| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
it was confirmed that ium produces an increase in 5-ht in the brainstem and also showed increased expression of tph1 at birth, with decreased expression of tph2. |
2013-02-05 |
2023-08-12 |
Not clear |
| Armen K Goenjian, Julia N Bailey, David P Walling, Alan M Steinberg, Devon Schmidt, Uma Dandekar, Ernest P Nobl. Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. Journal of affective disorders. vol 140. issue 3. 2013-01-31. PMID:22483952. |
to examine the potential contribution of the serotonin hydroxylase (tph1 and tph2) genes, and the serotonin transporter promoter polymorphism (5httlpr) to the unique and pleiotropic risk of ptsd symptoms and depressive symptoms. |
2013-01-31 |
2023-08-12 |
Not clear |
| Anna Schuhmacher, Tim Becker, Dan Rujescu, Boris B Quednow, Leonhard Lennertz, Michael Wagner, Jens Benninghoff, Marcella Rietschel, Heinz Häfner, Petra Franke, Wolfgang Wölwer, Wolfgang Gaebel, Wolfgang Maier, Rainald Mössne. Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics. Journal of psychiatric research. vol 46. issue 8. 2012-12-04. PMID:22655589. |
while the tph1 gene has been found to be associated with schizophrenia, studies focusing on tph2 variants did not yield conclusive results for schizophrenia or the response to antipsychotic medication. |
2012-12-04 |
2023-08-12 |
Not clear |
| Y Kawabata, T Hiraki, A Takeuchi, K Okub. Sex differences in the expression of vasotocin/isotocin, gonadotropin-releasing hormone, and tyrosine and tryptophan hydroxylase family genes in the medaka brain. Neuroscience. vol 218. 2012-11-16. PMID:22609934. |
male-biased expression of gnrh1, tph1, and tph2 was also evident in the supracommissural and posterior nuclei of the ventral telencephalic area (vs/vp), medial nucleus of the dorsal telencephalic area (dm), and thalamic dorsal posterior nucleus (dp), respectively. |
2012-11-16 |
2023-08-12 |
Not clear |
| Sara Trowbridge, Nicolas Narboux-Nême, Patricia Gaspa. Genetic models of serotonin (5-HT) depletion: what do they tell us about the developmental role of 5-HT? Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:20818612. |
serotonin (5-ht) depletion has been obtained via targeting of genes involved in 5-ht synthesis (tph1 and tph2), specification and determination of the 5-ht phenotype during development (gata3, pet1, and lmx1b), and 5-ht storage or clearance (vmat2 and sert). |
2012-01-17 |
2023-08-12 |
Not clear |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
availability of 5-ht depends on the expression of the enzyme tryptophan hydroxylase (tph), and the recent discovery of a dual system for 5-ht synthesis in the brain (tph2) and periphery (tph1) has renewed interest in studying the potential functions played by 5-ht in nonnervous tissues. |
2011-10-18 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
5-ht biosynthesis depends on tryptophan hydroxylase 1 (tph1) in ec cells and on tph2 in neurons; therefore, mice lacking tph1 and/or tph2 distinguish ec-derived from neuronal 5-ht. |
2011-08-22 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
deletion of tph2, but not tph1, decreased myenteric neuronal density and proportions of dopaminergic and gabaergic neurons but did not affect the extrinsic sympathetic innervation of the gut; intestinal transit slowed in mice lacking tph2 mice, but gastric emptying accelerated. |
2011-08-22 |
2023-08-12 |
mouse |
| Nurgul Carkaci-Salli, Ugur Salli, Kara L Kuntz-Melcavage, Michael M Pennock, Hande Ozgen, Izel Tekin, Willard M Freeman, Kent E Vran. TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin. vol 84. issue 6. 2011-07-18. PMID:21272616. |
the pineal gland was used as a control tissue that expresses tph1 (the peripheral enzyme), but not tph2. |
2011-07-18 |
2023-08-12 |
rat |
| Kwang-Yeon Choi, Ho-Kyoung Yoon, Yong-Ku Ki. Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. Psychiatry investigation. vol 7. issue 1. 2011-07-14. PMID:20396435. |
association between serotonin-related polymorphisms in 5ht2a, tph1, tph2 genes and bipolar disorder in korean population. |
2011-07-14 |
2023-08-12 |
Not clear |
| S Jun, R Kohen, K C Cain, M E Jarrett, M M Heitkempe. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21073637. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: tph1 and tph2. |
2011-05-31 |
2023-08-12 |
Not clear |
| M Camiller. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21159063. |
lx-1031 appears promising for chronic diarrhea associated with increased 5-ht expression including ibs-d. optimal doses, efficacy and safety in ibs clinical trials need to be fully elucidated; low systemic exposure, selectivity for tph1 over tph2, and lack of effect on brain 5-ht in several species suggest that lx-1031 is unlikely to cause affective disorders. |
2011-05-31 |
2023-08-12 |
human |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
raphe neurons of a brain-specific constitutive tph2 ko were completely devoid of tph2-positive neurons and, consequently, 5-ht in the brain, and also displayed no compensatory up-regulation of tph1 expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Susann Matthes, Valentina Mosienko, Saleh Bashammakh, Natalia Alenina, Michael Bade. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. vol 85. issue 2. 2010-10-04. PMID:20130443. |
the peripheral and cerebral biosynthesis of 5-ht is initiated by two distinct tryptophan hydroxylases: tph1 and tph2. |
2010-10-04 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
common variants in the tph1 and tph2 regions are not associated with persistent adhd in a combined sample of 1,636 adult cases and 1,923 controls from four european populations. |
2010-09-29 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
the tryptophan hydroxylase 1 and 2 (tph1 and tph2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. |
2010-09-29 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
in conclusion, in the single largest adhd genetic study of tph1 and tph2 variants presented to date (n = 3,559 individuals), we did not find consistent evidence for a substantial effect of common genetic variants on persistent adhd. |
2010-09-29 |
2023-08-12 |
Not clear |
| Nader Perroud, Elizabeth Neidhart, Brice Petit, Monique Vessaz, Térèse Laforge, Céline Relecom, Romano La Harpe, Alain Malafosse, Michel Guippon. Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 4. 2010-09-03. PMID:20052688. |
slc6a4, tph1, and tph2 mrna levels were measured in the ventral prefrontal cortex (vpfc) of 39 suicide completers and 40 matched controls. |
2010-09-03 |
2023-08-12 |
human |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Kyoichi Shiroiwa, Akitoyo Hishimoto, Kentaro Mouri, Masaaki Fukutake, Irwan Supriyanto, Naoki Nishiguchi, Osamu Shirakaw. Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neuroscience letters. vol 472. issue 3. 2010-06-11. PMID:20144688. |
although a genetic association of tryptophan hydroxylase isoform 1 (tph1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform tph2 is more relevant to the central nervous system and the association of tph2 gene with schizophrenia has been much less explored. |
2010-06-11 |
2023-08-12 |
Not clear |