| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenkai Yu, Xinyu Li, Chan Zhang, Pengpeng Niu, Jinghao Wu, Wenjun He, Kai Gao, Yuming Xu, Yusheng L. KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression. Biochemical pharmacology. 2024-11-27. PMID:39603516. |
in addition, sd led to a significant increase in the expression of kdm6b in the cerebral cortex of app/ps1 mice. |
2024-11-27 |
2024-11-30 |
mouse |
| Nils Hecht, Daisy Haddad, Konrad Neumann, Leonie Schumm, Nora F Dengler, Lars Wessels, Patrick Dömer, Simeon Helgers, Franziska Meinert, Sebastian Major, Coline L Lemale, Jens P Dreier, Peter Vajkoczy, Johannes Woitzi. Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke. Brain : a journal of neurology. 2024-11-14. PMID:39538992. |
spreading depolarization (sd) describes a propagating neuronal mass depolarization within the cerebral cortex that represents a mediator of infarct development and strongly stimulates the metabolic rate of o2 consumption. |
2024-11-14 |
2024-11-17 |
Not clear |
| Marie Bockenstedt, Amit Kumar, Victoria Laast, Alok Sharm. Historical Control Background Incidence of Spontaneous Nonneoplastic Lesions of Sprague Dawley Rats in 104-Week Carcinogenicity Studies. Toxicologic pathology. 2024-10-29. PMID:39469803. |
the most common nonnenoplastic findings in female sd rats were cystic degeneration of the adrenal cortex (64.7%) and ventral compression of the brain due to pituitary neoplasms (62.7%). |
2024-10-29 |
2024-10-31 |
rat |
| Cai-Rong Zhao, Xiang-Long Meng, Juan Wang, Hong-Yu Zhao, Xiang Han, Zi-Ang Li, Shuo-Sheng Zhan. [Immune mechanism of Daphnes Cortex and its processed products on CIA rats based on B7/CD28/CTLA-4 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 15. 2024-09-22. PMID:39307741. |
this study investigates the effects of daphnes cortex and its processed products on the differentiation of th17/treg cells in sd rats with type Ⅱ collagen-induced arthritis(cia).sixty-four sd rats were randomly divided into the normal group(normal),model group(model),fried daphne giraldii nitsche low-dose and high-dose groups(fdgn-l group, fdgn-h group),raw d. giraldii nitsche low-dose and high-dose groups(rdgn-l group, rdgn-h group),daphnetin group(daph group),and tripterygium glycosides group(gtw group).except for the normal group, the cia model was immunized on the seventh day after the first immunization, and was gavaged for 28 days after the second immunization.after sampling, the inflammation of articular synovial membrane in cia rats was observed by hematoxylin-eosin(he)staining; the levels of transforming growth factor-β(tgf-β),interferon-γ(ifn-γ),interleukin(il)-2,il-4,and il-10 in serum were detected by enzyme-linked immunosorbent assay(elisa); real-time reverse transcription-pcr(qrt-pcr)and western blot were used to detect the mrna and protein expressions of cluster of differentiation(cd) 80(b7-1),cd 86(b7-2),cd28,and cytotoxic t lymphocyte-associated antigen 4(ctla-4)in the synovial membrane of rats; flow cytometry was used to detect the proportion of th17 and treg cells in the synovial membrane of rats.the results showed that compared with the normal group, the joint synovial inflammation of rats in the model group was significantly aggravated, the arthritis index was significantly increased, and the immune organ index was increased(p<0.01).compared with the model group, each drug administration group could improve the joint inflammation of rats to varying degrees, reduce the arthritis index, inhibit synovial hyperplasia, and reduce the immune organ index; compared with the model group, the serum levels of il-2 and ifn-γ in each drug administration group were significantly decreased(p<0.01),tgf-β,il-4,and il-10 were significantly increased(p<0.01),the mrna and protein expressions of b7-1 and ctla-4 in the synovial membrane were significantly increased(p<0.01),and the proportion of th17 cells and treg cells in the joint tissue was significantly decreased(p<0.01).in conclusion, daphnes cortex inhibits the expression of th17 cells in cia rats and promotes the expression of treg cells by regulating the b7/cd28/ctla-4 pathway and the balance of th17/treg, thereby treating rheumatoid arthritis. |
