All Relations between sn and Substantia nigra

Publication Sentence Publish Date Extraction Date Species
Jin-Sun Park, Yea-Hyun Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Ki. Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease. Neurochemistry international. 2024-11-04. PMID:39491747. parkinson's disease (pd) is a neurodegenerative disorder triggered by the loss of dopaminergic neurons in the substantia nigra (sn). 2024-11-04 2024-11-06 mouse
Linglong Xiao, Mengqi Wang, Yifeng Shi, Xinyuejia Huang, Wei Zhang, Yang Wu, Hao Deng, Botao Xiong, Wei Pan, Jie Zhang, Wei Wan. Neuroinflammation-mediated white matter injury in Parkinson's disease and potential therapeutic strategies targeting NLRP3 inflammasome. International immunopharmacology. vol 143. issue Pt 3. 2024-11-03. PMID:39488915. most previous studies have focused on neuronal soma in substantia nigra (sn), while wm injury (wmi) in pd has been less studied. 2024-11-03 2024-11-06 Not clear
Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. 2024-11-02 2024-11-05 Not clear
Katharina Zühlsdorff, Júlia Sala-Bayo, Sammy Piller, Peter Zhukovsky, Thorsten Lamla, Wiebke Nissen, Moritz von Heimendahl, Serena Deiana, Janet R Nicholson, Trevor W Robbins, Johan Alsiö, Jeffrey W Dalle. Optogenetic activation of mesencephalic projections to the nucleus accumbens shell impairs probabilistic reversal learning by disrupting learning from negative reinforcement. The European journal of neuroscience. 2024-10-31. PMID:39479888. optogenetic stimulation of projection neurons from the substantia nigra (sn) to the dms, aligned either with reward receipt or omission or prior to making a choice, had no significant effect on reversal learning. 2024-10-31 2024-11-02 rat
Qiong Lyu, Rong Chen, Zhengang Qiu, Chuhuai Wang, Rongrong Li. Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study. Scientific reports. vol 14. issue 1. 2024-10-29. PMID:39468243. first, six geo datasets with transcriptomic data from the substantia nigra (sn) region of the brain were downloaded to find dysregulated druggable genes in pd. 2024-10-29 2024-10-31 Not clear
Riccardo Rocco Ferrari, Valentina Fantini, Maria Garofalo, Rosalinda Di Gerlando, Francesca Dragoni, Bartolo Rizzo, Erica Spina, Michele Rossi, Chiara Calatozzolo, Xhulja Profka, Mauro Ceroni, Antonio Guaita, Annalisa Davin, Stella Gagliardi, Tino Emanuele Polon. A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 20. 2024-10-26. PMID:39456899. in this study, a whole-transcriptome analysis was carried out on brain samples from the hippocampus (hi), temporal and parietal cortices (tc and pc, respectively), cingulate cortex (cg), and substantia nigra (sn) of six subjects with a definite ad diagnosis and three healthy age-matched controls in duplicate. 2024-10-26 2024-10-29 human
Xiangbo Zhang, Haiyang Yu, Juan Fen. Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson's disease. Frontiers in aging neuroscience. vol 16. 2024-10-24. PMID:39444806. the main pathological characteristics of pd are the loss of dopaminergic neurons in the substantia nigra (sn) as well as abnormal aggregation of α-synuclein (α-syn) monomers and oligomers, which results in formation of lewy bodies (lbs). 2024-10-24 2024-10-26 Not clear
Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. 2024-10-16 2024-10-19 mouse
Yueyan Qi, Yuxuan Dong, Jinhu Chen, Siyou Xie, Xin Ma, Xueping Yu, Yang Yu, Yanqin Wan. Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway. Experimental neurology. 2024-10-15. PMID:39406307. furthermore, sg5 inhibited mptp-triggered overactivation of microglia and astrocytes in the substantia nigra (sn), attenuated disruption of both blood-brain and intestinal barriers, and suppressed the release of inflammatory factors in the colon and sn. 2024-10-15 2024-10-18 mouse
Ya Gao, Shuyue Li, Jian Zhang, Yidan Zhang, Yuan Zhao, Shuming Zhang, Lujie Zuo, Guofeng Yan. Atractylenolide-I Ameliorates Motor Deficits and Reduces Inflammation of the Spinal Cord by SIRT1/PGC-1α Pathway in MPTP Subacute Mouse Model of Parkinson's Disease. Neuropsychiatric disease and treatment. vol 20. 2024-10-14. PMID:39399880. parkinson's disease (pd) is a neurodegenerative movement disorder that impacts various systems, including the substantia nigra (sn) par compacta (snpc) and extranigral regions like the spinal cord. 2024-10-14 2024-10-16 mouse
Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). 2024-10-04 2024-10-07 mouse
Alma Karen Lomeli-Lepe, José Luis Castañeda-Cabral, Mónica E Ureña-Guerrero, Graciela Gudiño Cabrera, Silvia Josefina López-Pére. Bee Venom Reduces Early Inflammation and Oxidative Stress Associated with Lipopolysaccharide-induced Alpha-synuclein in the Substantia Nigra-striatum Axis. Cell biochemistry and biophysics. 2024-09-29. PMID:39342536. we examined whether bv (1.5 mg/kg by acupoint injection st36 six times every 48 h) could change the α-syn and th expression measured by western blotting, also, observed the activation of microglia and astrocytes by immunofluorescence, quantified the proinflammatory cytokines levels of tumoral necrosis factor-α (tnf-α) and interleukin-1β (il-1β) by enzyme-linked immunosorbent assay (elisa), and estimated the lipid peroxidation and the activity of superoxide dismutase (sod) and catalase (cat) by colorimetric kits in lps-treated rats (2.5 µg by a single dose intranigral injection) in substantia nigra (sn) and striatum (str) brain areas. 2024-09-29 2024-10-01 rat
Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracellular α-synuclein (ɑ-syn) aggregates known as lewy bodies and lewy neurites. 2024-09-23 2024-09-26 mouse
Mei Jiang, Xu Deng, Zixiong Qiu, Jie Li, Zifan Song, Xiaoshuai Chen, Ruiqi Chen, Xianzhi Huang, Xiaojun Cui, Yuan F. Bibliometric analysis of global research trends in magnetic resonance imaging studies of substantia nigra in Parkinson's disease (2001-2024). Frontiers in aging neuroscience. vol 16. 2024-09-18. PMID:39291277. numerous studies have been conducted on the application of magnetic resonance imaging (mri) in investigating the substantia nigra (sn) in pd patients. 2024-09-18 2024-09-20 Not clear
Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. Brain : a journal of neurology. 2024-09-16. PMID:39282945. parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. 2024-09-16 2024-09-19 Not clear
Szu-Chi Liao, Kohei Kano, Sadhna Phanse, Mai Nguyen, Elyssa Margolis, YuHong Fu, Jonathan Meng, Mohamed Taha Moutaoufik, Zac Chatterton, Hiroyuki Aoki, Jeffrey Simms, Ivy Hsieh, Felecia Suteja, Yoshitaka Sei, Eric J Huang, Kevin McAvoy, Giovanni Manfredi, Glenda Halliday, Mohan Babu, Ken Nakamur. CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism. bioRxiv : the preprint server for biology. 2024-09-11. PMID:39257750. nonetheless, chchd2 t61i mice exhibited robust molecular changes in the brain including increased chchd2 insolubility, accumulation of chchd2 protein preferentially in the substantia nigra (sn), and elevated levels of α-synuclein. 2024-09-11 2024-09-13 mouse
Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). 2024-09-03 2024-09-05 Not clear
Mark J Connolly, Sujin Jiang, Lim C Samuel, Claire-Anne Gutekunst, Robert E Gross, Annaelle Devergna. Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures. PloS one. vol 19. issue 8. 2024-08-28. PMID:39197026. here, we characterize the involvement of the substantia nigra (sn) and somatosensory cortex (si) during temporal lobe (tl) seizures induced by penicillin injection in the hippocampus (hpc) of two nonhuman primates. 2024-08-28 2024-08-31 human
Zahra Baridjavadi, Mahmoud Mahmoudi, Narges Abdollahi, Negar Ebadpour, Samaneh Mollazadeh, Dariush Haghmorad, Seyed-Alireza Esmaeil. The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes. Cell biochemistry and function. vol 42. issue 7. 2024-08-27. PMID:39189398. parkinson's disease (pd) is a complex neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) in the brain and progressive loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. 2024-08-27 2024-08-30 Not clear
Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jian. GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy. Redox biology. vol 76. 2024-08-24. PMID:39180981. however, in contrast to the strikingly low levels of ghrelin, ghsr is highly expressed in the substantia nigra (sn). 2024-08-24 2024-08-28 mouse