| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the mrna expression levels of inflammatory factors and trem2 in hippocampus were evaluated by qrt-pcr, and the expression and localization of iba-1, cd206, cd86, and trem2 were determined by immunofluorescence staining. |
2024-10-29 |
2024-10-31 |
mouse |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Shuang Tang, Wenli Xing, Jin Yan, Lin Wang, Zhao Li, Yingwen Wang, Nina Gu, Xiaochuan Su. TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. Brain research. 2024-09-13. PMID:39270995. |
trem2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via pi3k/akt signaling pathway. |
2024-09-13 |
2024-09-16 |
mouse |
| Shuang Tang, Wenli Xing, Jin Yan, Lin Wang, Zhao Li, Yingwen Wang, Nina Gu, Xiaochuan Su. TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. Brain research. 2024-09-13. PMID:39270995. |
this study aims to investigate the role of the triggering receptor expressed on myeloid cells 2 (trem2) in mitigating hippocampal injury and associated cognitive impairments following sah. |
2024-09-13 |
2024-09-16 |
mouse |
| Shuang Tang, Wenli Xing, Jin Yan, Lin Wang, Zhao Li, Yingwen Wang, Nina Gu, Xiaochuan Su. TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. Brain research. 2024-09-13. PMID:39270995. |
our findings indicate that the upregulation of trem2 significantly alleviated long-term cognitive deficits and promoted the recovery of hippocampal neural activity post-sah. |
2024-09-13 |
2024-09-16 |
mouse |
| Shuang Tang, Wenli Xing, Jin Yan, Lin Wang, Zhao Li, Yingwen Wang, Nina Gu, Xiaochuan Su. TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. Brain research. 2024-09-13. PMID:39270995. |
in conclusion, trem2 upregulation mitigates long-term cognitive dysfunction following sah by attenuating hippocampal neuroinflammation via the pi3k/akt signaling pathway. |
2024-09-13 |
2024-09-16 |
mouse |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
taurine upregulated trem2 expression in the hippocampus and cortex. |
2024-03-29 |
2024-03-31 |
mouse |
| Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Che. miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway. The Kaohsiung journal of medical sciences. vol 40. issue 2. 2024-02-02. PMID:38305705. |
mir-107-5p expression, along with tlr4, apoe, and trem2 in hippocampal tissue homogenate, and nf-κb p65 protein expression in the nucleus and cytoplasm were assessed via rt-qpcr and western blot. |
2024-02-02 |
2024-02-04 |
mouse |
| Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteol. Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity. 2023-12-30. PMID:38159572. |
in the absence of trem2, developing neurons in the hippocampal cornus ammonis (ca)1 but not in ca3 subfield displayed compromised energetic metabolism, accompanied by reduced mitochondrial mass and abnormal organelle ultrastructure. |
2023-12-30 |
2024-01-05 |
Not clear |
| Meng Wang, Tao Wei, Chaoji Yu, Ruiyang Li, Yunsi Yin, Hanchen Yang, Run Di, Xinyi Xia, Qi Qin, Yi Tan. Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer's Disease. Molecular neurobiology. 2023-12-08. PMID:38066402. |
metabolomic analysis of hippocampal tissue from app/ps1 and app/ps1-trem2 knockout (ko) mice found that trem2 ko was associated with abnormalities in several metabolism pathways, and the effect was particularly pronounced in lipid metabolism and glucose metabolism pathways. |
2023-12-08 |
2023-12-17 |
mouse |
| Jianxiong Gui, Jie Liu, Lingman Wang, Hanyu Luo, Dishu Huang, Xiaoyue Yang, Honghong Song, Ziyao Han, Ran Ding, Jiaxin Yang, Li Jian. TREM2 mitigates NLRP3-mediated neuroinflammation through the NF-κB and PI3k/Akt signaling pathways in juvenile rats exposed to ambient particulate matter. Environmental science and pollution research international. 2023-11-06. PMID:37930574. |
our findings revealed that pm exposure reduced trem2 protein and mrna levels in the rat hippocampus and bv-2 cells. |
2023-11-06 |
2023-11-08 |
rat |
| Yan Sun, Hailou Zhang, Liu Ruiyi, Huang Rumin, Xiangrui Zhang, Shihan Zhou, Lei Wu, Boran Zhu, Haoxin W. Pyrolae herba alleviates cognitive impairment via TREM2 signaling to modulate neuroinflammation and neurogenesis in lipopolysaccharide-treated mice hippocampus. Journal of ethnopharmacology. 2023-09-22. PMID:37739108. |
pyrolae herba alleviates cognitive impairment via trem2 signaling to modulate neuroinflammation and neurogenesis in lipopolysaccharide-treated mice hippocampus. |
2023-09-22 |
2023-10-07 |
mouse |
| Shuwen Tan, Hui Gao, Jianyu Sun, Na Li, Yuxin Zhang, Liu Yang, Min Wang, Qiang Wang, Qian Zha. CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis. Neuromolecular medicine. 2023-01-13. PMID:36639554. |
moreover, in csr mice, the cd33 protein level in hippocampal tissue was significantly downregulated, but the trem2 protein level was increased. |
2023-01-13 |
2023-08-14 |
mouse |
| Chaitali Anand, Pedro D Maia, Justin Torok, Christopher Mezias, Ashish Ra. The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models. Scientific reports. vol 12. issue 1. 2022-12-08. PMID:36477076. |
trem2 appears to reduce tau accumulation rate while increasing its interregional spread from the hippocampal seed area, causing higher tau burden in the striatum, pallidum, and contralateral hippocampus. |
2022-12-08 |
2023-08-14 |
Not clear |
| Boram Kim, EunRan Suh, Aivi T Nguyen, Stefan Prokop, Bailey Mikytuck, Olamide A Olatunji, John L Robinson, Murray Grossman, Jeffrey S Phillips, David J Irwin, Dawn Mechanic-Hamilton, David A Wolk, John Q Trojanowski, Corey T McMillan, Vivianna M Van Deerlin, Edward B Le. TREM2 risk variants are associated with atypical Alzheimer's disease. Acta neuropathologica. 2022-09-16. PMID:36112222. |
pathologically, trem2 variant cases were associated with an atypical distribution of neurofibrillary tangle density with significantly lower hippocampal nft burden relative to neocortical nft accumulation. |
2022-09-16 |
2023-08-14 |
Not clear |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxi Chen, Yiping Li. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model. Physiology & behavior. 2022-04-22. PMID:35452628. |
treadmill exercise improve recognition memory by trem2 pathway to inhibit hippocampal microglial activation and neuroinflammation in alzheimer's disease model. |
2022-04-22 |
2023-08-13 |
Not clear |
| Jing Jiang, Hao Liu, Zidong Wang, Huiling Tian, Shun Wang, Jiayi Yang, Zhigang L. Effects of electroacupuncture on DNA methylation of the TREM2 gene in senescence-accelerated mouse prone 8 mice. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2022-03-02. PMID:35232269. |
to explore the mechanism by which electroacupuncture (ea) upregulates triggering receptor expressed on myeloid cells 2 (trem2) protein in the hippocampus of alzheimer's disease (ad) model animals from the perspective of trem2 dna methylation. |
2022-03-02 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
hippocampal overexpression of trem2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. |
2022-02-28 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
here, we investigated the effects of the hippocampal overexpression of trem2 on cognitive in long-term high-fat diet (hfd)-fed mice. |
2022-02-28 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
trem2 was overexpressed in the hippocampus 36 weeks after hfd feeding using adeno-associated virus vector (aav)-mediated gene delivery. |
2022-02-28 |
2023-08-13 |
mouse |