2024-09-22 |
2024-09-26 |
rat |
| Ruicheng Zhang, Lei Zhang, Wenqi Du, Jiao Tang, Long Yang, Deqin Geng, Yanbo Chen. Caffeine alleviate lipopolysaccharide-induced neuroinflammation and depression through regulating p-AKT and NF-κB. Neuroscience letters. 2024-08-06. PMID:39106918. |
open-filed and closed-field tests were applied to detect the behaviors of sd rats, while western blot was performed to measure the phosphorylation level of protein kinase b (p-akt) and nuclear factor κb (nf-κb) in the cortex after caffeine was orally administered. |
2024-08-06 |
2024-08-09 |
rat |
| Ruicheng Zhang, Lei Zhang, Wenqi Du, Jiao Tang, Long Yang, Deqin Geng, Yanbo Chen. Caffeine alleviate lipopolysaccharide-induced neuroinflammation and depression through regulating p-AKT and NF-κB. Neuroscience letters. 2024-08-06. PMID:39106918. |
mechanistic investigations demonstrated that caffeine down-regulated the expression of p-akt and nf-κb in lps-induced sd rats cortex. |
2024-08-06 |
2024-08-09 |
rat |
| Jeremy Sword, Ioulia V Fomitcheva, Sergei A Kiro. Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2024-07-25. PMID:39053498. |
in the normoxic cortex, spreading depolarization (sd) is a phenomenon underlying migraine aura. |
2024-07-25 |
2024-07-28 |
Not clear |
| Luciane da Silva Gonçalves, Gabriela Rusch, Amália Gonçalves Alves, Letícia Devantier Krüger, Mariana Parron Paim, Carolina Cristóvão Martins, Ketlyn Pereira da Motta, José Sebastião Dos Santos Neto, Cristiane Luchese, Ethel Antunes Wilhelm, César Augusto Brüning, Cristiani Folharini Bortolatt. Acute 2-phenyl-3-(phenylselanyl)benzofuran treatment reverses the neurobehavioral alterations induced by sleep deprivation in mice. Biochemical pharmacology. 2024-06-07. PMID:38848781. |
sebzf1 also reverted the increase in lipoperoxidation levels and glutathione peroxidase activity in the pre-frontal cortex in mice exposed to sd. |
2024-06-07 |
2024-06-10 |
mouse |
| Yanzhe Ning, Sitong Feng, Sisi Zheng, Ziyao Wu, Xinzi Liu, Linrui Dong, Hongxiao Ji. How BDNF affects working memory in acute sleep deprivation: The mediating role of spontaneous brain activity. Sleep medicine. vol 118. 2024-04-02. PMID:38564888. |
our results suggest that the association between bdnf and working memory may be mediated through regional spontaneous brain activity involving in the cerebral cortex, which may provide new sight into the interaction between neurotrophic factors and cognition, and potential targets for noninvasive brain stimulation on wm decline after acute sd. |
2024-04-02 |
2024-04-05 |
human |
| Jeremy Sword, Ioulia V Fomitcheva, Sergei A Kiro. Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328069. |
in the normoxic cortex, spreading depolarization (sd) is a phenomenon underlying migraine aura. |
2024-02-08 |
2024-02-10 |
Not clear |
| Xinyi Liu, Wenjia Zhang, Jie Dong, Zhiqiang Yan, Qiufeng Dong, Jing Feng, Yaling Lai, Hao Ya. Effects of sleep deprivation on language-related brain functional connectivity: differences by gender and age. Cognitive, affective & behavioral neuroscience. 2024-01-25. PMID:38273105. |
specifically, there were gender differences in the temporal association cortex and age differences in the parietal association cortex, during full sleep versus partial sd. |
2024-01-25 |
2024-01-28 |
Not clear |
| Bingcong Li, Yin-Ru Hsieh, Wen-De Lai, Te-Hsuan Tung, Yu-Xuan Chen, Chia-Hui Yang, Yu-Chiao Fang, Shih-Yi Huan. Melatonin Ameliorates Neuropsychiatric Behaviors, Gut Microbiome, and Microbiota-Derived Metabolites in Rats with Chronic Sleep Deprivation. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069141. |
four-week sd reduced the cerebral cortex expression of mt1, but not in the colon. |
2023-12-09 |
2023-12-17 |
rat |
