| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreia Morais, Tao Qin, Cenk Ayata, Andrea M Harriot. Inhibition of persistent sodium current reduces spreading depression-evoked allodynia in a mouse model of migraine with aura. Pain. 2023-06-15. PMID:37318029. |
the electrical sd threshold and kcl-induced sd frequency were examined in the cortex in male sprague-dawley rats after 1 hour pretreatment with gs-458967 (3 mg/kg, s.c.) or vehicle. |
2023-06-15 |
2023-08-14 |
mouse |
| K Suganya, E Kayalvizhi, K Senthil Kumar, R Muthulakshmi, R Yuvara. Regulation of pro and anti-inflammatory signaling molecules in effect of Withania Somnifera root extract treated sleep deprivation induced Wistar rats. Bioinformation. vol 16. issue 11. 2022-12-23. PMID:36561228. |
rt-pcr based mrna expression analysis of pro inflammatory (il-1β, il-6, mcp-1, tnf-α) and anti-inflammatory marker (il-10) in the cortex of control and sd rats were completed. |
2022-12-23 |
2023-08-14 |
rat |
| Ioulia V Fomitcheva, Jeremy Sword, Yang Shi, Sergei A Kiro. Plasticity of perisynaptic astroglia during ischemia-induced spreading depolarization. Cerebral cortex (New York, N.Y. : 1991). 2022-11-11. PMID:36368909. |
we used serial section electron microscopy to assess astroglial synaptic coverage in the sensorimotor cortex of urethane-anesthetized male and female mice during and after sd evoked by transient bilateral common carotid artery occlusion. |
2022-11-11 |
2023-08-14 |
mouse |
| Mariia P Smirnova, Tatiana M Medvedeva, Irina V Pavlova, Lyudmila V Vinogradov. Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140284. |
spreading depolarization (sd), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. |
2022-09-23 |
2023-08-14 |
Not clear |
| Mariia P Smirnova, Tatiana M Medvedeva, Irina V Pavlova, Lyudmila V Vinogradov. Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140284. |
spatiotemporal features of sds triggered in the amygdala indicated diverse patterns of the sd propagation to the cortex. |
2022-09-23 |
2023-08-14 |
Not clear |
| Qian-Nan Li, Jin-Feng Shang, Ting-Yue Jiang, Lei Bi, Jia-Kang Jiao, Ying-Hui Lu, Qi Song, Shabuer-Jiang Lizha, Xin Li. [Exploration of mechanism of "simultaneous treatment of brain and heart" of Naoxintong Capsules based on Toll-like receptor signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 15. 2022-09-01. PMID:36046901. |
this study aims to explore the mechanism of "simultaneous treatment of the brain and the heart" of naoxintong capsules(nxt) under cerebral ischemia based on toll-like receptor(tlr) signaling pathway.male sd rats were randomized into sham operation group, model group, nxt group, and positive drug group.middle cerebral artery occlusion(mcao) model rats were used in model group, nxt group, and positive drug group, respectively.neurological function was scored with the bederson scale, and brain infarct rate was measured by 2,3,5-triphenyltetrazolium chloride(ttc) staining.brain edema was detected with wet-dry weight method.hematoxylin-eosin(he) staining and tdt-mediated dutp nick-end labeling(tunel) staining were used to observe and count apoptotic cardiocytes.in addition, serum myocardial enzymes were measured.the expression of 8 tlr signaling pathway-related proteins interferon-α(ifn-α), interferon regulatory factor-3(irf3), interferon regulatory factor-7(irf7), tlr2, tlr4, tlr7, tlr9, and tumor necrosis factor-α(tnf-α) in the cerebral cortex and heart of rats was detected by western blot. |
2022-09-01 |
2023-08-14 |
rat |
