| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuejiao Chen, Yan Chen, Runzhe Shu, Shunyuan Lu, Ming-Min Gu, Chunling Shen, Zhugang Wang, Xiaofang Cu. Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice. Hereditas. vol 162. issue 1. 2025-03-04. PMID:40033362. |
in this study, in addition to its expression in the dorsal root ganglia (drg), the primary afferent center that transmits pain, we identified dense expression of mrgf, particularly concentrated in the purkinje cell layer of the mouse cerebellum. |
2025-03-04 |
2025-03-06 |
mouse |
| James Widner, Phyllis L Faust, Elan D Louis, Hirofumi Fujit. Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39974874. |
axonal pathology differentially affects human purkinje cell subtypes in the essential tremor cerebellum. |
2025-02-20 |
2025-02-23 |
human |
| Marianna Tolve, Janine Tutas, Ebru Özer-Yildiz, Ines Klein, Anne Petzold, Veronika J Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Guenter Schwarz, Tatiana Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L Kononenk. The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses. Cell reports. vol 44. issue 2. 2025-02-07. PMID:39918958. |
the endocytic adaptor ap-2 maintains purkinje cell function by balancing cerebellar parallel and climbing fiber synapses. |
2025-02-07 |
2025-02-10 |
mouse |
| Elizabeth Mercado Ayón, Ellarie Talgo, Liam Flatley, Jennifer Coulman, David R Lync. Neurochemical alterations in the cerebellum in Friedreich's Ataxia mouse models. Experimental neurology. 2025-02-04. PMID:39904419. |
the purkinje cell postsynaptic receptor nmdar1 significantly decreased only in the frdakd cerebellum while other nmda receptor subunits, largely found in non-purkinje cells, did not change. |
2025-02-04 |
2025-02-07 |
mouse |
| Laura Pérez-Revuelta, David Pérez-Boyero, Ester Pérez-Martín, Valeria Lorena Cabedo, Pablo González Téllez de Meneses, Eduardo Weruaga, David Díaz, José Ramón Alons. Neuroprotective Effects of VEGF-B in a Murine Model of Aggressive Neuronal Loss with Childhood Onset. International journal of molecular sciences. vol 26. issue 2. 2025-01-25. PMID:39859255. |
this study aimed to identify an effective therapy using neurotrophic factors to delay the rapid and aggressive cerebellar degeneration experienced by the purkinje cell degeneration (pcd) mouse, a model of childhood-onset neurodegeneration with cerebellar atrophy (condca). |
2025-01-25 |
2025-01-28 |
mouse |
| Paul Hage, Mohammad Amin Fakharian, Alden M Shoup, Jay S Pi, Ehsan Sedaghat-Nejad, Simon P Orozco, In Kyu Jang, Vivian Looi, Hisham Y Elseweifi, Nazanin Mohammadrezaei, Alexander N Vasserman, Toren Arginteanu, Reza Shadmeh. Control of tongue movements by the Purkinje cells of the cerebellum. bioRxiv : the preprint server for biology. 2025-01-20. PMID:39829829. |
we identified the lingual regions of the cerebellar vermis and then measured the contribution of each purkinje cell (p-cell) to control of the tongue by relying on the brief but complete suppression that they experienced following an input from the inferior olive. |
2025-01-20 |
2025-01-23 |
Not clear |
| Xiaoyan Hao, Zhengwei Hu, Mengjie Li, Shuo Zhang, Mibo Tang, Chenwei Hao, Shasha Qi, Yuanyuan Liang, Michael F Almeida, Kaitlan Smith, Chunyan Zuo, Yanmei Feng, Mengnan Guo, Dongrui Ma, Shuangjie Li, Zhiyun Wang, Yuemeng Sun, Zhifen Deng, Chengyuan Mao, Zongping Xia, Yong Jiang, Yanxia Gao, Yuming Xu, Jonathan C Schisler, Changhe Sh. E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A. The EMBO journal. 2025-01-13. PMID:39806097. |
these interventions protect against cerebellar neuropathologies, particularly purkinje neuron mitophagy dysfunction. |
2025-01-13 |
2025-01-16 |
Not clear |
| Pablo S Martínez Lozada, Rafael Mancero Montalvo, Andrea Iturralde Carrillo, Maria Montesdeoca-Lozada, Jose A Rodas, Jose E Leon-Roja. Roles of CDR2 and CDR2L in Anti-Yo Paraneoplastic Cerebellar Degeneration: A Literature Review. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39795928. |
notably, at least 50% of pcd cases involve anti-yo autoantibodies, also referred to as anti-pca1 (purkinje cell antigen 1) antibodies, which specifically target cerebellar degeneration-related protein 2 (cdr2) and its paralogue, cdr2-like (cdr2l). |
2025-01-11 |
2025-01-14 |
human |
| b' Ikhlass Haj Salem, Mathieu Blais, Valeria M Zuluaga-S\\xc3\\xa1nchez, Laurence Rouleau, Esther B E Becker, Nicolas Dupr\\xc3\\xa. ARSACS: Clinical Features, Pathophysiology and iPS-Derived Models. Cerebellum (London, England). vol 24. issue 1. 2025-01-03. PMID:39753868.' |
neuropathological findings revealed cerebellar atrophy of the superior cerebellar vermis and the anterior vermis associated with purkinje cell death, pyramidal degeneration, cortical atrophy, loss of motor neurons, and demyelinating neuropathy. |
