| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gisela Soledad Gualdoni, Camila Barril, Patricia Verónica Jacobo, Liliana Nazareth Pacheco Rodríguez, Elisa Cebra. Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis-vascularization of normal and experimental pathological mouse placenta related to maternal alcohol exposure. Frontiers in cell and developmental biology. vol 11. 2023-09-06. PMID:37670932. |
these placental angiogenic events are highly dependent on the coordination of several mechanisms at the early maternal-fetal interface, and one of them is the expression and activity of matrix metalloproteinases (mmps) and endothelial nitric oxide synthases (noss). |
2023-09-06 |
2023-10-07 |
mouse |
| Zhifang Tang, Hanzhen Feng, Xusheng Chen, Shuiyan Shao, Chuan L. SNORC knockdown alleviates inflammation, autophagy defect and matrix degradation of chondrocytes in osteoarthritis development. Molecular and cellular biochemistry. 2023-09-02. PMID:37659033. |
knocking down snorc in il-1β-induced chondrocytes obviously suppressed the production of nitric oxide (no), il-6, tumor necrosis factor (tnf)-α and prostaglandin e2 (pge2) to alleviate inflammation, and reduced the protein levels of a disintegrin and metalloproteinase with thrombospondin 5 (adamts5) and matrix metallopeptidase (mmp)13 and elevated collagen type 2 alpha 1 (col2a1) level to improve matrix degradation. |
2023-09-02 |
2023-09-07 |
rat |
| Laisla Zanetoni Martins, Maria Luiza Santos da Silva, Serginara David Rodrigues, Sáskia Estela Biasotti Gomes, Laura Molezini, Elen Rizzi, Marcelo Freitas Montenegro, Carlos Alan Dias-Junio. Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628999. |
placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (no) and the vascular activity of extracellular matrix metalloproteinase-2 (mmp-2). |
2023-08-26 |
2023-09-07 |
rat |
| Bingqing Wang, Yuqing Yang, Yichen Wang, Yanxin Yang, Yi Li, Chenxi Hu, Changyue Xu. Matrix stiffness regulates neovascular homeostasis through autophagy in nude mice. Journal of cellular physiology. 2023-08-11. PMID:37565586. |
endothelial function markers, such as endothelial nitric oxide synthase and e-selectin, were downregulated as the matrix stiffness increased. |
2023-08-11 |
2023-08-16 |
mouse |
| Judit Hodrea, Minh Ngoc Tran, Balazs Besztercei, Timea Medveczki, Attila J Szabo, Laszlo Őrfi, Illes Kovacs, Andrea Feket. Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511406. |
furthermore, flu demonstrated its protective effects by increasing the production of nitric oxide and facilitating the degradation of the extracellular matrix through the elevation of cathepsin k. these findings suggest that the s1r could be a novel target for the development of anti-fibrotic drugs and offer a new therapeutic approach for glaucoma. |
2023-07-29 |
2023-08-14 |
mouse |
| Cristal Jesus Toghi, Laisla Zanetoni Martins, Leonardo Lopes Pacheco, Edileia Souza Paula Caetano, Bruna Rahal Mattos, Elen Rizzi, Carlos Alan Dias-Junio. Pravastatin Prevents Increases in Activity of Metalloproteinase-2 and Oxidative Stress, and Enhances Endothelium-Derived Nitric Oxide-Dependent Vasodilation in Gestational Hypertension. Antioxidants (Basel, Switzerland). vol 12. issue 4. 2023-04-28. PMID:37107314. |
an impaired redox state leads to reduction in circulating nitric oxide (no) levels and activation of extracellular matrix metalloproteinases (mmps). |
2023-04-28 |
2023-08-14 |
rat |
| Guangqin Li, Jiahui Xian, Suisheng Li, Hui Su, Peisen Liao, Shihan Wang, Yawei Zhang, Wenqian Yang, Jun Yang, Yamei Sun, Yaling Jia, Qinglin Liu, Qinghua Li. Electrocatalytic Synthesis of Essential Amino Acids from Nitric Oxide Using Atomically Dispersed Fe on N-doped Carbon. Angewandte Chemie (International ed. in English). 2023-04-18. PMID:37072344. |
herein, we demonstrate an innovative method for artificial synthesis of essential α-amino acids from nitric oxide (no) by reacting with α-keto acids through electrocatalytic process with atomically dispersed fe supported on n-doped carbon matrix (ad-fe/nc) as the catalyst. |