| Noboru Usuda, Sho K Sugawara, Hiroyuki Fukuyama, Kimitaka Nakazawa, Kiyomi Amemiya, Yukio Nishimur. Quantitative comparison of corticospinal tracts arising from different cortical areas in humans. Neuroscience research. 2022-07-05. PMID:35787428. |
the corticospinal (cs) streamlines arose from nine cortical areas: primary motor area (mean ± sd = 49.71 ± 1.61%), dorsal (16.33 ± 1.37%) and ventral (11.02 ± 0.90%) premotor cortex, supplementary motor area (5.14 ± 0.36%), pre-supplementary motor area (2.46 ± 0.26%), primary somatosensory cortex (11.06 ± 0.91%), brodmann area 5 (0.88 ± 0.09%), caudal cingulate zone (1.70 ± 0.30%), and posterior part of the rostral cingulate zone (1.70 ± 0.34%). |
2022-07-05 |
2023-08-14 |
human |
| Daria Vinokurova, Andrey Zakharov, Kseniya Chernova, Gulshat Burkhanova-Zakirova, Viktor Horst, Coline L Lemale, Jens P Dreier, Roustem Khazipo. Depth-profile of impairments in endothelin-1 - induced focal cortical ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022-06-15. PMID:35702017. |
the level of impairments correlated strongly with the rate of spontaneous activity suppression, the rate of sd onset after et1 application, and the amplitude of giant negative ultraslow potentials (∼-70 mv), which developed during et1 application and were similar to the tent-shaped ultraslow potentials observed during focal ischemia in the human cortex. |
2022-06-15 |
2023-08-14 |
human |
| Sitong Lu, Jing Wang, Tianyi Sun, Haiqin Yan, Weiyan Zou, Huihui Li, Qi Qi, Meiqun Su. [IL-6 promotes the activation of rat astrocytes and down-regulation of the expression of Kir4.1 channel]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 4. 2022-05-18. PMID:35583060. |
methods astrocytes were separated from the cerebral cortex of newborn sd rats, and cultured in the presence of il-6 or combined with interleukin-6 receptor antagonist (il-6ra). |
2022-05-18 |
2023-08-13 |
rat |
| Ayberk Türkyılmaz, Safiye Gunes Sage. Two New Cases of Primary Microcephaly with Neuronal Migration Defect Caused by Truncating Mutations in the Molecular syndromology. vol 13. issue 1. 2022-02-28. PMID:35221876. |
two new cases of primary microcephaly with neuronal migration defect caused by truncating mutations in the autosomal recessive primary microcephaly (mcph) is a uncommon disorder due to congenital deficiency in the development of the cerebral cortex, characterized by a head circumference below 2 sd. |
2022-02-28 |
2023-08-13 |
Not clear |
| Yanjing Wang, Cimin Dai, Yongcong Shao, Chuan Wang, Qianxiang Zho. Changes in ventromedial prefrontal cortex functional connectivity are correlated with increased risk-taking after total sleep deprivation. Behavioural brain research. vol 418. 2021-12-11. PMID:34798167. |
this study investigated the relationship between functional connectivity in the vmpfc and cerebral cortex and the risk-taking tendency after sd. |
2021-12-11 |
2023-08-13 |
human |
| Yanjing Wang, Cimin Dai, Yongcong Shao, Chuan Wang, Qianxiang Zho. Changes in ventromedial prefrontal cortex functional connectivity are correlated with increased risk-taking after total sleep deprivation. Behavioural brain research. vol 418. 2021-12-11. PMID:34798167. |
correlation analysis was performed to evaluate changes in functional connectivity between the vmpfc and the cerebral cortex and risk-taking before and after sd. |
2021-12-11 |
2023-08-13 |
human |
| Yanjing Wang, Cimin Dai, Yongcong Shao, Chuan Wang, Qianxiang Zho. Changes in ventromedial prefrontal cortex functional connectivity are correlated with increased risk-taking after total sleep deprivation. Behavioural brain research. vol 418. 2021-12-11. PMID:34798167. |
