, Akihiro Inazu, Junji Koizumi, Katsuyuki Nakajima, Hiroshi Mabuch. Serum lipoprotein lipase mass: clinical significance of its measurement. Clinica chimica acta; international journal of clinical chemistry. vol 378. issue 1-2. 2007-04-17. PMID:17223095. |
studies have shown that pre-heparin plasma or serum lpl mass has significant relationships with serum lipids and lipoproteins, visceral fat area, insulin resistance, and even the development of coronary atherosclerosis in cross-sectional studies, although this might be a metabolic surrogate marker with almost no catalytic activities, which does not appear to be involved in catalyzing hydrolysis of tg in tg-rich lipoproteins. |
2007-04-17 |
2023-08-12 |
human |
| Jörgen Nordenström, Anders Thörne, Wiveca Aberg, Claes Carneheim, Thomas Olivecron. The hypertriglyceridemic clamp technique. Studies using long-chain and structured triglyceride emulsions in healthy subjects. Metabolism: clinical and experimental. vol 55. issue 11. 2006-11-21. PMID:17046545. |
plasma lipoprotein lipase (lpl) concentration was higher during stg than during lct clamping (6.06 +/- 0.62 vs 3.15 +/- 0.40 mu/ml; p < .05), and there was a positive correlation between the mean lpl concentration and the amount of infused tg during the steady-state period (r = 0.58; p < .05). |
2006-11-21 |
2023-08-12 |
human |
| Javier S Perona, Rosalía Rodríguez-Rodríguez, Valentina Ruiz-Gutierre. Effects of oleic acid rich oils on aorta lipids and lipoprotein lipase activity of spontaneously hypertensive rats. Journal of agricultural and food chemistry. vol 53. issue 18. 2005-10-11. PMID:16131150. |
after 12 weeks of feeding, we analyzed the tg and ce composition and the lipolytic (lipoprotein lipase, lpl, and non-lpl) activity in aortas of these animals. |
2005-10-11 |
2023-08-12 |
rat |
| Anne E Sumner, Gloria L Vega, David J Genovese, Karl B Finley, Richard N Bergman, Raymond C Bosto. Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase. Metabolism: clinical and experimental. vol 54. issue 7. 2005-08-23. PMID:15988699. |
the lack of an effect of insulin resistance on ph-lpl could allow lpl to clear tg even in the presence of insulin resistance and explain the coexistence of insulin resistance and normotriglyceridemia in african americans. |
2005-08-23 |
2023-08-12 |
human |
| Enqi Liu, Shuji Kitajima, Yasuki Higaki, Masatoshi Morimoto, Huijun Sun, Teruo Watanabe, Nobuhiro Yamada, Jianglin Fa. High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits. Metabolism: clinical and experimental. vol 54. issue 1. 2005-02-22. PMID:15562391. |
to examine the hypothesis that increased lpl activity may alter insulin sensitivity, we investigated glucose metabolism and insulin sensitivity in transgenic (tg) rabbits expressing the human lpl gene under the control of a i(2) -actin promoter. |
2005-02-22 |
2023-08-12 |
human |
| May Faraj, Allan D Sniderman, Katherine Cianflon. ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes. Journal of lipid research. vol 45. issue 4. 2004-12-03. PMID:14703506. |
however, asp and insulin increased the v(max) of in situ lpl activity ([(3)h]tg synthetic lipoprotein hydrolysis and [(3)h]nefa incorporation into adipocytes) by 60% and 41%, respectively (p
| 2004-12-03 |
2023-08-12 |
Not clear |
| Sarah F Leibowitz, Jordan T Dourmashkin, Guo-Qing Chang, James O Hill, Ellis C Gayles, Susan K Fried, Jian Wan. Acute high-fat diet paradigms link galanin to triglycerides and their transport and metabolism in muscle. Brain research. vol 1008. issue 2. 2004-07-21. PMID:15145753. |
with measurements of various parameters, the high-fat diet for 21 days produced the expected changes of: (1) a significant increase in total caloric intake and dissected fat pad weights; (2) a rise in leptin and the metabolites, triglycerides (tg), non-esterified fatty acids and glucose; (3) an increase in muscle beta-hydroxyacyl-coa dehydrogenase (hadh) and adipose lipoprotein lipase (alpl) activity, along with a decrease in lpl activity in muscle (mlpl); and (4) elevated galanin (gal) expression and peptide levels in the anterior region of the paraventricular nucleus (pvn), with no change in the arcuate nucleus. |
2004-07-21 |
2023-08-12 |
rat |
| Tomonari Koike, Jingyan Liang, Xiaofei Wang, Tomonaga Ichikawa, Masashi Shiomi, George Liu, Huijun Sun, Shuji Kitajima, Masatoshi Morimoto, Teruo Watanabe, Nobuhiro Yamada, Jianglin Fa. Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. The Journal of biological chemistry. vol 279. issue 9. 2004-05-03. PMID:14660566. |
in addition, overexpression of lpl significantly suppressed high fat diet-induced obesity and insulin resistance in tg whhl rabbits. |
2004-05-03 |
