| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
while tph2 synthesizes serotonin in the brain, tph1 is expressed in the gut and in other peripheral tissues and supplies platelets in the circulation with serotonin. |
2020-12-10 |
2023-08-13 |
mouse |
| Walter J Lukiw, Evgeny I Rogae. Genetics of Aggression in Alzheimer's Disease (AD). Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28443016. |
these genes encoded on five different chromosomes (chr) include the androgen receptor (ar; chrxq12), brain-derived neurotrophic factor (bdnf; chr11p14.1), catechol-o-methyl transferase (comt; chr22q11.21), neuronal specific nitric oxide synthase (nos1; chr12q24.22), dopamine beta-hydroxylase (dbh chr9q34.2) and tryptophan hydroxylase (tph1, chr11p15.1 and tph2, chr12q21.1). |
2020-10-01 |
2023-08-13 |
human |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |
| Bojan Mirkovic, David Cohen, Claudine Laurent, Malaika Lasfar, Christophe Marguet, Prsicille Gerardi. A case-control association study of 12 candidate genes and attempted suicide in French adolescents. International journal of adolescent medicine and health. vol 32. issue 1. 2020-04-22. PMID:28902619. |
we performed analysis on 22 single nucleotide polymorphisms (snps) in 12 genes (comt, crhr1, fkbp5, slc6a4, htr1b, htr2a, tph1, tph2, bdnf, ntrk2, nos1 and il28ra) for association with suicide attempt, hopelessness and impulsivity in an independent sample, composed of 98 adolescent suicide attempters who required hospitalization based on emergency assessments, and 150 healthy volunteers. |
2020-04-22 |
2023-08-13 |
human |
| Yi Chen, Haixia Xu, Mingyue Zhu, Kun Liu, Bo Lin, Ruxian Luo, Chuanbai Chen, Mengsen L. Stress inhibits tryptophan hydroxylase expression in a rat model of depression. Oncotarget. vol 8. issue 38. 2019-11-20. PMID:28968985. |
immunohistochemical analyses of tph1/2 showed less tph1 and tph2 expression, specifically tph2, in the brain, liver and kidney of the depressive rats than in the healthy rats; in addition, the two tph isoforms, tph1 and tph2, had different spatial distributions,the mrnas of the tph1/2 genes were significantly decreased and tph1/2 were highly methylated in the depressive model rat, but treatment with paroxetine ameliorated the expression and methylation of tph1/2. |
2019-11-20 |
2023-08-13 |
rat |
| Paulina Wigner, Piotr Czarny, Ewelina Synowiec, Michał Bijak, Katarzyna Białek, Monika Talarowska, Piotr Galecki, Janusz Szemraj, Tomasz Sliwinsk. Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-21. PMID:29314569. |
association between single nucleotide polymorphisms of tph1 and tph2 genes, and depressive disorders. |
2019-10-21 |
2023-08-13 |
Not clear |
| Paulina Wigner, Piotr Czarny, Ewelina Synowiec, Michał Bijak, Katarzyna Białek, Monika Talarowska, Piotr Galecki, Janusz Szemraj, Tomasz Sliwinsk. Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-21. PMID:29314569. |
the objective of our study was to confirm the association between the presence of polymorphic variants of tph1 and tph2 genes, and the development of depressive disorders. |
2019-10-21 |
2023-08-13 |
Not clear |
| V M Pokrovskii, Yu V Kashina, O V Kiek, O V Gumerova, V Yu Gorbunova, V G Abushkevich, A G Penzhoyan, N V Zabolotskik. Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism. Bulletin of experimental biology and medicine. vol 166. issue 4. 2019-07-15. PMID:30783842. |
we performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase tph1 (a218c polymorphism) and tph2 (g703t polymorphism), and serotonin receptors (htr2c and htr2a genes). |
2019-07-15 |
2023-08-13 |
human |
| b' Guillemette Fouquet, Tereza Coman, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin, hematopoiesis and stem cells. Pharmacological research. vol 140. 2019-05-13. PMID:30107202.' |
since the generation of tryptophan hydroxylase (tph1 and tph2) knockout mice, unsuspected roles have been identified for serotonin synthesized outside the brain. |
2019-05-13 |
2023-08-13 |
mouse |
| Claudia Schoenichen, Christoph Bode, Daniel Duerschmie. Role of platelet serotonin in innate immune cell recruitment. Frontiers in bioscience (Landmark edition). vol 24. 2019-04-01. PMID:30468670. |
peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (tph), which exists in two different isoforms: tph2 being responsible for serotonin synthesis in neurons and tph1 for generation of serotonin in peripheral organs. |
2019-04-01 |
2023-08-13 |
Not clear |
| Hailong Shi, Yaya Cui, Yifei Qi. Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical biology & drug design. vol 91. issue 1. 2019-02-20. PMID:28719094. |
two distinct tryptophan hydroxylases (tph), tph1 and tph2, are the rate-limiting enzymes in the 5-ht biosynthesis process. |
2019-02-20 |
2023-08-13 |
rat |
| J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Er. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 3. 2019-01-29. PMID:29358097. |
while effects of 5-httlpr and of a serotonergic multi-marker score (5-httlpr, tph1(rs1800532), tph2(rs4570625), htr1a(rs6295) and htr2a(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, dlpfc, and acc. |
2019-01-29 |
2023-08-13 |
human |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
genetic moderation of cocaine subjective effects by variation in the tph1, tph2, and slc6a4 serotonin genes. |
2018-07-27 |
2023-08-13 |
Not clear |
| D A Nikishin, N M Alyoshina, Y B Shmukle. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Doklady. Biochemistry and biophysics. vol 478. issue 1. 2018-04-09. PMID:29536299. |
using rt-pcr, we showed the presence of tph1 mrna in follicular cells and tph2 mrna in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. |
2018-04-09 |
2023-08-13 |
mouse |
| Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girard. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients. Neuroscience letters. vol 656. 2018-04-05. PMID:28716530. |
we aimed to investigate functional polymorphisms in eight genes (serotonin transporter, slc6a4; receptors, 5htr1a, 1b, 5htr2a; tryptophan hydroxylase, tph1, tph2; monoamine oxidase, maoa and g protein subunit beta 3, gnb3) to investigate their predictive value for suicide. |
2018-04-05 |
2023-08-13 |
Not clear |
| Kasper D Tidemand, Günther H Peters, Pernille Harris, Eva Stensgaard, Hans E M Christense. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. Biochemistry. vol 56. issue 46. 2017-12-19. PMID:29035515. |
tph1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while tph2 catalyzes this step in the brain. |
2017-12-19 |
2023-08-13 |
human |
| C Bonvicini, S V Faraone, C Scassellat. Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Molecular psychiatry. vol 21. issue 7. 2017-09-25. PMID:27217152. |
genes linked to dopaminergic, serotoninergic and noradrenergic signaling, metabolism (dbh, tph1, tph2, ddc, maoa, maob, bche and th), neurodevelopment (bdnf and others), the snare system and other forty genes/proteins related to different pathways were not meta-analyzed due to insufficient data. |
2017-09-25 |
2023-08-13 |
Not clear |
| M Gupta, D Neavin, D Liu, J Biernacka, D Hall-Flavin, W V Bobo, M A Frye, M Skime, G D Jenkins, A Batzler, K Kalari, W Matson, S S Bhasin, H Zhu, T Mushiroda, Y Nakamura, M Kubo, L Wang, R Kaddurah-Daouk, R M Weinshilbou. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Molecular psychiatry. vol 21. issue 12. 2017-09-21. PMID:26903268. |
knockdown (kd) and overexpression (oe) of tspan5 in a neuroblastoma cell line significantly altered the expression of serotonin pathway genes (tph1, tph2, ddc and maoa). |
2017-09-21 |
2023-08-13 |
Not clear |
| Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancour. Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. Biochimie. vol 140. 2017-09-15. PMID:28751217. |
moreover, it is not known if the two tryptophan hydroxylase isoforms (tph1 and tph2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. |
2017-09-15 |
2023-08-13 |
mouse |
| Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancour. Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. Biochimie. vol 140. 2017-09-15. PMID:28751217. |
this study demonstrates that both tph1 and tph2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development. |
2017-09-15 |
2023-08-13 |
mouse |