Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lushu Chen, HuiYing Zhang, Ying Zhang, Xiumiao Li, MeiHuan Wang, Yaming Shen, Yuan Cao, Yong Xu, Jin Ya. Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. Journal of neuroinflammation. vol 21. issue 1. 2024-10-29. PMID:39468551. |
notably, retinal microglia, the intrinsic immune cells of the retina, play a crucial role in the pathogenesis of retinopathy. |
2024-10-29 |
2024-10-31 |
Not clear |
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samue. Retinal ganglion cell circuits and glial interactions in humans and mice. Trends in neurosciences. 2024-10-25. PMID:39455342. |
rgcs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. |
2024-10-25 |
2024-10-29 |
mouse |
Yuedan Wang, Ying Li, Jiaqing Feng, Chuansen Wang, Yuwei Wan, Bingyang Lv, Yinming Li, Hao Xie, Ting Chen, Faxi Wang, Ziyue Li, Anhuai Yang, Xuan Xia. Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion. eLife. vol 13. 2024-10-09. PMID:39382568. |
a pronounced increase in microglia within the retina and peripheral leukocytes accessing the retina was observed during reperfusion periods. |
2024-10-09 |
2024-10-11 |
mouse |
Olivia Taylor, Nicholas DeGroff, Heithem El-Hodiri, Chengyu Gao, Andy J Fische. Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. bioRxiv : the preprint server for biology. 2024-10-01. PMID:39149287. |
further, ablation of microglia from the retina, wherein the formation of mgpcs in damaged retinas is impaired, has a significant impact upon expression patterns of s1p-related genes in mg. inhibition of s1pr1 and sphk1 partially rescued the formation of mgpcs in damaged retinas missing microglia. |
2024-10-01 |
2024-10-03 |
Not clear |
Olivia Taylor, Nicholas DeGroff, Heithem El-Hodiri, Chengyu Gao, Andy J Fische. Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. bioRxiv : the preprint server for biology. 2024-10-01. PMID:39149287. |
finally, we show that tgfβ/smad3 signaling in the resting retina maintains s1pr1 expression in mg. we conclude that the s1p signaling is dynamically regulated in mg and mgpcs and activation of s1p signaling depends, in part, on signals produced by reactive microglia. |
2024-10-01 |
2024-10-03 |
Not clear |
Ruihan Xiao, Xi Huang, Sheng Gao, Jianan Duan, Yun Zhang, Meixia Zhan. Microglia in retinal diseases: From pathogenesis towards therapeutic strategies. Biochemical pharmacology. 2024-09-22. PMID:39307318. |
microglia, a widely dispersed cohort of immune cells in the retina, are intricately involved in a diverse range of pivotal biological processes, including inflammation, vascular development, complement activation, antigen presentation, and phagocytosis. |
2024-09-22 |
2024-09-26 |
Not clear |
Ruihan Xiao, Xi Huang, Sheng Gao, Jianan Duan, Yun Zhang, Meixia Zhan. Microglia in retinal diseases: From pathogenesis towards therapeutic strategies. Biochemical pharmacology. 2024-09-22. PMID:39307318. |
recent studies on the ontogeny and broad functions of microglia in the retina have elucidated their characteristics during retinal development, homeostasis, and disease. |
2024-09-22 |
2024-09-26 |
Not clear |
Yuebing Wang, Sayaka Harada, Yoshio Goshima, Toshio Ohshim. Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury. Neuromolecular medicine. vol 26. issue 1. 2024-09-13. PMID:39266914. |
inhibition of crmp2 phosphorylation suppresses microglia activation in the retina and optic nerve and promotes optic nerve regeneration after optic nerve injury. |
2024-09-13 |
2024-09-15 |
mouse |
Eiman Mee. Role of Noncoding RNAs in Modulating Microglial Phenotype. Global medical genetics. vol 11. issue 4. 2024-09-11. PMID:39258255. |
microglia are immunocompetent cells that are present in the retina and central nervous system, and are involved in the development maintenance and immune functions in these systems. |
2024-09-11 |
2024-09-13 |
Not clear |
Eiman Mee. Role of Noncoding RNAs in Modulating Microglial Phenotype. Global medical genetics. vol 11. issue 4. 2024-09-11. PMID:39258255. |
microglia are also present in close association with resident cells in the retina where they engage in synapse formation, support normal functions, as well as immune defense. |
2024-09-11 |
2024-09-13 |
Not clear |