2023-08-12 |
human |
| Diane Brisson, Karine Ledoux, Yohan Bossé, Julie St-Pierre, Pierre Julien, Patrice Perron, Thomas J Hudson, Marie-Claude Vohl, Daniel Gaude. Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients. Pharmacogenetics. vol 12. issue 4. 2002-11-07. PMID:12042669. |
fenofibrate is a peroxisome proliferator-activated receptor alpha (pparalpha) agonist which regulates the transcription of genes encoding proteins involved in triglyceride (tg)-rich lipoproteins and lipoprotein lipase (lpl) metabolism. |
2002-11-07 |
2023-08-12 |
human |
| P J Voshol, M C Jong, V E Dahlmans, D Kratky, S Levak-Frank, R Zechner, J A Romijn, L M Haveke. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes. vol 50. issue 11. 2001-12-07. PMID:11679438. |
in conclusion, overexpression of human lpl in muscle increases intramuscular tg accumulation, but does not affect whole-body or muscle-specific insulin-mediated uptake, findings that argue against a simple causal relation between intramuscular tg content and insulin resistance. |
2001-12-07 |
2023-08-12 |
mouse |
| L Mantha, Y Deshaie. Energy intake-independent modulation of triglyceride metabolism by glucocorticoids in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 6. 2000-07-06. PMID:10848507. |
the study further shows that, contrary to ad libitum feeding conditions, most determinants of tg metabolism, such as hepatic tg stores, triglyceridemia, postheparin plasma lpl, and adipose tissue lpl, are minimally affected by glucocorticoids when consumption of a high-energy diet is restricted, suggesting that glucocorticoids affect tg metabolism mostly indirectly through their central action on ingestive behavior. |
2000-07-06 |
2023-08-12 |
rat |
| Z W Man, T Hirashima, S Mori, K Kawan. Decrease in triglyceride accumulation in tissues by restricted diet and improvement of diabetes in Otsuka Long-Evans Tokushima fatty rats, a non-insulin-dependent diabetes model. Metabolism: clinical and experimental. vol 49. issue 1. 2000-02-02. PMID:10647073. |
as a result, several findings were more evident in the restricted group than in the satiated group: (1) reductions in body weight and intraabdominal fat weight, decreases in plasma tg, insulin, and glucose levels, a decrease in the tg secretion rate, and an increase in plasma lipoprotein lipase (lpl) activity, (2) decreases in the tg content in the liver, pancreas, and muscle, (3) improvement of the glucose infusion rate (gir), and (4) a marked reduction of tg accumulation in the liver and pancreatic islets on histopathologic examination. |
2000-02-02 |
2023-08-12 |
rat |
| L Mantha, E Palacios, Y Deshaie. Modulation of triglyceride metabolism by glucocorticoids in diet-induced obesity. The American journal of physiology. vol 277. issue 2. 1999-09-23. PMID:10444552. |
the hsf diet also increased the acute postprandial rise in plasma insulin (4-fold) and tg (3-fold), fasting liver tg content (3-fold), triglyceridemia (54%), and adipose tissue lipoprotein lipase (lpl) activity (2-fold). |
1999-09-23 |
2023-08-12 |
rat |
| A Breidenbach, H Fuhrmann, E Deegen, A Lindholm, H P Sallman. Studies on equine lipid metabolism. 2. Lipolytic activities of plasma and tissue lipases in large horses and ponies. Zentralblatt fur Veterinarmedizin. Reihe A. vol 46. issue 1. 1999-04-16. PMID:10085766. |
abbreviations used: ada, adenosine deaminase; bw, body weight; ffa, free fatty acid; hsl, hormone-sensitive lipase; htgl, hepatic triglyceride lipase; lpl, lipoprotein lipase; ne, norepinephrine; sds, sodium dodecyl sulfate; tg, triglyceride; vldl, very low density lipoprotein. |
1999-04-16 |
2023-08-12 |
Not clear |
| P Maheux, S Azhar, P A Kern, Y D Chen, G M Reuve. Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia. vol 40. issue 7. 1997-10-15. PMID:9243108. |
the relationship between insulin-mediated glucose disposal and fasting insulin and triglyceride (tg) concentrations, plasma post-heparin lipoprotein lipase (ph-lpl) activity and mass, and adipose tissue lpl activity, mass, and mrna content was defined in 19 non-diabetic men. |
1997-10-15 |
2023-08-12 |
Not clear |
| P Maheux, S Azhar, P A Kern, Y D Chen, G M Reuve. Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia. vol 40. issue 7. 1997-10-15. PMID:9243108. |
insulin-mediated glucose uptake [as assessed by determining the steady-state plasma glucose (sspg) concentration during a continuous infusion of somatostatin, insulin, and glucose] was significantly correlated with fasting tg concentration (r = 0.54, p < 0.02), plasma ph-lpl activity (r = -0.52, p < 0.03) and mass (r = -0.49, p < 0.03), and adipose tissue lpl mrna content (r = -0.68, p < 0.001). |
1997-10-15 |
2023-08-12 |
Not clear |