All Relations between tph2 and adrenal

Publication Sentence Publish Date Extraction Date Species
Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. tph1 and tph2 immunostaining was observed in the adrenal medulla, and measurable levels of tph1 and tph2 protein and mrna were detected in rat adrenal glands from ctrl animals. 2024-10-28 2024-10-31 rat
Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. expression of tryptophan hydroxylase in rat adrenal glands: upregulation of tph2 by chronic stress. 2024-10-28 2024-10-31 rat
Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. on day 15, adrenal glands were collected for tph1 and tph2 immunohistochemistry, western blot, and rt-pcr; tph activity was estimated by quantification of 5-hydroxytryptophan (5-htp) and, indirectly, through measurement of 5-ht and 5-hydroxindolacetic acid (5-hiaa) levels and turnover (5-hiaa/5-ht ratio) by hplc. 2024-10-28 2024-10-31 rat
Guo-Lin Chen, Gregory M Mille. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22241550. particularly, based on findings on rhesus monkey tph2 genetics and other relevant literature, we propose that: (i) upon activation of adrenal cortisol secretion, the cortisol surge induces tph2 expression and de novo 5-ht synthesis; (ii) the induced 5-ht in turn inhibits cortisol secretion by modulating the adrenal sensitivity to acth via the suprachiasmatic nuclei (scn)-sns-adrenal system, such that it contributes to the feedback inhibition of cortisol production; (iii) basal tph2 expression or 5-ht synthesis, as well as early-life experience, influence basal cortisol primarily via the hormonal hpa axis; and (iv) 5'- and 3'-regulatory polymorphisms of tph2 may differentially influence the stress response, presumably due to their differential roles in gene expression regulation. 2012-05-22 2023-08-12 monkey