German Cuevas-Rios, Tawfik Abou Assale, Jannis Wissfeld, Annemarie Bungartz, Julia Hofmann, Thomas Langmann, Harald Neuman. Decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina. Glia. 2024-09-04. PMID:39228105. |
decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina. |
2024-09-04 |
2024-09-06 |
mouse |
Ping Song, Dhwani Parsana, Rupesh Singh, Lana M Pollock, Bela Anand-Apte, Brian D Perkin. Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39209978. |
microglia are resident immune cells in the central nervous system, including the retina that surveil the environment for damage and infection. |
2024-08-29 |
2024-09-04 |
zebrafish |
Katerina Palacka, Barbora Hermankova, Tereza Cervena, Pavel Rossner, Alena Zajicova, Eva Uherkova, Vladimir Holan, Eliska Javorkov. The Immunomodulatory Effect of Silver Nanoparticles in a Retinal Inflammatory Environment. Inflammation. 2024-08-27. PMID:39190103. |
these data indicate that agnps regulate reactivity of activated microglia in the diseased retina and thus could provide a beneficial effect for the treatment of several retinal diseases. |
2024-08-27 |
2024-08-30 |
mouse |
Yuxin Hu, Zhen Li, Hongxue Li, Qian Xu, Chengye Xu, Wenjian Lin, Xuefei Ma, Ming Hao, Hongyu Kuan. Severe hypoglycaemia-induced microglial inflammation damages microvascular endothelial cells, leading to retinal destruction. Diabetes & vascular disease research. vol 21. issue 4. 2024-08-26. PMID:39187253. |
human microglia (hmc) are stress-induced inflammatory cells of the retina. |
2024-08-26 |
2024-08-30 |
human |
Lingli Zhou, Zhenhua Xu, Haining Lu, Hongkwan Cho, Yangyiran Xie, Grace Lee, Kaoru Ri, Elia J Du. Suppression of inner blood-retinal barrier breakdown and pathogenic Müller glia activation in ischemia retinopathy by myeloid cell depletion. Journal of neuroinflammation. vol 21. issue 1. 2024-08-24. PMID:39182142. |
under non-ir conditions, plx treatment successfully depleted microglia in the retina. |
2024-08-24 |
2024-08-28 |
Not clear |
Jia Xu, Si-Jian Yu, Zi-Bing Ji. Assembling Retinal Organoids with Microglia. Journal of visualized experiments : JoVE. issue 209. 2024-08-14. PMID:39141532. |
microglia (mg) are unique resident macrophages in the retina and central nervous system (cns), serving crucial immunity functions. |
2024-08-14 |
2024-08-17 |
human |
Francisco Martín-Loro, Fátima Cano-Cano, María J Ortega, Belén Cuevas, Laura Gómez-Jaramillo, María Del Carmen González-Montelongo, Jan Cedric Freisenhausen, Almudena Lara-Barea, Antonio Campos-Caro, Eva Zubía, Manuel Aguilar-Diosdado, Ana I Arrob. Arylphthalide Delays Diabetic Retinopathy via Immunomodulating the Early Inflammatory Response in an Animal Model of Type 1 Diabetes Mellitus. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39126007. |
specifically, type 1 diabetes mellitus (t1d) has an immune component that may determine the evolution of dr by compromising the immune response of the retina, which is mediated by microglia. |
2024-08-10 |
2024-08-13 |
rat |
Giulia Midena, Luca Danieli, Elisabetta Pilotto, Luisa Frizziero, Edoardo Miden. Hyperreflective choroidal foci in diabetic eyes with and without macular edema: novel insights on diabetic choroidopathy. Experimental eye research. 2024-08-09. PMID:39122104. |
these hcf may represent, as in the retina, a sign of infiltration of inflammatory cells (mainly migrating microglia) into the choroid, according to the hypothesis raised by jerry lutty. |
2024-08-09 |
2024-08-13 |
human |
Chunge Ren, Min Chen, Bangqi Ren, Yuxiao Zeng, Qiang Tan, Qiyou Li, Xue Zhang, Yajie Fang, Yixiao Zhou, Weitao Zhang, Fang Chen, Baishijiao Bian, Yong Li. Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats. Neural regeneration research. 2024-08-05. PMID:39101643. |
concurrently, these small extracellular vesicles inhibited the activation of regional microglia, promoted the migration of transplanted retinal progenitor cells to the inner nuclear layer of the retina, and facilitated their differentiation into photoreceptors and bipolar cells. |
2024-08-05 |
2024-08-07 |
human |
Yumei Cao, Lei Qiao, Yingying Song, Yuanye Yan, Yewen Ni, Huiyu Xi, Jiayu Chen, Suyan Li, Haiyang Li. Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis. The American journal of pathology. 2024-07-20. PMID:39032599. |
microglia that reside in retina are activated after rd and are involved in the death of photoreceptor cells. |
2024-07-20 |
2024-07-24 |
rat |