| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mara H Cowen, Dustin Haskell, Kristi Zoga, Kirthi C Reddy, Sreekanth H Chalasani, Michael P Har. Conserved autism-associated genes tune social feeding behavior in C. elegans. Nature communications. vol 15. issue 1. 2024-10-29. PMID:39468047. |
we discover that conserved autism-associated genes (nrxn1(nrx-1), nlgn3(nlg-1), gria1,2,3(glr-1), gria2(glr-2), and glra2,gabra3(avr-15)) regulate aggregate feeding in c. elegans, a simple social behavior. |
2024-10-29 |
2024-10-31 |
caenorhabditis_elegans |
| Jonathan K Y Lai, Laurie C Doering, Jane A Foste. Developmental expression of the neuroligins and neurexins in fragile X mice. The Journal of comparative neurology. vol 524. issue 4. 2016-10-07. PMID:26235839. |
sex differences in hippocampal expression of nlgn2, nrxn1, nrxn2, and nrxn3 mrnas and in s1 cortex expression of nrxn3 mrnas were observed wt mice, whereas sex differences in nlgn3, nrxn1, nrxn2, and nrxn3 mrna expression in the hippocampus and in nlgn1, nrxn2 and nrxn3 mrna expression in s1 cortex were detected in fmr1-ko mice. |
2016-10-07 |
2023-08-13 |
mouse |
| Dhiraj Kumar, M K Thaku. Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice. Age (Dordrecht, Netherlands). vol 37. issue 2. 2016-02-11. PMID:25693924. |
when the expression of nrxn1 and nlgn3 was correlated with presynaptic density marker synaptophysin, it was found that synaptophysin protein expression in cerebral cortex was high at 10 weeks and decreased gradually up to 80 weeks, whereas in hippocampus, it decreased until 50 weeks and then increased remarkably at 80 weeks. |
2016-02-11 |
2023-08-13 |
mouse |
| Dhiraj Kumar, M K Thaku. Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice. Age (Dordrecht, Netherlands). vol 37. issue 2. 2016-02-11. PMID:25693924. |
thus, these findings showed that nrxn1 and nlgn3 are differentially expressed in cerebral cortex and hippocampus which might be responsible for alterations in synaptic plasticity during aging. |
2016-02-11 |
2023-08-13 |
mouse |
| Dhiraj Kumar, M K Thaku. Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice. Age (Dordrecht, Netherlands). vol 37. issue 2. 2016-02-11. PMID:25693924. |
neurexin1 (nrxn1) and neuroligin3 (nlgn3) are cell adhesion proteins, which play an important role in synaptic plasticity that declines with advancing age. |
2016-02-11 |
2023-08-13 |
mouse |
| Dhiraj Kumar, M K Thaku. Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice. Age (Dordrecht, Netherlands). vol 37. issue 2. 2016-02-11. PMID:25693924. |
however, in 80-week-old mice, nrxn1 and nlgn3 were further downregulated in cerebral cortex while nrxn1 was downregulated and nlgn3 was upregulated in hippocampus. |
2016-02-11 |
2023-08-13 |
mouse |
| Dhiraj Kumar, M K Thaku. Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice. Age (Dordrecht, Netherlands). vol 37. issue 2. 2016-02-11. PMID:25693924. |
furthermore, pearson's correlation analysis showed that synaptophysin had a strong relation with nrxn1 and nlgn3 in cerebral cortex and with nlgn3 in hippocampus. |
2016-02-11 |
2023-08-13 |
mouse |
| Dhiraj Kumar, Mahendra Kumar Thaku. Perinatal exposure to bisphenol-A impairs spatial memory through upregulation of neurexin1 and neuroligin3 expression in male mouse brain. PloS one. vol 9. issue 10. 2015-12-22. PMID:25330104. |
rt-pcr and immunoblotting results showed significant upregulation of nrxn1 and nlgn3 expression in both cerebral cortex and hippocampus of 3 and 8 weeks male mice. |
2015-12-22 |
2023-08-13 |
mouse |
| Dhiraj Kumar, Mahendra Kumar Thaku. Perinatal exposure to bisphenol-A impairs spatial memory through upregulation of neurexin1 and neuroligin3 expression in male mouse brain. PloS one. vol 9. issue 10. 2015-12-22. PMID:25330104. |
as synaptic plasticity is the cellular basis of memory, the present study investigated the effect of perinatal exposure to bpa on the expression of synaptic proteins neurexin1 (nrxn1) and neuroligin3 (nlgn3), dendritic spine density and spatial memory in postnatal male mice. |
2015-12-22 |
2023-08-13 |
mouse |
| Dhiraj Kumar, Mahendra Kumar Thaku. Perinatal exposure to bisphenol-A impairs spatial memory through upregulation of neurexin1 and neuroligin3 expression in male mouse brain. PloS one. vol 9. issue 10. 2015-12-22. PMID:25330104. |
thus our data suggest that perinatal exposure to bpa impairs spatial memory through upregulation of expression of synaptic proteins nrxn1 and nlgn3 and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice. |
2015-12-22 |
2023-08-13 |
mouse |
| Luigi Boccuto, Maria Lauri, Sara M Sarasua, Cindy D Skinner, Daniela Buccella, Alka Dwivedi, Daniela Orteschi, Julianne S Collins, Marcella Zollino, Paola Visconti, Barb Dupont, Danilo Tiziano, Richard J Schroer, Giovanni Neri, Roger E Stevenson, Fiorella Gurrieri, Charles E Schwart. Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders. European journal of human genetics : EJHG. vol 21. issue 3. 2013-09-20. PMID:22892527. |
it has been shown that many genes associated with asds are involved in the neuroligin-neurexin interaction at the glutamate synapse: nlgn3, nlgn4, nrxn1, cntnap2, and shank3. |
2013-09-20 |
2023-08-12 |
Not clear |
| Alison Millson, Danielle Lagrave, Mary J H Willis, Leslie R Rowe, Elaine Lyon, Sarah T Sout. Chromosomal loss of 3q26.3-3q26.32, involving a partial neuroligin 1 deletion, identified by genomic microarray in a child with microcephaly, seizure disorder, and severe intellectual disability. American journal of medical genetics. Part A. vol 158A. issue 1. 2013-06-20. PMID:22106001. |
mutations in neurexin 1 (nrxn1) as well as two other members of the neuroligin family, nlgn3 and nlgn4, have been associated with autism and mutations in nlgn4 have also been associated with intellectual disability, seizures, and eeg abnormalities. |
2013-06-20 |
2023-08-12 |
Not clear |