| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas Ramoz, Guiqing Cai, Jennifer G Reichert, Thomas E Corwin, Lauren A Kryzak, Christopher J Smith, Jeremy M Silverman, Eric Hollander, Joseph D Buxbau. Family-based association study of TPH1 and TPH2 polymorphisms in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 8. 2007-02-13. PMID:16958027. |
thus, it appears unlikely that the tph1 and tph2 genes play a significant role in the susceptibility to autism or to autism endophenotypes including socb and ssb. |
2007-02-13 |
2023-08-12 |
Not clear |
| Peter Zill, Andreas Büttner, Wolfgang Eisenmenger, Hans-Jürgen Möller, Manfred Ackenheil, Brigitta Bond. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study. Journal of psychiatric research. vol 41. issue 1-2. 2007-02-06. PMID:16023677. |
due to the lack of data about its anatomic expression in humans we performed a mrna expression analysis comparing tph1 and tph2 mrna in several regions of the human brain (cortex, thalamus, hypothalamus, hippocampus, amygdala, cerebellum and raphe nuclei). |
2007-02-06 |
2023-08-12 |
mouse |
| Peter Zill, Andreas Büttner, Wolfgang Eisenmenger, Hans-Jürgen Möller, Manfred Ackenheil, Brigitta Bond. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study. Journal of psychiatric research. vol 41. issue 1-2. 2007-02-06. PMID:16023677. |
the major finding of this study was the high expression level of tph2 mrna in the raphe nuclei ( approximately 4-fold more abundant than that of tph1). |
2007-02-06 |
2023-08-12 |
mouse |
| Rafael Ortíz-Alvarado, Omar Guzmán-Quevedo, Rosalio Mercado-Camargo, Thomas Haertle, Caroline Vignes, Francisco Bolaños-Jiméne. Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS letters. vol 580. issue 22. 2006-11-09. PMID:16989820. |
here, we show by quantitative real time rt-pcr that both isoforms of tryptophan hydroxylase (tph1 and tph2), the first and rate limiting enzyme of serotonin (5-ht) synthesis, are expressed in developing circumvallate papillae. |
2006-11-09 |
2023-08-12 |
mouse |
| Vincenzo De Luca, Olga Likhodi, Hubert H M Van Tol, James L Kennedy, Albert H C Won. Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects. The international journal of neuropsychopharmacology. vol 9. issue 1. 2006-09-19. PMID:15941494. |
while genetic association and mrna expression studies implicate the tryptophan hydroxylase isoform-1 gene (tph1) in depression and suicidality, the tph1 gene is 150-fold less expressed in mouse brain than tph2. |
2006-09-19 |
2023-08-12 |
mouse |
| Stacey A Sakowski, Timothy J Geddes, Donald M Kuh. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16405505. |
isoform 1 (tph1) is found in the pineal gland and gut, and isoform 2 (tph2) is selectively expressed in brain. |
2006-03-30 |
2023-08-12 |
mouse |
| Kazuhiro Nakamura, Yuko Sugawara, Keiko Sawabe, Akiko Ohashi, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji, Qing Shun Lin, Hiroyuki Nishimura, Hiroyuki Hasegawa, Sachiko Hiros. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407550. |
tph1 showed higher affinity to tryptophan and stronger enzyme activity than tph2 in a condition reflecting that of the developing brainstem. |
2006-03-17 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| Vincenzo De Luca, Olga Likhodi, Hubert H M Van Tol, James L Kennedy, Albert H C Won. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology. vol 183. issue 3. 2006-01-04. PMID:16240163. |
although the tryptophan hydroxylase isoform-1 gene (tph1) has been reported to have a genetic association with bipolar disorder and schizophrenia, the tph1 isoform is expressed at much lower levels than tph2 (150-fold less in the mouse brain). |
2006-01-04 |
2023-08-12 |
mouse |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
we thus cloned specific tph1 and tph2 partial cdnas and assessed the daily profiles of tph mrna levels by in situ hybridization in the rat raphe nuclei. |
2005-10-18 |
2023-08-12 |
rat |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
our results demonstrate that: (i) tph2 gene is exclusively expressed in the raphe nuclei, whereas tph1 gene is expressed in the pineal gland; (ii) under light-dark cycle (ld), tph2 mrna levels present daily variation within both median and dorsal raphe nuclei; (iii) under constant darkness tph2 mrna levels in both nuclei exhibit the same variation reported under ld cycle. |
2005-10-18 |
2023-08-12 |
rat |
| Jeffrey McKinney, Per M Knappskog, Jan Haavi. Different properties of the central and peripheral forms of human tryptophan hydroxylase. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663479. |
the differences between tph1 and tph2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for tph from different sources in the past. |
2005-05-26 |
2023-08-12 |
human |
| Martin Preisig, François Ferrero, Alain Malafoss. Monoamine oxidase a and tryptophan hydroxylase gene polymorphisms: are they associated with bipolar disorder? American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 5. issue 1. 2005-05-24. PMID:15727488. |
with respect to tph1 and tph2, the majority of studies did not provide evidence for an association between these genes and bipolar disorder. |
2005-05-24 |
2023-08-12 |
human |
| Jian Liang, James H Wessel, P Michael Iuvone, Gianluca Tosini, Chiaki Fukuhar. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194882. |
to that end, we measured tph1 (classical tph) and tph2 mrna levels using real-time quantitative rt-pcr in the retina. |
2004-09-16 |
2023-08-12 |
rat |
| Jian Liang, James H Wessel, P Michael Iuvone, Gianluca Tosini, Chiaki Fukuhar. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194882. |
our data demonstrate that tph1 mrna is the prevalent form expressed in the retina; tph2 mrna is also present but the level is very low. |
2004-09-16 |
2023-08-12 |
rat |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
the rate limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes: the well characterized tph1 gene and a recently identified tph2 gene. |
2004-07-19 |
2023-08-12 |
mouse |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
based on the study of a mutant mouse in which the tph1 gene has been inactivated by replacement of the beta-galactosidase gene, we established that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the non-neuronal tph1, as detected by beta-galactosidase expression, is expressed in the pineal gland and the enterochromaffin cells. |
2004-07-19 |
2023-08-12 |
mouse |
| Paresh D Patel, Crystal Pontrello, Sharon Burk. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biological psychiatry. vol 55. issue 4. 2004-03-08. PMID:14960297. |
robust and tissue-specific expression of tph2 versus tph1 in rat raphe and pineal gland. |
2004-03-08 |
2023-08-12 |
rat |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes, the well characterized tph1 gene and a recently identified tph2 gene. |
2004-01-05 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
in this article, based on the study of a mutant mouse in which the tph1 gene has been inactivated by replacement with the beta-galactosidase gene, we establish that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the nonneuronal tph1, as detected by beta-galactosidase expression, is in the pineal gland and the enterochromaffin cells. |
2004-01-05 |
2023-08-12 |
mouse |