| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Costanzo Frau, Frank M Corriga. Verbal Abuse, Depersonalization, and the Innate Alarm and Defensive Systems: A Single Case Illustration of Treatment with Deep Brain Reorienting. Journal of child & adolescent trauma. vol 18. issue 1. 2025-03-18. PMID:40098781. |
it is argued that suddenly aversive experiences engage the brainstem locus coeruleus in widespread noradrenergic activation of the thalamus and cortex such that the balance of functioning within the cortex becomes disturbed and a subjective experience of chronic depersonalization results. |
2025-03-18 |
2025-03-20 |
Not clear |
| Simon Lui, Arash Tadjalli, Jimmy Fraigne, John Peeve. Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity. Physiological reports. vol 13. issue 5. 2025-03-11. PMID:40067835. |
in adult male sprague-dawley rats, we demonstrate that hltf can also be triggered in the absence of repeated apneas by intermittent optogenetic stimulation of locus coeruleus (lc) neurons, or through pharmacological activation of adenosine-a2a-receptors at the level of brainstem xii motor pool. |
2025-03-11 |
2025-03-14 |
rat |
| Mayumi Watanabe, Akira Uematsu, Joshua P Johanse. Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus. Molecular psychiatry. 2025-03-07. PMID:40055498. |
noradrenaline from the brainstem locus coeruleus (lc) is activated during aversive emotion-inducing experiences, participates in extinction learning and is upregulated in individuals suffering from anxiety and trauma related disorders. |
2025-03-07 |
2025-03-12 |
rat |
| Xuefeng Yang, Fernando Tavares Fedumenti, Niels Niethard, Manfred Hallschmid, Jan Born, Karsten Raus. Regulation of peripheral glucose levels during human sleep. Sleep. 2025-02-23. PMID:39987458. |
they possibly reflect noradrenergic regulation of sympathetic activity via the brainstem locus coeruleus, and may be of relevance in clinical conditions with concurrent disturbances of sleep and glucose regulation. |
2025-02-23 |
2025-02-26 |
human |
| Kelsey E McDermott, Carol A Barne. Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques. Neurobiology of aging. vol 148. 2025-02-05. PMID:39908645. |
the locus coeruleus (lc) is a brainstem nucleus that provides the primary source of noradrenaline (na) in the nervous system and optimizes behavioral performance in mammals. |
2025-02-05 |
2025-02-08 |
human |
| Maxime Van Egro. Clinical Manifestations. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 3. 2025-01-03. PMID:39750625. |
the brainstem locus coeruleus (lc) is among the first sites of alzheimer's disease (ad) pathology, accruing hyperphosphorylated tau as early as in young adulthood. |
2025-01-03 |
2025-01-05 |
Not clear |
| Justin Tanner, Gerrit Orthlieb, Stephen Helms Tiller. Effect of touch on proprioception: non-invasive trigeminal nerve stimulation suggests general arousal rather than tactile-proprioceptive integration. Frontiers in human neuroscience. vol 18. 2024-10-29. PMID:39469503. |
task attention and arousal are physiologically regulated by the reticular activating system (ras), a brainstem circuit including the locus coeruleus (lc). |
2024-10-29 |
2024-10-31 |
Not clear |
| Changlin Wang, Sishi Chen, Zihan Cheng, Shiyong Xia, Chang Jun Fei, Li Ye, Liang Gong, Chunhua Xi, Yu Wan. Characteristics of locus coeruleus functional connectivity network in patients with comorbid migraine and insomnia. The journal of headache and pain. vol 25. issue 1. 2024-09-28. PMID:39333887. |
the locus coeruleus (lc), a brainstem region responsible for norepinephrine synthesis, participates in pain modulation, sleep/wake cycles, and emotional regulation, rendering it a potential nexus in the comorbidity of migraine and insomnia. |
2024-09-28 |
2024-10-01 |
Not clear |
| Fayaz A Mir, Sushil K Jh. The Kir channel in the nucleus tractus solitarius integrates the chemosensory system with REM sleep executive machinery for homeostatic balance. Scientific reports. vol 14. issue 1. 2024-09-17. PMID:39289431. |
the locus coeruleus (lc), nucleus tractus solitarius (nts), and retrotrapezoid nucleus (rtn) are critical chemosensory regions in the brainstem. |
2024-09-17 |
2024-09-20 |
Not clear |
| Shir Confino, Yair Wexler, Adar Medvetzky, Yotam Elazary, Zohar Ben-Moshe, Joel Reiter, Talya Dor, Simon Edvardson, Gali Prag, Tamar Harel, Yoav Gothil. A deleterious variant of INTS1 leads to disrupted sleep-wake cycles. Disease models & mechanisms. vol 17. issue 8. 2024-08-27. PMID:39189071. |
furthermore, ints1-deficent larvae exhibited elevated levels of dopamine β-hydroxylase (dbh) mrna in the locus coeruleus, a wakefulness-inducing brainstem center. |
2024-08-27 |
2024-08-30 |
human |