these results demonstrate that lack of sleep substantially impairs functional connectivity between the vmpfc and the cerebral cortex, which in turn predicts the risk-taking behavior found after sd. |
2021-12-11 |
2023-08-13 |
human |
| Refat Aboghazleh, Ellen Parker, Lynn T Yang, Daniela Kaufer, Jens P Dreier, Alon Friedman, Gerben van Hamere. Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769073. |
severe impact, however, led to immediate death in 24% of animals, and was electrocorticographically characterized by non-spreading depression (nsd) of activity followed by terminal sd in both cortex and brainstem. |
2021-11-18 |
2023-08-13 |
rat |
| Maryam Anzabi, Baoqiang Li, Hui Wang, Sreekanth Kura, Sava Sakadžić, David Boas, Leif Østergaard, Cenk Ayat. Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 9. 2021-11-17. PMID:33593116. |
spreading depolarization (sd) is associated with profound oligemia and reduced oxygen availability in the mouse cortex during the depolarization phase. |
2021-11-17 |
2023-08-13 |
mouse |
| Tamas Csipo, Agnes Lipecz, Cameron Owens, Peter Mukli, Jonathan W Perry, Stefano Tarantini, Priya Balasubramanian, Ádám Nyúl-Tóth, Valeriya Yabluchanska, Farzaneh A Sorond, J Mikhail Kellawan, György Purebl, William E Sonntag, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanski. Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:34697326. |
functional nirs analysis revealed that sd significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. |
2021-10-29 |
2023-08-13 |
human |
| Yang Liu, Xue-Bin Hu, Li-Zhi Zhang, Zi Wang, Rong F. Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion. Translational stroke research. vol 12. issue 1. 2021-10-22. PMID:32221863. |
to achieve this aim, adult male sprague-dawley (sd) rats were given right cerebral cortex injections of short hairpin rna (shrna) adenovirus (av) particles to knock down arginyl-trna synthetase, and a non-targeting control (ntc) vector or phosphate-buffered solution served as the controls. |
2021-10-22 |
2023-08-13 |
rat |
| Yedan Liu, Huawei Zhang, Celeste Yc Wu, Tina Yu, Xing Fang, Jane J Ryu, Baoying Zheng, Zongbo Chen, Richard J Roman, Fan Fa. 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility. Prostaglandins & other lipid mediators. vol 154. 2021-09-24. PMID:33753221. |
het0016 enhanced cbf and impaired its autoregulation in the surface and deep cortex of sd rats. |
2021-09-24 |
2023-08-13 |
rat |
| João Paulo Mota Telles, Leonardo Christiaan Welling, Antonio Carlos Samaia da Silva Coelho, Nícollas Nunes Rabelo, Manoel Jacobsen Teixeira, Eberval Gadelha Figueired. Cortical spreading depolarization and ketamine: a short systematic review. Neurophysiologie clinique = Clinical neurophysiology. vol 51. issue 2. 2021-09-16. PMID:33610431. |
cortical spreading depolarization (sd) describes pathological waves characterized by an almost complete sustained depolarization of neurons and astrocytes that spreads throughout the cortex. |
2021-09-16 |
2023-08-13 |
Not clear |
| Isabel J Sible, Belinda Yew, Shubir Dutt, Katherine J Bangen, Yanrong Li, Daniel A Natio. Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults. Neurobiology of aging. vol 105. 2021-08-27. PMID:34034215. |
for every sd increase in bpv, perfusion decreased in medial orbitofrontal cortex (ß = -.36; p = 0.008), hippocampus (ß = -.37; p = 0.005), entorhinal cortex (ß = -.48; p < 0.001), precuneus (ß = -.31; p = 0.02), inferior parietal cortex (ß = -.44; p < 0.001), and inferior temporal cortex (ß = -.46; p < 0.001). |
2021-08-27 |
2023-08-13 |
human |