| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew J Rossman, Rachel A Gioscia-Ryan, Zachary S Clayton, Michael P Murphy, Douglas R Seal. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clinical science (London, England : 1979). vol 134. issue 12. 2020-10-07. PMID:32584404. |
vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix. |
2020-10-07 |
2023-08-13 |
Not clear |
| Li Zeng, Cai Zhi Xiao, Zi Ting Deng, Rong Heng L. Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:28167976. |
the expression of c-terminal crosslinking telopeptide of type ii collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin e2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor |
2020-10-01 |
2023-08-13 |
rat |
| Atsushi Mizuma, Midori A Yenar. Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke. Frontiers in neurology. vol 8. 2020-10-01. PMID:28936196. |
inflammatory mediators involved in this response include cytokines, chemokines, adhesion molecules, and several immune molecule effectors such as matrix metalloproteinases-9, inducible nitric oxide synthase, nitric oxide, and reactive oxygen species. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zile, Napp. Diastolic Heart Failure. Current treatment options in cardiovascular medicine. vol 2. issue 5. 2020-09-30. PMID:11096548. |
mechanism-targeted therapy (future directions): modify neurohumoral activation using renin, angiotensin, and aldosterone system antagonists (ace inhibitors, angiotensin ii receptor blockade, aldosterone and renin antagonist); endothelin antagonists; nitric oxide agonists; and atrial natruretic peptide agonists; alter intracellular mechanisms; alter extracellular matrix structures. |
2020-09-30 |
2023-08-12 |
Not clear |
| Evgeny Sidorov, Dharambir K Sanghera, Jairam K P Vanamal. Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective. Journal of stroke. vol 21. issue 1. 2020-09-30. PMID:30732441. |
although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. |
2020-09-30 |
2023-08-13 |
Not clear |
| Abdulrazaq Yahaya, Damilola Babatunde, Lamidi W B Olaniyan, Oluranti Agbool. Application of chromatographic techniques in the analysis of total nitrosamines in water. Heliyon. vol 6. issue 3. 2020-09-28. PMID:32154411. |
nitrosamines are a potential source of nitric oxide (no) which can bind with metals present in the sample matrix leading to formation of metal - nitrosyl complexes and dissolved metals have the potential to increase the total nitrosamines in water. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yifan Wu, Zhanghong Wang, Zeng Lin, Xin Fu, Jingdi Zhan, Kehe Y. Salvianolic Acid A Has Anti-Osteoarthritis Effect Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32581777. |
we evaluated the expression of pro-inflammatory mediators and cartilage matrix catabolic enzymes in chondrocytes by elisa, griess reaction, immunofluorescence, and western blot, which includes nitric oxide (no), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6), prostaglandin e2 (pge2), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), mmps (mmp-3, mmp-13), and adamts-5. |
2020-09-28 |
2023-08-13 |
Not clear |
| Angel Mercy Sylus, Hanumanthappa Nandeesha, Thiagaraju Chitr. Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study. International journal of reproductive biomedicine. vol 18. issue 8. 2020-09-28. PMID:32923927. |
obesity, inflammation and alterations in matrix metalloproteinase-9 (mmp-9) and nitric oxide (no) levels are involved in the development of polycystic ovary syndrome (pcos). |
2020-09-28 |
2023-08-13 |
Not clear |
| Undurti N Da. Bioactive lipids in intervertebral disc degeneration and its therapeutic implications. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31533969. |
recent studies showed that ivd degeneration could be an inflammatory condition characterized by increased production of matrix metalloproteinases, tnf-α, nitric oxide, il-6, il-17, il-9, and prostaglandin e2, and decreased formation of anti-inflammatory molecules such as lipoxin a4. |
2020-09-15 |
2023-08-13 |
Not clear |
| Douglas R Seals, Erzsebet E Nagy, Kerrie L Morea. Aerobic exercise training and vascular function with ageing in healthy men and women. The Journal of physiology. vol 597. issue 19. 2020-09-09. PMID:31077372. |
vascular ageing is driven by oxidative stress, which reduces nitric oxide (no) bioavailability and stimulates changes in the extracellular matrix. |
2020-09-09 |
2023-08-13 |
Not clear |
| Jian-Sheng Wang, Wei-Wei Xiao, Yong-Sheng Zhong, Xue-Dong Li, Shi-Xin Du, Peng Xie, Gui-Zhou Zheng, Jing-Ming Ha. Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30565728. |
in addition, repression of gal-3 obviously impeded lps-stimulated inflammation damage as exemplified by a reduction in the release of inflammatory mediators interleukin (il)-1β, il-6, and tumor necrosis factor-α, as well as the production of nitric oxide and prostaglandin e2 (pge2) concomitant with the downregulation of matrix metalloproteinases (mmp)-13 and mmp-3 expression in atdc5 cells after lps administration. |