| Jung-Ick Byun, Geon-Ho Jahng, Chang-Woo Ryu, Soonchan Park, Kun Hee Lee, Sung Ok Hong, Ki-Young Jung, Won Chul Shi. Low arousal threshold is associated with altered functional connectivity of the ascending reticular activating system in patients with obstructive sleep apnea. Scientific reports. vol 14. issue 1. 2024-08-09. PMID:39122842. |
three brainstem nuclei-the locus coeruleus (lc), laterodorsal tegmental nucleus (ldtg), and ventral tegmental area (vta)-associated with osa in our previous study were used as seeds. |
2024-08-09 |
2024-08-13 |
human |
| Raisa Monteiro, Maheshkumar Kumar Sivasubramanian, Kelly S Harrison, Bhuvana Plakkot, Hafez Sadeghi, Madhan Subramanian, Clinton Jone. Examination of neuro-inflammation and senescence in brainstem of aged mice latently infected with human alphaherpesvirus 1 (HSV-1). Virus research. 2024-06-16. PMID:38880336. |
two important segments of the brainstem were examined in this study: principal sensory nucleus of the spinal trigeminal tract (pr5) because it receives direct afferent inputs from tg, and locus coeruleus (lc) because it is indirectly connected to pr5 and lc sends axonal projections to cortical structures, which may facilitate viral spread from brainstem to the brain. |
2024-06-16 |
2024-06-19 |
mouse |
| Amelien Vreven, Gary Aston-Jones, Anthony E Pickering, Gina R Poe, Barry Waterhouse, Nelson K Tota. In search of the locus coeruleus: guidelines to identify anatomical boundaries and physiological properties of the blue spot in mice, fish, finches and beyond. Journal of neurophysiology. 2024-06-06. PMID:38842506. |
one brain structure with neurochemical and anatomical homology throughout vertebrate species is the locus coeruleus (lc), a small collection of norepinephrine (ne) containing neurons in the brainstem that project throughout the central nervous system. |
2024-06-06 |
2024-06-08 |
mouse |
| Liyi Chen, Zhengdao Deng, Boateng Asamoah, Myles Mc Laughli. Trigeminal nerve direct current stimulation causes sustained increase in neural activity in the rat hippocampus. Brain stimulation. 2024-05-13. PMID:38740183. |
the tn gives input to brainstem nuclei, including the locus coeruleus that controls noradrenaline release across brain regions, including hippocampus. |
2024-05-13 |
2024-05-27 |
rat |
| Charles Rodenkirch, Qi Wan. Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation. Biology. vol 13. issue 2. 2024-02-23. PMID:38392298. |
the brainstem noradrenergic nucleus, the locus coeruleus (lc), exerts heavy influences on sensory processing, perception, and cognition through its diffuse projections throughout the brain. |
2024-02-23 |
2024-02-25 |
rat |
| Benjamin S Zide, Nancy J Donovan, Soyoung Lee, Sukriti Nag, David A Bennett, Heidi I L Jacob. Social activity mediates locus coeruleus tangle-related cognition in older adults. Molecular psychiatry. 2024-02-14. PMID:38355788. |
conversely, accumulation of tau tangles in the brainstem locus coeruleus nuclei is recently studied as a very early marker of alzheimer's disease (ad) pathogenesis and cognitive vulnerability, even among older adults without cognitive impairment or significant cerebral ad pathologies. |
2024-02-14 |
2024-02-17 |
Not clear |
| Liyi Chen, Zhengdao Deng, Boateng Asamoah, Myles Mc Laughli. Trigeminal nerve direct current stimulation causes sustained increase in neural activity in the rat hippocampus. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168241. |
the tn gives input to brainstem nuclei, including the locus coeruleus that controls noradrenaline release across brain regions, including hippocampus. |
2024-01-03 |
2024-01-06 |
rat |
| Masoumeh Kourosh Kourosh-Arami, Alireza Komaki, Masoumeh Gholam. The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem. Protein and peptide letters. 2023-11-27. PMID:38008945. |
hypocretin is involved in both arousal and addiction, and brainstem areas such as the locus coeruleus (lc), paragigantocellularis (pgi), and dorsal raphe (dr) contribute to these functions. |
2023-11-27 |
2023-11-28 |
Not clear |
| Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raed. Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus. Neurobiology of disease. 2023-11-17. PMID:37977430. |
the locus coeruleus (lc) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. |
2023-11-17 |
2023-11-20 |
rat |
| Sarah Nadine Meissner, Marc Bächinger, Sanne Kikkert, Jenny Imhof, Silvia Missura, Manuel Carro Dominguez, Nicole Wenderot. Self-regulating arousal via pupil-based biofeedback. Nature human behaviour. 2023-10-31. PMID:37904022. |
applying pupil self-regulation systematically modulates activity of the locus coeruleus and other brainstem structures involved in arousal control. |
2023-10-31 |
2023-11-08 |
human |