2025-01-03 |
2025-01-06 |
Not clear |
| Devry Mourra, Angela M Cavalieri, Madison M Casey, Mesut Sahin, Eric J Lan. Cerebellar Transcranial AC Stimulation Produces a Frequency-Dependent Bimodal Cerebellar Output Pattern. Cerebellum (London, England). vol 24. issue 1. 2025-01-02. PMID:39745631. |
previously, we showed that ac stimulation applied to the cerebellar surface produced a strong, frequency-dependent modulation of purkinje cell (pc) and cerebellar nuclear (cn) cell activity. |
2025-01-02 |
2025-01-04 |
rat |
| Kazuhiko Namikawa, Sol Pose-Méndez, Reinhard W Köste. Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum. Cellular and molecular life sciences : CMLS. vol 82. issue 1. 2024-12-26. PMID:39725709. |
genetic diseases of the human cerebellum often lead to degeneration of the principal neuron, the purkinje cell, resulting in locomotive deficits and socio-emotional impairments. |
2024-12-26 |
2024-12-29 |
human |
| Christine Li Mei Lee, Claire J Brabander, Yoko Nomura, Yasunari Kanda, Sachiko Yoshid. Embryonic exposure to acetamiprid insecticide induces CD68-positive microglia and Purkinje cell arrangement abnormalities in the cerebellum of neonatal rats. Toxicology and applied pharmacology. 2024-12-24. PMID:39719252. |
embryonic exposure to acetamiprid insecticide induces cd68-positive microglia and purkinje cell arrangement abnormalities in the cerebellum of neonatal rats. |
2024-12-24 |
2024-12-27 |
rat |
| Kim V Annink, Ilona C E van Leeuwen, Nina A Smeets, Lianne A J Peeters, Niek E van der Aa, Thomas Alderliesten, Floris Groenendaal, Reint K Jellema, Cora H A Nijboer, Peter G J Nikkels, Martin Lammens, Manon J N L Benders, Freek E Hoebeek, Jeroen Dudin. Uneven Distribution of Purkinje Cell Injury in the Cerebellar Vermis of Term Neonates with Hypoxic-Ischemic Encephalopathy. Cerebellum (London, England). vol 24. issue 1. 2024-12-19. PMID:39699839. |
uneven distribution of purkinje cell injury in the cerebellar vermis of term neonates with hypoxic-ischemic encephalopathy. |
2024-12-19 |
2024-12-21 |
Not clear |
| Rossella Conti, Céline Auge. Associative plasticity of granule cell inputs to cerebellar Purkinje cells. eLife. vol 13. 2024-12-11. PMID:39660722. |
granule cells of the cerebellum make up to 175,000 excitatory synapses on a single purkinje cell, encoding the wide variety of information from the mossy fibre inputs into the cerebellar cortex. |
2024-12-11 |
2024-12-13 |
Not clear |
| Mohammad Amin Fakharian, Alden M Shoup, Paul Hage, Hisham Y Elseweifi, Reza Shadmeh. A vector calculus for neural computation in the cerebellum. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605699. |
here, we found that in the marmoset cerebellum, spike-triggered averaging identified a potent vector unique to each purkinje cell (p-cell) along which the spikes of that cell displaced the eyes. |
2024-11-28 |
2024-11-30 |
marmoset |
| Nagham Khouri-Farah, Qiuxia Guo, Thomas A Perry, Ryan Dussault, James Y H L. bioRxiv : the preprint server for biology. 2024-11-22. PMID:39574602. |
mammalian cerebellar development is thought to be influenced by distinct purkinje cell (pc) subtypes. |
2024-11-22 |
2024-11-24 |
Not clear |
| Hiroshi Nishiyama, Naoko Nishiyama, Boris V Zemelma. Purkinje cell ablation and Purkinje cell-specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses. The Journal of physiology. 2024-11-19. PMID:39558452. |
purkinje cell ablation and purkinje cell-specific deletion of tsc1 in the developing cerebellum strengthen cerebellothalamic synapses. |
2024-11-19 |
2024-11-22 |
mouse |
| Silas E Busch, Christian Hanse. Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554002. |
non-allometric expansion and enhanced compartmentalization of purkinje cell dendrites in the human cerebellum. |
2024-11-18 |
2024-11-22 |
mouse |
| Silas E Busch, Christian Hanse. Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554002. |
purkinje cell (pc) dendrites are optimized to integrate the vast cerebellar input array and drive the sole cortical output. |
2024-11-18 |
2024-11-22 |
mouse |
| Bernardo Flores-Prieto, Flower Caycho-Salazar, Jorge Manzo, María Elena Hernández-Aguilar, Alfonso Genaro Coria-Avila, Deissy Herrera-Covarrubias, Fausto Rojas-Dúran, Gonzalo Emiliano Aranda-Abreu, Cesar Antonio Pérez-Estudillo, María Rebeca Toledo-Cárdena. Effect of Enriched Environment on Cerebellum and Social Behavior of Valproic Zebrafish. NeuroSci. vol 5. issue 2. 2024-11-01. PMID:39483495. |
to test this hypothesis, we assessed social behavior, cerebellar volume, and purkinje cell populations via histology and immunohistochemistry after exposing the fish to ee. |
2024-11-01 |
2024-11-03 |
zebrafish |