2020-07-20 |
2023-08-13 |
Not clear |
| Jyotsna Joshi, Mohammadreza Dehghan Abnavi, Chandrasekhar R Kothapall. Synthesis and secretome release by human bone marrow mesenchymal stem cell spheroids within three-dimensional collagen hydrogels: Integrating experiments and modelling. Journal of tissue engineering and regenerative medicine. vol 13. issue 10. 2020-07-16. PMID:31350819. |
we here elucidated the synthesis and deposition of ecm (e.g., elastin, sulfated glycosaminoglycans, hyaluronan, collagen type iii, laminin, fibrillin, lysyl oxidase, and nitric oxide synthases), matrix metalloproteinases (mmps) and their inhibitors (timps), and other secretome (cytokines, chemokines, and growth factors) in adult human bm-msc spheroid cultures within three-dimensional collagen gels. |
2020-07-16 |
2023-08-13 |
human |
| Regina A Nascimento, Jose S Possomato-Vieira, Giselle F Bonacio, Elen Rizzi, Carlos A Dias-Junio. Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats. Cells. vol 8. issue 11. 2020-07-06. PMID:31703340. |
reductions of circulating nitric oxide are followed by hypertension during pregnancy and increased activity of matrix metalloproteinases-2 and -9 in rats. |
2020-07-06 |
2023-08-13 |
rat |
| Regina A Nascimento, Jose S Possomato-Vieira, Giselle F Bonacio, Elen Rizzi, Carlos A Dias-Junio. Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats. Cells. vol 8. issue 11. 2020-07-06. PMID:31703340. |
hypertensive pregnancy has been associated with reduced nitric oxide (no), bioavailability, and increased activity of matrix metalloproteinases (mmps). |
2020-07-06 |
2023-08-13 |
rat |
| Carmela Rita Balistreri, Maurizio Forte, Ernesto Greco, Francesco Paneni, Elena Cavarretta, Giacomo Frati, Sebastiano Sciarrett. An overview of the molecular mechanisms underlying development and progression of bicuspid aortic valve disease. Journal of molecular and cellular cardiology. vol 132. 2020-07-01. PMID:31103478. |
among these, genes involved in the regulation of extracellular matrix remodelling, epithelial to mesenchymal transition and nitric oxide metabolism appear to be the main contributors to bav pathogenesis. |
2020-07-01 |
2023-08-13 |
Not clear |
| M Carla Crescitelli, M Belén Rauschemberger, Sabrina Cepeda, Marisa Sandoval, Virginia L Massheime. Role of estrone on the regulation of osteoblastogenesis. Molecular and cellular endocrinology. vol 498. 2020-06-24. PMID:31525430. |
the hormone significantly increased cell proliferation (38% above control), nitric oxide production (108% above control), alkaline phosphatase activity (50% above control), in addition to stimulation of extracellular matrix mineralization. |
2020-06-24 |
2023-08-13 |
Not clear |
| Kurt Farrell, Phillip Simmers, Gautam Mahajan, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pinet, Chandrasekhar R Kothapall. Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide. Experimental cell research. vol 384. issue 1. 2020-06-15. PMID:31473210. |
abdominal aortic aneurysms (aaa) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (no) signaling, and inflammation, influencing smooth muscle cell (smc) phenotype and gene expression. |
2020-06-15 |
2023-08-13 |
human |
| Jun Yao, Huiping Long, Jianping Zhao, Gang Zhong, Jia L. Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. Life sciences. vol 253. 2020-06-15. PMID:31927051. |
the result showed that nifedipine inhibited the expression of matrix metalloprotein(mmp)-13, interleukin (il)-1β, il-6, tumor necrosis factor (tnf)-α, cyclooxygenase (cox)-2, inducible nitric oxide (no) synthase (inos), and prostaglandin e2 (pge2), as well as reduced ros production in human oa chondrocytes, which was partially reversed by br. |
2020-06-15 |
2023-08-13 |
human |
| Bozidarka Zaric, Milan Obradovic, Andreja Trpkovic, Maciej Banach, Dimitri P Mikhailidis, Esma R Isenovi. Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications. Current medicinal chemistry. vol 27. issue 7. 2020-04-28. PMID:31480995. |
ecs synthesize and release compounds such as nitric oxide (no), metabolites of arachidonic acid, reactive oxygen species (ros) and enzymes that degrade the extracellular matrix. |
2020-04-28 |
2023-08-13 |
Not clear |
| Gordon Minru Xiong, Shaojun Yuan, Chek Kun Tan, Jun Kit Wang, Yang Liu, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choon. Endothelial cell thrombogenicity is reduced by ATRP-mediated grafting of gelatin onto PCL surfaces. Journal of materials chemistry. B. vol 2. issue 5. 2020-04-08. PMID:32261529. |
we observed that polycaprolactone (pcl) surfaces functionalized with poly(glycidyl methacrylate) [(p(gma)] brushes via atom transfer radical polymerization (atrp) alone resulted in the enhancement of an activated ec profile characterized by low production of nitric oxide (no), platelet activation and elevated expression levels of von willebrand factor (vwf) and matrix metalloproteinase-2 (mmp-2). |
2020-04-08 |
2023-08-13 |
Not clear |