| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Tan, Xiujuan Deng, Xiaoning Tan, Guangbo Ta. Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets. Medicine. vol 103. issue 43. 2024-10-29. PMID:39470521. |
the dmr results suggested that the use of hmgcr lipid-lowering drugs (such as statins) and pcsk9 inhibitors has a protective effect against sleep apnea syndrome. |
2024-10-29 |
2024-10-31 |
Not clear |
| Wei Tan, Xiujuan Deng, Xiaoning Tan, Guangbo Ta. Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets. Medicine. vol 103. issue 43. 2024-10-29. PMID:39470521. |
according to our dmr analysis, hmgcr and pcsk9, which act by lowering serum ldl-c levels, were inversely associated with the risk of sleep apnea syndrome (or = 0.627; 95% ci = 0.511-0.767; p = 6.30e-06) (or = 0.775; 95% ci = 0.677-0.888; p = .0002). |
2024-10-29 |
2024-10-31 |
Not clear |
| Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study. BMJ (Clinical research ed.). vol 357. 2019-11-20. PMID:28663202. |
low ldl cholesterol, pcsk9 and hmgcr genetic variation, and risk of alzheimer's disease and parkinson's disease: mendelian randomisation study. |
2019-11-20 |
2023-08-13 |
Not clear |
| Viktor Hamrefors, Marju Orho-Melander, Ronald M Krauss, Bo Hedblad, Peter Almgren, Göran Berglund, Olle Melande. A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women. Journal of lipid research. vol 51. issue 3. 2010-05-07. PMID:19773416. |
in patients with asymptomatic plaque in the right carotid artery, thus candidates for statin therapy, we related score ldl [apob(rs693), apoe(rs4420638), hmgcr(rs12654264), ldlr(rs1529729), and pcsk9(rs11591147)] and score hdl [abca1(rs3890182), cetp(rs1800775), lipc(rs1800588), and lpl(rs328)] as well as the combined score ldl+hdl to fluvastatin-induced ldl reduction (+/- metoprolol) (n = 395) and hdl increase (n = 187) following 1 year of fluvastatin treatment. |
2010-05-07 |
2023-08-12 |
Not clear |