| Giulia Siena, Francesca di Nardo, Barbara Contiero, Tommaso Banzato, Chiara Milan. Preliminary Evaluation of Cortical and Medullary Echogenicity in Normal Canine Fetal Kidneys during the Last 10 Days of Pregnancy. Veterinary sciences. vol 10. issue 11. 2023-11-26. PMID:37999462. |
the mean gray level (mgl) and sd of a manually drawn region of interest (roi) in the renal cortex and medulla were measured using the fiji image j software (image j 1.51h, java 1.6 0_24 64 bit). |
2023-11-26 |
2023-11-28 |
Not clear |
| James Hubbard, David Berry, Aakash Chauhan, Chris Casstevens, Alexander Y Shin, Reid A Abram. A three-dimensional computed tomography study of the palmar ulnar corner fragment in distal radial fractures. The Journal of hand surgery, European volume. 2023-11-17. PMID:37974338. |
three types emerged: type 1 fragments involved 37% (sd 10) of the radiocarpal articular surface and were extended in the sagittal plane; type 2 fragments involved 28% (sd 10) of the articular surface and had a long palmar cortex, of which 57% had palmar carpal subluxation; and type 3 fragments involved 13% (sd 2) of the articular surface, had a short palmar cortex and all had palmar carpal subluxation. |
2023-11-17 |
2023-11-20 |
Not clear |
| Stuart M Cain, Sascha R A Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C Yung, Andrew Bauman, Yi Yang, Glen B Baker, Piotr Kozlowski, Brian A MacVicar, Terrance P Snutc. Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1. Molecular brain. vol 16. issue 1. 2023-11-04. PMID:37924146. |
spreading depolarization (sd) is a neurophysiological phenomenon that can occur during migraine with aura by propagating a wave of silenced neuronal function through cortex and sometimes subcortical brain structures. |
2023-11-04 |
2023-11-08 |
mouse |
| Yan Wu, Pengfei Li, Narayan Bhat, Hongkuan Fan, Meng Li. Effects of repeated sleep deprivation on brain pericytes in mice. Scientific reports. vol 13. issue 1. 2023-08-07. PMID:37550395. |
the present study examined how acute or repeated sd impairs brain pericytes by measuring the cerebrospinal fluid (csf) levels of soluble platelet-derived growth factor receptor beta (spdgfrβ) and quantifying pericyte density in the cortex, hippocampus, and subcortical area of the pdgfrβ-p2a-creer |
2023-08-07 |
2023-08-14 |
mouse |
| Saikat Mukherjee, Mahsa Mirzaee, Jeffrey Titho. Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow. Scientific reports. vol 13. issue 1. 2023-07-31. PMID:37524734. |
we first use high order numerical simulations to solve a system of physiologically realistic reaction-diffusion equations which govern the spatiotemporal dynamics of ions in the extracellular and intracellular spaces of the brain cortex during sd. |
2023-07-31 |
2023-08-14 |
Not clear |
| Bulat Mingazov, Daria Vinokurova, Andrei Zakharov, Roustem Khazipo. Comparative Study of Terminal Cortical Potentials Using Iridium and Ag/AgCl Electrodes. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445945. |
brain ischemia induces slow voltage shifts in the cerebral cortex, including waves of spreading depolarization (sd) and negative ultraslow potentials (nups), which are considered as brain injury markers. |
2023-07-14 |
2023-08-14 |
rat |
| Amit Marmelshtein, Anabel Eckerling, Barak Hadad, Shamgar Ben-Eliyahu, Yuval Ni. Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex. Current biology : CB. 2023-06-29. PMID:37385257. |
here, we recorded spiking activity in the rat auditory cortex along with polysomnography while presenting sounds during sd followed by recovery sleep. |
2023-06-29 |
2023-08-14 |
rat |
| Amit Marmelshtein, Anabel Eckerling, Barak Hadad, Shamgar Ben-Eliyahu, Yuval Ni. Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex. Current biology : CB. 2023-06-29. PMID:37385257. |
our results show that processes akin to those in nrem sleep invade the activity of cortical circuits during sd, even in the early sensory cortex. |
2023-06-29 |
2023-08-14 |
rat |