2023-04-18 |
2023-08-14 |
Not clear |
| Yifei Sun, Keiichi Asano, Lauriane Sedes, Anna Cantalupo, Jens Hansen, Ravi Iyengar, Martin J Walsh, Francesco Ramire. Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells. JCI insight. 2023-04-06. PMID:37022786. |
smc3 highly express genes related to extracellular matrix formation and nitric oxide signaling, whereas ec4 transcriptional profile is enriched in smc, fibroblast, and immune cell-related genes. |
2023-04-06 |
2023-08-14 |
mouse |
| Chin-Feng Hsuan, Sean I F Teng, Chih-Neng Hsu, Daniel Liao, Allen Jiun-Wei Chang, Hsiao-Lin Lee, Siow-Wey Hee, Yi-Cheng Chang, Lee-Ming Chuan. Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979641. |
the molecular mechanism of diabetic cardiomyopathy includes impaired nutrient-sensing signaling, dysregulated autophagy, impaired mitochondrial energetics, altered fuel utilization, oxidative stress and lipid peroxidation, advanced glycation end-products, inflammation, impaired calcium homeostasis, abnormal endothelial function and nitric oxide production, aberrant epidermal growth factor receptor signaling, the activation of the renin-angiotensin-aldosterone system and sympathetic hyperactivity, and extracellular matrix accumulation and fibrosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Adityanarayan Mohapatra, Jagannath Mondal, Padmanaban Sathiyamoorthy, Ayeskanta Mohanty, Vishnu Revuri, Santhosh Kalash Rajendrakumar, Yong-Kyu Lee, In-Kyu Par. Thermosusceptible Nitric-Oxide-Releasing Nitrogel for Strengthening Antitumor Immune Responses with Tumor Collagen Diminution and Deep Tissue Delivery during NIR Laser-Assisted Photoimmunotherapy. ACS applied materials & interfaces. 2023-03-10. PMID:36896475. |
herein, a cancer treatment approach that combines photothermal therapy (ptt) and nitric oxide (no) gas therapy for tumor extracellular matrix (ecm) degradation, along with nlg919, an indoleamine 2,3-dioxygenase (ido) inhibitor that reduces tryptophan catabolism to kynurenine, and dmxaa, a stimulator of interferon gene (sting) agonist that stimulates antigen cross-presentation, is proposed to overcome this issue. |
2023-03-10 |
2023-08-14 |
Not clear |
| Hugh S Markus, Frank Erik de Leeu. Cerebral small vessel disease: Recent advances and future directions. International journal of stroke : official journal of the International Stroke Society. vol 18. issue 1. 2022-12-28. PMID:36575578. |
recent advances have implicated molecular processes related to endothelial dysfunction, nitric oxide synthesis, blood-brain barrier integrity, maintenance and repair of the extracellular matrix, and inflammation. |
2022-12-28 |
2023-08-14 |
Not clear |
| Sahar Foshati, Maryam Poursadeghfard, Zahra Heidari, Reza Aman. The efficacy and safety of ginger supplementation in patients with multiple sclerosis: A rationale and study protocol for a double-blind randomized controlled trial. Health science reports. vol 6. issue 1. 2022-12-26. PMID:36570345. |
therefore, we aim to determine the effect of ginger supplementation on neurofilament light chain, matrix metalloproteinase-9, interleukin-17, nitric oxide, complete and differential blood counts, disability status, quality of life, gastrointestinal symptoms, and body mass index (bmi) in ms patients. |
2022-12-26 |
2023-08-14 |
Not clear |
| Seonyoung Kim, Ji Yeon Lee, Jeong-Yong Park, YongGyeong Kim, Chang-Ho Kan. Nutrients. vol 14. issue 22. 2022-11-29. PMID:36432555. |
all lab strains (lacticaseibacillus rhamnosus mg4706, mg4709, and mg4711) inhibited nitric oxide (no)/inducible nitric oxide synthase (inos) in p. gingivalis lps-activated raw264.7 cells and pro-inflammatory cytokines (il-1β and il-6) and matrix metalloproteinase (mmp-8 and mmp-9) in hgf-1 cells. |
2022-11-29 |
2023-08-16 |
human |
| Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Y. AZD6738 Decreases Intraocular Pressure and Inhibits Fibrotic Response in Trabecular Meshwork through CHK1/P53 Pathway. Biochemical pharmacology. 2022-11-08. PMID:36347274. |
further, we demonstrated that azd6738 reduces cell viability and migration, and inhibit the expression of fibrosis-related factors including fibronectin (fn), α-smooth muscle actin (α-sma), laminin subunit beta 1 (lamb1), matrix metallopeptidase (mmp) family including mmp2 and mmp9, collagen Ⅰ (col1), and collagen Ⅳ (col4), reduce gap junctions, altered cytoskeleton and nitric oxide production in tgf-β1-induced human trabecular meshwork cells (htmcs) through the chk1/p53 pathway, which were affected aqueous humor (ah) production and outflow pathway. |
2022-11-08 |
2023-08-14 |
mouse |
| Vishal Patel, Amit Joharapurkar, Mukul Jai. Therapeutic Potential of Diacerein in Management of Pain. Current drug research reviews. vol 14. issue 3. 2022-10-25. PMID:36281831. |
the effect of diacerein and rhein on mediators of pain, such as transient receptor potential cation channel subfamily v (trpv1), substance p, glutamate, inflammatory cytokines, nitric oxide, matrix metalloproteinases, histamine, palmitoylethanolamide, nuclear factor-kappa b (nfkb), and prostaglandin, has also been discussed. |
2022-10-25 |
2023-08-14 |
Not clear |
| Alia H Mallah, Mahmoud Amr, Arda Gozen, Juana Mendenhall, Bernard J Van-Wie, Nehal I Abu-Lai. Interleukin 1β and lipopolysaccharides induction dictate chondrocyte morphological properties and reduce cellular roughness and adhesion energy comparatively. Biointerphases. vol 17. issue 5. 2022-09-30. PMID:36180273. |
nitric oxide, prostaglandin 2 (pge2), and matrix metalloproteinases 3 (mmp3) contents; viability of cells; and extracellular matrix components were quantified. |
2022-09-30 |
2023-08-14 |
cattle |
| Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Ta. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164879. |
the protein expression of inflammatory factors cyclooxygenase-2(cox-2), inducible nitric oxide synthetase(inos), tumor necrosis factor-α(tnf-α), and interleukin-1β(il-1β) in each group were detected by western blot, and the protein expression of matrix metalloprotease-13(mmp-13), aggrecan, collagen Ⅱ, fibroblast growth factor 2(fgf2) by immunofluorescence staining. |
2022-09-27 |
2023-08-14 |
rat |
| T A Kuznetsova, B G Andryukov, S F Polovov, A K Gazh. Modern aspects of burn injury immunopathogenesis and immuno-biochemical markers of wound healing (review of literature). Klinicheskaia laboratornaia diagnostika. vol 67. issue 8. 2022-09-12. PMID:36095081. |
the characteristics of the main immuno-biochemical markers of burn injury (cytokines and growth factors, nitric oxide, matrix metalloproteases, bacteria concentration levels) are present. |
2022-09-12 |
2023-08-14 |
Not clear |
| Taryn E Murray, Christy M Richards, Victoria N Robert-Gostlin, Anna K Bernath, Ivan A Lindhout, Andis Klegeri. Potential neurotoxic activity of diverse molecules released by astrocytes. Brain research bulletin. 2022-08-21. PMID:35988785. |
some of these molecules are neuroprotective and inflammation resolving while others, including reactive oxygen species (ros), nitric oxide (no), matrix metalloproteinase (mmp)-9, l-glutamate, and tumor necrosis factor α (tnf), are well-established toxins known to cause damage to surrounding cells and tissues. |
2022-08-21 |
2023-08-14 |
cat |
| Velmurugan Shanmugham, Ravi Subba. Capsanthin from Capsicum annum fruits exerts anti-glaucoma, antioxidant, anti-inflammatory activity, and corneal pro-inflammatory cytokine gene expression in a benzalkonium chloride-induced rat dry eye model. Journal of food biochemistry. 2022-07-27. PMID:35892258. |
capsanthin ameliorated in reducing oxidative stress by increasing serum antioxidant levels such as glutathione peroxidase (gpx), nitric oxide (no), and lactoferrin (ltf) and inhibiting matrix metalloproteinases 2 and 9 (mmp2 and mmp9) (p < .0001). |
2022-07-27 |
2023-08-14 |
rat |