| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
a secondary objective was to analyze 17 other variants in serotonergic system genes (htr1a, htr2a, htr1b, htr2c, tph1, tph2) potentially involved in the mechanism of action of venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Kanu Megha, Pravin S Deshmukh, Alok K Ravi, Ashok K Tripathi, Mahesh P Abegaonkar, Basu D Banerje. Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain. Cell biochemistry and biophysics. vol 73. issue 1. 2017-01-18. PMID:25672490. |
tyrosine hydroxylase (th) (for da, ne and e) and tryptophan hydroxylase (tph1 and tph2) (for serotonin) was also estimated. |
2017-01-18 |
2023-08-13 |
human |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
we showed in isolated islets and min6 cells that gcs decreased expression and activity of the two key enzymes of serotonin synthesis, tryptophan hydroxylase 1 (tph1) and 2 (tph2), leading to reduced serotonin contents. |
2016-07-18 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
finally, islets from mice deleted for the gr in the pancreas displayed an increased expression of tph1 and tph2 and a strong increased serotonin content per islet. |
2016-07-18 |
2023-08-13 |
mouse |
| Harleen Hehar, Keith Yeates, Bryan Kolb, Michael J Esser, Richelle Mychasiu. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway. PloS one. vol 10. issue 10. 2016-06-10. PMID:26448536. |
as these behaviours are believed to be associated with the frontostriatal circuit involving the nucleus accumbens (nac) and the prefrontal cortex (pfc), the expression patterns of 8 genes (comt, drd2, drd3, drd4, maoa, sert, tph1, and tph2) from these two regions were examined. |
2016-06-10 |
2023-08-13 |
rat |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
serotonin synthesis is a 2-step process, the first step of which is mediated by the rate-limiting activity of tph enzymes, belonging to the family of aromatic amino acid hydroxylases and existing in two isoforms, tph1 and tph2, responsible for the production of peripheral and brain serotonin, respectively. |
2016-05-13 |
2023-08-13 |
mouse |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Blümer, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinber. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature medicine. vol 21. issue 2. 2015-04-09. PMID:25485911. |
serotonin (5-hydroxytryptamine, 5-ht) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (tph1) and tph2, respectively. |
2015-04-09 |
2023-08-13 |
mouse |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| Sang-Eun Jun, Ruth Kohen, Kevin C Cain, Monica E Jarrett, Margaret M Heitkempe. TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome. Biological research for nursing. vol 16. issue 1. 2014-07-30. PMID:23172723. |
tph is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, tph1 and tph2. |
2014-07-30 |
2023-08-12 |
human |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| François Reichardt, Charlotte Baudry, Lisa Gruber, Gemma Mazzuoli, Raphaël Moriez, Christian Scherling, Patrick Kollmann, Hannelore Daniel, Sigrid Kisling, Dirk Haller, Michel Neunlist, Michael Scheman. Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice. The Journal of physiology. vol 591. issue 20. 2014-06-20. PMID:23940384. |
this was associated with increased tissue acetylcholine and 5-hydroxytryptamine (5-ht) content, and increased expression of tph1 and tph2. |
2014-06-20 |
2023-08-12 |
mouse |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Richard Musil, Peter Zill, Florian Seemüller, Brigitta Bondy, Sebastian Meyer, Ilja Spellmann, Wolfram Bender, Mazda Adli, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Wolfgang Maier, Marcella Rietschel, Dan Rujescu, Rebecca Schennach, Hans-Jürgen Möller, Michael Riede. Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:23063133. |
common polymorphisms involved in the tryptophan hydroxylase 1 (tph1) and 2 (tph2), serotonin transporter, monoamine oxidase a (maoa) and brain-derived neurotrophic factor (bdnf) were investigated in a naturalistic inpatient study of the german research network on depression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
associations between variations in tph1 , tph2 and slc6a4 genes and postpartum depression: a study in the jordanian population. |
2013-11-22 |
2023-08-12 |
Not clear |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
in this study, we investigated the association between tryptophan hydroxylase-1 (tph1 ) (218a>c), tryptophan hydroxylase-2 ( tph2 ) (1463g>a) and serotonin carrier family 6, member 4 (slc6a4) [long (l) vs. short (s)] gene polymorphisms with post-partum depression (ppd) in women from jordan. |
2013-11-22 |
2023-08-12 |
Not clear |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
genotyping was carried out using restriction fragment length polymorphism (rflp) for tph1 , amplification refractory mutation system (arms) for tph2 and polymerase chain reaction (pcr) for slc6a4 s and l. the edinburgh postnatal depression scale was used to screen postpartum women. |
2013-11-22 |
2023-08-12 |
Not clear |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
surprisingly, deletion of tryptophan hydroxylase-1 (tph1), upon which 5-ht biosynthesis in ec cells depends, does not alter constitutive gi motility, whereas deletion of tph2, upon which biosynthesis of neuronal 5-ht depends, slows intestinal transit and accelerates gastric emptying. |
2013-07-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
tph1 deletion, however, protects mice from experimental inflammation; 5-ht potentiation and tph2 deletion each make inflammation more severe. |
2013-07-01 |
2023-08-12 |
mouse |
| C A Browne, F E O'Brien, T J Connor, T G Dinan, J F Crya. Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: effects of stress. Neuroscience. vol 225. 2013-04-16. PMID:22917616. |
in the hippocampus tph1 and tph2 mrna expression was increased in c57bl/6j but not balb/c mice in response to lps challenge and swim-stress. |
2013-04-16 |
2023-08-12 |
mouse |