| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mara H Cowen, Dustin Haskell, Kristi Zoga, Kirthi C Reddy, Sreekanth H Chalasani, Michael P Har. Conserved autism-associated genes tune social feeding behavior in C. elegans. Nature communications. vol 15. issue 1. 2024-10-29. PMID:39468047. |
nrx-1 functions in chemosensory neurons (adl and ash) independently of its postsynaptic partner nlg-1 to regulate social feeding. |
2024-10-29 |
2024-10-31 |
caenorhabditis_elegans |
| Mara H Cowen, Dustin Haskell, Kristi Zoga, Kirthi C Reddy, Sreekanth H Chalasani, Michael P Har. Conserved autism-associated genes tune social feeding behavior in C. elegans. Nature communications. vol 15. issue 1. 2024-10-29. PMID:39468047. |
glutamate from these neurons is also crucial for aggregate feeding, acting independently of nrx-1 and nlg-1. |
2024-10-29 |
2024-10-31 |
caenorhabditis_elegans |
| Mara H Cowen, Dustin Haskell, Kristi Zoga, Kirthi C Reddy, Sreekanth H Chalasani, Michael P Har. Conserved autism-associated genes tune social feeding behavior in C. elegans. Nature communications. vol 15. issue 1. 2024-10-29. PMID:39468047. |
we discover that conserved autism-associated genes (nrxn1(nrx-1), nlgn3(nlg-1), gria1,2,3(glr-1), gria2(glr-2), and glra2,gabra3(avr-15)) regulate aggregate feeding in c. elegans, a simple social behavior. |
2024-10-29 |
2024-10-31 |
caenorhabditis_elegans |
| Xia-Jing Tong, Eduardo Javier López-Soto, Lei Li, Haowen Liu, Daniel Nedelcu, Diane Lipscombe, Zhitao Hu, Joshua M Kapla. Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels. Neuron. vol 95. issue 2. 2017-09-14. PMID:28669545. |
in c. elegans, post-synaptic neurexin (nrx-1) and pre-synaptic neuroligin (nlg-1) mediate a retrograde synaptic signal that inhibits acetylcholine (ach) release at neuromuscular junctions. |
2017-09-14 |
2023-08-13 |
Not clear |
| Géraldine S Maro, Shangbang Gao, Agnieszka M Olechwier, Wesley L Hung, Michael Liu, Engin Özkan, Mei Zhen, Kang She. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron. vol 86. issue 6. 2015-09-01. PMID:26028574. |
in the absence of both madd-4 and nrx-1, nlg-1 and gaba(a) receptors fail to cluster, and gabaergic synaptic transmission is severely compromised. |
2015-09-01 |
2023-08-13 |
caenorhabditis_elegans |
| Zhitao Hu, Sabrina Hom, Tambudzai Kudze, Xia-Jing Tong, Seungwon Choi, Gayane Aramuni, Weiqi Zhang, Joshua M Kapla. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science (New York, N.Y.). vol 337. issue 6097. 2012-09-13. PMID:22859820. |
here, we found that caenorhabditis elegans neurexin (nrx-1) and neuroligin (nlg-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. |
2012-09-13 |
2023-08-12 |
caenorhabditis_elegans |
| Fernando Calahorro, Encarna Alejandre, Manuel Ruiz-Rubi. Osmotic avoidance in Caenorhabditis elegans: synaptic function of two genes, orthologues of human NRXN1 and NLGN1, as candidates for autism. Journal of visualized experiments : JoVE. issue 34. 2010-01-15. PMID:20010541. |
to evaluate the implications of neurexin and neuroligin in high osmotic strength avoidance, we show the different response of c. elegans mutants defective in nrx-1 and nlg-1 genes, using a method based on a 4m fructose ring. |
2010-01-15 |
2023-08-12 |
mouse |