| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
furthermore, trem2 markedly increased the number of iba-1/arg-1-positive microglia in the hippocampus, suppressed neuroinflammation and microglial activation. |
2022-02-28 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
in sum, hippocampal trem2 plays an important role in improving hfd-induced cognitive dysfunction and promoting microglial polarization towards the m2 anti-inflammatory phenotype. |
2022-02-28 |
2023-08-13 |
mouse |
| Milan Stoiljkovic, Karel Otero Gutierrez, Craig Kelley, Tamas Horvath, Mihaly Hajo. Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid-β pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109230. |
impact of trem2 on hippocampal network oscillations in tg2576 mice modeling amyloid-β pathology. |
2022-02-03 |
2023-08-13 |
mouse |
| Rui Wang, Zhiyong Zhou, Dongfan Wang, Qingqing Zhao, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Chengfu Yuan, Ding Yuan, Ting Wan. Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway. Food & function. vol 12. issue 14. 2021-11-30. PMID:34075926. |
meanwhile, hfd increased the protein levels of pro-inflammatory factors including inos, cox-2 and il-1β but decreased the protein levels of anti-inflammatory factors such as cd206, tgf-β, ym-1 and arg 1 in the prefrontal cortex and hippocampus, downregulated the protein levels of trem2 and pi3k and decreased the phosphorylation level of akt, which can be reversed by cr treatment. |
2021-11-30 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
knockdown of astrocytic trem2 in the hippocampus relieves cognitive decline in elderly male mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Tao Yu, Hui Fu, Jing-Jing Sun, Dan-Rui Ding, Hua Wan. miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus. Experimental brain research. vol 239. issue 11. 2021-10-26. PMID:34476536. |
we examined changes in the expression of microrna-106b-5p (mirna-106b-5p), repulsive guidance molecule a (rgma), triggering receptor expressed on myeloid cells 2 (trem2), and the microglia-related markers interleukin (il)-1β, il-4, il-6, il-10, inducible nitric oxide synthase (inos), and arginase-1 (arg-1) in the mouse hippocampus of the lithium-pilocarpine-induced se mouse model. |
2021-10-26 |
2023-08-13 |
mouse |
| Tao Yu, Hui Fu, Jing-Jing Sun, Dan-Rui Ding, Hua Wan. miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus. Experimental brain research. vol 239. issue 11. 2021-10-26. PMID:34476536. |
we observed that mir-106b-5p level increased while both rgma and trem2 levels decreased post-se and showed associations with microglial activation and inflammation in the mouse hippocampus, suggesting their potential as se therapeutic targets. |
2021-10-26 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
the prevailing phenotype of trem2 r47h knock-in mice was decreased expression levels of trem2 in microglia, which resulted in decreased density of microglia in the hippocampus. |
2021-08-30 |
2023-08-13 |
mouse |
| Zhangjin Qin, Min Gu, Jian Zhou, Wenbo Zhang, Nan Zhao, Yang Lü, Weihua Y. Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ Synapse (New York, N.Y.). vol 74. issue 10. 2021-08-10. PMID:32412103. |
here, levels of trem2 gene and protein levels were observed to be higher in both cortex and hippocampus of the aβ |
2021-08-10 |
2023-08-13 |
Not clear |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
we compared the hippocampal gene and protein expressions of trem2 between the vd mice and sham-operated mice at different time points. |
2021-06-30 |
2023-08-13 |
mouse |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
interestingly, overexpression of trem2 by intracerebroventricular injection of a lentiviral vector that encoded trem2 (lv-trem2) significantly improved the spatial learning and memory and attenuated the hippocampal neural loss in vd mice. |
2021-06-30 |
2023-08-13 |
mouse |
| Milan Stoiljkovic, Karel Otero Gutierrez, Craig Kelley, Tamas L Horvath, Mihály Hajó. TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal of Alzheimer's disease : JAD. 2021-06-14. PMID:34120899. |
trem2 deficiency disrupts network oscillations leading to epileptic activity and aggravates amyloid-β-related hippocampal pathophysiology in mice. |
2021-06-14 |
2023-08-13 |
mouse |
| Nicole Scott-Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteol. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO journal. vol 39. issue 16. 2021-04-06. PMID:32657463. |
in hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed ps using annexin v or through microglial loss of trem2. |
2021-04-06 |
2023-08-13 |
mouse |
| Yaping Wang, Yan Lin, Linhan Wang, Hongrui Zhan, Xiaoting Luo, Yanyan Zeng, Wen Wu, Xingmei Zhang, Fang Wan. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging. vol 12. issue 20. 2021-03-29. PMID:33065553. |
in this study it has been demonstrated that the expression of trem2 was upregulated in hippocampus of 5xfad mice, whereas trem2 knock-out mediated by aav significantly increased the levels of pro-inflammatory cytokines and aggravated cognitive defect. |
2021-03-29 |
2023-08-13 |
mouse |
| Ke Fang, Hua-Rong Li, Xing-Xing Chen, Xin-Ran Gao, Ling-Ling Huang, An-Qi Du, Chuan Jiang, Hua Li, Jin-Fang G. Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32009956. |
results of western blot showed that the expression levels of bdnf, copine 6, p-trkb, and the triggering receptors expressed on myeloid cells (trem) 1 were decreased in both the hippocampus and the prefrontal cortex (pfc) of lps-challenged rats, while the expression of trem2 was increased. |
2020-09-28 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
up-regulation of trem2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
various immunohistochemical techniques and western blot analyses were applied to examine expressions of trem2, microglia, aβ, neuronal migration protein doublecortin (dcx) and bdnf in the hippocampus of mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Liang Sheng, Mingming Chen, Keshu Cai, Yu Song, Dongsheng Yu, Hui Zhang, Guangxu X. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31219699. |
aav infection induced microglial trem2 overexpression in the hippocampus of wild-type (wt) and thymus cell antigen 1-enhanced green fluorescent protein mice. |
2020-05-27 |
2023-08-13 |
mouse |
| Liang Sheng, Mingming Chen, Keshu Cai, Yu Song, Dongsheng Yu, Hui Zhang, Guangxu X. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31219699. |
additionally, hippocampal overexpression of trem2 in wt mice results in significant synaptic impairment. |
2020-05-27 |
2023-08-13 |
mouse |
| Yun Yang, Xiaomu Wu, Xinhui Qu, Xinrong Wang, Chaoqun Luo, Lingjuan Li, Kunnan Zhan. The Effect of Triggering Receptor Expressed by Myeloid Cells 2 Modified Bone Marrow Mesenchymal Stem Cells on Alzheimer's Disease-Mouse Model. Annals of clinical and laboratory science. vol 49. issue 1. 2019-07-16. PMID:30814074. |
this study aims to explore the effect of trem2 modified bmscs on hippocampus of ad mice. |
2019-07-16 |
2023-08-13 |
mouse |